Indian Journal of Pharmaceutical Sciences最新文献

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Synthesis, Cannabinoid Receptor Targeted Molecular Docking of Some New Pyrazole Derivatives as Hypolipidemic and Anti- Obesity Agents 一些新型吡唑类降血脂和抗肥胖药物的合成及大麻素受体靶向分子对接
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1084
M. Rani, R. Chauhan, S. Sharma, A. Singh, H. Badwik, A. Mishra, J. Dwivedi
{"title":"Synthesis, Cannabinoid Receptor Targeted Molecular Docking of Some New Pyrazole Derivatives as Hypolipidemic and Anti- Obesity Agents","authors":"M. Rani, R. Chauhan, S. Sharma, A. Singh, H. Badwik, A. Mishra, J. Dwivedi","doi":"10.36468/pharmaceutical-sciences.1084","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1084","url":null,"abstract":"caused notable reduction in body weight of high fat diet rats. Compound 4b i.e. (Z)-3-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylprop-2-en-1-one has ability to reduce body weight and improve lipid profile in rats and requires further studies to establish its safety and efficacy in preclinical and clinical subjects.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composite Ion Responsive In Situ Gel Based on Gellan/Carboxymethyl Cellulose Blend for Improved Gelation and Sustained Acyclovir Ocular Release 基于结冷胶/羧甲基纤维素混合物的复合离子响应原位凝胶的改进凝胶化和阿昔洛韦眼部持续释放
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1125
A. Chowhan, B. Ghosh, T. Giri
{"title":"Composite Ion Responsive In Situ Gel Based on Gellan/Carboxymethyl Cellulose Blend for Improved Gelation and Sustained Acyclovir Ocular Release","authors":"A. Chowhan, B. Ghosh, T. Giri","doi":"10.36468/pharmaceutical-sciences.1125","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1125","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nifedipine Gastro Retentive Drug Delivery System: Formulation Characterization and Evaluation 硝苯地平胃保留给药系统:配方表征与评价
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1133
Swati Ughade, R. D. Bawankar, D. R. Mundhada
{"title":"Nifedipine Gastro Retentive Drug Delivery System: Formulation Characterization and Evaluation","authors":"Swati Ughade, R. D. Bawankar, D. R. Mundhada","doi":"10.36468/pharmaceutical-sciences.1133","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1133","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Screening of Secondary Metabolites and Semi-Synthetic Analogues of Ramalina leiodea (Nyl.) Nyl. against Free Radicals Inflammation and Cancer Cell Lines Ramalina leiodea (Nyl.)次生代谢产物及半合成类似物的筛选Nyl。抗自由基、炎症和癌细胞系
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1146
K. Killari, D. Prasanth, P. K. Pasala, S. Panda, M. S. Samanth, H. Polimati, V. B. Tatipamula
{"title":"Screening of Secondary Metabolites and Semi-Synthetic Analogues of Ramalina leiodea (Nyl.) Nyl. against Free Radicals Inflammation and Cancer Cell Lines","authors":"K. Killari, D. Prasanth, P. K. Pasala, S. Panda, M. S. Samanth, H. Polimati, V. B. Tatipamula","doi":"10.36468/pharmaceutical-sciences.1146","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1146","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arsenic Compounds Arsenic Trioxide and Tetraarsenic Oxide Attenuate 3-Methylcholanthrene-Induced Cytotoxicity in Human Keratinocytes 三氧化二砷和四氧化二砷减弱3-甲基胆蒽诱导的人角质形成细胞的细胞毒性
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1147
J. Kim, Ildoo Kim
{"title":"Arsenic Compounds Arsenic Trioxide and Tetraarsenic Oxide Attenuate 3-Methylcholanthrene-Induced Cytotoxicity in Human Keratinocytes","authors":"J. Kim, Ildoo Kim","doi":"10.36468/pharmaceutical-sciences.1147","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1147","url":null,"abstract":"Kim et al. : Arsenic Compounds Attenuate 3-Methylcholanthrene-Induced Cytotoxicity As complex mixtures of carcinogenic metalloids, arsenic compounds have been reported to possess anticytotoxic and antitumor effects. In this study, we evaluated the in vitro protective effects of arsenic compounds tetraarsenic oxide and arsenic trioxide against 3-methylcholanthrene-induced toxicity in human keratinocytes. Human keratinocytes were treated with varying concentrations of arsenic compounds alone or in combination with 3-methylcholanthrene. Treatment with arsenic compounds did not significantly affect cell viability, whereas, 3-methylcholanthrene significantly reduced the viability of human keratinocytes. Furthermore, both tetraarsenic oxide and arsenic trioxide decreased the expression of cytochrome P4501A1 at messenger ribonucleic acid and protein levels in human keratinocytes cells treated with 3-methylcholanthrene. In addition, these arsenic compounds increased the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1, which was shown to be inhibited by 3-methylcholanthrene treatment. Together, these findings suggest that tetraarsenic oxide and tetraarsenic oxide significantly inhibit 3-methylcholanthrene-induced cytotoxicity in human keratinocytes by decreasing the expression of cytochrome P4501A1 and increasing the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1. Additionally, tetraarsenic oxide was found to be more effective than arsenic trioxide against 3-methylcholanthrene-induced cytotoxicity in vitro .","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Efficacy and Safety Analysis of Glucocorticoids plus Immunosuppressive Agents for Systemic Lupus Erythematosus and its Influence on N-Glycan 糖皮质激素联合免疫抑制剂治疗系统性红斑狼疮的临床疗效及安全性分析及对n -聚糖的影响
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.675
Min Jiang, H. Mei, YU L., Yanhua Tang, Chunhong Shi, J. Liu
