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Dynamized Aloysia Polystachya (Griseb.) Essential Oil: A Promising Antimicrobial Product. 动态水杨花(Griseb)精油:一种很有前途的抗菌产品。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 DOI: 10.1055/s-0042-1748320
Talita Thomaz Nader, Alexandre Henrique Leonel, Camila Yamasita Henrique, Silvia Helena Taleb Contini, Eduardo José Crevelin, Suzelei de Castro França, Bianca Waléria Berton, Ana Maria Soares Pereira
{"title":"Dynamized Aloysia Polystachya (Griseb.) Essential Oil: A Promising Antimicrobial Product.","authors":"Talita Thomaz Nader,&nbsp;Alexandre Henrique Leonel,&nbsp;Camila Yamasita Henrique,&nbsp;Silvia Helena Taleb Contini,&nbsp;Eduardo José Crevelin,&nbsp;Suzelei de Castro França,&nbsp;Bianca Waléria Berton,&nbsp;Ana Maria Soares Pereira","doi":"10.1055/s-0042-1748320","DOIUrl":"https://doi.org/10.1055/s-0042-1748320","url":null,"abstract":"<p><strong>Background: </strong>Compounds from vegetal matter have therapeutic potential to control highly prevalent microorganisms that are resistant to commonly used antimicrobial drugs. Dynamization of compounds can either maintain or improve their therapeutic effects, and make their use safer, especially those compounds whose therapeutic dose is close to the toxic limit. <i>Aloysia polystachya</i> (Griseb.) stands out among aromatic plants with antimicrobial potential.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the antimicrobial activity of dynamized and crude forms of <i>A. polystachya</i> essential oil against <i>Candida albicans</i>, <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>.</p><p><strong>Methods: </strong>Essential oil was extracted from <i>A. polystachya</i> dry leaves, solubilized, and dynamized at 1 cH potency as recommended by the Brazilian Homeopathic Pharmacopoeia. Antimicrobial activity against <i>C. albicans</i>, <i>E. coli</i> and <i>S. aureus</i> of the samples was assayed using the plate microdilution method.</p><p><strong>Results: </strong>Dynamized <i>A. polystachya</i> essential oil at the concentration of 1 μg/mL inhibited the growth of all the microbial species analyzed. The minimum inhibitory concentration of dynamized essential oil was smaller than crude essential oil for <i>S. aureus</i>, <i>E. coli</i> and <i>C. albicans</i>.</p><p><strong>Conclusion: </strong>It is reported for the first time that <i>A. polystachya</i> dynamized essential oil can effectively suppress microbial growth, and it is a promising adjuvant to treat infections with pathogenic <i>S. aureus</i>, <i>E. coli</i> and <i>C. albicans</i>.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"120-124"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Attitudes To and Uptake of Repertory Software in Homeopathy Clinical Practice-Results of an International Survey. 顺势疗法临床实践中对储备软件的态度和吸收——一项国际调查的结果。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 DOI: 10.1055/s-0042-1748841
Alastair C Gray, Parker Pracjek, Denise Straiges
{"title":"Attitudes To and Uptake of Repertory Software in Homeopathy Clinical Practice-Results of an International Survey.","authors":"Alastair C Gray,&nbsp;Parker Pracjek,&nbsp;Denise Straiges","doi":"10.1055/s-0042-1748841","DOIUrl":"https://doi.org/10.1055/s-0042-1748841","url":null,"abstract":"<p><strong>Background: </strong>Despite the substantial size of the maturing complementary medicine (CM) industry, the technologies used by practitioners have received little research attention. In the clinical delivery of homeopathy services, repertory software can be employed to cross-reference client symptoms with numerous databases, making the process of seeking a clinical intervention quicker and more accurate. The purpose of the study is to learn about the quantitative patterns of usage, uptake and attitudes to repertory software amongst professional homeopaths.</p><p><strong>Methods: </strong>An online cross-sectional survey of 15 questions was completed by practicing professional homeopaths between August 2016 and May 2017, using non-probability snowball sampling. Questions gathered demographic information, reflections and attitudes on the use of electronic repertories in clinical homeopathy practice.</p><p><strong>Results: </strong>In total, 59% of respondents reported using software regularly in practice and 71% found that it adds clear value in their work. Sixty-eight percent of respondents learned about repertory software during homeopathy training, and 47% were introduced to software when they began clinical practice. Lack of sufficient training is a very important barrier to the use of repertory software, indicating that more robust and accessible software training is needed for practitioners. Many respondents agreed with a statement that repertory software represents good value for money and yet 46% agreed that it is cost prohibitive for most practitioners, signaling a challenge for software companies. Few respondents reported regularly using more than three of the most common repertory features.