Homeopathy最新文献

{"title":"Homeopathy for Chronic Non-specific Low Back Pain: Study Protocol for a Randomized, Double-Blind, Crossover, Placebo-Controlled Clinical Trial Investigating the Efficacy of the Biotherapic Lumbar Vertebra (The BIOVERT Trial).","authors":"Ubiratan Cardinalli Adler, Maristela Schiabel Adler, Helen Nogueira Carrer, Deise Lilian Costa Dias, José Nelson Martins Diniz, Manoela Gomes Grossi, Neli Aparecida Martins Sugimoto, Edson Zangiacomi Martinez","doi":"10.1055/s-0043-1778062","DOIUrl":"10.1055/s-0043-1778062","url":null,"abstract":"<p><strong>Background: </strong>Chronic non-specific low back pain (CNSLBP) lacks identifiable anatomical pathology and effective pharmacological treatment. Alternative approaches in homeopathy, specifically clinical homeopathy, utilize ultra-diluted (potentized) biological products. In Brazil, standardized biotherapics from sheep tissues, particularly fifty-millesimal (LM) potencies of sheep <i>Lumbar Vertebra</i>, have shown promise in alleviating CNSLBP.</p><p><strong>Objectives: </strong>Our objective is to present the study protocol of a clinical trial that will assess the efficacy and safety of the biotherapic <i>Lumbar Vertebra</i> LM2 in the short-term management of CNSLBP and to estimate its therapeutic duration.</p><p><strong>Methods: </strong>A randomized, double-blind, crossover, placebo-controlled clinical trial spanning 8 weeks per participant was designed. Participants will include 120 individuals (aged 20 to 60 years) with clinically diagnosed CNSLBP by the study's physiotherapist. Exclusion criteria are radicular pain, signs of radiculopathy, specific lumbar spine disorders, pregnancy, or puerperium (up to 60 days after delivery). The medical intervention includes participants being randomly assigned to one of two treatment sequences: homeopathy-placebo or placebo-homeopathy. The treatments will consist of <i>Lumbar Vertebra</i> LM2 oral solution, topical cream, and indistinguishable placebos. Each treatment period will span 2 weeks, with a 4-week washout interval between them. Primary outcome is the assessment of changes in self-reported pain levels using the numeric rating scale (NRS) score, analyzed with a random effects model across both treatment periods. Secondary outcomes are assessment of changes in self-reported disability levels using the Oswestry Disability Index (ODI), analyzed with a random effects model across both treatment periods, and pain and disability variations, evaluated by the NRS score and ODI respectively, after the first and second treatment periods. Adverse events will be assessed at weeks 2 and 8. Pain medications will be used concomitantly. Adherence will be evaluated by the weight of medication returned/standard weight.</p><p><strong>Discussion: </strong>The BIOVERT (Bioactive Vertebra) trial protocol is designed to investigate a homeopathic strategy for short-term CNSLBP treatment. Favorable outcomes for homeopathy could prompt subsequent studies evaluating the long-term effectiveness of LM potencies of <i>Lumbar Vertebra</i> for CNSLBP.</p><p><strong>Trial registration: </strong>UMIN Clinical Trials Registry - ID: UMIN000051957.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"231-238"},"PeriodicalIF":16.4,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140174503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Eupatorium Perfoliatum 30C in Preventing Dengue Fever-A Prospective, Community-Based, Open Label, Parallel Cohort Study in Delhi, India.","authors":"Debadatta Nayak, Lovepreet Kaur, Rupali Bhalerao, Karanpreet Nahar, Hanuman Ram, Pawan Sharma, Ankit Gupta, Smita Singh, Anil Khurana, Raj Kumar Manchanda","doi":"10.1055/s-0044-1788663","DOIUrl":"https://doi.org/10.1055/s-0044-1788663","url":null,"abstract":"<p><strong>Objective: </strong> The study was undertaken to evaluate the protective effect of <i>Eupatorium perfoliatum</i> (EP) 30C on the incidence of dengue fever.</p><p><strong>Design: </strong> This study was designed as a prospective, open label, parallel cohort study.</p><p><strong>Interventions: </strong> Participants were enrolled in two medicine cohort (MC) communities and one control cohort (CC) community. Participants in MC who were more than 5 years of age received four medicated globules and those aged between 1 and 5 years received two medicated globules of EP 30C once a week for 10 weeks. Participants in CC received no medical intervention. Both cohorts received information and educational material regarding dengue.</p><p><strong>Outcome measures: </strong> The primary outcome was incidence of dengue cases based on laboratory confirmation or the clinical definition of dengue as per the case definition notified by the National Vector-Borne Disease Control Program, Government of India, during the 14 weeks of intervention and observation.