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Indian Journal of Pharmaceutical Sciences最新文献

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Synthesis, Cannabinoid Receptor Targeted Molecular Docking of Some New Pyrazole Derivatives as Hypolipidemic and Anti- Obesity Agents 一些新型吡唑类降血脂和抗肥胖药物的合成及大麻素受体靶向分子对接
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1084
M. Rani, R. Chauhan, S. Sharma, A. Singh, H. Badwik, A. Mishra, J. Dwivedi
{"title":"Synthesis, Cannabinoid Receptor Targeted Molecular Docking of Some New Pyrazole Derivatives as Hypolipidemic and Anti- Obesity Agents","authors":"M. Rani, R. Chauhan, S. Sharma, A. Singh, H. Badwik, A. Mishra, J. Dwivedi","doi":"10.36468/pharmaceutical-sciences.1084","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1084","url":null,"abstract":"caused notable reduction in body weight of high fat diet rats. Compound 4b i.e. (Z)-3-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylprop-2-en-1-one has ability to reduce body weight and improve lipid profile in rats and requires further studies to establish its safety and efficacy in preclinical and clinical subjects.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Composite Ion Responsive In Situ Gel Based on Gellan/Carboxymethyl Cellulose Blend for Improved Gelation and Sustained Acyclovir Ocular Release 基于结冷胶/羧甲基纤维素混合物的复合离子响应原位凝胶的改进凝胶化和阿昔洛韦眼部持续释放
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1125
A. Chowhan, B. Ghosh, T. Giri
{"title":"Composite Ion Responsive In Situ Gel Based on Gellan/Carboxymethyl Cellulose Blend for Improved Gelation and Sustained Acyclovir Ocular Release","authors":"A. Chowhan, B. Ghosh, T. Giri","doi":"10.36468/pharmaceutical-sciences.1125","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1125","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nifedipine Gastro Retentive Drug Delivery System: Formulation Characterization and Evaluation 硝苯地平胃保留给药系统:配方表征与评价
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1133
Swati Ughade, R. D. Bawankar, D. R. Mundhada
{"title":"Nifedipine Gastro Retentive Drug Delivery System: Formulation Characterization and Evaluation","authors":"Swati Ughade, R. D. Bawankar, D. R. Mundhada","doi":"10.36468/pharmaceutical-sciences.1133","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1133","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Screening of Secondary Metabolites and Semi-Synthetic Analogues of Ramalina leiodea (Nyl.) Nyl. against Free Radicals Inflammation and Cancer Cell Lines Ramalina leiodea (Nyl.)次生代谢产物及半合成类似物的筛选Nyl。抗自由基、炎症和癌细胞系
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1146
K. Killari, D. Prasanth, P. K. Pasala, S. Panda, M. S. Samanth, H. Polimati, V. B. Tatipamula
{"title":"Screening of Secondary Metabolites and Semi-Synthetic Analogues of Ramalina leiodea (Nyl.) Nyl. against Free Radicals Inflammation and Cancer Cell Lines","authors":"K. Killari, D. Prasanth, P. K. Pasala, S. Panda, M. S. Samanth, H. Polimati, V. B. Tatipamula","doi":"10.36468/pharmaceutical-sciences.1146","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1146","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Arsenic Compounds Arsenic Trioxide and Tetraarsenic Oxide Attenuate 3-Methylcholanthrene-Induced Cytotoxicity in Human Keratinocytes 三氧化二砷和四氧化二砷减弱3-甲基胆蒽诱导的人角质形成细胞的细胞毒性
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1147
J. Kim, Ildoo Kim
{"title":"Arsenic Compounds Arsenic Trioxide and Tetraarsenic Oxide Attenuate 3-Methylcholanthrene-Induced Cytotoxicity in Human Keratinocytes","authors":"J. Kim, Ildoo Kim","doi":"10.36468/pharmaceutical-sciences.1147","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1147","url":null,"abstract":"Kim et al. : Arsenic Compounds Attenuate 3-Methylcholanthrene-Induced Cytotoxicity As complex mixtures of carcinogenic metalloids, arsenic compounds have been reported to possess anticytotoxic and antitumor effects. In this study, we evaluated the in vitro protective effects of arsenic compounds tetraarsenic oxide and arsenic trioxide against 3-methylcholanthrene-induced toxicity in human keratinocytes. Human keratinocytes were treated with varying concentrations of arsenic compounds alone or in combination with 3-methylcholanthrene. Treatment with arsenic compounds did not significantly affect cell viability, whereas, 3-methylcholanthrene significantly reduced the viability of human keratinocytes. Furthermore, both tetraarsenic oxide and arsenic trioxide decreased the expression of cytochrome P4501A1 at messenger ribonucleic acid and protein levels in human keratinocytes cells treated with 3-methylcholanthrene. In addition, these arsenic compounds increased