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Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway. 脂联素-2通过AKT/c-Jun通路抑制胰腺癌干性。
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-09-01 Epub Date: 2022-07-06 DOI: 10.1007/s13577-022-00735-z
Peipei Hao, Jiamin Zhang, Shu Fang, Miaomiao Jia, Xian Xian, Sinan Yan, Yunpeng Wang, Qian Ren, Fengming Yue, Huixian Cui
{"title":"Lipocalin-2 inhibits pancreatic cancer stemness via the AKT/c-Jun pathway.","authors":"Peipei Hao, Jiamin Zhang, Shu Fang, Miaomiao Jia, Xian Xian, Sinan Yan, Yunpeng Wang, Qian Ren, Fengming Yue, Huixian Cui","doi":"10.1007/s13577-022-00735-z","DOIUrl":"10.1007/s13577-022-00735-z","url":null,"abstract":"<p><p>Cancer stem cells (CSCs) are involved in cancer recurrence and metastasis owing to their self-renewal properties and drug-resistance capacity. Lipocalin-2 (Lcn2) of the lipocalin superfamily is highly expressed in pancreatic cancer. Nevertheless, reports on the involvement of Lcn2 in the regulation of pancreatic CSC properties are scant. This study is purposed to investigate whether Lcn2 plays a crucial role in CSC renewal and stemness maintenance in pancreatic carcinoma. Immunohistochemistry results of tumor tissue chips together with Gene Expression Omnibus sequencing files confirmed that Lcn2 is highly expressed in pancreatic carcinoma compared with that in normal tissues. The exogenous expression of Lcn2 attenuated CSC-associated SOX2, CD44, and EpCAM expression and suppressed sarcosphere formation and tumorigenesis in the pancreatic carcinoma cell line PANC-1, which showed low expression of Lcn2. However, Lcn2 knockout in BxPC-3 cell line, which presented high Lcn2 expression, promoted CSC stemness, further enhancing sarcosphere formation and tumorigenesis. Moreover, Lcn2 was found to regulate stemness in pancreatic cancer depending on the activation of AKT and c-Jun. Lcn2 suppresses stemness properties in pancreatic carcinoma by activating the AKT-c-Jun pathway, and thus, it may be a novel candidate to suppress the stemness of pancreatic cancer. This study provides a new insight into disease progression.</p>","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 5","pages":"1475-1486"},"PeriodicalIF":4.3,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40566491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the MKK/p38MAPK signaling pathway. RIG-I通过调节MKK/p38MAPK信号通路的激活，在黑色素瘤中发挥肿瘤抑制作用
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-07-01 Epub Date: 2022-04-13 DOI: 10.1007/s13577-022-00698-1
Rui Guo, Shun-Yuan Lu, Jin-Xia Ma, Qian-Lan Wang, Lu Zhang, Ling-Yun Tang, Yan Shen, Chun-Ling Shen, Jin-Jin Wang, Li-Ming Lu, Zhu-Gang Wang, Hong-Xin Zhang
{"title":"RIG-I acts as a tumor suppressor in melanoma via regulating the activation of the MKK/p38MAPK signaling pathway.","authors":"Rui Guo, Shun-Yuan Lu, Jin-Xia Ma, Qian-Lan Wang, Lu Zhang, Ling-Yun Tang, Yan Shen, Chun-Ling Shen, Jin-Jin Wang, Li-Ming Lu, Zhu-Gang Wang, Hong-Xin Zhang","doi":"10.1007/s13577-022-00698-1","DOIUrl":"10.1007/s13577-022-00698-1","url":null,"abstract":"<p><p>Studies have indicated that RIG-I may act as a tumor suppressor and participate in the tumorigenesis of some malignant diseases. However, RIG-I induces distinct cellular responses via different downstream signaling pathways depending on the cell type. To investigate the biological function and underlying molecular mechanism of RIG-I in the tumorigenesis of melanoma, we constructed RIG-I knockout, RIG-I-overexpressing B16-F10 and RIG-I knockdown A375 melanoma cell lines, and analyzed the RIG-I-mediated change in the biological behavior of tumor cells in spontaneous and poly (I:C)-induced RIG-I activation. Cell proliferation, cell cycling, apoptosis and migration were detected by CCK-8 assay, BrdU incorporation assay, Annexin V-PI staining assay and Transwell assay, respectively. In vivo tumorigenicity was evaluated by tumor xenograft growth in nude mice and subsequently by Ki67 staining and TUNEL assays. Furthermore, Western blotting was utilized to explore the underlying mechanism of RIG-I in melanoma cells. Our data showed that RIG-I promotes apoptosis and inhibits proliferation by G1 phase cell cycle arrest in the melanoma cell lines. Mechanistically, RIG-I induced the phosphorylation of p38 MAPK and MAPK kinases MKK3 and MKK4. In conclusion, the current study demonstrated that RIG-I suppressed the development of melanoma by regulating the activity of the MKK/p38 MAPK signaling pathway, which is relevant to research on novel therapeutic targets for this malignant disease.</p>","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1071-1083"},"PeriodicalIF":4.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9226095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45370864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Increased neuropilin-1 expression by COVID-19: a possible cause of long-term neurological complications and progression of primary brain tumors. COVID-19导致神经匹林-1表达增加:可能导致长期神经系统并发症和原发性脑肿瘤进展
