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Indian Journal of Pharmaceutical Sciences最新文献

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Development and Validation of Stability Indicating High Performance Liquid Chromatography Method for Determination of Molnupiravir in Capsule Dosage Form 高效液相色谱法测定莫诺比拉韦胶囊剂型的稳定性及验证
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1156
R. B. Patel, R. V. Solanki, S. P. Chauhan, D. M. Patel
{"title":"Development and Validation of Stability Indicating High Performance Liquid Chromatography Method for Determination of Molnupiravir in Capsule Dosage Form","authors":"R. B. Patel, R. V. Solanki, S. P. Chauhan, D. M. Patel","doi":"10.36468/pharmaceutical-sciences.1156","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1156","url":null,"abstract":"A simple, rapid and novel reverse phase-high performance liquid chromatography method was developed for quantification of molnupiravir in its capsule dosage form which is recently approved for phase III clinical trials in moderate coronavirus disease patients in India. The chromatographic separation of Molnupiravir was achieved on reverse phase-high performance liquid chromatography using Eclipse Plus C18 (150×4.6 mm, 5 µ) column with buffer (pH 4.5) and methanol (70:30 v/v) as mobile phase. Method was validated in accordance with recommendations of International Council for Harmonisation Q2 (R1) guidelines. The linearity of the method was found to be excellent over the concentration range of 49.80-149.40 µg/ml. The mean of the coefficient of determinations (r2, n=3) was found to be 0.9999. The precision values (percentage relative standard deviation) and overall percentage recovery was found to be acceptable. The proposed method effectively separated the drug from its degradation products. Hence, it can be used as a stability-indicating assay method for the routine analysis of molnupiravir in pharmaceutical formulations.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135360873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correlation between Prenatal Ultrasound Diagnosis of Dilated Fetal Bowel and Fetal Prognosis 产前超声诊断胎儿肠扩张与胎儿预后的关系
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.727
Jianqiang Su, Na Li, Congxin Sun, Guihong Chen, Yanhong Zhang, Lihua Liang, Xiaoliu Shao
{"title":"Correlation between Prenatal Ultrasound Diagnosis of Dilated Fetal Bowel and Fetal Prognosis","authors":"Jianqiang Su, Na Li, Congxin Sun, Guihong Chen, Yanhong Zhang, Lihua Liang, Xiaoliu Shao","doi":"10.36468/pharmaceutical-sciences.spl.727","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.727","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of the Minimum Inhibitory Concentration of Antibiotics against the Lactococcus Genus 抗生素对乳球菌属细菌最低抑菌浓度分析
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.709
Jinshang Liu, Cong Nie
{"title":"Analysis of the Minimum Inhibitory Concentration of Antibiotics against the Lactococcus Genus","authors":"Jinshang Liu, Cong Nie","doi":"10.36468/pharmaceutical-sciences.spl.709","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.709","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Impact of Early Goal-Directed Therapy in Conjunction with Glucocorticoids in the Prognosis of Septic Shock 早期目标导向治疗联合糖皮质激素对感染性休克预后的影响
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.704
C. Y. Quan, Xiaoli Wang, Qijun Zhang
{"title":"The Impact of Early Goal-Directed Therapy in Conjunction with Glucocorticoids in the Prognosis of Septic Shock","authors":"C. Y. Quan, Xiaoli Wang, Qijun Zhang","doi":"10.36468/pharmaceutical-sciences.spl.704","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.704","url":null,"abstract":"Quan et al. : Impact of Early Goal-Directed Therapy in the Prognosis of Septic Shock To assess the efficacy of early goal-directed therapy in conjunction with glucocorticoids on the prognosis of septic shock is the objective of the study. 60 septic shock patients admitted to the hospital from June 2019 to August 2022 were split into control cohort and observation cohort according to the method of random number table, with 40 patients in every cohort. Both cohorts underwent standard therapy, with the observation cohort additionally receiving intravenous hydrocortisone drip and early goal-directed therapy, all of which were continuously treated for 7 d. The baseline data of all patients, such as sex, age, infection site, sequential organ failure assessment score and immune cell level, were recorded in detail, and the C-reactive protein, intensive care unit hospitalization time, and the duration of mechanical ventilation was observed for patients. The therapeutic impact of early goal-directed therapy combined with glucocorticoids on septic shock in the analysis period aims to inform the optimal therapy strategy selection. Following therapy, the cluster of differentiation 4 + , cluster of differentiation 8 + and cluster of differentiation 4 + /cluster of differentiation 8 + ratios in both the therapy and control cohorts increased significantly, exhibiting statistical significance. The therapy cohort demonstrated a notable decrease in C-reactive protein, intensive care unit hospitalization duration and mechanical ventilation time when compared to the control cohort, with the difference being statistically significant. Early goal-directed therapy combined with glucocorticoid can enhance the cellular immune function of patients with septic shock, reduce the systemic inflammatory reaction and improve the prognosis.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigation on Potential Targets of Fuyuan Xingnao Decoction in the Treatment of Intracerebral Hemorrhage Based on Network Pharmacology 基于网络药理学的复元醒脑汤治疗脑出血的潜在靶点研究
