Immunity最新文献_第5页

An anti-aging vaccine: BCG turns back the clock on remyelination failure 抗衰老疫苗：卡介苗让再髓鞘化失败的时间倒流

IF 32.4 1区医学

Immunity Pub Date : 2024-09-10 DOI: 10.1016/j.immuni.2024.08.001

Janssen M. Kotah, Bart J.L. Eggen

引用次数: 0

The epigenomic matrix of tissue-specific immune memory 组织特异性免疫记忆的表观基因组基质

IF 32.4 1区医学

Immunity Pub Date : 2024-09-10 DOI: 10.1016/j.immuni.2024.08.009

Sarah Adamo, Marcus Buggert

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Microbes and metabolites in immunity 免疫中的微生物和代谢物

IF 32.4 1区医学

Immunity Pub Date : 2024-09-10 DOI: 10.1016/j.immuni.2024.08.011

Eran Elinav, Suzanne Devkota, Marlies Meisel, Shu Zhu, Hiutung Chu, Haiwei Chen, Jens Puschhof, Florencia McAllister, Randall Jeffrey Platt, Kenya Honda

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The inflammaging clock strikes IL-11! 发炎时钟敲响了 IL-11！

IF 32.4 1区医学

Immunity Pub Date : 2024-09-10 DOI: 10.1016/j.immuni.2024.08.010

Saad Khan, Veronica Chang, Daniel A. Winer

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Long-distance microbial mechanisms impacting cancer immunosurveillance. 影响癌症免疫监视的远距离微生物机制

IF 25.5 1区医学

Immunity Pub Date : 2024-09-10 Epub Date: 2024-08-15 DOI: 10.1016/j.immuni.2024.07.020

Laurence Zitvogel, Marine Fidelle, Guido Kroemer

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Microglia bridge brain activity and blood pressure 小胶质细胞桥接大脑活动和血压

IF 32.4 1区医学

Immunity Pub Date : 2024-09-10 DOI: 10.1016/j.immuni.2024.08.006

Yanxia Rao, Bo Peng

引用次数: 0

BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses. 卡介苗接种会改变人类骨髓中祖细胞的表观遗传结构，从而影响先天性免疫反应。

IF 25.5 1区医学

Immunity Pub Date : 2024-09-10 Epub Date: 2024-08-16 DOI: 10.1016/j.immuni.2024.07.021

Sarah J Sun, Raúl Aguirre-Gamboa, L Charlotte J de Bree, Joaquin Sanz, Anne Dumaine, Walter J F M van der Velden, Leo A B Joosten, Shabaana Khader, Maziar Divangahi, Mihai G Netea, Luis B Barreiro

{"title":"BCG vaccination alters the epigenetic landscape of progenitor cells in human bone marrow to influence innate immune responses.","authors":"Sarah J Sun, Raúl Aguirre-Gamboa, L Charlotte J de Bree, Joaquin Sanz, Anne Dumaine, Walter J F M van der Velden, Leo A B Joosten, Shabaana Khader, Maziar Divangahi, Mihai G Netea, Luis B Barreiro","doi":"10.1016/j.immuni.2024.07.021","DOIUrl":"10.1016/j.immuni.2024.07.021","url":null,"abstract":"Although the Bacille-Calmette-Guérin (BCG) vaccine is used to prevent tuberculosis, it also offers protection against a diverse range of non-mycobacterial infections. However, the underlying protective mechanisms in humans are not yet fully understood. Here, we surveyed at single-cell resolution the gene expression and chromatin landscape of human bone marrow, aspirated before and 90 days after BCG vaccination or placebo. We showed that BCG alters both the gene expression and epigenetic profiles of human hematopoietic stem and progenitor cells (HSPCs). Changes in gene expression occurred primarily within uncommitted stem cells. By contrast, changes in chromatin accessibility were most prevalent within differentiated progenitor cells at sites influenced by Kruppel-like factor (KLF) and early growth response (EGR) transcription factors and were highly correlated (r > 0.8) with the interleukin (IL)-1β secretion capacity of paired peripheral blood mononuclear cells (PBMCs). Our findings shed light on BCG vaccination's profound and lasting effects on HSPCs and its influence on innate immune responses and trained immunity.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2095-2107.e8"},"PeriodicalIF":25.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes. 快速分离吞噬体可对人类小胶质细胞吞噬体进行无偏见的多组学分析。

IF 25.5 1区医学

Immunity Pub Date : 2024-09-10 Epub Date: 2024-08-15 DOI: 10.1016/j.immuni.2024.07.019

Emile Wogram, Felix Sümpelmann, Wentao Dong, Eshaan Rawat, Inés Fernández Maestre, Dongdong Fu, Brandyn Braswell, Andrew Khalil, Joerg M Buescher, Gerhard Mittler, Georg H H Borner, Andreas Vlachos, Stefan Tholen, Oliver Schilling, George W Bell, Angelika S Rambold, Asifa Akhtar, Oliver Schnell, Jürgen Beck, Monther Abu-Remaileh, Marco Prinz, Rudolf Jaenisch

