Homeopathy最新文献

{"title":"Assessing the Feasibility of a Two-Cohort Design to Assess the Potential of Homeopathic Medicinal Products to Reduce Antimicrobial Resistance in Turkeys (The HOMAMR Project)—Study Protocol","authors":"Silvia Baur-Bernhardt, Annemarie Käsbohrer, Marcus Georg Doherr, Diana Meemken, Lena Sonnenschein-Swanson, Birgit Ursula Stetina, Mary-Ann Sommer, Petra Weiermayer","doi":"10.1055/s-0044-1781448","DOIUrl":"https://doi.org/10.1055/s-0044-1781448","url":null,"abstract":"<p>\u0000<b>Background</b> Antimicrobial resistance (AMR) is a serious public health concern worldwide. The European Union requires a reduction in the use of antibiotics by 50% by 2030, with separate regulations on organic production that give preference to homeopathy and phytotherapy in organic farms before the use of conventional medicines (including antibiotics). We have therefore designed a two-phased project whose overarching aim is to investigate the potential role of homeopathic medicinal products (HMPs) in combating AMR in turkeys (the HOMAMR project): a two-cohort feasibility study using turkey-farm data that have been collected and analyzed retrospectively, followed by a prospective two-cohort study in turkey farms that would examine the impact of HMPs on changing antibiotic use.</p> <p>\u0000<b>Objective</b> The objective of this paper is to describe the protocol for the first phase of HOMAMR, which is a study under field conditions to assess the feasibility of collecting data retrospectively about turkeys that have been managed conventionally only or with HMPs.</p> <p>\u0000<b>Methods</b> Surveys performed on farms in Germany and Austria, including interviews with consenting farmers, will determine the feasibility of comparing retrospectively gathered data on antibiotic use and performance/production data in two cohorts of turkeys: (1) homeopathic treatment with conventional care (antibiotics) added if necessary or (2) conventional care (antibiotics) only. Co-primary outcomes to be studied are the amount of antimicrobial use and production period-related mortality. In addition, other production/performance parameters will be compared between the two treated cohorts.</p> <p>\u0000<b>Conclusion</b> To our knowledge, this is the first feasibility study on the treatment of turkeys using homeopathy, and whose retrospectively obtained data will inform a prospective study that would examine the impact of HMPs on antibiotic use in commercial turkey raising, fattening and breeding production.</p> ","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"18 1","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140589136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facilitating Healing in Diabetic Foot Ulcers Using Homeopathy in a Multi-Disciplinary Integrative Approach: Two Evidence-Based Case Reports.","authors":"Hima Bindu Ponnam","doi":"10.1055/s-0044-1779723","DOIUrl":"https://doi.org/10.1055/s-0044-1779723","url":null,"abstract":"<p><strong>Background: </strong> A rising incidence of diabetic foot ulcers (DFUs) in India has escalated the rate of lower limb amputations in the country. The present study aims to evaluate the potential healing properties of homeopathic medicines as a part of the integrative management of DFUs through two evidence-based case reports.</p><p><strong>Methods: </strong> Two patients with DFUs, identified as Wagner grade 2, having had diabetes for 12 years, were treated with individualized homeopathic medicine within a multi-disciplinary approach. Both cases were on oral hypoglycemic agents for managing blood sugar, continued their diabetic medication, and were advised to use regular wound dressings. The DFUs were assessed using the Pressure Ulcer Scale for Healing (PUSH) score at baseline and every 4 weeks until complete wound healing. Neuropathic changes were evaluated by the 10g monofilament tactile test, and the Modified Naranjo Criteria for Homeopathy-Causal Attribution Inventory (MONARCH) tool was used to assess the likelihood of there being a causal relationship between clinical improvement and the homeopathic intervention.