Homeopathy最新文献

{"title":"Contributing Reviewers in 2022.","authors":"","doi":"10.1055/s-0042-1760385","DOIUrl":"https://doi.org/10.1055/s-0042-1760385","url":null,"abstract":"","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"i-ii"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9074420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The In-Vitro Effect of Homeopathically Prepared Rubus idaeus and 680 nm Laser Irradiation on Cervical Cancer Cells.","authors":"Kelley S Joubert,&nbsp;Blassan P George,&nbsp;Radmila Razlog,&nbsp;Heidi Abrahamse","doi":"10.1055/s-0042-1747683","DOIUrl":"https://doi.org/10.1055/s-0042-1747683","url":null,"abstract":"<p><strong>Background: </strong> Cervical cancer (CC) is the second leading cancer in women and is the most common in those aged 15 to 44 years. Medicinal plant extracts have been used as homeopathic preparations for health benefits. <i>Rubus idaeus</i> (<i>RI</i>) <i>is</i> used to treat disorders of the female genital tract and produces cytotoxic effects. However, the use of homeopathically prepared <i>RI</i> in combination with low level laser therapy has not previously been explored.</p><p><strong>Aim: </strong> The study aims to investigate the in-vitro effects of homeopathically prepared <i>RI</i> alone and in combination as a potential photosensitizer with Low-level laser irradiation (LLLI) at fluencies of 5, 10, and 15 J/cm².</p><p><strong>Methods: </strong> HeLa CC cells were treated with <i>RI</i> (D3, D6, and 30cH homeopathic preparations). Cells were then treated with <i>RI</i> IC₅₀ and 680 nm laser diode at 5, 10, and 15 J/cm² fluencies, and the results compared with untreated control cells. Trypan blue viability, lactate dehydrogenase (LDH) cytotoxicity, and adenosine triphosphate (ATP) proliferation assays were used to analyze the cellular dose-responses along with inverted microscopy, Hoechst staining and Annexin-V/PI staining.</p><p><strong>Results: </strong> <i>RI</i> D3 alone demonstrated an ability to reduce cellular viability to 59% and also to reduce ATP levels. The subsequent combined treatment protocol of <i>RI</i> D3 with all fluencies of laser demonstrated an increase in cellular ATP and increased LDH levels compared with the control.</p><p><strong>Conclusion: </strong> The increased ATP and LDH levels observed in the combined treatment protocol of 680 nm laser and <i>RI</i> D3 at fluencies of 5, 10 and 15 J/cm², show that the Warburg effect might have been induced in the CC cells - an increase in glucose uptake and the preferential production of lactate, even in the presence of oxygen. More research, including work on other cell lines, needs to be conducted to identify if <i>RI</i> and perhaps a different wavelength of laser irradiation could have potential in inducing cell death in cancer cells.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"50-56"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10563713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathic Treatment in Patients with COVID-19: Analysis of Clinical Evolution and Comparison between Cases in 2020 and 2021.","authors":"Fernanda Maria Simões da Costa Fujino,&nbsp;Ana Amélia Campos Claro Olandim,&nbsp;Jennifer Anne Coggan,&nbsp;Antonio Deusany de Carvalho Junior,&nbsp;Adriana de Queiroz Soares Bufalo,&nbsp;Eduardo Nishimiya Takeyama,&nbsp;Soraya Cristina Sant'Ana,&nbsp;Vagner Doja Barnabé,&nbsp;Nilson Roberti Benites","doi":"10.1055/s-0042-1749447","DOIUrl":"https://doi.org/10.1055/s-0042-1749447","url":null,"abstract":"<p><strong>Background: </strong> The manifestations of coronavirus disease 2019 (COVID-19) can result in several prognoses and lead patients to look for appropriate complementary or alternative treatment options according to their personal situation and available health care. Patients with mild symptoms or those who have not yet reached the maximum severity of their condition are those who seek outpatient care, where homeopathic treatment might be considered, given the well documented history of this medical system in several epidemics in the past.</p><p><strong>Objective: </strong> The aim of this study was to compare the homeopathic treatment used for symptomatic cases of COVID-19 in March and April 2020 with cases treated in March and April 2021.</p><p><strong>Method: </strong> This is a retrospective observational study based on the analysis of the medical records of symptomatic COVID-19 patients treated on an outpatient basis with homeopathy at the Hahnemanniano George Galvão Institute in São Paulo, Brazil. We analyzed 54 cases, divided into two samples (27 cases in each year), similar in relation to age, gender and origin of the patients.