{"title":"Clinical Efficacy and Safety Analysis of Glucocorticoids plus Immunosuppressive Agents for Systemic Lupus Erythematosus and its Influence on N-Glycan","authors":"Min Jiang, H. Mei, YU L., Yanhua Tang, Chunhong Shi, J. Liu","doi":"10.36468/pharmaceutical-sciences.spl.675","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.675","url":null,"abstract":":","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary Construction of Prognostic Risk Early Warning Model for Renal Cell Carcinoma with Type 2 Diabetes Mellitus Based on SMOTE Algorithm 基于SMOTE算法的2型糖尿病肾细胞癌预后风险预警模型初步构建
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.679
Yang Liu, Ling-Bin Meng, Jinawei Li, Guisong Qi, Miaomiao Song
{"title":"Preliminary Construction of Prognostic Risk Early Warning Model for Renal Cell Carcinoma with Type 2 Diabetes Mellitus Based on SMOTE Algorithm","authors":"Yang Liu, Ling-Bin Meng, Jinawei Li, Guisong Qi, Miaomiao Song","doi":"10.36468/pharmaceutical-sciences.spl.679","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.679","url":null,"abstract":"with type 2 diabetes mellitus combined with renal cell carcinoma are closely related to poor prognosis. Based on this, the individualized early warning model established by synthetic minority oversampling technique oversampling algorithm is beneficial to patients with high risk of poor prognosis early identification.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Role of SAR1B on Modulation of Nasopharyngeal Carcinoma Progression via Negative Regulation of Target of Rapamycin Complex 1 Signaling SAR1B通过负调控雷帕霉素复合体1信号靶调控鼻咽癌进展的作用
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.684
Xuebing Liu, Lei Chen, Shuying Ma
{"title":"Role of SAR1B on Modulation of Nasopharyngeal Carcinoma Progression via Negative Regulation of Target of Rapamycin Complex 1 Signaling","authors":"Xuebing Liu, Lei Chen, Shuying Ma","doi":"10.36468/pharmaceutical-sciences.spl.684","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.684","url":null,"abstract":"To speculate an autophagy gene, secretion associated Ras related guanosine triphosphatase 1B related signaling pathway for nasopharyngeal carcinoma based on both in vitro and in vivo experiments. 120 nasopharyngeal carcinoma biopsies (pathologically confirmed) were analyzed and the differentially expressed genes were explored. The internal molecular mechanism was further investigated using the human nasopharyngeal carcinoma cell lines, CNE1, HONE1 and C666-1. The cell proliferation capacity examination and the metabolic assays were performed in CNE1 cell line. The subcutaneous xenograft tumor mice model was also established. Secretion associated Ras related guanosine triphosphatase 1B demonstrated a remarkable decreased activity in nasopharyngeal carcinoma tissues compared with sibling paracancerous tissues. The key components in mammalian target of rapamycin complex 1 but not mammalian target of rapamycin complex 2 were greatly enhanced in nasopharyngeal carcinoma tissues. Moreover, the secretion associated Ras related guanosine triphosphatase 1B displayed a significant decreasing expression pattern and the mammalian target of rapamycin complex 1 kept an upward trend as the tumor, node and metastases stage progressed. The clinical significances for nasopharyngeal carcinoma tumor progression were calculated based on statistical analysis. The cell proliferation assay suggested that secretion associated Ras related guanosine triphosphatase 1B manipulated nasopharyngeal carcinoma cell proliferation via mammalian target of rapamycin complex 1/p70 ribosomal protein kinase 1 dependent signaling pathway. At the same time, transfection of secretion associated Ras related guanosine triphosphatase 1B small interfering ribonucleic acid could significantly enhanced the glycolytic capacity and glycolytic reserve of nasopharyngeal carcinoma cells compared with negative control. Silencing of secretion associated Ras related guanosine triphosphatase 1B promoted xenograft tumour growth, which could be greatly suppressed by rapamycin treatment in a dosage-dependent manner. The study shed a variety of insights for nasopharyngeal carcinoma from an innovative direction","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of PRECEDE-PROCEED Model in Health Education of Young and Middle-Aged with Lumbar Disc Herniation 前-后模式在中青年腰椎间盘突出症健康教育中的应用
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.622
Z. Wang, Y. Zhong, Yan Dai, W. Wang, Wenli Su, Liuqing Wu, Mengwen Chen
{"title":"Application of PRECEDE-PROCEED Model in Health Education of Young and Middle-Aged with Lumbar Disc Herniation","authors":"Z. Wang, Y. Zhong, Yan Dai, W. Wang, Wenli Su, Liuqing Wu, Mengwen Chen","doi":"10.36468/pharmaceutical-sciences.spl.622","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.622","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69634330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic Potential of Pomegranate (Punica granatum Linn.) against Breast Cancer 石榴对乳腺癌的治疗潜力
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.626
H. Tashkandi
{"title":"Therapeutic Potential of Pomegranate (Punica granatum Linn.) against Breast Cancer","authors":"H. Tashkandi","doi":"10.36468/pharmaceutical-sciences.spl.626","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.626","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69634380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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