</p><p><strong>Conclusion: </strong>This preliminary study presents some potentially significant uptake, usage and attitude markers that stand to shed light on the practice of homeopathy and the place of emerging technologies such as repertory software. Ultimately, more research is needed to help identify and address the challenges, risks and tensions around integration of practice-enhancing technologies in CM educational and clinical settings to best serve the diverse and changing needs of practitioners.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"97-106"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9574814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Individualized Homeopathic Medicines in Treatment of Hyperuricemia: Evaluation by Double-Blind, Randomized, Placebo-Controlled Trial. 个体化顺势疗法药物治疗高尿酸血症:双盲、随机、安慰剂对照试验评价
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 DOI: 10.1055/s-0042-1751272
Priyanka Ghosh, Subhasish Ganguly, Shyamal Kumar Mukherjee, Souvik Dutta, Abdur Rahaman Shaikh, Sk Swaif Ali, Navin Kumar Singh, Pulakendu Bhattacharya, Munmun Koley, Subhranil Saha
{"title":"Individualized Homeopathic Medicines in Treatment of Hyperuricemia: Evaluation by Double-Blind, Randomized, Placebo-Controlled Trial.","authors":"Priyanka Ghosh,&nbsp;Subhasish Ganguly,&nbsp;Shyamal Kumar Mukherjee,&nbsp;Souvik Dutta,&nbsp;Abdur Rahaman Shaikh,&nbsp;Sk Swaif Ali,&nbsp;Navin Kumar Singh,&nbsp;Pulakendu Bhattacharya,&nbsp;Munmun Koley,&nbsp;Subhranil Saha","doi":"10.1055/s-0042-1751272","DOIUrl":"https://doi.org/10.1055/s-0042-1751272","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperuricemia (HU) is a major health issue in India and across the globe. It increases the disease burden and hampers quality of life. This study was aimed at exploring the effects of individualized homeopathic medicines (IHMs) against placebo in the treatment of HU.</p><p><strong>Methods: </strong>This double-blind, randomized, placebo-controlled trial was conducted on 60 patients suffering from HU in the outpatient department of D. N. De Homoeopathic Medical College and Hospital, Kolkata. Each patient received either IHMs or identical-looking placebos, along with advice on dietary modifications irrespective of codes. Serum uric acid (SUA) level was the primary outcome measure; the HU quality of life questionnaire (HUQLQ) and the Measure Yourself Medical Outcome Profile version 2 (MYMOP-2) were the secondary outcomes; all measured at baseline, and every month, up to 3 months. Group differences were examined by two-way (split-half) repeated-measures analysis of variance after adjusting for baseline differences. Significance level was set at <i>p</i> ≤0.05, two-tailed.</p><p><strong>Results: </strong>The intention-to-treat sample (<i>n</i> = 58) was analyzed. Between-group differences in SUA levels (<i>F</i> <sub>1, 56</sub> = 13.833, <i>p</i> <0.001), HUQLQ scores (<i>F</i> <sub>1, 56</sub> = 32.982, <i>p</i> <0.001) and MYMOP-2 profile scores (<i>F</i> <sub>1, 56</sub> = 23.873, <i>p</i> <0.001) were statistically significant, favoring IHMs against placebos, with medium to large effect sizes. <i>Calcarea carbonica</i> and <i>Pulsatilla nigricans</i> were the most frequently prescribed medicines. No serious adverse events were reported from either of the groups.</p><p><strong>Conclusion: </strong>IHMs showed significantly better results than placebos in reducing SUA levels and improving quality of life in patients suffering from HU.</p><p><strong>Trial registration: </strong>CTRI/2019/10/021503; UTN: U1111-1241-1431.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"85-96"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9566467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Women in Homeopathy. 顺势疗法中的女性。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 DOI: 10.1055/s-0043-1767817
Robert T Mathie
