Homeopathy最新文献

{"title":"Arsenicum album Induces Cell Cycle Arrest and Apoptosis, and Inhibits Epithelial-Mesenchymal Transition in Hormone-Dependent MCF7 Breast Cancer Cells.","authors":"Nilanjana Basu,&nbsp;Manoj Garg,&nbsp;Chanderdeep Tandon,&nbsp;Bhudev Chandra Das,&nbsp;Simran Tandon","doi":"10.1055/s-0042-1755364","DOIUrl":"https://doi.org/10.1055/s-0042-1755364","url":null,"abstract":"<p><strong>Background: </strong>Arsenic trioxide (As₂O₃) has been in therapeutic use since the 18th century for various types of cancers including skin and breast; however, it gained popularity following FDA approval for its use against acute promyelocytic leukemia. This present work was designed to evaluate the anti-cancer potential of a homeopathic potency of arsenic trioxide (<i>Arsenicum album</i> 6C) in hormone-dependent breast cancer.</p><p><strong>Methods: </strong>Breast cancer cells (MCF7) were treated with <i>Arsenicum album</i> (<i>Ars</i> 6C) to evaluate its anti-proliferative and apoptotic potential. We examined the effect of <i>Ars</i> 6C on the cell cycle, wound healing, reactive oxygen species (ROS) generation, and modulation of expression of key genes which are aberrant in cancer.</p><p><strong>Results: </strong>Treating breast cancer cells with <i>Ars</i> 6C halted the cell cycle at the sub-G0 and G2/M phases, which could be attributed to DNA damage induced by the generation of ROS. Apoptotic induction was associated with upregulation of Bax expression, with concurrent downregulation of the Bcl-2 gene. <i>Ars</i> 6C was also seen to reverse epithelial to mesenchymal transition and reduce the migration of breast cancer cells.</p><p><strong>Conclusion: </strong>The findings suggest that <i>Ars</i> has significant anti-proliferative and apoptotic potential against breast cancer cells. Further studies are required to elucidate the mechanism by which <i>Ars</i> exerts its effect in the <i>in vivo</i> setting.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 3","pages":"160-169"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10529244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effects of Administering Ultradiluted Avena sativa and Echinacea angustifolia on the Hematological Parameters of Magellanic penguins (Spheniscus magellanicus) during the Reproductive Period.","authors":"Franscinne Brait Narita,&nbsp;Melina Castilho de Souza Balbueno,&nbsp;Michele Legnaro Yang,&nbsp;Kleber da Cunha Peixoto,&nbsp;Ralph E T Vanstreels,&nbsp;Cidéli de Paula Coelho","doi":"10.1055/s-0042-1751308","DOIUrl":"10.1055/s-0042-1751308","url":null,"abstract":"<p><strong>Background and aims: </strong>Penguins are seabirds that manifest physiological and immunological alterations during the reproductive season. The objectives of this study were to evaluate the laboratory parameters of male and female Magellanic penguins and to determine the penguins' hematological response to homeopathic medicines during that reproductive period.</p><p><strong>Methods: </strong>Penguins (<i>N</i> = 18), kept under human care in a zoological park setting, were evaluated during the reproductive period and were divided randomly into two groups: a group subjected to treatment with <i>Echinacea angustifolia</i> 6cH and <i>Avena sativa</i> 6cH (<i>N</i> = 8; four breeding couples), and a placebo control group (<i>N</i> = 10; five breeding couples). The investigators were blinded to treatment allocation. Two-way ANOVA was performed to determine whether the experimental group (control or verum) and the sex of the animal had any significant effect on the variation of each hematological parameter between the samples. One-way ANOVA was performed on hematological parameters for which the sex did not present a significant effect. The significance level was <i>p</i> ≤0.05.