</p><p><strong>Results: </strong> The analysis included 20,607 participants residing in three slums of Delhi, of which MC and CC included 15,298 and 5,309 participants respectively. The overall protective effect of EP 30C in MC against probable/laboratory-confirmed dengue was 59.59% (95% confidence interval [CI], 50.74 to 66.85, <i>p</i> = 0.0001). The overall protective effect of EP 30C against laboratory-confirmed dengue was 72.78% (95% CI, 54.45 to 83.74, <i>p</i> = 0.0001): 26 cases per 15,298 (0.13 per 1,000 person-weeks) in MC versus 33 cases per 5,309 (0.46 per 1,000 person-weeks) in CC.</p><p><strong>Conclusion: </strong> The use of EP 30C was associated with some protection against probable and laboratory-confirmed dengue.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathy at a Turning Point.","authors":"Andrea Dei","doi":"10.1055/s-0044-1789000","DOIUrl":"https://doi.org/10.1055/s-0044-1789000","url":null,"abstract":"","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142286068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathy, Acupuncture and Phytotherapy in the Veterinary Treatment or Prophylaxis of Diseases in Animals: An Overview of Systematic Reviews","authors":"Edna Cristiane da Matta, Maristela Takeda, Nathalia Salles Scortegagna de Medeiros, Jorge Kioshi Hosomi, Leoni Villano Bonamin","doi":"10.1055/s-0044-1788570","DOIUrl":"https://doi.org/10.1055/s-0044-1788570","url":null,"abstract":"<p>\u0000<b>Introduction</b> Complementary and alternative veterinary medicine (CAVM) has been intensively used, and there is currently an increasing demand for a more rigorous approach regarding its clinical effectiveness.</p> <p>\u0000<b>Aims</b> The objectives of this overview were: first, to identify systematic reviews on homeopathy, acupuncture and phytotherapy in veterinary medicine and assess their methodological quality; and second, to map interventions and findings in the treatment or prophylaxis of any medical conditions in any animal species for which high-quality systematic reviews had identified reliable evidence of efficacy or effectiveness in randomized controlled trials (RCTs) or controlled clinical trials (CCTs).</p> <p>\u0000<b>Method</b> The study was an overview of systematic reviews published in the years 2000 to 2022 inclusive. The following databases were used: CAB Abstracts, PubMed and Vet Index, from which the abstracts of 173 articles were extracted, 22 of which were initially included for complete analysis. After excluding 15 studies according to the exclusion/inclusion criteria, 7 review papers were comprehensively analyzed. The review quality was assessed by the Measurement Tool to Assess Systematic Reviews (AMSTAR 2) method. The reported RCTs/CCTs in these reviews were analyzed for their reliability, and the results were classified according to statistical significance and risk of bias.</p> <p>\u0000<b>Results</b> Seven eligible systematic reviews reported studies on dogs, horses, cats, cattle, sheep, goats, swine, rabbits and poultry. The number of primary RCTs/CCTs was 38 for homeopathy, 35 for acupuncture, and 171 for phytotherapy. The AMSTAR 2 evaluation ranked two reviews of veterinary homeopathy as high-quality, in which two placebo-controlled RCTs comprised reliable evidence, one of which reported efficacy of homeopathy as prophylaxis for diarrhea in pigs. The systematic reviews of acupuncture and phytotherapy were all of low quality, preventing formal assessment of their reviewed RCTs/CCTs.</p> <p>\u0000<b>Conclusion</b> Only the systematic reviews of homeopathy were rated of sufficient quality to enable the assessment of reliable evidence within their reviewed RCTs. Contemporary high-quality systematic reviews of clinical trials in each of the three areas of CAVM are required.</p> ","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"45 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacoeconomic Study of Homeopathic Medicines: A Critical Appraisal of Methods and Conclusions Shows Serious Cause for Concern.","authors":"Angelina J Mosley","doi":"10.1055/s-0044-1788921","DOIUrl":"https://doi.org/10.1055/s-0044-1788921","url":null,"abstract":"","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"48 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Solvatochromic Dyes Track a Homeopathic Preparation through Water-Stream Systems in a Program to Control Tick Infestation at a Wild Animal Rehabilitation Center in Brazil","authors":"Nathalia Salles Scortegagna de Medeiros, Andréia Adelaide G. Pinto, Sérgio Frana, Mônica Filomena Souza, Ivana Barbosa Suffredini, Steven John Cartwright, Leoni Villano