Indian journal of experimental biology最新文献_第6页

Outcomes of wuhan, alpha, delta, omicron and other variants in severe acute respiratory syndrome coronavirus-2 武汉、阿尔法、德尔塔、奥密克戎和其他变异株在严重急性呼吸综合征冠状病毒2型中的结果

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.4375

引用次数: 1

Utility of risk prediction nomogram for lymph node metastasis in the elderly with undifferentiated early gastric cancer 风险预测列线图在老年未分化早期癌症淋巴结转移中的应用

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.4376

Yajun Zhang, Tiansheng Yin, Yang Liu, Jiajun Xiao

{"title":"Utility of risk prediction nomogram for lymph node metastasis in the elderly with undifferentiated early gastric cancer","authors":"Yajun Zhang, Tiansheng Yin, Yang Liu, Jiajun Xiao","doi":"10.56042/ijeb.v61i08.4376","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.4376","url":null,"abstract":"Gastric cancer (also called stomach cancer) is the 5 th most common cancer the human population suffer from, particularly in East Asia. For effective prevention, it is important to find biomarkers for early-stage diagnosis and prognosis. Further, finding the risk factors that are associated with undifferentiated early gastric cancer is the utmost required. Here, we explored the clinicopathological characteristics of undifferentiated early gastric cancer (EGC) in the elderly, and the risk factors for lymph node metastasis. A total of 187 elderly patients with undifferentiated EGC were selected as subjects, whose clinical data were analyzed retrospectively. They were divided into lymph node metastasis and non-lymph node metastasis groups, and the risk factors for lymph node metastasis were analyzed by univariate and multivariate logistic regression analyses. A nomogram model was established to predict the risk of lymph node metastasis, and then validated. Lymph node metastasis was detected in 32 (17.11%) of the 187 cases. Univariate analysis showed that tumor diameter, depth of invasion, vascular tumor thrombus and local ulcer affected lymph node metastasis ( P <0.05). Multivariate logistic regression analysis revealed that tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer were independent risk factors ( P <0.05). The nomogram model was constructed based on the independent risk factors, and its concordance index and area under the receiver operating characteristic curve were 0.756 (95%CI: 0.684-0.830) and 0.758 (95%CI: 0.701-0.815), respectively. Calibration curve and model calibration curve suggested that the predicted probability of the model was consistent with the actual one, indicating high accuracy. Lymph node metastasis of the elderly with undifferentiated EGC is affected by many factors, among which tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer are independent risk factors.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44634707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing mortality in ICU hospitalized patients with severe sepsis: A systematic review and meta-analysis ICU重症脓毒症住院患者死亡率的影响因素:系统回顾和荟萃分析

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.4373

Keke Wu, Yun Luo, J. Qin, Xiaxia Xu

{"title":"Factors influencing mortality in ICU hospitalized patients with severe sepsis: A systematic review and meta-analysis","authors":"Keke Wu, Yun Luo, J. Qin, Xiaxia Xu","doi":"10.56042/ijeb.v61i08.4373","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.4373","url":null,"abstract":"Sepsis is one of the primary causes of mortality in the world. When the sepsis develops into acute organ dysfunction it is considered severe. Severe sepsis increases the economic burden by means of potential treatment for inflammatory responses and multiple organ failure. Several factors, including age, inappropriate use of antibiotics, comorbidities, multiple organ dysfunction, and site of infection, are considered to increase mortality risk in severe septic patients. This systematic review analyses various factors influencing mortality in ICU-hospitalized patients with severe sepsis. A systematic search for relevant articles up to September 2022 was carried out on 6 electronic databases, including Scopus, MEDLINE, PubMed, ScienceDirect, Embase and Google Scholar. Of 1078 articles, only nine studies were reviewed after meeting the inclusion criteria. Meta-analysis of three studies reveal significantly more fatality in older patients than the younger (OR; 2.28: 1.65, 3.15: 95% CI: I 2 = 11%, P <0.00001). The number of organ failure also significantly influences the mortality with the mortality rate being higher for patients with ≥4 organ failures (OR; 0.19: 0.11, 0.30: 95% CI: I 2 = 93%: P <0.00001). The mortality rates for hospital-acquired, community-acquired and ICU-acquired infections were 0.41 (95% CI; 0.18, 0.69), 0.40 (95% CI; 0.20, 0.63), and 0.42 (95% CI; 0.44, 0.53), respectively. Gender shows no significant difference on mortality rates (OR; 1.05: 0.95, 1.16: 95% CI: I 2 = 27%: p = 0.35). Age, the number of organ failures, and the acquisition sites seem to significantly influence the mortality, while gender has an insignificant influence on the mortality of ICU-admitted severe septic patients.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48183793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes 在与糖尿病相关的不可预测的慢性轻度应激模型中大鼠心脏的细胞外基质重塑

