Homeopathy最新文献

{"title":"Bayesian Estimates of Prevalence and Likelihood Ratio for Four Carcinosin Symptoms across Varied Clinical Conditions.","authors":"Trisha Manna, Md Sakhawat Hossain, Arpita Basu, Saima Shamim, Soumya Bhattacharyya, Subhranil Saha, Munmun Koley, Ashabul Mondal, Debasish Majumdar, Lex Rutten","doi":"10.1055/a-2877-0729","DOIUrl":"https://doi.org/10.1055/a-2877-0729","url":null,"abstract":"<p><strong>Background: </strong>In homeopathy, symptoms are central to remedy selection and are traditionally validated through clinical experience and materia medica descriptions. Prognostic factor research using likelihood ratios (LRs) offers a quantitative approach to determine how strongly individual symptoms predict treatment response. This study evaluated the prognostic relevance of four commonly described symptoms of <i>Carcinosin</i>-history of tuberculosis, sleeplessness, enjoyment of watching a thunderstorm, and artistic personality-using LR and Bayesian methods.</p><p><strong>Methods: </strong>This analytical, longitudinal, real-world study was conducted in the outpatient departments of an Indian homeopathic hospital. Adults with chronic diseases of at least 1 year's duration were included. Clinical outcomes were assessed using the Outcome Related to Impact on Daily Living (ORIDL) scale, with scores ≥ 2 indicating meaningful improvement. For each symptom, 2 × 2 contingency tables were constructed, and positive and negative LRs with 95% confidence intervals (CIs) were calculated for four <i>Carcinosin</i> symptoms. A Bayesian updating simulation was performed to estimate cumulative diagnostic probability from sequential symptom combinations.</p><p><strong>Results: </strong>Since 20 participants in the other-medicines group were lost to follow-up, a total of 1,614 participants were analyzed, of whom 128 received <i>Carcinosin</i>. The highest prognostic strength was observed for <i>enjoyment of watching a thunderstorm</i> (LR+ 5.6, 95% CI 4.5-7.0) and <i>artistic personality</i> (LR+ 4.6, 95% CI 3.7-5.8). <i>Sleeplessness</i> showed moderate association (LR+ 2.0, 95% CI 1.7-2.3), while <i>history of tuberculosis</i> demonstrated weak to modest discriminative value (LR+ 1.4, 95% CI 1.1-1.9). Bayesian updating indicated that behavioral symptoms produced the largest upgrade in posterior probability, reaching approximately 79% when all four symptoms were sequentially combined.</p><p><strong>Conclusion: </strong>Behavioral and personality-based symptoms provided substantially stronger prognostic support for <i>Carcinosin</i> prescribing than historical or general physical features. LR and Bayesian frameworks offered a practical, quantitative method for validating materia medica symptoms and refining individualized homeopathic prescribing.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Empirical Evaluation of the Repertory Rubric \"Anger, Consoled, when\" Using Likelihood Ratio-based Prognostic Factor Analysis in Individualized Homeopathic Practice.","authors":"Deepanwita Bhattacharyya, Sk Monsur Alam, Rajat Kumar Pal, Subhranil Saha, Soumya Bhattacharyya, Munmun Koley, Shifa Hashmi, Tuhina Parveen, Shubhadeep Das, Quamar Sultana, Ashabul Mondal, Lex Rutten","doi":"10.1055/a-2890-5821","DOIUrl":"https://doi.org/10.1055/a-2890-5821","url":null,"abstract":"<p><strong>Background: </strong>The rubric \"Anger, consoled, when\" is described in several homeopathic repertories and materia medica sources, but its prognostic relevance has not been quantitatively examined. This study applied likelihood ratio (LR)-based prognostic factor research (PFR) to evaluate its real-world utility in individualized homeopathic practice, aiming to bridge traditional knowledge with evidence-based validation.</p><p><strong>Methods: </strong>This analytical epidemiological longitudinal study prospectively documented clinical outcomes in routine outpatient care at D. N. De Homoeopathic Medical College and Hospital, Kolkata, India. Adult patients receiving individualized homeopathic treatment were followed for 3 months. Clinical outcomes were assessed using the Outcome Related to Impact on Daily Living (ORIDL) scale, with scores ≥ + 2 indicating clinically meaningful improvement. Remedy-specific LR+ and LR- with 95% confidence intervals (CIs) were calculated using 2 × 2 contingency tables. LR+ indicates the certainty that the given medicine will work in the given condition; LR- indicates the relationship between a symptom and a medicine if the symptom is absent. In addition, phi (<i>Φ</i>) coefficient statistics were applied to quantify the strength and direction of symptom-medicine associations, providing complementary effect-size information that enhanced interpretation of the prognostic relationships.