</p><p><strong>Results: </strong> The development was distinct in the 2 years, with improvement of symptoms after 3 days of the first homeopathic prescription in 2020 whilst in 2021 the improvement occurred from the sixth day onward. The most frequently prescribed homeopathic medicine also differed in the two samples (<i>Antimonium tartaricum</i> in 2020; <i>Arsenicum album</i> in 2021), which indicates the different disease characteristics at these two moments of the epidemic.</p><p><strong>Conclusion: </strong> In 2020, the symptomatology of the cases was mainly acute and the main medicine was <i>Antimonium tartaricum</i>. By comparison, in 2021 a greater interference from individuals' previous chronic miasmatic disease may explain the change in the main medicines used that year, with <i>Arsenicum album</i> being the most prescribed in the cases studied.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"3-11"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9136352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HRI Online 2022: Leading International Experts Illustrate the Positive Impact of Increased Collaboration in Homeopathy Research.","authors":"E Rachel Roberts,&nbsp;José E Eizayaga,&nbsp;Esther T van der Werf,&nbsp;Alexander L Tournier","doi":"10.1055/s-0042-1757770","DOIUrl":"https://doi.org/10.1055/s-0042-1757770","url":null,"abstract":"<p><p>The Homeopathy Research Institute (HRI) welcomed more than 450 people from 35 countries to their first online event on June 25, 2022. The one-day programme featured an excellent line-up of international speakers and provided a unique interactive platform in keeping with the theme of the event - Key Collaborations in Homeopathy Research. Scientists from a range of different research fields gave an exceptional insight into the current status of homeopathy research. Here we give an overview of the most significant findings in both clinical and basic research presented during HRI Online 2022.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"65-69"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10570144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathic Eupatorium perfoliatum in the Treatment of COVID-19.","authors":"Diego Tomassone","doi":"10.1055/s-0042-1755363","DOIUrl":"https://doi.org/10.1055/s-0042-1755363","url":null,"abstract":"I am writing this letter to share my homeopathic clinical experience in Italy, according to my detailed observations from December 2019 to April 2022 in the treatment of coronavirus disease 2019 (COVID-19), and consequently to commend the unicist homeopathic approach I took in treating more than 1,000 cases. From December 2019, when severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was not yet noted, I received in my outpatient clinic several cases of “strange flu” which, in some cases and in a few days, degenerated into pulmonary infection. As usual, I treated the first cases individually, looking for the most similar unitary remedy, because it is well known that individual unicist therapy is always the best solution to any problem, as masterfully expressed by Dr. Hahnemann (§ 153,154,155,273).1 As I treated the individual cases, in a few weeks I began to notice a certain similarity in the symptomatology that each of them presented. After deepening my consideration of the Materia Medica and the Repertory in the context of the bythen identified COVID-19, I decided to study in depth this symptomatology to see if it was possible to find the “genusepidemicus”of thedisease, as taughtbyDr.Hahnemann (§ 99–103, paragraphs never modified in the various editions),2–6 and in perfect agreement with the logic of homeopathy proposed by Stuart Close: exact observation, correct interpretation, rational explanation and scientific construction.7 When repertorizing with the help of the software “Complete Dynamics Master Edition”, the “key symptoms” I found most frequently were essentially always those concerning the 20 rubrics shown in ►Fig. 1, in which the remedy Eupatorium perfoliatum emerges strongly, whatever counting or method proposed by the software one chooses to use (Böenninghausenmethod, standard or simple counting, etc.), always highly repertorized, as can be seen in ►Fig. 1.8 Prescribing the remedy Eupatorium perfoliatum 30C from the very first cases, according to Hahnemann’s dictates that are indicated in the sixth edition of the “Organon of Medicine”, I was able to verify not only the goodness of this repertorization, but also the