Indian Journal of Pharmaceutical Sciences最新文献

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Effect and Mechanism of Dexmedetomidine on Inhibiting Proliferation, Migration and Invasion of Ovarian Cancer Cell Strain SKOV3 右美托咪定抑制卵巢癌细胞株SKOV3增殖、迁移和侵袭的作用及机制
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1070
Defei Xian, Qin Tang
{"title":"Effect and Mechanism of Dexmedetomidine on Inhibiting Proliferation, Migration and Invasion of Ovarian Cancer Cell Strain SKOV3","authors":"Defei Xian, Qin Tang","doi":"10.36468/pharmaceutical-sciences.1070","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1070","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70214928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paeoniflorin Derivaties from Peony Roots Affecting Osteoblastic and Osteoclastic Differentiation 牡丹根芍药苷衍生物对成骨细胞和破骨细胞分化的影响
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1139
E. Cho, Min-Sung Ko, C. H. Lee, Sul Lee, K. Hwang, So-Young Park
{"title":"Paeoniflorin Derivaties from Peony Roots Affecting Osteoblastic and Osteoclastic Differentiation","authors":"E. Cho, Min-Sung Ko, C. H. Lee, Sul Lee, K. Hwang, So-Young Park","doi":"10.36468/pharmaceutical-sciences.1139","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1139","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Electrocardiogram Observation on Chemotherapy and Radiotherapy Combined with Trastuzumab in Breast Cancer Postoperative Patients 化疗、放疗联合曲妥珠单抗对乳腺癌术后患者心电图观察的影响
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.691
Shan Huang, Xiaolei Wang, Lan Ma
{"title":"Effect of Electrocardiogram Observation on Chemotherapy and Radiotherapy Combined with Trastuzumab in Breast Cancer Postoperative Patients","authors":"Shan Huang, Xiaolei Wang, Lan Ma","doi":"10.36468/pharmaceutical-sciences.spl.691","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.691","url":null,"abstract":": Effect","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Alendronate Sodium Combined with Alpha-Calciferol on Chronic Obstructive Pulmonary Disease with Osteoporosis 阿仑膦酸钠联合α -钙化醇治疗慢性阻塞性肺疾病合并骨质疏松的疗效观察
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.676
Longqiang Guo, Degang Tao, Bing Chen, Hui Zhu, Fei Wang
{"title":"Effect of Alendronate Sodium Combined with Alpha-Calciferol on Chronic Obstructive Pulmonary Disease with Osteoporosis","authors":"Longqiang Guo, Degang Tao, Bing Chen, Hui Zhu, Fei Wang","doi":"10.36468/pharmaceutical-sciences.spl.676","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.676","url":null,"abstract":"We attempt to explore and study the effect of alendronate sodium combined with alpha-calciferol on chronic obstructive pulmonary disease patients with osteoporosis treatment and the changes of serum receptor activator for nuclear factor kappa B ligand and osteoprotegerin levels. We randomly selected 56 patients in the hospital from December 2021 to December 2022 as the study subjects. According to the time of admission, we divided them into two parts. 28 patients were given routine treatment as the control group and the other 28 patients were given alendronate sodium combined with alpha-calciferol as the observation group. Evaluate and compare both groups on the clinical efficacy rate and measure the serum receptor activator for nuclear factor kappa B ligand level and osteoprotegerin level after taking the fasting venous blood of the patients. The adverse reactions occurred during the treatment were counted and adverse reactions rate was calculated. The results showed that observation group had higher clinical control ratio and effective ratio than control group. In addition, observation group possessed higher clinical efficacy efficiency value of the patients than control group and the improvement was more obvious (p<0.05). In terms of serum level results, observation group had better data values of patients than control group. The serum receptor activator for nuclear factor kappa B ligand level, osteoprotegerin level, forced vital capacity 1 level and forced vital capacity 1/forced vital capacity values of patients in observation group were significantly improved than those in control group (p<0.05). In terms of adverse reaction evaluation, observation group during treatment had lower adverse reactions rate than control group (p<0.05). Alendronate sodium combined with alpha-calciferol can improve the clinical efficacy of chronic obstructive pulmonary disease and osteoporosis patients to a certain extent, and have a better effect on serum receptor activator for nuclear factor kappa B ligand, osteoprotegerin level and lung function.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Complement C1qA and Complement C1qB on the Prognosis of Osteosarcoma 补体C1qA和补体C1qB对骨肉瘤预后的影响
