Indian journal of experimental biology最新文献_第6页

Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and liver FGF-21 in fructose-induced metabolic syndrome rats 姜黄素对果糖代谢综合征大鼠血浆TBARS和IL-6、脂肪组织AFABP-4和肝脏FGF-21的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.3879

Suzan Murato ğ lu Severcan, Gülce Koca, C. Severcan, Canan Yılmaz, ÖzgeTu ğ çe Pa ş ao ğ lu, Hatice Pa ş ao ğ lu

{"title":"Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and liver FGF-21 in fructose-induced metabolic syndrome rats","authors":"Suzan Murato ğ lu Severcan, Gülce Koca, C. Severcan, Canan Yılmaz, ÖzgeTu ğ çe Pa ş ao ğ lu, Hatice Pa ş ao ğ lu","doi":"10.56042/ijeb.v61i08.3879","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.3879","url":null,"abstract":"Elucidation of the positive effects of curcumin on oxidative damage and inflammation, as well as clarifying the parameters related to adipose tissue and liver, would contribute furthermore to literature. Here, we have demonstrated the potential healing effects of curcumin in rats with metabolic syndrome (MetS). Twenty-four adult male Wistar albino rats were selected for the study. Only corn oil was administered to the control group rats, while corn oil and 20% fructose were administered to the MetS group rats for eight weeks. The curcumin dose groups were administered 100 and 200 mg/kg of curcumin dissolved in corn oil along with 20% fructose. Plasma TBARS, IL-6, adipose AFABP-4 and liver FGF-21 levels were determined using the ELISA method. It was observed that plasma TBARS and IL-6 levels were significantly decreased in the 100 and 200 mg/kg curcumin dose groups compared to the MetS group ( P ≤ 0.008). Adipose tissue A-FABP-4 levels in the 200 mg/kg curcumin dose group were significantly decreased compared to the MetS group ( P ≤ 0.008). FGF-21 levels in the 100 mg/kg and 200 mg/kg curcumin dose groups were significantly increased compared to the MetS group ( P ≤ 0.008). The healing effects of curcumin administration on MetS were effective on inflammation and lipid peroxidation. Curcumin administration decreased the adipose tissue AFABP-4 levels and increased the liver FGF-21 levels.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49190355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Circ_0004214 prevents human cardiomyocytes from doxorubicin induced cardiotoxicity by governing the miR-22-3p/GATA4 pathway Circ_0004214通过调控miR-22-3p/GATA4途径阻止人心肌细胞发生阿霉素诱导的心脏毒性

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.3674

L. Yang, Ya., Nan Liu, Yi Gu, Lan Zhu, Q. Guo

{"title":"Circ_0004214 prevents human cardiomyocytes from doxorubicin induced cardiotoxicity by governing the miR-22-3p/GATA4 pathway","authors":"L. Yang, Ya., Nan Liu, Yi Gu, Lan Zhu, Q. Guo","doi":"10.56042/ijeb.v61i08.3674","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.3674","url":null,"abstract":"In a clinical setting, the likelihood of doxorubicin (DOX) causing cardiotoxicity is high. However, the underlying mechanism remains obscure. In this study, we investigated whether DOX toxicity is associated with the deregulation of circular RNA_0004212 (circ_0004214). Circ_0004214, microRNA-22-3p (miR-22-3p), and GATA binding protein 4 (GATA4) expression in human cardiomyocyte AC16 cells was detected via RT-qPCR. Lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) production, malondialdehyde (MDA) content, and 4-hydroxynonenal (4-HNE) content were assessed using corresponding commercial kits. Cell viability and apoptosis were analyzed using cell counting kit-8 (CCK-8) and flow cytometry assays. Western blot assay was used to evaluate apoptosis-related markers and GATA4 protein levels. Dual-luciferase reporter validated the relationship between miR-22-3p and circ_0004214 or GATA4. Declined circ_0004214 was viewed in DOX-treated AC16 cells. DOX treatment weakened cell viability, and promoted oxidative stress and apoptosis, which was ameliorated via circ_0004214 overexpression. In addition, circ_0004214 promoted GATA4 expression by decoying miR-22-3p. Overall, the results have demonstrated that circ_0004214 protects against DOX-induced cardiotoxicity via governing miR-22-3p/GATA4 pathway, and thereby reveal promising therapeutic strategies against cardiotoxicity.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48056937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ganoderma applanatum (Pers.) Pat. augments antitumor activity of doxorubicin and provides chemoprevention to murine tumor model 平顶灵芝(Pers.)帕特。增强阿霉素抗肿瘤活性，对小鼠肿瘤模型有化学预防作用

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.3873

引用次数: 0

BRMS1L mediated effect of miR-20a-5p expression on proliferation and apoptosis of gastric cancer cells BRMS1L介导miR-20a-5p表达对胃癌细胞增殖和凋亡的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2536

引用次数: 0

Effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes of patients with unexplained recurrent spontaneous abortion 补肾活血方加减联合主动免疫治疗对不明原因反复自然流产患者免疫调节功能及妊娠结局的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2468

引用次数: 0

Serum triacylglycerol: A putative early biomarker of disease severity of Type 2 diabetes mellitus compared to microalbuminuria 血清三酰甘油：与微量白蛋白尿相比，2型糖尿病疾病严重程度的早期生物标志物

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2214

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Evaluation of radioprotective properties of Trianthema portulacastrum L. stem extract in vivo 马齿苋茎提取物的体内辐射防护性能评价

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2216

引用次数: 0

Effect of external washing with self-made Xiaofeng Jiedu powder on expressions of serum inflammatory cytokines in patients with cutaneous adverse events induced by programmed cell death protein 1 inhibitor 自制消风解毒散外洗对程序性细胞死亡蛋白1抑制剂所致皮肤不良事件患者血清炎症因子表达的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2464

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From error to uncertainty: A search for variabilities in the laboratory reports 从错误到不确定性：对实验室报告可变性的探索

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2284

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Diagnostic and prognostic values of abdominal ultrasound combined with urinary intestinal fatty acid binding protein for neonatal necrotizing enterocolitis 腹部超声联合尿肠脂肪酸结合蛋白对新生儿坏死性小肠结肠炎的诊断及预后价值

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2467

引用次数: 0