</p><p><strong>Results: </strong>Significant effects were seen regarding the following: mean corpuscular volume (MCV), in which the verum group showed an increase (29.78 ± 52.95 fL) while the control group showed stability/reduction (-3.08 ± 46.36 fL) (<i>p</i> = 0.049); proportion of heterophils, in which the verum group showed a less marked increase (8.38 ± 12.53%) than that of the control group (18.00 ± 9.37%) (<i>p</i> = 0.010); lymphocyte concentration, in which the verum group showed less marked reduction (-4.39 ± 2.21 × 109 cells/L) than that of the control group (-1.56 ± 2.76 × 109 cells/L) (<i>p</i> = 0.001); and proportion of lymphocytes, in which the verum group showed a less marked reduction (-6.75 ± 10.35%) than that of the control group (-17.3 ± 8.73%) (<i>p</i> = 0.002).</p><p><strong>Conclusion: </strong>Comparison of samples collected before and during the reproductive period showed that, regardless of group allocation, there were differences in the effects on MCV, heterophils and lymphocytes. Treatment with <i>Echinacea angustifolia</i> and <i>Avena sativa</i> resulted in maintenance of lymphocyte levels in Magellanic penguins during the breeding period, thus aiding these birds' immunity.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 3","pages":"198-204"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathy as an Adjuvant to Standard Care in Moderate and Severe Cases of COVID-19: A Single-Blind, Randomized, Placebo-Controlled Study.","authors":"Harleen Kaur,&nbsp;Subhash Kaushik,&nbsp;Gurpreet Singh,&nbsp;Arvind Kumar,&nbsp;Shweta Singh,&nbsp;Tania Chatterjee,&nbsp;Syed Ali,&nbsp;Khushbu Gautam,&nbsp;Maneet Parewa,&nbsp;Naval Kumar Verma,&nbsp;Sushma Bhatnagar,&nbsp;Suraj Pal Singh,&nbsp;Varun Shekhar,&nbsp;Anil Khurana","doi":"10.1055/s-0042-1755365","DOIUrl":"https://doi.org/10.1055/s-0042-1755365","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate whether individualized homeopathic medicines have a greater adjunctive effect than adjunctive placebos in the treatment of moderate and severe cases of coronavirus disease 2019 (COVID-19).</p><p><strong>Methods: </strong>The study was a randomized, single-blind, prospective, placebo-controlled clinical trial set in the clinical context of standard care.</p><p><strong>Intervention: </strong>Patients of either sex, admitted in a tertiary care hospital, suffering from moderate or severe COVID-19 and above 18 years of age were included. In total, 150 patients were recruited and then randomly divided into two groups to receive either individualized homeopathic medicines or placebos, in addition to the standard treatment of COVID-19.</p><p><strong>Outcome measures: </strong>The primary outcome was time taken to achieve RT-PCR-confirmed virus clearance for COVID-19. Secondary outcomes were changes in the Clinical Ordinal Outcomes Scale (COOS) of the World Health Organization, the patient-reported MYMOP2 scale, and several biochemical parameters. Parametric data were analyzed using unpaired <i>t</i>-test. Non-parametric data were analyzed using the Wilcoxon signed rank test. Categorical data were analyzed using Chi-square test.</p><p><strong>Results: </strong>In total, 72 participants of the add-on homeopathy (AoH) group showed conversion of RT-PCR status to negative, in an average time of 7.53 ± 4.76 days (mean ± SD), as compared with 11.65 ± 9.54 days in the add-on placebo (AoP) group (<i>p</i> = 0.001). The mean COOS score decreased from 4.26 ± 0.44 to 3.64 ± 1.50 and from 4.3 ± 0.46 to 4.07 ± 1.8 in the AoH and AoP groups respectively (<i>p</i> = 0.130). The mortality rate for the AoH group was 9.7% compared with 17.3% in the AoP group. The MYMOP2 scores between the two groups differed significantly (<i>p</i> = 0.001), in favor of AoH. Inter-group differences in the pre- and post- mean values of C-reactive protein, fibrinogen, total leukocyte count, platelet count and alkaline phosphatase were each found to be statistically significant (<i>p</i> <0.05), favoring AoH; six other biochemical parameters showed no statistically significant differences.</p><p><strong>Conclusion: </strong>The study suggests homeopathy may be an effective adjunct to standard care for treating moderate and severe COVID-19 patients. More rigorous, including double-blinded, studies should be performed to confirm or refute these initial findings.