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.2286

Houcine Dab, S. Hamed, W. Hodroj, L. Zourgui

{"title":"Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes","authors":"Houcine Dab, S. Hamed, W. Hodroj, L. Zourgui","doi":"10.56042/ijeb.v61i08.2286","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.2286","url":null,"abstract":"The coexistence of depression and diabetes is a serious challenge in cardiovascular disease. However, extracellular matrix (ECM) under stress model associated or not with diabetes remains unknown. This study aims to investigate the involvement of diabetes and unpredictable chronic mild stress (UCMS) on ECM remodelling. Rats were exposed to UCMS, diabetes or combined treatment. mRNA expression of matrix metalloproteinases (MMP-2 and MMP-9), plasminogen activator (t-PA) and inhibitor (PAI-1) was examined by Q-RT-PCR. ECM was determined by ELISA. MMP-2 and MMP-9 mRNA was lower in diabetes ( P <0.05). UCMS increased MMP-2 and MMP-9 compared to control and diabetic group. Compared to the control and diabetes groups, MMP-2 and MMP-9 mRNA was significantly increased in the combined treatment group. UCMS increased MMP-2 expression in the diabetic group ( P <0.01). Compared to control, gelatinase activity was higher in diabetes and UCMS ( P <0.05). Combined diabetes and UCMS significantly increased gelatinase activity compared to T2D and UCMS groups. Collagen, hydroxyproline and fibronectin content were significantly increased in diabetes and combined groups. UCMS combined with diabetes exacerbated diabetes-induced MMPs and fibronectin deposition. In conclusion, comorbidity between diabetes and UCMS may exacerbate ECM remodelling. These findings will be useful in understanding diabetes-induced cardiovascular disease.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42292261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and liver FGF-21 in fructose-induced metabolic syndrome rats 姜黄素对果糖代谢综合征大鼠血浆TBARS和IL-6、脂肪组织AFABP-4和肝脏FGF-21的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.3879

Suzan Murato ğ lu Severcan, Gülce Koca, C. Severcan, Canan Yılmaz, ÖzgeTu ğ çe Pa ş ao ğ lu, Hatice Pa ş ao ğ lu

{"title":"Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and liver FGF-21 in fructose-induced metabolic syndrome rats","authors":"Suzan Murato ğ lu Severcan, Gülce Koca, C. Severcan, Canan Yılmaz, ÖzgeTu ğ çe Pa ş ao ğ lu, Hatice Pa ş ao ğ lu","doi":"10.56042/ijeb.v61i08.3879","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.3879","url":null,"abstract":"Elucidation of the positive effects of curcumin on oxidative damage and inflammation, as well as clarifying the parameters related to adipose tissue and liver, would contribute furthermore to literature. Here, we have demonstrated the potential healing effects of curcumin in rats with metabolic syndrome (MetS). Twenty-four adult male Wistar albino rats were selected for the study. Only corn oil was administered to the control group rats, while corn oil and 20% fructose were administered to the MetS group rats for eight weeks. The curcumin dose groups were administered 100 and 200 mg/kg of curcumin dissolved in corn oil along with 20% fructose. Plasma TBARS, IL-6, adipose AFABP-4 and liver FGF-21 levels were determined using the ELISA method. It was observed that plasma TBARS and IL-6 levels were significantly decreased in the 100 and 200 mg/kg curcumin dose groups compared to the MetS group ( P ≤ 0.008). Adipose tissue A-FABP-4 levels in the 200 mg/kg curcumin dose group were significantly decreased compared to the MetS group ( P ≤ 0.008). FGF-21 levels in the 100 mg/kg and 200 mg/kg curcumin dose groups were significantly increased compared to the MetS group ( P ≤ 0.008). The healing effects of curcumin administration on MetS were effective on inflammation and lipid peroxidation. Curcumin administration decreased the adipose tissue AFABP-4 levels and increased the liver FGF-21 levels.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49190355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of respiratory muscle assessment-based muscle relaxation training on postoperative pulmonary function rehabilitation, sputum excretion and quality of life of patients receiving thoracic surgeries 基于呼吸肌评估的肌肉放松训练对胸部手术患者术后肺功能康复、排痰和生活质量的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.2499

