Indian journal of experimental biology最新文献_第5页

The Effect of KATP Openers and Blockers on AKT and mTOR mRNA Levels in the Hippocampus and Cortex of Rats with Penicillin-Induced Epilepsy KATP开放剂和阻滞剂对青霉素致癫痫大鼠海马和皮质AKT和mTOR mRNA水平的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-09-01 DOI: 10.56042/ijeb.v61i09.1547

引用次数: 0

Determination of lithium toxicity by apoptosis and different biomarkers on Carassius auratus (Linn.) tissues 细胞凋亡和不同生物标志物对鲫鱼组织锂毒性的测定

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-09-01 DOI: 10.56042/ijeb.v61i09.5115

引用次数: 0

Correlation between musculoskeletal ultrasound signs of gouty arthritis and disease activity 痛风性关节炎的肌肉骨骼超声征象与疾病活动度的相关性

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-09-01 DOI: 10.56042/ijeb.v61i09.5188

引用次数: 0

Downregulation of Wnt/β-catenin self-renewal pathway in cervical cancer cells by polyphenolic compounds 多酚类化合物下调宫颈癌症细胞Wnt/β-catenin自我更新途径

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-09-01 DOI: 10.56042/ijeb.v61i09.3875

引用次数: 0

Corynoxine and corynoxine B enhance the antitumor activity of gemcitabine in Panc-1 cells via ROS-p38 signaling pathway 炔诺星和炔诺星B通过ROS-p38信号通路增强吉西他滨对Panc-1细胞的抗肿瘤活性

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.3878

Limin Yin, Chaohong Shi, Zhong-xiang Zhang, Wensheng Wang, Ming Li

{"title":"Corynoxine and corynoxine B enhance the antitumor activity of gemcitabine in Panc-1 cells via ROS-p38 signaling pathway","authors":"Limin Yin, Chaohong Shi, Zhong-xiang Zhang, Wensheng Wang, Ming Li","doi":"10.56042/ijeb.v61i08.3878","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.3878","url":null,"abstract":"Pancreatic ductal adenocarcinoma (PDAC) is one of the most malignant tumors, and effective therapeutic interventions for PDAC are limited. While Corynoxine (Cory) and its isomer Cory B have been identified as autophagy inducers in neuronal cells, it remains unclear whether they exert a therapeutic effect on PDAC. Here, we performed cell counting kit-8 (CCK8), colony formation, 5-Ethynyl-2′-deoxyuridine (EDU) staining, TUNEL, and flow cytometry assays to evaluate the effects of Cory on PDAC. Western blotting was conducted to analyze the protein expression levels. We showed that Cory and Cory B enhanced cell growth arrest and pro-apoptotic effects of gemcitabine (Gem) on Gem-resistant Panc-1 cells. Mechanistic studies revealed that increased production of reactive oxygen species (ROS) and p38 activation were closely associated with Cory and Cory B-induced cell death. Pretreatment with ROS scavenger N-acetylcysteine blocked Cory and Cory B-induced cell death. Moreover, p38 inhibitor SB203580 prevented cell death induced by Cory and Cory B. Overall, Cory and Cory B increase the sensitivity of Gem-resistant Panc-1 cells to Gem through the activation of ROS-dependent p38 signaling pathway. Our results indicate that Cory and Cory B might be potential approaches for PDAC therapy.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46626385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Outcomes of wuhan, alpha, delta, omicron and other variants in severe acute respiratory syndrome coronavirus-2 武汉、阿尔法、德尔塔、奥密克戎和其他变异株在严重急性呼吸综合征冠状病毒2型中的结果

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.4375

引用次数: 1

Utility of risk prediction nomogram for lymph node metastasis in the elderly with undifferentiated early gastric cancer 风险预测列线图在老年未分化早期癌症淋巴结转移中的应用

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.4376

Yajun Zhang, Tiansheng Yin, Yang Liu, Jiajun Xiao

{"title":"Utility of risk prediction nomogram for lymph node metastasis in the elderly with undifferentiated early gastric cancer","authors":"Yajun Zhang, Tiansheng Yin, Yang Liu, Jiajun Xiao","doi":"10.56042/ijeb.v61i08.4376","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.4376","url":null,"abstract":"Gastric cancer (also called stomach cancer) is the 5 th most common cancer the human population suffer from, particularly in East Asia. For effective prevention, it is important to find biomarkers for early-stage diagnosis and prognosis. Further, finding the risk factors that are associated with undifferentiated early gastric cancer is the utmost required. Here, we explored the clinicopathological characteristics of undifferentiated early gastric cancer (EGC) in the elderly, and the risk factors for lymph node metastasis. A total of 187 elderly patients with undifferentiated EGC were selected as subjects, whose clinical data were analyzed retrospectively. They were divided into lymph node metastasis and non-lymph node metastasis groups, and the risk factors for lymph node metastasis were analyzed by univariate and multivariate logistic regression analyses. A nomogram model was established to predict the risk of lymph node metastasis, and then validated. Lymph node metastasis was detected in 32 (17.11%) of the 187 cases. Univariate analysis showed that tumor diameter, depth of invasion, vascular tumor thrombus and local ulcer affected lymph node metastasis ( P <0.05). Multivariate logistic regression analysis revealed that tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer were independent risk factors ( P <0.05). The nomogram model was constructed based on the independent risk factors, and its concordance index and area under the receiver operating characteristic curve were 0.756 (95%CI: 0.684-0.830) and 0.758 (95%CI: 0.701-0.815), respectively. Calibration curve and model calibration curve suggested that the predicted probability of the model was consistent with the actual one, indicating high accuracy. Lymph node metastasis of the elderly with undifferentiated EGC is affected by many factors, among which tumor diameter >2 cm, invasion to submucosa, vascular tumor thrombus and local ulcer are independent risk factors.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44634707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors influencing mortality in ICU hospitalized patients with severe sepsis: A systematic review and meta-analysis ICU重症脓毒症住院患者死亡率的影响因素:系统回顾和荟萃分析