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.702
Yanqi Luo, Shuangyang Li, Yanjiao Li, Xue Bai, Bangjiang Fang
{"title":"Investigation on Potential Targets of Fuyuan Xingnao Decoction in the Treatment of Intracerebral Hemorrhage Based on Network Pharmacology","authors":"Yanqi Luo, Shuangyang Li, Yanjiao Li, Xue Bai, Bangjiang Fang","doi":"10.36468/pharmaceutical-sciences.spl.702","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.702","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meta-Analysis on Clinical Outcomes of Paclitaxel-Coated Balloon Angioplasty in Femoral Popliteal Artery Occlusion 紫杉醇包被球囊血管成形术治疗股腘动脉闭塞的临床结果荟萃分析
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.716
Kaifeng Tang, J. Ye, S. Mao, H. Wang, Yuanyuan Chen
{"title":"Meta-Analysis on Clinical Outcomes of Paclitaxel-Coated Balloon Angioplasty in Femoral Popliteal Artery Occlusion","authors":"Kaifeng Tang, J. Ye, S. Mao, H. Wang, Yuanyuan Chen","doi":"10.36468/pharmaceutical-sciences.spl.716","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.716","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"265 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Activities of Daily Living Predict Contrast-Associated Acute Kidney Injury among Population Undergoing Coronary Angiography 在接受冠状动脉造影的人群中，日常生活活动预测对比相关的急性肾损伤
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.706
Q. R. Jiang, Siwei Yang, C. C. Lai, Z. M. A. Alsalman, P. Wang, X. L. Hu, W. B. Zhang, Y. X. Wang
{"title":"Activities of Daily Living Predict Contrast-Associated Acute Kidney Injury among Population Undergoing Coronary Angiography","authors":"Q. R. Jiang, Siwei Yang, C. C. Lai, Z. M. A. Alsalman, P. Wang, X. L. Hu, W. B. Zhang, Y. X. Wang","doi":"10.36468/pharmaceutical-sciences.spl.706","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.706","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"223 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical Efficacy of Medroxyprogesterone Combined with Different Antibiotics in the Treatment of Chronic Endometritis 甲羟孕酮联合不同抗生素治疗慢性子宫内膜炎的临床疗效观察
4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.spl.699
Lan Li, Jialin Li, Min Wang
{"title":"Clinical Efficacy of Medroxyprogesterone Combined with Different Antibiotics in the Treatment of Chronic Endometritis","authors":"Lan Li, Jialin Li, Min Wang","doi":"10.36468/pharmaceutical-sciences.spl.699","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.spl.699","url":null,"abstract":"","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135361904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kaempferol Promotes Apoptosis and Inhibited Autophagy in A549 Cells via MicroRNA-199/Mammalian Target of Rapamycin Axis 山奈酚通过MicroRNA-199/哺乳动物雷帕霉素轴靶蛋白促进A549细胞凋亡和抑制自噬
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1089
Junjie Wang, Bo Han
{"title":"Kaempferol Promotes Apoptosis and Inhibited Autophagy in A549 Cells via MicroRNA-199/Mammalian Target of Rapamycin Axis","authors":"Junjie Wang, Bo Han","doi":"10.36468/pharmaceutical-sciences.1089","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1089","url":null,"abstract":"Wang","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Formulation and Optimization of Propranolol Bilayer Tablets: A Potential Approach for Effective Management of Hypertension 心得安双层片的处方与优化:有效治疗高血压的潜在途径
IF 0.5 4区 医学
Indian Journal of Pharmaceutical Sciences Pub Date : 2023-01-01 DOI: 10.36468/pharmaceutical-sciences.1081
H. Mourya, N. Garud, R. Joshi, W. Akram, N. Singh
{"title":"Formulation and Optimization of Propranolol Bilayer Tablets: A Potential Approach for Effective Management of Hypertension","authors":"H. Mourya, N. Garud, R. Joshi, W. Akram, N. Singh","doi":"10.36468/pharmaceutical-sciences.1081","DOIUrl":"https://doi.org/10.36468/pharmaceutical-sciences.1081","url":null,"abstract":"The purpose of this investigation is to formulate and evaluate the antihypertensive drug propranolol hydrochloride sustained-release bilayer tablets. In this formulation, one layer provides a loading dose through the immediate release of the drug and the other layer provides a maintenance dose for up to 12 h through controlled release. Different quantities of polymers such as Kyron T-314, Hydroxypropyl methylcellulose-K4M, and ethyl cellulose were used to make bi-layer tablets by direct compression. The compatibility study of pharmaceutical excipients was conducted through Fourier transform infrared spectroscopy studies and no interaction was found. The pre-compression parameter for the angle of repose, bulk density, tapped density and compressibility index was assessed on the produced granules and the findings were good. The tablets were evaluated for the post-compression parameters for thickness, hardness, friability and in vitro release studies. In vitro dissolution study was approved out for 12 h using United States Pharmacopeia dissolution apparatus I using phosphate buffer of pH 1.2 and 6.8 as dissolution medium. Hydroxypropyl methylcellulose-K4M and ethylcellulose were used in combination in all formulations but optimized formulation propranolol hydrochloride tablet 4 showed a higher rate of drug release up to 12 h as compared to the other formulation and optimized formulations propranolol hydrochloride tablet 4 follows the Higuchi model with non-fickian diffusion based on regression coefficient of the kinetics data of cumulative drug release from the dosage form.","PeriodicalId":13292,"journal":{"name":"Indian Journal of Pharmaceutical Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69606690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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