Bonamin","doi":"10.1055/s-0044-1787783","DOIUrl":"https://doi.org/10.1055/s-0044-1787783","url":null,"abstract":"<p>\u0000<b>Introduction</b> In 2021, the area of CRAS (Centro de Reabilitação de Animais Selvagens – Wild Animal Rehabilitation Center), located in a state park in Campo Grande City, Mato Grosso do Sul, Brazil, was suffering from a tick infestation affecting wild animals that inhabit the area and humans that visited its trails. Following a formal technical–scientific cooperation agreement between IMASUL, an institute for the environment in Mato Grosso do Sul state, and SIGO Homeopatia, a formulated homeopathic complex (<i>Formula Parques Urbanos</i>, FPU) was designed and prepared specifically to treat the animals. This environmental intervention used specially designed slow-release water biodegradable devices. Tracking the FPU signal in water was necessary to monitor and manage the intervention.</p> <p>\u0000<b>Aims</b> Our aims were (1) to evaluate, among six previously standardized solvatochromic dyes, which would serve as a marker for the homeopathic complex under study; and (2) to evaluate whether the chosen solvatochromic dye could map the propagation of the homeopathic complex activity throughout the stream system from water samples harvested at different locations over time.</p> <p>\u0000<b>Method</b> Water samples were harvested from each point at different times, filtered, frozen, and sent to the laboratory, where they were prepared at 1cH potency for analysis using 30% ethanol as the vehicle. Solvatochromic dyes were used to analyze the samples since they alter their absorbance when in contact with homeopathic potencies. Of the six dyes tested, Coumarin 7 was found to be the most suitable for tracking the FPU complex. A static and average unidirectional magnetic field of 2,400 Gauss (240 mT), generated by a neodymium magnet, was applied to the samples immediately before reading.</p> <p>\u0000<b>Results</b> There were significant differences in the delta absorbance of dyes when adding treated/potentized water samples, making it possible to map the propagation of the FPU signal throughout the park over time. The signals were identifiable at the same point 1 minute and 32 days after the insertion of the device into the water. These signals were also identifiable after 75 minutes and 8 days at a point far from the insertion place.</p> <p>\u0000<b>Conclusion</b> Coumarin 7 was the best marker for the homeopathic complex (FPU) used to treat the wild animals living in the park. The microplates/enzyme-linked immunosorbent assay reader method and the application of a magnetic field to samples were shown to be effective in tracing homeopathic signals by changes in dye absorbance (<i>p</i> ≤ 0.02) in a real-life situation, with large volumes of water, involving many environmental variables, and over large distances.</p> ","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"37 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142181201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of Aqueous Ultra-high Homeopathic Potencies: Nanoparticle Tracking Analysis.","authors":"Michel Van Wassenhoven, Martine Goyens, Pierre Dorfman, Philippe Devos, Jean-Louis Demangeat","doi":"10.1055/s-0044-1787782","DOIUrl":"https://doi.org/10.1055/s-0044-1787782","url":null,"abstract":"<p><strong>Background and objectives: </strong> Over the past decade, research using various methods has claimed the material nature, including nanoparticles (NPs), of high homeopathic potencies. The current study aims to verify these findings using NP tracking analysis (NTA).</p><p><strong>Methods: </strong> Six independent serial dilutions of commonly used homeopathic medicines-either soluble (<i>Gelsemium</i>, <i>Pyrogenium</i>, <i>Kalium mur</i>) or insoluble (<i>Cuprum</i>, <i>Argentum</i>, <i>Silicea</i>)-were prepared according to European Pharmacopoeia standards. We compared the homeopathic dynamisations (DYNs) in pure water with their potentised controls and with simple dilutions (DIL) up to 30cH/10^-60. We also tested the influence of the container (glass or PET) on the solvent controls.</p><p><strong>Results: </strong> We observed the presence of particles from 20 to 300-400 nm in all DYNs, DILs and controls, except in pure unstirred water. The sizes and size distributions of NPs in high homeopathic potencies were smaller than those in controls for soluble sources and larger for insoluble sources, even above 11cH. The opposite behaviour was observed in the number of NPs. When comparing DYN and DIL, the number, size, presence of aggregates or chains and brightness of NPs increased with DYNs, which was also observed above 11cH. Many NPs scattered light of low intensity, indicating the presence of material particles. The container had a significant effect on the number and size of NPs, indicating the involvement of the atmosphere and leaching processes.