{"title":"Rapid phagosome isolation enables unbiased multiomic analysis of human microglial phagosomes.","authors":"Emile Wogram, Felix Sümpelmann, Wentao Dong, Eshaan Rawat, Inés Fernández Maestre, Dongdong Fu, Brandyn Braswell, Andrew Khalil, Joerg M Buescher, Gerhard Mittler, Georg H H Borner, Andreas Vlachos, Stefan Tholen, Oliver Schilling, George W Bell, Angelika S Rambold, Asifa Akhtar, Oliver Schnell, Jürgen Beck, Monther Abu-Remaileh, Marco Prinz, Rudolf Jaenisch","doi":"10.1016/j.immuni.2024.07.019","DOIUrl":"10.1016/j.immuni.2024.07.019","url":null,"abstract":"Microglia are the resident macrophages of the central nervous system (CNS). Their phagocytic activity is central during brain development and homeostasis-and in a plethora of brain pathologies. However, little is known about the composition, dynamics, and function of human microglial phagosomes under homeostatic and pathological conditions. Here, we developed a method for rapid isolation of pure and intact phagosomes from human pluripotent stem cell-derived microglia under various in vitro conditions, and from human brain biopsies, for unbiased multiomic analysis. Phagosome profiling revealed that microglial phagosomes were equipped to sense minute changes in their environment and were highly dynamic. We detected proteins involved in synapse homeostasis, or implicated in brain pathologies, and identified the phagosome as the site where quinolinic acid was stored and metabolized for de novo nicotinamide adenine dinucleotide (NAD+) generation in the cytoplasm. Our findings highlight the central role of phagosomes in microglial functioning in the healthy and diseased brain.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2216-2231.e11"},"PeriodicalIF":25.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141995692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination. 接种非典-CoV-2 疫苗后，天真个体早期抗体分泌细胞反应的亲和性-非依赖性记忆 B 细胞来源。

IF 25.5 1区医学

Immunity Pub Date : 2024-09-10 Epub Date: 2024-08-20 DOI: 10.1016/j.immuni.2024.07.023

Zhe Li, Anna Obraztsova, Fuwei Shang, Opeyemi Ernest Oludada, Joshua Malapit, Katrin Busch, Monique van Straaten, Erec Stebbins, Rajagopal Murugan, Hedda Wardemann

{"title":"Affinity-independent memory B cell origin of the early antibody-secreting cell response in naive individuals upon SARS-CoV-2 vaccination.","authors":"Zhe Li, Anna Obraztsova, Fuwei Shang, Opeyemi Ernest Oludada, Joshua Malapit, Katrin Busch, Monique van Straaten, Erec Stebbins, Rajagopal Murugan, Hedda Wardemann","doi":"10.1016/j.immuni.2024.07.023","DOIUrl":"10.1016/j.immuni.2024.07.023","url":null,"abstract":"Memory B cells (MBCs) formed over the individual's lifetime constitute nearly half of the circulating B cell repertoire in humans. These pre-existing MBCs dominate recall responses to their cognate antigens, but how they respond to recognition of novel antigens is not well understood. Here, we tracked the origin and followed the differentiation paths of MBCs in the early anti-spike (S) response to mRNA vaccination in SARS-CoV-2-naive individuals on single-cell and monoclonal antibody levels. Pre-existing, highly mutated MBCs showed no signs of germinal center re-entry and rapidly developed into mature antibody-secreting cells (ASCs). By contrast, and despite similar levels of S reactivity, naive B cells showed strong signs of antibody affinity maturation before differentiating into MBCs and ASCs. Thus, pre-existing human MBCs differentiate into ASCs in response to novel antigens, but the quality of the humoral and cellular anti-S response improved through the clonal selection and affinity maturation of naive precursors.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":" ","pages":"2191-2201.e5"},"PeriodicalIF":25.5,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming 抑制性共受体Lag3通过抑制依赖于Myc的代谢程序来支持Foxp3+调节性T细胞的功能

IF 32.4 1区医学

Immunity Pub Date : 2024-09-04 DOI: 10.1016/j.immuni.2024.08.008

Dongkyun Kim, Giha Kim, Rongzhen Yu, Juyeun Lee, Sohee Kim, Mia R. Gleason, Kevin Qiu, Elena Montauti, Li Lily Wang, Deyu Fang, Jaehyuk Choi, Navdeep S. Chandel, Samuel Weinberg, Booki Min

{"title":"Inhibitory co-receptor Lag3 supports Foxp3+ regulatory T cell function by restraining Myc-dependent metabolic programming","authors":"Dongkyun Kim, Giha Kim, Rongzhen Yu, Juyeun Lee, Sohee Kim, Mia R. Gleason, Kevin Qiu, Elena Montauti, Li Lily Wang, Deyu Fang, Jaehyuk Choi, Navdeep S. Chandel, Samuel Weinberg, Booki Min","doi":"10.1016/j.immuni.2024.08.008","DOIUrl":"https://doi.org/10.1016/j.immuni.2024.08.008","url":null,"abstract":"Lymphocyte activation gene 3 (Lag3) is an inhibitory co-receptor expressed on activated T cells and has been proposed to regulate regulatory T (Treg) cell function. However, its precise modality and mechanisms remain elusive. We generated Treg cell-specific Lag3-mutant mouse models and found that Lag3 was essential for Treg cell control of autoimmunity. RNA sequencing analysis revealed that Lag3 mutation altered genes associated with metabolic processes, especially Myc target genes. Myc expression in Lag3-mutant Treg cells was increased to the level seen in conventional T helper (Th)1-type effector cells and directly correlated with their metabolic profiles and in vivo suppressive functions. The phosphatidylinositol 3-kinase (PI3K)-Akt-Rictor pathway was activated in Lag3-mutant Treg cells, and inhibiting PI3K, Rictor, or lactate dehydrogenase A (Ldha), a key Myc target enzyme converting pyruvate to lactate, was sufficient to restore normal metabolism and suppressive function in Lag3-mutant Treg cells. These findings indicate that Lag3 supports Treg cell suppression partly by tuning Myc-dependent metabolic programming.","PeriodicalId":13269,"journal":{"name":"Immunity","volume":"12 1","pages":""},"PeriodicalIF":32.4,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0