{"title":"Women in Homeopathy.","authors":"Robert T Mathie","doi":"10.1055/s-0043-1767817","DOIUrl":"https://doi.org/10.1055/s-0043-1767817","url":null,"abstract":"As stated on our publisher’swebsite, “Morewomen than ever before are choosing to pursue careers in both medicine and medical research; however, a gender gap still exists. According to the UN, women make up 70% of health and social care workers, but only 37% of first authors on medical research articles. At Thieme, we believe the key to closing the gender gap in medicine is to uplift women’s voices”.1 Thieme has therefore created its Women in Medicine collection, “which aims to highlight and celebrate the work and contributions to medicine by female-identifying people from around the world”. Our journal is supporting this important project through its connected Women in Homeopathy collection, available to view via the Authors tab on the homepage. Akin to the format of a Virtual Special Issue, its content is articles published in Homeopathy from 2022 onward that have prominently female authorship. We hope that the new online collection adds encouragement to women to continue in homeopathy research and to submit ever more work to the journal. The contribution by women has been a stand-out feature of Homeopathy for many years, and female authorship is again well represented in this current issue of the journal. Each of the first two papers is a randomised controlled trial (RCT) in humans, on the novel topics of ringworm and hyperuricemia, with inconclusive and positive findings respectively.2,3 An international survey on the uptake and prevalence of the use of repertory software among homeopathy practitioners is the topic of our third article.4 The ever-eclectic nature of homeopathy research is reflected in the remaining papers: an RCT on homeopathic products as a complementary dietary additive for pigs5; an in-vitro experiment on the antimicrobial activity of dynamised essential oil of the medicinal plant Aloysia polystachya6; and the laboratory development of a method to immobilise solvatochromic dyes on cellulose films that will refine the investigation of dye–potency interactions.7 The issue is suitably completed by a clinical case report, from an allfemale group of authors, detailing the effective use of homeopathy to treat a woman with multiple chronic conditions.8","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"73"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9538472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immobilization of Solvatochromic Dyes on Transparent Cellulose Films: an Improved Method for the Study of Homeopathic Potencies. 透明纤维素膜固定化溶剂致变色染料:一种研究顺势疗法药效的改进方法。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 DOI: 10.1055/s-0042-1751255
Steven J Cartwright
{"title":"Immobilization of Solvatochromic Dyes on Transparent Cellulose Films: an Improved Method for the Study of Homeopathic Potencies.","authors":"Steven J Cartwright","doi":"10.1055/s-0042-1751255","DOIUrl":"https://doi.org/10.1055/s-0042-1751255","url":null,"abstract":"<p><strong>Background: </strong>Highly diluted and succussed solutions (homeopathic potencies) have been shown to interact with a wide range of solvatochromic dyes based on changes in their UV-visible spectra. Studies so far have involved free dyes in solution, but there is a pressing need to find ways to investigate the potency-dye interaction using isolated dye molecules to ask more searching physico-chemical questions regarding the fundamental nature of potencies.</p><p><strong>Aims and methods: </strong>The aims of the present study have been to look for ways to covalently immobilize solvatochromic dyes onto transparent cellulose films and hence be in a position to investigate dye-potency interactions without the complication of dye-dye interactions, including dye aggregation, which can occur with free dyes in solution.</p><p><strong>Results: </strong>To date, a total of nine different dyes have been immobilized on cellulose films using epoxide activation of hydroxyl groups on the cellulose surface. Using this method, studies have begun looking at the time course of potency action on one of these immobilized dyes, Brooker's merocyanine. Results show that the interaction of <i>Arsenicum</i> 10M with this dye consists of three phases-an initial growth phase, a sustained plateau of interaction, and a final decline phase lasting several days.</p><p><strong>Conclusion: </strong>A method has been developed that successfully immobilizes solvatochromic dyes onto transparent cellulose film. These films can then be used in a spectrophotometer to study at a much more detailed level how potencies interact with dyes compared with using free dyes in solution. Results indicate that the information gained in this way provides new insights regarding the fundamental nature of potencies. Specifically, studies using immobilized Brooker's merocyanine with <i>Arsenicum</i> 10M reveal that the lifetime of the potency is much longer than expected and that its action consists of three distinct phases, suggesting a resonant interaction with the dye. How resonant interaction might help to explain the clinical action of potencies is discussed.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"125-134"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Multimorbidity in a 35-Year-Old Female Patient Treated with Homeopathy: A Case Report. 顺势疗法治疗35岁女性多病1例。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 DOI: 10.1055/s-0042-1749594