the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1, which was shown to be inhibited by 3-methylcholanthrene treatment. Together, these findings suggest that tetraarsenic oxide and tetraarsenic oxide significantly inhibit 3-methylcholanthrene-induced cytotoxicity in human keratinocytes by decreasing the expression of cytochrome P4501A1 and increasing the expression of nicotinamide adenine dinucleotide phosphate quinone oxidoreductase 1. Additionally, tetraarsenic oxide was found to be more effective than arsenic trioxide against 3-methylcholanthrene-induced cytotoxicity in vitro .","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69607587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Alveolar Lavage Fluid Second-Generation Sequencing in the Treatment of Severe Pneumonia 肺泡灌洗液二代测序在重症肺炎治疗中的应用
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.673
M. He, Yalin Chen, Longwu Yu
{"title":"Application of Alveolar Lavage Fluid Second-Generation Sequencing in the Treatment of Severe Pneumonia","authors":"M. He, Yalin Chen, Longwu Yu","doi":"10.36468/pharmaceutical-sciences.spl.673","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.673","url":null,"abstract":"He et","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Efficacy and Safety Analysis of Glucocorticoids plus Immunosuppressive Agents for Systemic Lupus Erythematosus and its Influence on N-Glycan 糖皮质激素联合免疫抑制剂治疗系统性红斑狼疮的临床疗效及安全性分析及对n -聚糖的影响
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.675
Min Jiang, H. Mei, YU L., Yanhua Tang, Chunhong Shi, J. Liu
{"title":"Clinical Efficacy and Safety Analysis of Glucocorticoids plus Immunosuppressive Agents for Systemic Lupus Erythematosus and its Influence on N-Glycan","authors":"Min Jiang, H. Mei, YU L., Yanhua Tang, Chunhong Shi, J. Liu","doi":"10.36468/pharmaceutical-sciences.spl.675","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.675","url":null,"abstract":":","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary Construction of Prognostic Risk Early Warning Model for Renal Cell Carcinoma with Type 2 Diabetes Mellitus Based on SMOTE Algorithm 基于SMOTE算法的2型糖尿病肾细胞癌预后风险预警模型初步构建
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.679
Yang Liu, Ling-Bin Meng, Jinawei Li, Guisong Qi, Miaomiao Song
{"title":"Preliminary Construction of Prognostic Risk Early Warning Model for Renal Cell Carcinoma with Type 2 Diabetes Mellitus Based on SMOTE Algorithm","authors":"Yang Liu, Ling-Bin Meng, Jinawei Li, Guisong Qi, Miaomiao Song","doi":"10.36468/pharmaceutical-sciences.spl.679","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.679","url":null,"abstract":"with type 2 diabetes mellitus combined with renal cell carcinoma are closely related to poor prognosis. Based on this, the individualized early warning model established by synthetic minority oversampling technique oversampling algorithm is beneficial to patients with high risk of poor prognosis early identification.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Interference of Monoclonal Anti-Cluster of Differentiation 47 on Transfusion Compatibility Testing 单克隆抗分化簇47对输血相容性检测的干扰
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.606
Dan Xu, Xiuwen Ni, Tao Chen
{"title":"The Interference of Monoclonal Anti-Cluster of Differentiation 47 on Transfusion Compatibility Testing","authors":"Dan Xu, Xiuwen Ni, Tao Chen","doi":"10.36468/pharmaceutical-sciences.spl.606","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.606","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
C-C Motif Ligand 21/C-C Motif Chemokine Receptor 7 Modulated Tumor Properties for Non-Small Cell Lung Cancer Brain Metastasis Patients C-C基序配体21/C-C基序趋化因子受体7调控非小细胞肺癌脑转移患者的肿瘤特性
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.608
Y. W. Li, Feng He, Shuang Liu, Yu Zhang, Ling Li, Bin Wang, Lan Lan, Zheyi Pan
{"title":"C-C Motif Ligand 21/C-C Motif Chemokine Receptor 7 Modulated Tumor Properties for Non-Small Cell Lung Cancer Brain Metastasis Patients","authors":"Y. W. Li, Feng He, Shuang Liu, Yu Zhang, Ling Li, Bin Wang, Lan Lan, Zheyi Pan","doi":"10.36468/pharmaceutical-sciences.spl.608","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.608","url":null,"abstract":"axis could modulate tumor growth and survival time in vivo . Collectively, these data initiated a C-C motif ligand 21/C-C motif chemokine receptor 7-Janus kinase 2/signal transducer and activator of transcription 3 signaling for non-small cell lung cancer patients with brain metastasis, which shed various beneficial insights for future study.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69621494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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