</p><p><strong>Results: </strong>From 1,740 screened patients, 1,699 (97.5%) completed follow-up (mean age: 42.3 years; 62% female). A total of 73 homeopathic medicines were prescribed. <i>Chamomilla</i> exhibited the highest prognostic rule-in value (LR+ 2.0, 95% CI: 1.6 to 2.5), whereas <i>Natrum muriaticum</i> demonstrated the strongest symptom-remedy association (<i>Φ</i> = 0.118). Moderate associations (LR+ 1.5-1.9) occurred with <i>Kalium iodatum</i>, <i>Natrum muriaticum</i>, <i>Arsenicum album</i>, <i>Natrum carbonicum</i>, <i>Sepia officinalis</i>, and <i>Staphysagria macrosperma</i>. Phi analysis confirmed significant positive correlations (<i>Φ</i> = 0.12-0.18, <i>p</i> < 0.01) for <i>Natrum muriaticum</i>, <i>Chamomilla</i>, <i>Sepia officinalis</i> and <i>Arsenicum album</i>; <i>Causticum</i> showed a negative association (<i>Φ</i> = - 0.11, <i>p</i> = 0.03).</p><p><strong>Conclusion: </strong>The LR-PFR empirically validated rubric \"Anger, consoled, when\", identifying <i>Chamomilla</i> as the prognostically strongest remedy, whereas <i>Natrum muriaticum</i> demonstrated the strongest statistical association with the rubric. Integrating phi into PFR enhanced the interpretation of association magnitude, thereby informing evidence-based repertory updates and clinical decision-making in homeopathy.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of Homeopathic Stannum metallicum 30x against Pulsed Electromagnetic GHz Radiation: A Real-World Study.","authors":"Paul Doesburg, Claudia Scherr, Jens-Otto Andersen, Alexander L Tournier, Stephan Baumgartner","doi":"10.1055/a-2849-3991","DOIUrl":"https://doi.org/10.1055/a-2849-3991","url":null,"abstract":"<p><strong>Background: </strong>The pervasive use of cell phones has led to a substantial increase in pulsed electromagnetic fields (EMFs) in our immediate environment. For pharmaceuticals, close proximity EMF effects are considered analogous to those of conventional heating, whilst the effect on homeopathic preparations remains inconclusive.</p><p><strong>Objectives: </strong>Accordingly, we investigated whether pulsed EMF in the GHz range affects homeopathic preparations regarding their biological effects under real-world conditions.</p><p><strong>Methods: </strong><i>Stannum metallicum</i> 30x (nominal dilution 10^-30 of the original substance), and lactose 30x as a control, were subjected to 14 hours of close proximity cell phone irradiation (2G, second-generation wireless technology, open vocal call) or remained untreated. The homeopathic samples were positioned in a circle at the perimeter of a rotating plate adjacent to the cell phone (minimal distance, <i>d</i> = 7 cm) to ensure homogeneous exposure. Biological effects were investigated in a <i>Lepidium sativum</i> (cress) bioassay, assessing four independent outcome parameters. Experiments were performed in parallel at two independent laboratories. Experimental stability was monitored throughout the entire investigation with systematic negative control (SNC) experiments.</p><p><strong>Results: </strong>Untreated <i>Stannum metallicum</i> 30x exhibited significant effects compared to lactose 30x for all four outcome parameters in the bioassay used (<i>p</i> ≤ 0.05), while the cell phone-irradiated samples induced no effects at all. No significant effects were observed in any of the evaluations of the SNC experiments, indicative of a stable experimental set-up and a reliable and specific treatment effect.</p><p><strong>Conclusion: </strong>This is the first investigation that provides conclusive data that exposure of a homeopathic preparation to pulsed GHz EMF inactivates the homeopathic preparation regarding its biological effects. This finding cannot be extrapolated to other preparations or organisms, but warrants further investigation for potential implications in the clinical use of homeopathic preparations. Further in-depth follow-up studies under controlled laboratory conditions may contribute to substantiating hypotheses regarding the mode of action of ultra-molecular homeopathic preparations.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Epistemic Fragility in Homeopathy: Revisiting Reproducibility in an Individualized Therapeutic Paradigm.","authors":"Kishan Kumar Brij, Haobam Vidyalaxmi Devi, Megha Chaudhary","doi":"10.1055/a-2900-0873","DOIUrl":"https://doi.org/10.1055/a-2900-0873","url":null,"abstract":"","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149127386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized Homeopathic Medicines in Treating Depression, Anxiety, and Stress in Adults with Osteoarthritis of the Knee: A Double-Blind, Randomized, Placebo-Controlled Trial.","authors":"Meghamala Chakraborty, Rajat Chattapadhyay, Madhushree Mondal, Sayantan Bhowmick, Rayba Khatoon, Sanjay Sarkar, Tuhina Parveen, Priyanka Sen, Munmun Koley, Subhranil Saha","doi":"10.1055/a-2850-9160","DOIUrl":"https://doi.org/10.1055/a-2850-9160","url":null,"abstract":"<p><strong>Background: </strong>Knee osteoarthritis (OA) is frequently accompanied by depression, anxiety and stress, worsening pain, disability and quality of life. Evidence for individualized homeopathic medicines (IHMs) in addressing these co-existing psychological and physical burdens remains limited. This trial aimed to evaluate the efficacy and safety of IHMs compared with placebo in adults with knee OA and co-morbid depression, anxiety and/or stress.