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 3","pages":"184-197"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10529243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contemporary Expertise in Homeopathy.","authors":"Robert T Mathie","doi":"10.1055/s-0043-1770737","DOIUrl":"https://doi.org/10.1055/s-0043-1770737","url":null,"abstract":"Our journal must keep pace with contemporary expertise and active participation in the field of homeopathy, particularly in its clinical and research development. A key facet of any academic journal is the individual and collective membership of its Editorial Advisory Board (EAB), who help to ensure a rich supply of current ideas, articles and peerreviewer input. We have recently reviewed and updated Homeopathy’s EAB team, the first timewe have done so since 2019. In enhancing its overall specialist knowledge base, research activity and relevant geographic spread, the journal is welcoming 15 new EABmembers: Harleen Kaur, Munmun Koley, Praveen Oberai, Subhranil Saha, Simran Tandon (India), Patrízia Ana Bricarello, Cidéli Coelho, Elizabeth C. Perez Hurtado (Brazil), Jean Duckworth, Esther van derWerf, Elizabeth Thompson (UK), Maria Olga Kokornaczyk, Sandra Würtenberger (Switzerland), Joyce Frye (USA), and José Manuel Mazón-Suástegui (Mexico). Five individuals are departing from the EAB after many years of committed contribution to the journal: Philippe Belon, Brian Berman, Martin Chaplin, Klaus Linde and Lionel Milgrom. Not untypically, the current issue ofHomeopathy includes contributions from amongst its EAB membership, with articles in both fundamental and clinical research. The former add further evidence for physical or biological effects of homeopathic medicines in the laboratory setting,1–3while the latter report in vivo effects of homeopathy from clinical trials in humans4,5 and, notably, in penguins.6 The final article is a case report of a woman who received treatment for two concurrent clinical complaints using individualised homeopathic medicine.7","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 3","pages":"143"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9894169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nanomaterial Characterisation of Diluted Platina and Alcohol Control Samples.","authors":"E S Rajendran","doi":"10.1055/s-0042-1755335","DOIUrl":"https://doi.org/10.1055/s-0042-1755335","url":null,"abstract":"<p><strong>Background: </strong>The healing effects of homeopathic ultra-high potencies (UHPs) have always been a puzzle for material science, though recent research papers have now characterised the nanomaterial nature of several such UHPs. This study aimed to analyse the material content of clinically used potencies of the homeopathic medicine <i>Platina</i> (platinum) compared with alcohol control samples.</p><p><strong>Methods: </strong>Potencies of <i>Platina</i> were analysed under dynamic light scattering (DLS), high resolution transmission electron microscopy (HRTEM) with energy dispersive spectroscopy (EDS) and selected area electron diffraction (SAED) to identify the nanomaterial content. As control samples, both unsuccussed and potencies of alcohol were analysed by using DLS and HRTEM.</p><p><strong>Results: </strong><i>Platina</i> 30c to CM: Nanoparticles were identified under DLS (mean particle size varying from 1.3 nm in 30c to 6.5 nm in CM) and HRTEM (particle size varying from 3.31 to 12.7 nm in 30c to 1.94 to 8.54 nm in CM). EDS confirmed the presence of platinum in all the samples of <i>Platina</i>. SAED analysis of <i>Platina</i> 30c, <i>2</i>00c, 1M and 10M confirmed also the presence of platinum dioxide (PtO₂). For control samples, DLS and the HRTEM analyses of pharmaceutical grade unsuccussed alcohol and potentized <i>Alcohol</i> (6c, 12c and 30c) did not show any particles.</p><p><strong>Conclusion: </strong>Homeopathic potentization generated NPs of platinum in ultra-dilutions. NPs in potencies of <i>Platina</i> showed platinum in EDS and PtO₂ in SAED. Importantly, control samples of alcohol did not show the presence of particles under DLS or HRTEM.