</p><p><strong>Conclusion: </strong> Homeopathic medicines contain NPs with specific properties, even when diluted beyond Avogadro's number. Homeopathic potentisation is not a simple dilution. The starting material, the solvent used, the type of container and the manufacturing method influence the characteristics of these NPs. The nature of these NPs is not known, but most likely they are a mixture of nanobubbles and elements from the atmosphere and container, including insoluble ones.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142017302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Role of Homeopathic Intervention in Post-COVID Functional Gastrointestinal Disorders: A Case Series of 12 Patient Profiles.","authors":"Hima Bindu Ponnam, Siva Subrahmanyam Chirravuri, Shanmukha Priya Konduru, Swathi Jammalamadaka","doi":"10.1055/s-0044-1787003","DOIUrl":"https://doi.org/10.1055/s-0044-1787003","url":null,"abstract":"<p><strong>Background: </strong> In the last 2 years of the pandemic, a wide range of cases of post-COVID functional gastrointestinal disorders (PC-FGIDs) has been reported.</p><p><strong>Aim: </strong> This case series aimed to investigate the role of homeopathic intervention in the treatment of PC-FGIDs.</p><p><strong>Methods: </strong> This is a retrospective analysis of the clinical data of individuals who had suffered from PC-FGIDs that were diagnosed based on clinical symptoms using the Gastrointestinal Symptoms Rating Scale (GSRS) and treated exclusively with individualized homeopathic medicines. Cases that had undergone regular monthly assessment using the GSRS and had a Post-COVID-19 Functional Status (PCFS) score for up to 3 months were considered.</p><p><strong>Results: </strong> Thirty cases were screened and twelve were included according to the study criteria. The mean age of seven women and five men was 36 years. GSRS and PCFS scores showed marked improvement in each of 10 cases within the 3-month treatment period.</p><p><strong>Conclusion: </strong> Homeopathic intervention proved beneficial in 10 of 12 patients with PC-FGIDs. The findings may help researchers plan future controlled clinical studies in this field.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.2,"publicationDate":"2024-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Three Powerful Traditions of Thinking that Constitute Homeopathy.","authors":"Josef M Schmidt","doi":"10.1055/s-0043-1775814","DOIUrl":"10.1055/s-0043-1775814","url":null,"abstract":"<p><p>By means of a historical, classical philological and philosophical approach, this paper attempts to demonstrate that homeopathy is based on three powerful traditions of thinking, which can be traced back to Ancient Greece's pre-Socratic era. Actually, it seems to be constituted by what may be termed <i>lógos</i>-, <i>hómoion</i>- and <i>iásthai</i>-thinking: that is, thinking in terms of rationality, similarity and healing. By contrast, modern medicine tends to be aligned with just one of these traditions, at the expense of the others, this being not without risk and adverse effects. It is mainly determined by the first type of rationality that genealogically derives from, and is therefore compatible with, the logic of economics whose predominance in the health care systems of modern societies is progressively rising. Homeopathy, however, may not be sufficiently and fairly understood without taking into account the complementary forms of thinking on which it also rests, such as the principle of similarity in an all-encompassing sense, and ancient healing knowledge in the tradition of catharsis. As a corollary of being essentially constituted by the three, homeopathy may persistently be in need of a dynamic equilibrium of its three constituent bases. Attempts to approach homeopathy from only one of the indicated modes of thinking fail to grasp its essence and result in figments or caricatures of what homeopathy was originally meant to be.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"176-185"},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11281835/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Patient Tapestry: Harnessing the Importance of Patient Perspectives in Advancing Homeopathy Research.","authors":"Abhijit Dutta","doi":"10.1055/s-0043-1775995","DOIUrl":"10.1055/s-0043-1775995","url":null,"abstract":"","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"205-208"},"PeriodicalIF":1.2,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138482352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}