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.610
Bo Wen Wu, E. Y. Qiu, Weizhen Zeng, J. Chen, Z. Z. Li, A. Wu
{"title":"Impact of Complement C1qA and Complement C1qB on the Prognosis of Osteosarcoma","authors":"Bo Wen Wu, E. Y. Qiu, Weizhen Zeng, J. Chen, Z. Z. Li, A. Wu","doi":"10.36468/pharmaceutical-sciences.spl.610","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.610","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Glaucocalyxin B Relieving Dyskinesia Inflammation and Oxidative Stress in Parkinson's Disease Model Rats by Activating the NRF2/HO-1 Pathway 青光素B通过激活NRF2/HO-1通路缓解帕金森病模型大鼠运动障碍炎症和氧化应激
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1175
Z. Lin, Yunsu Wang, Yanling Gao
{"title":"Glaucocalyxin B Relieving Dyskinesia Inflammation and Oxidative Stress in Parkinson's Disease Model Rats by Activating the NRF2/HO-1 Pathway","authors":"Z. Lin, Yunsu Wang, Yanling Gao","doi":"10.36468/pharmaceutical-sciences.1175","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1175","url":null,"abstract":"To analyze that glaucocalyxin B can alleviate dyskinesia, inflammatory response and oxidative stress in Parkinson's disease model rats by activating the nuclear factor erythroid 2–related factor 2/heme oxygenase-1 pathway. 150 adults were divided into 5 groups, namely, the sham operation group (healthy mice), the Parkinson's group and the low-dose group (Parkinson+20 ng/ml) glaucocalyxin B), the medium-dose group (Parkinson+40 ng/ml glaucocalyxin B) and high-dose group (Parkinson+60 ng/ml glaucocalyxin B). The number of adjustment steps, the number of forepaw movements and the number of positive reactions in each group at 0 d have no difference; on the 3rd d in the Parkinson's group, dose group were reduced than in the sham operation group; on the 7th d, the number of steps in the Parkinson's group, and dose groups were reduced than the sham operation group. The tumor necrosis factor-alpha, interleukin-1 beta and interleukin-6 in the Parkinson's disease group, and dose groups were raised than those in the sham operation group, while these in the dose groups were reduced than in the Parkinson's group. The reactive oxidative stress concentration and myeloperoxidase activity of the Parkinson's group, dose group were raised than those of the sham operation group, while in the dose group were reduced than the Parkinson's group; superoxide dismutase activity level was reduced than the sham operation group. The levels of nuclear factor erythroid 2-related factor and heme oxygenase-1 in the Parkinson's group, dose groups were raised than those in the sham operation group, while in the dose groups were raised than those in the Parkinson's group. Further, in the low, medium and high dose groups increased with the increase of dose (p<0.05). Glaucocalyxin B can alleviate the dyskinesia of Parkinson's disease model rats and reduce the inflammatory response and oxidative stress response in rats, its relevant mechanism via activating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135360879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sodium Propionate Treatment Improves Facial Pain and Changes of Intestinal Flora and its Metabolites Induced by Stimulation of Dura Inflammation Soup in Rats 丙酸钠治疗可改善硬脑膜炎汤刺激大鼠面部疼痛及肠道菌群及其代谢物的变化
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.697
Jing Liu, C. Li, Wenjing Tang, S. Miao, Li Kang, S. Yu
{"title":"Sodium Propionate Treatment Improves Facial Pain and Changes of Intestinal Flora and its Metabolites Induced by Stimulation of Dura Inflammation Soup in Rats","authors":"Jing Liu, C. Li, Wenjing Tang, S. Miao, Li Kang, S. Yu","doi":"10.36468/pharmaceutical-sciences.spl.697","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.697","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Establishment of Co-Culture Model of Primary Mature Adipocytes and Hepatocytes in Non-Alcoholic Fatty Liver Model Rats and its Effect on Hepatocyte Steatosis 非酒精性脂肪肝模型大鼠原代成熟脂肪细胞与肝细胞共培养模型的建立及其对肝细胞脂肪变性的影响
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.700
Yichen Peng, D. Zheng, Yurong Zhang, Xianglin Chen, Jing Wang
{"title":"Establishment of Co-Culture Model of Primary Mature Adipocytes and Hepatocytes in Non-Alcoholic Fatty Liver Model Rats and its Effect on Hepatocyte Steatosis","authors":"Yichen Peng, D. Zheng, Yurong Zhang, Xianglin Chen, Jing Wang","doi":"10.36468/pharmaceutical-sciences.spl.700","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.700","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect and Safety of Amoxicillin-Clavulanate Potassium and Ceftriaxone Combined with Pulmonary Physical Therapy on Neonatal Pneumonia 阿莫西林-克拉维酸钾联合头孢曲松联合肺部物理治疗新生儿肺炎的疗效及安全性