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 3","pages":"144-151"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10154148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Recurrent Urinary Tract Infection Successfully Treated during Homeopathic Supportive Care in Oncology.","authors":"Jean-Lionel Bagot,&nbsp;Georges Stahl","doi":"10.1055/s-0042-1758554","DOIUrl":"https://doi.org/10.1055/s-0042-1758554","url":null,"abstract":"<p><strong>Introduction: </strong>A 32-year-old patient with colon cancer consulted for homeopathic supportive care (HSC). She had also suffered from recurrent urinary tract infections (RUTIs) for 20 years. Could homeopathy treat these two very different issues with the same medicine?</p><p><strong>The patient's main concerns: </strong>Though the main reason for the consultation was a fear of the side effects of chemotherapy, the presence of <i>Escherichia coli</i>-induced RUTIs affected the patient's quality of life.</p><p><strong>Interventions and outcomes: </strong>The repertory listing highlighted <i>Pulsatilla</i> as the patient's homeopathic constitutional medicine. It was prescribed both for HSC and also for RUTI. In association with <i>Arsenicum album</i> and <i>Nerves</i>, <i>Pulsatilla e</i>nabled a good tolerance to chemotherapy, with rapid recovery from peripheral neuropathies. In combination with <i>Colibacillinum</i>, <i>Pulsatilla</i> provided relapse-free curing of the RUTIs. The MOdified NARanjo Criteria for Homeopathy (MONARCH) Inventory score was +9.</p><p><strong>Conclusion: </strong>The one individual's two different clinical complaints were treated with a constitutional homeopathic medicine, <i>Pulsatilla</i>, which covered the whole case. However, in HSC, the use of the constitutional remedy alone is rarely sufficient: it was reinforced by individualised symptomatic medication, organotherapy and isotherapy. For RUTI, isopathic and tubercular miasmatic treatments were each helpful. For both complaints, individualised homeopathy gave rapid, long-lasting and effective results.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 3","pages":"205-212"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Self-assembled Patterns Formed in Evaporating Droplets to Analyze Bi-component Homeopathic Preparations in the Low Dilution Range.","authors":"Maria Olga Kokornaczyk,&nbsp;Sandra Würtenberger,&nbsp;Stephan Baumgartner","doi":"10.1055/s-0042-1759543","DOIUrl":"https://doi.org/10.1055/s-0042-1759543","url":null,"abstract":"<p><strong>Background: </strong>Homeopathic complex remedies, composed of several homeopathic medicines in the low potency range, are frequently used in the treatment of a number of common disorders. At the same time, they represent an almost unexplored area of research. Are complex remedies just additive mixtures of the components, or are there interactions between the latter leading to new properties of the complex?</p><p><strong>Methods: </strong>In the present study, we analyzed as an example the simple bi-component complex, <i>Luffa</i> 4x - <i>Mercurius bijodatus</i> 9x, by means of patterns from evaporated droplets and tested what influences the complex's single compounds have upon the patterns and if there are any interactions. For this purpose, we compared in a series of five experiments patterns from evaporated droplets of the complex, <i>Luffa</i> 4x - <i>Mercurius bijodatus</i> 9x, and three comparison samples in which one or both of the complex's compounds were replaced by potentized solute. The patterns were photographed and evaluated for their gray-level distribution and texture using the software <i>ImageJ</i>. The experimental set-up's stability was tested by means of systematic control experiments.</p><p><strong>Results: </strong>We found that <i>Mercurius bijodatus</i> 9x significantly influenced the patterns of <i>Luffa</i> 4x, increasing their homogeneity; at the same time, the patterns of <i>Mercurius bijodatus</i> 9x combined with solvent were more heterogeneous than those obtained from a control consisting of two pure solvents.