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-07-01 Epub Date: 2022-05-09 DOI: 10.1007/s13577-022-00716-2
Hamidreza Zalpoor, Hooriyeh Shapourian, Abdullatif Akbari, Shaghayegh Shahveh, Leila Haghshenas
{"title":"Increased neuropilin-1 expression by COVID-19: a possible cause of long-term neurological complications and progression of primary brain tumors.","authors":"Hamidreza Zalpoor, Hooriyeh Shapourian, Abdullatif Akbari, Shaghayegh Shahveh, Leila Haghshenas","doi":"10.1007/s13577-022-00716-2","DOIUrl":"10.1007/s13577-022-00716-2","url":null,"abstract":"","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1301-1303"},"PeriodicalIF":4.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9084541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43427481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
miR-203a-3p-DNMT3B feedback loop facilitates non-small cell lung cancer progression. miR-203a-3p-DNMT3B反馈回路促进非小细胞肺癌癌症进展
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-07-01 Epub Date: 2022-06-07 DOI: 10.1007/s13577-022-00728-y
Pingshan Yang, Dongdong Zhang, Fengli Zhou, Wenyou Chen, Chuang Hu, Duqing Xiao, Songwang Cai
{"title":"miR-203a-3p-DNMT3B feedback loop facilitates non-small cell lung cancer progression.","authors":"Pingshan Yang, Dongdong Zhang, Fengli Zhou, Wenyou Chen, Chuang Hu, Duqing Xiao, Songwang Cai","doi":"10.1007/s13577-022-00728-y","DOIUrl":"10.1007/s13577-022-00728-y","url":null,"abstract":"<p><p>It has been reported that microRNA-203a-3p (miR-203a-3p) modulates cell proliferation, migration and invasion in a variety of cancer cell types. However, little is known about its role in lung cancer progression. The present study found that miR-203a-3p was downregulated in non-small cell lung cancer (NSCLC) cell lines and tissues. Overexpression of miR-203a-3p inhibits NSCLC cell proliferation, migration and invasion, and promotes cellular apoptosis in vitro. Restoration of miR-203a-3p expression in A549 and NCI-H520 cells enhances their chemosensitivity. Further experiments showed that DNA methyltransferase 3B (DNMT3B) was a direct target of miR-203a-3p. In addition, the present results revealed that promoter hypermethylation was the potential mechanism responsible for low miR-203a-3p expression in NSCLC. Notably, feedback regulation between miR-203a-3p and DNMT3B was observed in NSCLC. Moreover, Overexpression of miR-203a-3p reduces tumor growth in vivo. In summary, the present study has identified an miR-203a-3p-DNMT3B feedback loop that facilitates NSCLC progression.</p>","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1219-1233"},"PeriodicalIF":4.3,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48381309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Long noncoding RNA ZBTB40-IT1 regulates bone mass by directing the differentiation of human bone marrow mesenchymal stromal cells via the microRNA-514a-3p/FOXO4 axis 长链非编码RNA ZBTB40-IT1通过microRNA-514a-3p/FOXO4轴调控人骨髓间充质间质细胞的分化，从而调控骨量
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-06-09 DOI: 10.1007/s13577-022-00730-4
Zhe Shi, Qiang Zhong, Yuhang Chen, Xi Luo
{"title":"Long noncoding RNA ZBTB40-IT1 regulates bone mass by directing the differentiation of human bone marrow mesenchymal stromal cells via the microRNA-514a-3p/FOXO4 axis","authors":"Zhe Shi, Qiang Zhong, Yuhang Chen, Xi Luo","doi":"10.1007/s13577-022-00730-4","DOIUrl":"https://doi.org/10.1007/s13577-022-00730-4","url":null,"abstract":"","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1408 - 1423"},"PeriodicalIF":4.3,"publicationDate":"2022-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46036308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression 长链非编码RNA TRIM52- as1通过增加TRIM52的表达来抑制microRNA-577促进弥漫性大B细胞淋巴瘤的进展
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-06-08 DOI: 10.1007/s13577-022-00725-1