</p><p><strong>Methods: </strong>A double-blind, randomized (2:1), placebo-controlled, clinical trial was conducted at a teaching hospital in Kolkata, India. One hundred and ten participants aged between 50 and 70 years with knee OA (American College of Rheumatology [ACR] criteria) and mild-to-moderate depression (DASS-21) were randomized to receive IHMs plus concomitant care (CC) or placebo plus concomitant care for 3 months. Remedies were individualized through standardized homeopathic case-taking. Outcomes (DASS-21, Knee Injury and Osteoarthritis Outcome Score [KOOS], WOMAC, and Measure Yourself Medical Outcome Profile version 2 [MYMOP-2]) were assessed monthly for 3 months. Efficacy was assessed using multivariate linear mixed-effects models (primary test: Intervention × time interaction). Area under the curve analyses, effect sizes, and sensitivity analyses using Generalized Estimating Equations, and responder analyses were performed. Adjusted <i>p</i>-values used the Holm-Bonferroni method.</p><p><strong>Results: </strong>A significant group-by-time interaction favored IHMs for DASS-21 depression (<i>p</i> < 0.001), anxiety, and stress, alongside clinically meaningful improvements in KOOS and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain, function, and quality of life (most adjusted <i>p</i> < 0.001). Responder rates were higher with IHMs (59% vs. 11%). Mediation analysis indicated that pain reduction partially explained improvements in depression. No adverse events were reported.</p><p><strong>Conclusion: </strong>IHMs produced significant improvements in both psychological symptoms and physical outcomes related to knee OA compared with placebo, reflecting a holistic therapeutic effect without adverse events.</p><p><strong>Trial registration: </strong>CTRI/2024/03/064632.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149038411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Integrative Homeopathic Approach in the Management of Class II Mesangial Lupus Nephritis: A Case Report.","authors":"Punam Kumari, Yogyata Kashyap","doi":"10.1055/a-2838-7238","DOIUrl":"https://doi.org/10.1055/a-2838-7238","url":null,"abstract":"<p><strong>Background: </strong>Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder with frequent renal involvement that significantly influences disease prognosis. Class II mesangial lupus nephritis represents an early histopathological stage and may present with persistent proteinuria and recurrent disease flares. Conventional long-term management often requires prolonged corticosteroid and immunosuppressive therapy, which may lead to adverse effects and therapeutic dependency.</p><p><strong>Case summary: </strong>A 20-year-old male with SLE and biopsy-proven Class II mesangial lupus nephritis presented with recurrent febrile episodes, fatigue, weight loss, thrombocytopenia and persistent proteinuria, despite extended treatment with corticosteroids, mycophenolate mofetil and hydroxychloroquine. Individualized homeopathic treatment was initiated in February 2022 following a comprehensive constitutional assessment. <i>Lycopodium clavatum</i> was prescribed as the principal remedy, with <i>Serum anguillae</i> used supportively during periods of urinary involvement, in accordance with classical homeopathic principles. The patient was followed clinically and through periodic laboratory investigations for over 3 years.</p><p><strong>Results: </strong>During follow-up, the frequency and intensity of febrile episodes gradually declined, with improvement in appetite, body weight and overall well-being. Laboratory findings demonstrated improvement in platelet counts and relative stabilization of renal parameters, including reduction in proteinuria and protein-creatinine ratio over time. Corticosteroids were tapered and eventually discontinued under specialist supervision without major documented exacerbation. Causal attribution assessment using the MONARCH inventory yielded a total score of +8, suggesting a temporal association between the individualized homeopathic intervention and the observed clinical course.