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.4373

Keke Wu, Yun Luo, J. Qin, Xiaxia Xu

{"title":"Factors influencing mortality in ICU hospitalized patients with severe sepsis: A systematic review and meta-analysis","authors":"Keke Wu, Yun Luo, J. Qin, Xiaxia Xu","doi":"10.56042/ijeb.v61i08.4373","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.4373","url":null,"abstract":"Sepsis is one of the primary causes of mortality in the world. When the sepsis develops into acute organ dysfunction it is considered severe. Severe sepsis increases the economic burden by means of potential treatment for inflammatory responses and multiple organ failure. Several factors, including age, inappropriate use of antibiotics, comorbidities, multiple organ dysfunction, and site of infection, are considered to increase mortality risk in severe septic patients. This systematic review analyses various factors influencing mortality in ICU-hospitalized patients with severe sepsis. A systematic search for relevant articles up to September 2022 was carried out on 6 electronic databases, including Scopus, MEDLINE, PubMed, ScienceDirect, Embase and Google Scholar. Of 1078 articles, only nine studies were reviewed after meeting the inclusion criteria. Meta-analysis of three studies reveal significantly more fatality in older patients than the younger (OR; 2.28: 1.65, 3.15: 95% CI: I 2 = 11%, P <0.00001). The number of organ failure also significantly influences the mortality with the mortality rate being higher for patients with ≥4 organ failures (OR; 0.19: 0.11, 0.30: 95% CI: I 2 = 93%: P <0.00001). The mortality rates for hospital-acquired, community-acquired and ICU-acquired infections were 0.41 (95% CI; 0.18, 0.69), 0.40 (95% CI; 0.20, 0.63), and 0.42 (95% CI; 0.44, 0.53), respectively. Gender shows no significant difference on mortality rates (OR; 1.05: 0.95, 1.16: 95% CI: I 2 = 27%: p = 0.35). Age, the number of organ failures, and the acquisition sites seem to significantly influence the mortality, while gender has an insignificant influence on the mortality of ICU-admitted severe septic patients.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48183793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes 在与糖尿病相关的不可预测的慢性轻度应激模型中大鼠心脏的细胞外基质重塑

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.2286

Houcine Dab, S. Hamed, W. Hodroj, L. Zourgui

{"title":"Extracellular matrix remodelling in rat heart in an unpredictable chronic mild stress model associated with diabetes","authors":"Houcine Dab, S. Hamed, W. Hodroj, L. Zourgui","doi":"10.56042/ijeb.v61i08.2286","DOIUrl":"https://doi.org/10.56042/ijeb.v61i08.2286","url":null,"abstract":"The coexistence of depression and diabetes is a serious challenge in cardiovascular disease. However, extracellular matrix (ECM) under stress model associated or not with diabetes remains unknown. This study aims to investigate the involvement of diabetes and unpredictable chronic mild stress (UCMS) on ECM remodelling. Rats were exposed to UCMS, diabetes or combined treatment. mRNA expression of matrix metalloproteinases (MMP-2 and MMP-9), plasminogen activator (t-PA) and inhibitor (PAI-1) was examined by Q-RT-PCR. ECM was determined by ELISA. MMP-2 and MMP-9 mRNA was lower in diabetes ( P <0.05). UCMS increased MMP-2 and MMP-9 compared to control and diabetic group. Compared to the control and diabetes groups, MMP-2 and MMP-9 mRNA was significantly increased in the combined treatment group. UCMS increased MMP-2 expression in the diabetic group ( P <0.01). Compared to control, gelatinase activity was higher in diabetes and UCMS ( P <0.05). Combined diabetes and UCMS significantly increased gelatinase activity compared to T2D and UCMS groups. Collagen, hydroxyproline and fibronectin content were significantly increased in diabetes and combined groups. UCMS combined with diabetes exacerbated diabetes-induced MMPs and fibronectin deposition. In conclusion, comorbidity between diabetes and UCMS may exacerbate ECM remodelling. These findings will be useful in understanding diabetes-induced cardiovascular disease.","PeriodicalId":13290,"journal":{"name":"Indian journal of experimental biology","volume":" ","pages":""},"PeriodicalIF":0.6,"publicationDate":"2023-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42292261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of respiratory muscle assessment-based muscle relaxation training on postoperative pulmonary function rehabilitation, sputum excretion and quality of life of patients receiving thoracic surgeries 基于呼吸肌评估的肌肉放松训练对胸部手术患者术后肺功能康复、排痰和生活质量的影响

IF 0.6 4区生物学

Indian journal of experimental biology Pub Date : 2023-07-31 DOI: 10.56042/ijeb.v61i08.2499

引用次数: 0