Jayasubhashini Mallangi, Jyotika Chaudhuri, Roja Varanasi, Praveen Oberai
{"title":"Multimorbidity in a 35-Year-Old Female Patient Treated with Homeopathy: A Case Report.","authors":"Jayasubhashini Mallangi,&nbsp;Jyotika Chaudhuri,&nbsp;Roja Varanasi,&nbsp;Praveen Oberai","doi":"10.1055/s-0042-1749594","DOIUrl":"https://doi.org/10.1055/s-0042-1749594","url":null,"abstract":"<p><strong>Background: </strong>Multimorbidity, a prevailing trend in the primary care population of all ages, is a challenge for health care systems that are largely configured for single disease management. Homeopathy has shown competence in the management of chronic diseases, whether they occur as a single ailment or as a multimorbidity.</p><p><strong>Case history: </strong>A 35-year-old female patient presenting with hemorrhoids, low back pain, hypothyroidism, fibroadenosis breasts (bilateral), and fibroid uterus was given homeopathic treatment for 33 months at Nandigama AYUSH Lifestyle Disorders Clinic, Andhra Pradesh. She was prescribed the homeopathic medicines <i>Lachesis mutus</i> and <i>Thyroidinum</i> at different time intervals based on the totality of symptoms.</p><p><strong>Results: </strong>Following treatment, a reduction in the size of the uterine fibroid and complete regression of breast lumps in ultrasonography were noted. The modified Naranjo criteria total score was 10 out of 13. Further, significant improvement in symptoms and laboratory parameters, such as triiodothyronine (T3), tetra-iodothyronine (T4), and thyroid-stimulating hormone (TSH), indicated that a well-chosen homeopathic medicine may be beneficial in managing multimorbidity.</p><p><strong>Conclusion: </strong>This case study reveals a positive role of homeopathic treatment in multimorbidity. More case studies and well-designed controlled research should be used to further investigate homeopathic intervention in multimorbidity.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"135-142"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9947238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Homeopathic Products as a Complementary Dietary Additive for Pigs in their Growing and Finishing Phases. 顺势疗法产品作为猪生长发育和肥育阶段的补充膳食添加剂。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 Epub Date: 2022-09-02 DOI: 10.1055/s-0042-1749147
Geraldyne Nunes Wendt, Jansller Luiz Genova, Liliana Bury de Azevedo, Paulo Evaristo Rupolo, Cristine Regina Gregory, Josiane Aparecida Volpato, Silvana Teixeira Carvalho, Paulo Levi de Oliveira Carvalho, Tiago Junior Pasquetti
{"title":"Homeopathic Products as a Complementary Dietary Additive for Pigs in their Growing and Finishing Phases.","authors":"Geraldyne Nunes Wendt,&nbsp;Jansller Luiz Genova,&nbsp;Liliana Bury de Azevedo,&nbsp;Paulo Evaristo Rupolo,&nbsp;Cristine Regina Gregory,&nbsp;Josiane Aparecida Volpato,&nbsp;Silvana Teixeira Carvalho,&nbsp;Paulo Levi de Oliveira Carvalho,&nbsp;Tiago Junior Pasquetti","doi":"10.1055/s-0042-1749147","DOIUrl":"10.1055/s-0042-1749147","url":null,"abstract":"<p><strong>Background: </strong>Homeopathic products (HP) have been proposed for the prevention of disease and as a complementary dietary additive in pig farming, with resulting improved performance and quality of life of the animals and with benefits for food safety. The aim of this study was to assess the addition of HP to pig feed and its effects on growth performance, dietary protein utilization, nutrient digestibility, meat quality, and economic feasibility.</p><p><strong>Methods: </strong>A total of 80 male pigs, body weight 32.8±2.3kg, were allocated in a randomized design, with two treatments of 10 replications and four animals per experimental unit. Treatments were composed of a control diet (CD) or CD+HP (Finalvitaplus+Figotonus, 1.1kg/ton feed of each product). The outcome measures used were growth performance (body weight gain) and feed efficiency (body weight gain per unit of feed consumed), efficiency of dietary protein utilization (blood urea nitrogen), nutrient digestibility (apparent digestibility coefficient and apparent nutrient digestibility), meat quality (including pH, temperature, color, liquid loss by cooking and thawing, intramuscular fat and meat tenderness), and economic feasibility (cost of the diets).