</p><p><strong>Conclusion: </strong>This case report describes a temporal association between adjunctive individualized homeopathic treatment and clinical stabilization in Class II mesangial lupus nephritis. The findings should be interpreted cautiously. This report does not support the replacement of standard-of-care therapy but suggests a possible supportive role that warrants further systematic investigation.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148989862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Routine Data Collection of Patients Attending Clinics operated by Homeopathy UK: A Cohort Study.","authors":"Philippa Fibert, Jenny Thomas, Androulla Pillos-Smith","doi":"10.1055/a-2849-2350","DOIUrl":"https://doi.org/10.1055/a-2849-2350","url":null,"abstract":"<p><strong>Background: </strong>Reporting clinical outcome data in a unified way enables better understanding of service utilisation, patient profiles and perceived treatment benefit. Such reports may provide better representation of the homeopathic experience than randomised controlled trials, where ecological, model and external validity are often sacrificed for internal validity.</p><p><strong>Methods: </strong>Appointment and outcome data from Homeopathy UK clinics over six financial years are consolidated to assess trends in service usage: patient demographics, appointment patterns, remedies prescribed, and conditions seen. Clinical outcomes are documented using Outcome in Relation to Impact on Daily Living (ORIDL). Maximum ORIDL scores are calculated to capture the greatest impact of treatment to date.</p><p><strong>Results: </strong>2,523 appointments for 1,025 patients across 12 clinics took place between 2017 and 2023. Fifty-eight percent (595/1,025) had at least one follow-up (average 2.46). 75.3% of the appointments were for female patients. The mean age was 48.3 years. The most frequently treated conditions across appointments were anxiety (10.3%), eczema (5.5%) and depression (3.6%). 20% of appointments were for mental health conditions. Main condition ORIDL scores were available for 542 patients: ≥ +1 (<i>N</i> = 441); ≥ +2 (<i>N</i> = 272), of whom <i>N</i> = 40 considered their main condition cured (≥ +4); negative scores (<i>N</i> = 4); no change (<i>N</i> = 97). Wellbeing ORIDL scores were available for 546 patients: ≥ +1 (<i>N</i> = 447); ≥ +2 (<i>N</i> = 272), of whom <i>N</i> = 29 considered their wellbeing back to normal (≥ +4); negative scores (<i>N</i> = 5); no change (<i>N</i> = 94). The most commonly prescribed remedies were <i>Nat-mur</i>, <i>Sulph</i> and <i>Sep</i>.</p><p><strong>Conclusion: </strong>Consistent, routine outcome measurement in clinical practice is important, and this large dataset offers useful information. Patients came to the clinics with various conditions, but the number coming for treatment of mental health conditions is notable. Just over half of those with more than one appointment perceived meaningful improvement due to the homeopathic intervention. Continued data collection can inform service development, patient benefit and clinical research.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148929669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Callithrix jacchus Using Platynosomum sp. 30cH Biotherapeutic: A Case Report.","authors":"Jéssica A Martins, Melina C S Balbueno, Cidéli P Coelho","doi":"10.1055/a-2843-8171","DOIUrl":"https://doi.org/10.1055/a-2843-8171","url":null,"abstract":"<p><strong>Background: </strong>Platynosomiasis is a disease caused by a biliary fluke, which can lead to chronic weight loss and liver damage, contributing to declining health and high mortality rates in non-human primates. The aim of this study was to describe the treatment of platynosomiasis using a <i>Platynosomum</i> sp. 30cH biotherapeutic.</p><p><strong>Methods: </strong>A female <i>Callithrix jacchus</i> presented loss of appetite, abdominal distension, pain, and diarrhea. Ultrasound examination revealed findings suggestive of platynosomiasis. The treatment with biotherapeutic <i>Platynosomum</i> sp. 30cH was started, and one globule was given twice a day. Ultrasound monitoring was carried out monthly, and the condition improved during a period of 90 days.</p><p><strong>Results: </strong>Ultrasound monitoring was carried out monthly, and the condition improved in 90 days with the biotherapeutic <i>Platynosomum</i> sp. 30 cH. The MOdified NARanjo Criteria for Homeopathy (MONARCH) score was +10, suggesting a causal link between the use of homeopathic therapy and clinical outcome.</p><p><strong>Conclusion: </strong>Biotherapy is an option to be considered for the treatment of platynosomiasis in non-human primates.