effectiveness of the remedyeven for the rubric “Smell; Loss of, wanting”, where it is not included as an elective remedy. In the course of 2020, I searched the homeopathicmedical literature to see if there had been any other proposals from other homeopaths, and I first came across the Indian Government's proposal for using Arsenicum album,9 and Dr. Bhatia's analysis of a series of elective remedies in which Eupatorium perfoliatumwas also included in people who presented with symptoms that were not severe.10 I subsequently read other papers, none of which however mentioned Eupatorium perfoliatum, and none gave precise indications on the use of a single remedy, at least in the early stageswhere no severe respiratory symptoms were present.11–15 Fig. 1 Repertorization of the most common COVID-19 symptoms found in my ","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"70-72"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9122312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Evolution of Miasm Theory and Its Relevance to Homeopathic Prescribing.","authors":"George Vithoulkas,&nbsp;Dmitry Chabanov","doi":"10.1055/s-0042-1751257","DOIUrl":"https://doi.org/10.1055/s-0042-1751257","url":null,"abstract":"<p><p>For most health professionals who have chosen the challenging path of comprehending classical homeopathy, the theory of miasms is the most intriguing part of our science and is an area where much misunderstanding, criticism and controversy prevails. There are now a large number of opposing ideas and opinions on the subject of miasms, with various classifications, many of which we believe to be erroneous and which confuse many homeopaths and result in incorrect prescriptions.Here we clarify the main postulates of Hahnemann's miasm theory and analyse how his followers transformed his ideas over the next century in the light of medical discoveries. This allows us to understand the limited relevance of miasm theory to modern day prescribing and offer a new and precise definition of the term miasm in relation to modern diseases such as cancer and autoimmune diseases. How we apply this theory to the health challenges of the 21^st century, such as increasing environmental pollution and other toxins, may play an important role in the future wellbeing of the human population.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"57-64"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/65/44/10-1055-s-0042-1751257.PMC9868969.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10601306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Test of a Homeopathic Algorithm for COVID-19: the Importance of a Broad Perspective.","authors":"Anjali Miglani,&nbsp;Raj Kumar Manchanda,&nbsp;Amrit Kalsi,&nbsp;Prabhjeet Kaur,&nbsp;Beenu Saini,&nbsp;Amit Arora,&nbsp;Cheshta Nagrath,&nbsp;Jithesh Thavarayil Kannoth,&nbsp;Ram Kumar Kudiyarasu,&nbsp;Rahul Vardaan,&nbsp;Smita Brahmachari,&nbsp;Ankit Gupta,&nbsp;Shelly Arora,&nbsp;Shirin Balan,&nbsp;Kavita Sharma,&nbsp;Malaya Kumar Ray,&nbsp;Anu Chawla,&nbsp;Manjula Ghuliani,&nbsp;Anurag Pandey,&nbsp;Philippa Fibert,&nbsp;Lex Rutten","doi":"10.1055/s-0042-1746196","DOIUrl":"https://doi.org/10.1055/s-0042-1746196","url":null,"abstract":"<p><strong>Background: </strong> Most of the symptoms of coronavirus disease 2019 (COVID-19) are covered by large repertory rubrics and hence many remedies have been proposed as \"genus epidemicus\". The aim of this study was to combine the information from various data collections to prepare a COVID-19 Bayesian mini-repertory/an algorithm-based application (app) and test it.</p><p><strong>Methods: </strong> In July 2021, 1,161 COVID-19 cases from 100 practitioners globally were combined. These data were used to calculate \"condition-confined\" likelihood ratios (LRs) for 59 symptoms of COVID-19. Out of these, 35 symptoms of the 11 medicines that had at least 20 cases each were considered. The information was entered in a spreadsheet (algorithm) to calculate combined LRs of specific combinations of symptoms. The algorithm contained the medicines <i>Arsenicum album</i>, <i>Belladonna</i>, <i>Bryonia alba</i>, <i>Camphora</i>, <i>Gelsemium sempervirens</i>, <i>Hepar sulphuris</i>, <i>Mercurius solubilis</i>, <i>Nux vomica</i>, <i>Phosphorus</i>, <i>Pulsatilla</i> and <i>Rhus toxicodendron</i>. To test concordance, the doctors were then invited to re-enter the symptoms of their cases into this algorithm.