</p><p><strong>Conclusion: </strong>In this phenomenological assay, the complex <i>Luffa</i> 4x - <i>Mercurius bijodatus</i> 9x does not correspond to a simple addition of the components. The exact nature of the underlying interaction needs to be elucidated in further investigations.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 3","pages":"152-159"},"PeriodicalIF":1.7,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/83/06/10-1055-s-0042-1759543.PMC10411094.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10156581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamized Aloysia Polystachya (Griseb.) Essential Oil: A Promising Antimicrobial Product.","authors":"Talita Thomaz Nader,&nbsp;Alexandre Henrique Leonel,&nbsp;Camila Yamasita Henrique,&nbsp;Silvia Helena Taleb Contini,&nbsp;Eduardo José Crevelin,&nbsp;Suzelei de Castro França,&nbsp;Bianca Waléria Berton,&nbsp;Ana Maria Soares Pereira","doi":"10.1055/s-0042-1748320","DOIUrl":"https://doi.org/10.1055/s-0042-1748320","url":null,"abstract":"<p><strong>Background: </strong>Compounds from vegetal matter have therapeutic potential to control highly prevalent microorganisms that are resistant to commonly used antimicrobial drugs. Dynamization of compounds can either maintain or improve their therapeutic effects, and make their use safer, especially those compounds whose therapeutic dose is close to the toxic limit. <i>Aloysia polystachya</i> (Griseb.) stands out among aromatic plants with antimicrobial potential.</p><p><strong>Objective: </strong>The aim of this study was to evaluate the antimicrobial activity of dynamized and crude forms of <i>A. polystachya</i> essential oil against <i>Candida albicans</i>, <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>.</p><p><strong>Methods: </strong>Essential oil was extracted from <i>A. polystachya</i> dry leaves, solubilized, and dynamized at 1 cH potency as recommended by the Brazilian Homeopathic Pharmacopoeia. Antimicrobial activity against <i>C. albicans</i>, <i>E. coli</i> and <i>S. aureus</i> of the samples was assayed using the plate microdilution method.</p><p><strong>Results: </strong>Dynamized <i>A. polystachya</i> essential oil at the concentration of 1 μg/mL inhibited the growth of all the microbial species analyzed. The minimum inhibitory concentration of dynamized essential oil was smaller than crude essential oil for <i>S. aureus</i>, <i>E. coli</i> and <i>C. albicans</i>.</p><p><strong>Conclusion: </strong>It is reported for the first time that <i>A. polystachya</i> dynamized essential oil can effectively suppress microbial growth, and it is a promising adjuvant to treat infections with pathogenic <i>S. aureus</i>, <i>E. coli</i> and <i>C. albicans</i>.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"120-124"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9578562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attitudes To and Uptake of Repertory Software in Homeopathy Clinical Practice-Results of an International Survey.","authors":"Alastair C Gray,&nbsp;Parker Pracjek,&nbsp;Denise Straiges","doi":"10.1055/s-0042-1748841","DOIUrl":"https://doi.org/10.1055/s-0042-1748841","url":null,"abstract":"<p><strong>Background: </strong>Despite the substantial size of the maturing complementary medicine (CM) industry, the technologies used by practitioners have received little research attention. In the clinical delivery of homeopathy services, repertory software can be employed to cross-reference client symptoms with numerous databases, making the process of seeking a clinical intervention quicker and more accurate. The purpose of the study is to learn about the quantitative patterns of usage, uptake and attitudes to repertory software amongst professional homeopaths.</p><p><strong>Methods: </strong>An online cross-sectional survey of 15 questions was completed by practicing professional homeopaths between August 2016 and May 2017, using non-probability snowball sampling. Questions gathered demographic information, reflections and attitudes on the use of electronic repertories in clinical homeopathy practice.