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Retrospective Comparative Study of Concordance Between Artificial Intelligence Remedy Suggestion and Synthesis Repertory Results in Urinary Tract Infection Cases.","authors":"Akshara Thayyil, Sandhya Kondalakadu, Anita Lobo, Manish Kumar Tiwari","doi":"10.1055/a-2836-9686","DOIUrl":"https://doi.org/10.1055/a-2836-9686","url":null,"abstract":"<p><strong>Background: </strong>Homeopathic prescribing traditionally relies on detailed case taking, repertorization, and consultation of the materia medica to identify the most appropriate simillimum. With the emergence of artificial intelligence (AI)-based tools, it has become possible to obtain rapid remedy suggestions based on symptom input, potentially bypassing classical repertorization steps. The extent to which such AI-generated suggestions align with classical repertorial outcomes remains insufficiently explored.</p><p><strong>Objective: </strong>To determine the concordance between remedies suggested by an AI-based tool and those obtained through classical repertorization using the Synthesis Repertory in cases of urinary tract infection (UTI).</p><p><strong>Methods: </strong>A retrospective comparative study was conducted on 34 well-documented UTI cases. Each case was repertorized using the Synthesis Repertory via Radar software, and the first 10 remedies were recorded. The same symptom totality was entered into an AI-based tool (HomeoXpert by Nambisons), accessed through ChatGPT, to obtain a single remedy suggestion. Concordance was classified as an exact match (same first remedy), within the first 10 repertorial remedies, or absent.</p><p><strong>Results: </strong>Exact concordance between the AI-suggested remedy and the first repertorial remedy was observed in three cases (8.8%). In 18 cases (53%), the AI-suggested remedy appeared within the first 10 repertorial remedies. In 13 cases (38.2%), the AI-suggested remedy did not appear among the first 10 repertorial remedies.</p><p><strong>Conclusion: </strong>AI-based remedy suggestions showed partial concordance with classical repertorial outcomes, most commonly appearing within the first 10 remedies rather than as an exact match. These findings suggest that AI tools may serve as supportive aids in the preliminary stages of remedy consideration but cannot replace classical repertorization and clinical judgment in homeopathic prescribing.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do Distinct Homeopathic Potencies of Arnica montana Differentially Modulate Fibroblast Proliferation and Migration In Vitro?","authors":"Adalet Kutlu, Sibel Özdaş, Hayrunnisa Yeşil Sarsmaz, Şeyma Taşdemir, Seren Gülşen Gürgen","doi":"10.1055/a-2849-8472","DOIUrl":"https://doi.org/10.1055/a-2849-8472","url":null,"abstract":"<p><strong>Context: </strong><i>Arnica montana</i> (<i>A. montana</i>) is widely used in homeopathy for trauma-related wound management; however, the cellular and molecular effects of different homeopathic potencies remain unclear.</p><p><strong>Objectives: </strong>This study aimed to determine whether different homeopathic potencies of <i>A. montana</i> induce distinct, potency-specific effects on fibroblast proliferation, migration, and wound healing-related protein expression <i>in vitro</i>.</p><p><strong>Methods: </strong>3T3-L1 fibroblasts were treated with 6q, 30cH, or 200cH potencies of <i>A. montana</i> for up to 72 hours. Cell morphology was assessed by phase-contrast microscopy; viability and proliferation by MTT assay; and wound closure by scratch-wound migration assay. Laminin, fibronectin, fibroblast growth factor (FGF), and transforming growth factor-beta 1 (TGF-β1) protein levels were quantified using ELISA and immunocytochemistry. Control groups included untreated medium and vehicle (unsuccussed solvent).</p><p><strong>Results: </strong>Scratch-wound assays demonstrated a marked, potency-specific enhancement of fibroblast migration and wound closure following treatment with <i>A. montana</i>, with the 200cH potency inducing the most rapid and complete closure over 72 hours. These functional effects were accompanied by increased fibroblast proliferation at later time points and higher intracellular levels of laminin, fibronectin, FGF and TGF-β1 protein, particularly in the 200cH group, while cell morphology remained unaffected across all conditions.</p><p><strong>Conclusion: </strong>Among the tested potencies, <i>A. montana</i> 200cH showed the greatest stimulatory effect on fibroblast proliferation, migration, and wound healing-related protein expression. This study provides the first comparative evaluation of multiple <i>A. montana</i> potencies in a fibroblast wound-healing model, suggesting a potential potency-associated cellular response <i>in vitro</i>.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.1,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148812740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}