</p><p><strong>Results: </strong>There was no effect (<i>p</i> >0.05) of treatments on growth performance of the pigs, though the group that received HP showed an 8.93% greater feed efficiency than the control group (<i>p</i>=0.077). The animals in the control group had a 14.37% higher blood urea nitrogen concentration in the finishing I phase (70-100kg body weight) compared with those fed HP (<i>p</i>=0.028), indicating lower protein utilization in the controls. There was comparative improvement in digestibility coefficient and in nutrient digestibility in pigs fed HP in the growing-finishing phase (<i>p</i> <0.05). There was no differential effect of treatments on meat quality or economic feasibility (<i>p</i> >0.05).</p><p><strong>Conclusion: </strong>The addition of HP to the diet of growing-finishing pigs produced some improvement in their dietary protein utilization, nutrient digestibility and feed efficiency, though it did not affect their growth performance, meat quality or economic feasibility.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"107-109"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Individualized Homeopathic Medicines in the Treatment of Tinea Corporis: Double-Blind, Randomized, Placebo-Controlled Trial. 个体化顺势疗法药物治疗体癣:双盲、随机、安慰剂对照试验。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-05-01 DOI: 10.1055/s-0042-1750799
Bakibillah Laskar, Swapan Paul, Abhijit Chattopadhyay, Avaranjika Karuppusamy, Dharshna Balamurugan, Puja Bhakta, Sourav Das, Siddhartha Pal, Navin Kumar Singh, Munmun Koley, Subhranil Saha
{"title":"Individualized Homeopathic Medicines in the Treatment of Tinea Corporis: Double-Blind, Randomized, Placebo-Controlled Trial.","authors":"Bakibillah Laskar,&nbsp;Swapan Paul,&nbsp;Abhijit Chattopadhyay,&nbsp;Avaranjika Karuppusamy,&nbsp;Dharshna Balamurugan,&nbsp;Puja Bhakta,&nbsp;Sourav Das,&nbsp;Siddhartha Pal,&nbsp;Navin Kumar Singh,&nbsp;Munmun Koley,&nbsp;Subhranil Saha","doi":"10.1055/s-0042-1750799","DOIUrl":"https://doi.org/10.1055/s-0042-1750799","url":null,"abstract":"<p><strong>Introduction: </strong>Tinea corporis (TC; ringworm or dermatophytosis) is a superficial skin infection caused by <i>Microsporum</i>, <i>Epidermophyton</i> and <i>Trichophyton</i> genera of dermatophytes. We compared the effects of individualized homeopathic medicines (IHMs) in fifty-millesimal (LM) potencies against placebo in TC.</p><p><strong>Methods: </strong>A double-blind, randomized, placebo-controlled, two parallel arms trial was conducted on 62 individuals suffering from TC at the National Institute of Homoeopathy, India. Participants were randomized in a 1:1 ratio to receive either IHMs in LM potencies or identical-looking placebos for a period of 3 months. The primary outcome measure was the number of participants showing complete disappearance of skin lesions after 3 months. Secondary outcomes were a numeric rating scale (NRS) measuring intensity of itching and the Skindex-29 questionnaire (overall, and three sub-scales - degree of symptoms, psychological functioning, emotional status). All were assessed at baseline and every month, up to 3 months. The intention-to-treat sample was analyzed to detect inter-group differences using two-way repeated measures analysis of variance after adjusting for baseline differences.</p><p><strong>Results: </strong>The primary outcome revealed no improvement in either of the groups (<i>χ</i> <sup>2</sup> = 0.012, <i>p</i> = 0.999). Inter-group differences in some of the secondary outcomes favored IHMs against placebo - itching NRS (mean group difference after 3 months: -0.7 (95% confidence interval [CI], -1.1 to -0.4; <i>p</i> = 0.001); Skindex-29 overall (mean group difference after 3 months: 3.2 [95% CI, -0.6 to 7.0; <i>p</i> = 0.009]); Skindex-29 degree of symptoms (mean group difference after 3 months: 0.9 [95% CI, -0.2 to 1.9; <i>p</i> = 0.007]); and Skindex-29 psychological functioning (mean group difference after 3 months: 1.7 [95% CI, 0-3.4; <i>p</i> = 0.002]).</p><p><strong>Conclusion: </strong>Results were negative on the primary outcome; however, secondary outcomes included some statistically significant results favoring IHMs against placebo after 3 months.</p><p><strong>Trial registration: </strong>CTRI/2019/11/021999; UTN: U1111-1242-0070.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"74-84"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9566462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Searching for the Genus Epidemicus in Chinese Patients: Findings from the Clificol COVID-19 Clinical Case Registry. 在中国患者中寻找流行病学属:来自cliicol COVID-19临床病例登记处的发现。
IF 1.7 4区 医学
Homeopathy Pub Date : 2023-02-01 DOI: 10.1055/s-0042-1750380
Alexander Tournier, Yvonne Fok, Robbert van Haselen, Aaron To
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引用次数: 2
Transition and Evolution in Homeopathy Research. 顺势疗法研究的转变与发展。
IF 1.2 4区 医学
Homeopathy Pub Date : 2023-02-01 Epub Date: 2023-01-23 DOI: 10.1055/s-0042-1760101
Robert T Mathie
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引用次数: 0
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