Effect of curcumin on plasma TBARS and IL-6, adipose tissue AFABP-4 and liver FGF-21 in fructose-induced metabolic syndrome rats

Abstract

Elucidation of the positive effects of curcumin on oxidative damage and inflammation, as well as clarifying the parameters related to adipose tissue and liver, would contribute furthermore to literature. Here, we have demonstrated the potential healing effects of curcumin in rats with metabolic syndrome (MetS). Twenty-four adult male Wistar albino rats were selected for the study. Only corn oil was administered to the control group rats, while corn oil and 20% fructose were administered to the MetS group rats for eight weeks. The curcumin dose groups were administered 100 and 200 mg/kg of curcumin dissolved in corn oil along with 20% fructose. Plasma TBARS, IL-6, adipose AFABP-4 and liver FGF-21 levels were determined using the ELISA method. It was observed that plasma TBARS and IL-6 levels were significantly decreased in the 100 and 200 mg/kg curcumin dose groups compared to the MetS group ( P ≤ 0.008). Adipose tissue A-FABP-4 levels in the 200 mg/kg curcumin dose group were significantly decreased compared to the MetS group ( P ≤ 0.008). FGF-21 levels in the 100 mg/kg and 200 mg/kg curcumin dose groups were significantly increased compared to the MetS group ( P ≤ 0.008). The healing effects of curcumin administration on MetS were effective on inflammation and lipid peroxidation. Curcumin administration decreased the adipose tissue AFABP-4 levels and increased the liver FGF-21 levels.