</p><p><strong>Results: </strong> The algorithm was re-tested on 358 cases, and concordance was seen in 288 cases. On analysis of the data, bias was noticed in the <i>Merc</i> group, which was therefore excluded from the algorithm. The remaining 10 medicines, representing 81.8% of all cases, were included in the preparation of the next version of the homeopathic mini-repertory and app.</p><p><strong>Conclusion: </strong> The Bayesian mini-repertory and app is based on qualitative clinical experiences of various doctors in COVID-19 and gives indications for specific medicines for common COVID-19 symptoms. It is freely available [English: https://hpra.co.uk/; Spanish: https://hpra.co.uk/es ] for further testing and utilization by the profession.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"22-29"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9120752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Homeopathic Medicines in Second Wave of COVID-19: Prognostic Factor Research.","authors":"Raj Kumar Manchanda,&nbsp;Anjali Miglani,&nbsp;Moumita Chakraborty,&nbsp;Amrit Kalsi,&nbsp;Baljeet Singh Meena,&nbsp;Prabhjeet Kaur,&nbsp;Beenu Saini,&nbsp;Amit Arora,&nbsp;Cheshta Nagrath,&nbsp;Jithesh Thavarayil Kannoth,&nbsp;Ram Kumar Kudiyarasu,&nbsp;Rahul Vardaan,&nbsp;Smita Brahmachari,&nbsp;Yogesh Kumar,&nbsp;B Amitav,&nbsp;Pramod Konthembath,&nbsp;Ankit Gupta,&nbsp;Suresh Kumar Lolugu,&nbsp;Pawan Goel,&nbsp;Shelly Arora,&nbsp;Shirin Balan,&nbsp;Kavita Sharma,&nbsp;Anu Chawla,&nbsp;Malaya Kumar Ray,&nbsp;Vineetha Susan Jacob,&nbsp;Udesh Kumar,&nbsp;Vikas Kumar Verma,&nbsp;Rahul Kumar Singh,&nbsp;Abishes Saha,&nbsp;Manjula Ghuliani,&nbsp;Paramjeet Kaur,&nbsp;Shruti Gora,&nbsp;Meeta Gupta,&nbsp;Brender Sharma,&nbsp;Lex Rutten","doi":"10.1055/s-0042-1748881","DOIUrl":"https://doi.org/10.1055/s-0042-1748881","url":null,"abstract":"<p><strong>Background: </strong>The clinical profile and course of COVID-19 evolved perilously in a second wave, leading to the use of various treatment modalities that included homeopathy. This prognostic factor research (PFR) study aimed to identify clinically useful homeopathic medicines in this second wave.</p><p><strong>Methods: </strong>This was a retrospective, multi-centred observational study performed from March 2021 to May 2021 on confirmed COVID-19 cases who were either in home isolation or at COVID Care Centres in Delhi, India. The data were collected from integrated COVID Care Centres where homeopathic medicines were prescribed along with conventional treatment. Only those cases that met a set of selection criteria were considered for analysis. The likelihood ratio (LR) was calculated for the frequently occurring symptoms of the prescribed medicines. An LR of 1.3 or greater was considered meaningful.</p><p><strong>Results: </strong>Out of 769 confirmed COVID-19 cases reported, 514 cases were selected for analysis, including 467 in home isolation. The most common complaints were cough, fever, myalgia, sore throat, loss of taste and/or smell, and anxiety. Most cases improved and there was no adverse reaction. Certain new symptoms, e.g., headache, dryness of mouth and conjunctivitis, were also seen. Thirty-nine medicines were prescribed, the most frequent being <i>Bryonia alba</i> followed by <i>Arsenicum album</i>, <i>Pulsatilla nigricans</i>, <i>Belladonna</i>, <i>Gelsemium sempervirens</i>, <i>Hepar sulphuris</i>, <i>Phosphorus</i>, <i>Rhus toxicodendron</i> and <i>Mercurius solubilis</i>. By calculating LR, the prescribing indications of these nine medicines were ascertained.</p><p><strong>Conclusion: </strong>Add-on use of homeopathic medicines has shown encouraging results in the second wave of COVID-19 in integrated care facilities. Further COVID-related research is required to be undertaken on the most commonly prescribed medicines.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"12-21"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10633843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-Vitro Growth Kinetics of Mesenchymal Stem Cells in Cytotoxicity Tests Using Low-Diluted Viscum Album.","authors":"Ana Catarina Viana Valle,&nbsp;Hilana Dos Santos Sena Brunel,&nbsp;Bruno Stéfano Lima Dallago,&nbsp;Lucas Santana Rodrigues,&nbsp;Patrícia Furtado Malard,&nbsp;Rosiane Andrade da Costa,&nbsp;Rafael Rossetto,&nbsp;Rosângela Vieira de Andrade","doi":"10.1055/s-0042-1747682","DOIUrl":"https://doi.org/10.1055/s-0042-1747682","url":null,"abstract":"<p><strong>Introduction: </strong> The use of mesenchymal stem cells (MSC) in cytotoxicity tests is an <i>in-vitro</i> alternative model for predicting initial doses. Homeopathic medicines may stimulate the immune system to combat a pathology effectively and have been used for over two centuries. <i>Viscum album</i> (VA) extracts are widely used in the treatment of cancer, due to their immunomodulatory, cytotoxic and pro-apoptotic properties.