引用次数: 0

Circ_0004214 prevents human cardiomyocytes from doxorubicin induced cardiotoxicity by governing the miR-22-3p/GATA4 pathway Circ_0004214通过调控miR-22-3p/GATA4途径阻止人心肌细胞发生阿霉素诱导的心脏毒性

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.3674

L. Yang, Ya., Nan Liu, Yi Gu, Lan Zhu, Q. Guo

{"title":"Circ_0004214 prevents human cardiomyocytes from doxorubicin induced cardiotoxicity by governing the miR-22-3p/GATA4 pathway","authors":"L. Yang, Ya., Nan Liu, Yi Gu, Lan Zhu, Q. Guo","doi":"10.56042/ijeb.v61i08.3674","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.3674","url":null,"abstract":"In a clinical setting, the likelihood of doxorubicin (DOX) causing cardiotoxicity is high. However, the underlying mechanism remains obscure. In this study, we investigated whether DOX toxicity is associated with the deregulation of circular RNA_0004212 (circ_0004214). Circ_0004214, microRNA-22-3p (miR-22-3p), and GATA binding protein 4 (GATA4) expression in human cardiomyocyte AC16 cells was detected via RT-qPCR. Lactate dehydrogenase (LDH) release, reactive oxygen species (ROS) production, malondialdehyde (MDA) content, and 4-hydroxynonenal (4-HNE) content were assessed using corresponding commercial kits. Cell viability and apoptosis were analyzed using cell counting kit-8 (CCK-8) and flow cytometry assays. Western blot assay was used to evaluate apoptosis-related markers and GATA4 protein levels. Dual-luciferase reporter validated the relationship between miR-22-3p and circ_0004214 or GATA4. Declined circ_0004214 was viewed in DOX-treated AC16 cells. DOX treatment weakened cell viability, and promoted oxidative stress and apoptosis, which was ameliorated via circ_0004214 overexpression. In addition, circ_0004214 promoted GATA4 expression by decoying miR-22-3p. Overall, the results have demonstrated that circ_0004214 protects against DOX-induced cardiotoxicity via governing miR-22-3p/GATA4 pathway, and thereby reveal promising therapeutic strategies against cardiotoxicity.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48056937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ganoderma applanatum (Pers.) Pat. augments antitumor activity of doxorubicin and provides chemoprevention to murine tumor model 平顶灵芝(Pers.)帕特。增强阿霉素抗肿瘤活性，对小鼠肿瘤模型有化学预防作用

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.3873

引用次数: 0

BRMS1L mediated effect of miR-20a-5p expression on proliferation and apoptosis of gastric cancer cells BRMS1L介导miR-20a-5p表达对胃癌细胞增殖和凋亡的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2536

引用次数: 0

Effects of modified Bushen Huoxue Prescription combined with active immunotherapy on immunomodulatory functions and pregnancy outcomes of patients with unexplained recurrent spontaneous abortion 补肾活血方加减联合主动免疫治疗对不明原因反复自然流产患者免疫调节功能及妊娠结局的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-06-28 DOI: 10.56042/ijeb.v61i07.2468

引用次数: 0