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.731
Jing Li, Di Zhang, Wenxiu Yao
{"title":"Effect and Safety of Amoxicillin-Clavulanate Potassium and Ceftriaxone Combined with Pulmonary Physical Therapy on Neonatal Pneumonia","authors":"Jing Li, Di Zhang, Wenxiu Yao","doi":"10.36468/pharmaceutical-sciences.spl.731","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.731","url":null,"abstract":"The main objective of this study was to determine the effect, safety and intestinal microecology of amoxicillin-clavulanate potassium, ceftriaxone combined with pulmonary physical therapy on neonatal pneumonia. A total of 180 neonatal pneumonia patients in our hospital were studied and divided into research group (n=90) and control group (n=90). The control group was treated with amoxicillin-clavulanate potassium and ceftriaxone and the study group was treated with pulmonary physiotherapy on the basis of control group. The treatment cycle was 7 d. The two groups were compared with total response rate, symptom resolution time, lung function index, inflammatory factor index, adverse reactions and the number of major probiotics in the intestine. The total effective rate of the research group was significantly higher than that of the control group, the symptom disappearance time of the research group was shorter than that of the control group and the lung function index was better than that of the control group. The inflammatory factor index, the incidence of adverse reactions was lower than that of the control group and the main probiotics in the intestinal tract of the research group was more than that of the control group (p<0.05). For neonatal pneumonia, on the basis of amoxicillin-clavulanate potassium and ceftriaxone, supplemented with pulmonary physical therapy, the effect is better, the safety is high and it can improve the lung function level of patients, reduce the level of inflammatory factors and balance the gut microbiome.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135595962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Integrated Analysis of Transcriptome in Interleukin-10 Treated Peripheral Blood Cell Reveal Conservative Differential Expressed Genes 白细胞介素-10处理的外周血细胞转录组综合分析揭示保守差异表达基因
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1088
T. Chen, J. Liu, Z. Ding
{"title":"Integrated Analysis of Transcriptome in Interleukin-10 Treated Peripheral Blood Cell Reveal Conservative Differential Expressed Genes","authors":"T. Chen, J. Liu, Z. Ding","doi":"10.36468/pharmaceutical-sciences.1088","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1088","url":null,"abstract":"Chen et al. : Integrated Analysis of Transcriptome in Interleukin-10 Interleukin 10 is one of the important cytokines of immune system inflammatory response in critical diseases such as sepsis. The regulation mechanism of its signal pathway and the mining of key members can provide targets for disease diagnosis and treatment. A large number of studies have analyzed the response of interleukin 10 treated cells by means of transcriptome and identified the members of signal pathway from differentially expressed genes. However, the conditions of different studies are different, resulting in great differences in results. It is necessary to integrate and analyze the inherent differentially expressed genes. In this study, we collected 17 sets of transcriptome experimental results, all of which were analyzed in the treatment of interleukin 10 in peripheral blood cells. Through meta-analysis of 4695 gene expression in all experiments, we screened 134 genes, which were statistically significant differentially expressed genes in the random effect model (p<0.005). These genes enrich biological pathways related to immunity and wounding. Among them, the p value of tissue inhibitor of metalloproteinase 1, leupaxin, FAM20A Golgi associated secretory pathway pseudo kinase and interferon induced protein 44 is ≤9.82e-06. In 17 groups of experiments, the difference trend is relatively consistent and more experiments have detected more than twice the difference. These genes are valuable biomarkers for interleukin 10 related diseases such as sepsis. At the same time, it is a key member of the relatively more conservative interleukin 10 signaling pathway under different conditions.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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