</p><p><strong>Objective: </strong> This study aimed to evaluate the <i>in-vitro</i> growth kinetics of canine MSC in relation to cytotoxicity, cell differentiation and expression of pluripotentiality markers, using a VA preparation at the D1D2 (1×10^-1, 1×10^-2 potency (VAD1D2).</p><p><strong>Methods: </strong> MSC were obtained from adipose tissue sampled from a healthy dog that was undergoing an elective veterinary procedure and with its owner's permission. The experiments were performed in three groups: MSC treated with VAD1D2 or diluent or untreated (control). The cytotoxicity was evaluated by MTT assay. The differentiation was induced in three lineages, and apoptotic cell labeling was performed by an Annexin-V test.</p><p><strong>Results: </strong> At the concentration of 10 μL/mL of VA, the number of cells after <i>in-vitro</i> culture was maintained when compared with the control (untreated) group. A significant and gradual decrease in cell viability was recorded as VA concentrations increased. The apoptosis analysis showed that VA at 20 μL/mL presented absolute percentages of initial apoptosis twice as high as at 10 μL/mL, which was similar to the control (untreated group).</p><p><strong>Conclusion: </strong> The results suggest that the use of efficient methods to assess the <i>in-vitro</i> cytotoxicity of VA-based homeopathic medicines using MSC lineages may predict the potential action at different concentrations. These findings demonstrated that VAD1D2 interferes with canine MSC growth kinetics.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"112 1","pages":"40-49"},"PeriodicalIF":1.7,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/02/d9/10-1055-s-0042-1747682.PMC9868971.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10614419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Individualized Homeopathic Medicines in Treatment of Acne Vulgaris: A Double-Blind, Randomized, Placebo-Controlled Trial.","authors":"Shruti Rai,&nbsp;Gobind Narayan Gupta,&nbsp;Subhas Singh,&nbsp;James Michael,&nbsp;Pankhuri Misra,&nbsp;Bharti Gupta,&nbsp;Suman Singh,&nbsp;Akshaya Prakash,&nbsp;Maneela Tomar,&nbsp;Satarupa Sadhukhan,&nbsp;Munmun Koley,&nbsp;Subhranil Saha","doi":"10.1055/s-0041-1739397","DOIUrl":"https://doi.org/10.1055/s-0041-1739397","url":null,"abstract":"<p><strong>Background: </strong>Acne is estimated to affect 9.4% of the global population, making it the 8^th most prevalent disease worldwide. Acne vulgaris (AV) is among the diseases that directly affect quality of life. This trial evaluated the efficacy of individualized homeopathic medicines (IHM) against placebo in AV.</p><p><strong>Methods: </strong>In this double-blind, randomized, placebo-controlled trial conducted at the National Institute of Homoeopathy, India, 126 patients suffering from AV were randomized in a 1:1 ratio to receive either IHM (verum) in centesimal potencies or identical-looking placebo (control). The primary outcome measure was the Global Acne Grading System score; secondary outcomes were the Cardiff Acne Disability Index and Dermatology Life Quality Index questionnaires - all measured at baseline and 3 months after the intervention. Group differences and effect sizes (Cohen's <i>d</i>) were calculated on the intention-to-treat sample.</p><p><strong>Results: </strong>Overall, improvements were greater in the IHM group than placebo, with small to medium effect sizes after 3 months of intervention; however, the inter-group differences were statistically non-significant. <i>Sulphur</i> (17.5%), <i>Natrum muriaticum</i> (15.1%), <i>Calcarea phosphorica</i> (14.3%), <i>Pulsatilla nigricans</i> (10.3%), and <i>Antimonium crudum</i> (7.1%) were the most frequently prescribed medicines; <i>Pulsatilla nigricans</i>, <i>Tuberculinum bovinum</i> and <i>Natrum muriaticum</i> were the most effective of those used. No harms, unintended effects, homeopathic aggravations or any serious adverse events were reported from either group.</p><p><strong>Conclusion: </strong>There was non-significant direction of effect favoring homeopathy against placebo in the treatment of AV.</p><p><strong>Trial registration: </strong>CTRI/2018/11/016248; UTN: U1111-1221-8164.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"111 4","pages":"240-251"},"PeriodicalIF":1.7,"publicationDate":"2022-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10413147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}