</p><p><strong>Results: </strong>In total, 59% of respondents reported using software regularly in practice and 71% found that it adds clear value in their work. Sixty-eight percent of respondents learned about repertory software during homeopathy training, and 47% were introduced to software when they began clinical practice. Lack of sufficient training is a very important barrier to the use of repertory software, indicating that more robust and accessible software training is needed for practitioners. Many respondents agreed with a statement that repertory software represents good value for money and yet 46% agreed that it is cost prohibitive for most practitioners, signaling a challenge for software companies. Few respondents reported regularly using more than three of the most common repertory features.</p><p><strong>Conclusion: </strong>This preliminary study presents some potentially significant uptake, usage and attitude markers that stand to shed light on the practice of homeopathy and the place of emerging technologies such as repertory software. Ultimately, more research is needed to help identify and address the challenges, risks and tensions around integration of practice-enhancing technologies in CM educational and clinical settings to best serve the diverse and changing needs of practitioners.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"97-106"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9574814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized Homeopathic Medicines in Treatment of Hyperuricemia: Evaluation by Double-Blind, Randomized, Placebo-Controlled Trial.","authors":"Priyanka Ghosh,&nbsp;Subhasish Ganguly,&nbsp;Shyamal Kumar Mukherjee,&nbsp;Souvik Dutta,&nbsp;Abdur Rahaman Shaikh,&nbsp;Sk Swaif Ali,&nbsp;Navin Kumar Singh,&nbsp;Pulakendu Bhattacharya,&nbsp;Munmun Koley,&nbsp;Subhranil Saha","doi":"10.1055/s-0042-1751272","DOIUrl":"https://doi.org/10.1055/s-0042-1751272","url":null,"abstract":"<p><strong>Introduction: </strong>Hyperuricemia (HU) is a major health issue in India and across the globe. It increases the disease burden and hampers quality of life. This study was aimed at exploring the effects of individualized homeopathic medicines (IHMs) against placebo in the treatment of HU.</p><p><strong>Methods: </strong>This double-blind, randomized, placebo-controlled trial was conducted on 60 patients suffering from HU in the outpatient department of D. N. De Homoeopathic Medical College and Hospital, Kolkata. Each patient received either IHMs or identical-looking placebos, along with advice on dietary modifications irrespective of codes. Serum uric acid (SUA) level was the primary outcome measure; the HU quality of life questionnaire (HUQLQ) and the Measure Yourself Medical Outcome Profile version 2 (MYMOP-2) were the secondary outcomes; all measured at baseline, and every month, up to 3 months. Group differences were examined by two-way (split-half) repeated-measures analysis of variance after adjusting for baseline differences. Significance level was set at <i>p</i> ≤0.05, two-tailed.</p><p><strong>Results: </strong>The intention-to-treat sample (<i>n</i> = 58) was analyzed. Between-group differences in SUA levels (<i>F</i> _{1, 56} = 13.833, <i>p</i> <0.001), HUQLQ scores (<i>F</i> _{1, 56} = 32.982, <i>p</i> <0.001) and MYMOP-2 profile scores (<i>F</i> _{1, 56} = 23.873, <i>p</i> <0.001) were statistically significant, favoring IHMs against placebos, with medium to large effect sizes. <i>Calcarea carbonica</i> and <i>Pulsatilla nigricans</i> were the most frequently prescribed medicines. No serious adverse events were reported from either of the groups.</p><p><strong>Conclusion: </strong>IHMs showed significantly better results than placebos in reducing SUA levels and improving quality of life in patients suffering from HU.</p><p><strong>Trial registration: </strong>CTRI/2019/10/021503; UTN: U1111-1241-1431.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 2","pages":"85-96"},"PeriodicalIF":1.7,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9566467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}