Fang Zhao, Shu-cui Li, Jingjing Liu, Juan Wang, Bo Yang
{"title":"Long non-coding RNA TRIM52-AS1 sponges microRNA-577 to facilitate diffuse large B cell lymphoma progression via increasing TRIM52 expression","authors":"Fang Zhao, Shu-cui Li, Jingjing Liu, Juan Wang, Bo Yang","doi":"10.1007/s13577-022-00725-1","DOIUrl":"https://doi.org/10.1007/s13577-022-00725-1","url":null,"abstract":"","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1234 - 1247"},"PeriodicalIF":4.3,"publicationDate":"2022-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46711234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Transcriptomic and epigenomic analyses explore the potential role of H3K4me3 in neomycin-induced cochlear Lgr5+ progenitor cell regeneration of hair cells 转录组学和表观基因组学分析探讨H3K4me3在新霉素诱导的耳蜗Lgr5中的潜在作用+ 毛细胞的祖细胞再生
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-06-06 DOI: 10.1007/s13577-022-00727-z
Xiangyu Ma, Shasha Zhang, Shijie Qin, Jiamin Guo, Jia Yuan, Ruiying Qiang, Sha Zhou, Wei Cao, Jianming Yang, Fei Ma, R. Chai
{"title":"Transcriptomic and epigenomic analyses explore the potential role of H3K4me3 in neomycin-induced cochlear Lgr5+ progenitor cell regeneration of hair cells","authors":"Xiangyu Ma, Shasha Zhang, Shijie Qin, Jiamin Guo, Jia Yuan, Ruiying Qiang, Sha Zhou, Wei Cao, Jianming Yang, Fei Ma, R. Chai","doi":"10.1007/s13577-022-00727-z","DOIUrl":"https://doi.org/10.1007/s13577-022-00727-z","url":null,"abstract":"","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1030 - 1044"},"PeriodicalIF":4.3,"publicationDate":"2022-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41691186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
ATP-gated P2X7 receptor as a potential target for prostate cancer atp门控P2X7受体作为前列腺癌的潜在靶点
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-06-03 DOI: 10.1007/s13577-022-00729-x
C. Qiao, Yiqing Tang, Qian Li, Xiaodi Zhu, X. Peng, R. Zhao
{"title":"ATP-gated P2X7 receptor as a potential target for prostate cancer","authors":"C. Qiao, Yiqing Tang, Qian Li, Xiaodi Zhu, X. Peng, R. Zhao","doi":"10.1007/s13577-022-00729-x","DOIUrl":"https://doi.org/10.1007/s13577-022-00729-x","url":null,"abstract":"","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1346 - 1354"},"PeriodicalIF":4.3,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48876119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Establishment and characterization of NCC-SS5-C1: a novel patient-derived cell line of synovial sarcoma NCC-SS5-C1的建立和表征:一种新的滑膜肉瘤患者来源的细胞系
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-06-02 DOI: 10.1007/s13577-022-00721-5
Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, R. Tsuchiya, T. Ono, Taro Akiyama, Jun Sugaya, Naoki Kojima, A. Yoshida, A. Kawai, T. Kondo
{"title":"Establishment and characterization of NCC-SS5-C1: a novel patient-derived cell line of synovial sarcoma","authors":"Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, R. Tsuchiya, T. Ono, Taro Akiyama, Jun Sugaya, Naoki Kojima, A. Yoshida, A. Kawai, T. Kondo","doi":"10.1007/s13577-022-00721-5","DOIUrl":"https://doi.org/10.1007/s13577-022-00721-5","url":null,"abstract":"","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1290 - 1297"},"PeriodicalIF":4.3,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43357557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Establishment and characterization of NCC-GCTB5-C1: a novel cell line of giant cell tumor of bone 骨巨细胞瘤新细胞系NCC-GCTB5-C1的建立与表征
IF 4.3 3区 生物学
Human Cell Pub Date : 2022-06-02 DOI: 10.1007/s13577-022-00724-2
Taro Akiyama, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, R. Tsuchiya, T. Ono, Suguru Fukushima, Y. Toda, Naoki Kojima, A. Yoshida, Seji Ohtori, A. Kawai, T. Kondo
{"title":"Establishment and characterization of NCC-GCTB5-C1: a novel cell line of giant cell tumor of bone","authors":"Taro Akiyama, Yuki Yoshimatsu, Rei Noguchi, Yooksil Sin, R. Tsuchiya, T. Ono, Suguru Fukushima, Y. Toda, Naoki Kojima, A. Yoshida, Seji Ohtori, A. Kawai, T. Kondo","doi":"10.1007/s13577-022-00724-2","DOIUrl":"https://doi.org/10.1007/s13577-022-00724-2","url":null,"abstract":"","PeriodicalId":13228,"journal":{"name":"Human Cell","volume":"35 1","pages":"1621 - 1629"},"PeriodicalIF":4.3,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44015940","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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