{"title":"Association between Lung Microbiota Dysbiosis and Sepsis Induced Acute Respiratory Distress Syndrome","authors":"Jingkun Ye, Zhuandi Lin, Yuxia He, Shan Li","doi":"10.36468/pharmaceutical-sciences.spl.692","DOIUrl":null,"url":null,"abstract":"Ye et al. : Microbiota Dysbiosis in Sepsis Induced Acute Respiratory Distress Syndrome Sepsis is associated with acute respiratory distress syndrome, which has a significant impact on the prognosis of patients. Several studies have shown that the microbiota plays a significant role in sepsis-induced acute respiratory distress syndrome, but the relationship between the microbiota and sepsis-induced acute respiratory distress syndrome is not fully understood. We conducted a case-control and single-center study in 19 sepsis-induced acute respiratory distress syndrome patients and 36 sepsis-non-induced acute respiratory distress syndrome patients to investigate the clinical features and microbiota expression. There were 55 subjects enrolled, 19 of whom suffered acute respiratory distress syndrome due to sepsis. A significant increase in the abundance of Pseudomonas aeruginosa , leptospiral virus, Cytomegalovirus , Klebsiella pneumoniae , Streptococcus pneumoniae , Candida albicans , Escherichia coli , Epstein-Barr virus and Staphylococcus aureus . Besides, expressions of peripheral T lymphocytes (cluster of differentiation 3 + , cluster of differentiation 4 + and cluster of differentiation 3 + , cluster of differentiation 8 + ) was much higher in the sepsis-induced acute respiratory distress syndrome group than that in the sepsis non-induced acute respiratory distress syndrome group. The acute physiology and chronic health evaluation II scores, duration of mechanical ventilation and mortality with 28 d and 90 d were much higher in the sepsis-induced acute respiratory distress syndrome group. Patients with sepsis-induced acute respiratory distress syndrome had worse clinical outcomes and a higher expression of peripheral T lymphocytes, as well as the relative abundance of microbiota dysbiosis.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.4000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Indian Journal of Pharmaceutical Sciences","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.36468/pharmaceutical-sciences.spl.692","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHARMACOLOGY & PHARMACY","Score":null,"Total":0}
引用次数: 0
Abstract
Ye et al. : Microbiota Dysbiosis in Sepsis Induced Acute Respiratory Distress Syndrome Sepsis is associated with acute respiratory distress syndrome, which has a significant impact on the prognosis of patients. Several studies have shown that the microbiota plays a significant role in sepsis-induced acute respiratory distress syndrome, but the relationship between the microbiota and sepsis-induced acute respiratory distress syndrome is not fully understood. We conducted a case-control and single-center study in 19 sepsis-induced acute respiratory distress syndrome patients and 36 sepsis-non-induced acute respiratory distress syndrome patients to investigate the clinical features and microbiota expression. There were 55 subjects enrolled, 19 of whom suffered acute respiratory distress syndrome due to sepsis. A significant increase in the abundance of Pseudomonas aeruginosa , leptospiral virus, Cytomegalovirus , Klebsiella pneumoniae , Streptococcus pneumoniae , Candida albicans , Escherichia coli , Epstein-Barr virus and Staphylococcus aureus . Besides, expressions of peripheral T lymphocytes (cluster of differentiation 3 + , cluster of differentiation 4 + and cluster of differentiation 3 + , cluster of differentiation 8 + ) was much higher in the sepsis-induced acute respiratory distress syndrome group than that in the sepsis non-induced acute respiratory distress syndrome group. The acute physiology and chronic health evaluation II scores, duration of mechanical ventilation and mortality with 28 d and 90 d were much higher in the sepsis-induced acute respiratory distress syndrome group. Patients with sepsis-induced acute respiratory distress syndrome had worse clinical outcomes and a higher expression of peripheral T lymphocytes, as well as the relative abundance of microbiota dysbiosis.
期刊介绍:
The Indian Journal of Pharmaceutical Sciences (IJPS) is a bi-monthly Journal, which publishes original research work that contributes significantly to further the scientific knowledge in Pharmaceutical Sciences (Pharmaceutical Technology, Pharmaceutics, Biopharmaceutics, Pharmacokinetics, Pharmaceutical/Medicinal Chemistry, Computational Chemistry and Molecular Drug Design, Pharmacognosy and Phytochemistry, Pharmacology and Therapeutics, Pharmaceutical Analysis, Pharmacy Practice, Clinical and Hospital Pharmacy, Pharmacovigilance, Pharmacoepidemiology, Pharmacoeconomics, Drug Information, Patient Counselling, Adverse Drug Reactions Monitoring, Medication Errors, Medication Optimization, Medication Therapy Management, Cell Biology, Genomics and Proteomics, Pharmacogenomics, Bioinformatics and Biotechnology of Pharmaceutical Interest). The Journal publishes original research work either as a Full Research Paper or as a Short Communication. Review Articles on current topics in Pharmaceutical Sciences are also considered for publication by the Journal.