</p><p><strong>Results: </strong> The DFUs showed healing within 12 weeks, with a significant improvement in the PUSH score, though there was no change in tactile sensation as assessed by the monofilament test. The MONARCH tool yielded +9 in both cases, indicating the likelihood of a causal relationship between the clinical outcome and homeopathic intervention. The homeopathic medicines <i>Arsenicum album</i> and <i>Lachesis</i> respectively were found useful by each patient.</p><p><strong>Conclusion: </strong> Homeopathy appeared beneficial in facilitating the early healing of DFUs within a multi-disciplinary integrative approach.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":""},"PeriodicalIF":1.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140039205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HRI London 2023: The Homeopathy Research Community Reunites after a 4-Year Hiatus, Sparking Fresh Collaborations between Researchers 'Old and New'.","authors":"E Rachel Roberts, Angelina J Mosley, Esther T van der Werf, Alexander L Tournier","doi":"10.1055/s-0043-1777120","DOIUrl":"10.1055/s-0043-1777120","url":null,"abstract":"<p><p>The Homeopathy Research Institute's (HRI) 5th international research conference took place in the heart of London, from 16th to 18th June 2023. With 230 attendees from 27 countries, HRI's conferences remain truly international. HRI London 2023 will be remembered for its inspiring blend of 'old and new', with a programme notable for the maturity of the evidence presented by experienced names drawing on decades of work, as well as the enthusiasm and skill of up-and-coming researchers who took the floor to present their new findings. In this report, we present scientific highlights from the event.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"113 1","pages":"49-52"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individualized Homeopathic Medicines in the Management of Symptomatic Adenotonsillar Hypertrophy in Children: A Prospective Observational Study.","authors":"Hima Bindu Ponnam, Roja Varanasi, Ratan Chandra Shil, Vinitha E R, Meetu Goel, Sunil Ramteke, D Karthikeyan, D D Arya, Trupti Laxmi Swain, Navita Bagdi, Priyanka Srivastava, R K Manchanda, Praveen Oberai","doi":"10.1055/s-0043-1762591","DOIUrl":"10.1055/s-0043-1762591","url":null,"abstract":"<p><strong>Background: </strong>Globally, adenotonsillar hypertrophy (ATH) is one of the most prevalent upper respiratory tract disorders of children, with associated troublesome symptoms such as sleep apnea and cognitive disturbances. In this study, we evaluated the potential role of individualized homeopathic medicines in the management of symptomatic ATH in children.</p><p><strong>Methods: </strong>A multicenter prospective observational study was conducted at five institutes under the Central Council for Research in Homoeopathy, India. Primary and secondary outcomes (symptom score for adenoids, other symptoms of ATH, Mallampati score, tonsillar size, Sleep-Related Breathing Disorder of the Paediatric Sleep Questionnaire [SRBD-PSQ]) were assessed through standardized questionnaires at baseline and at 3, 6, 9 and 12 months. Radiological investigations for assessing the adenoid/nasopharyngeal (A/N) ratio were carried out at baseline, 6 and 12 months. All analyses were carried out using an intention-to-treat approach.</p><p><strong>Results: </strong>A total of 340 children were screened and 202 children suffering from ATH were enrolled and followed up monthly for 12 months. Each patient received individualized homeopathic treatment based on the totality of symptoms. Statistically significant reductions in adenoid symptom score, Mallampati score (including tonsillar size), SRBD-PSQ sleep quality assessment and A/N ratio were found over time up to 12 months (<i>p</i> < 0.001). Homeopathic medicines frequently indicated were <i>Calcarea carbonicum, Phosphorus, Silicea, Sulphur, Calcarea phosphoricum, Pulsatilla, Lycopodium and Tuberculinum</i>. No serious adverse events were recorded during the study period.</p><p><strong>Conclusion: </strong>This study suggests that homeopathic medicines may play a beneficial role in the management of symptomatic ATH in children. Well-designed comparative trials are warranted.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"32-40"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9302133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aspirin 15cH has Different Effects on Morphology and Function of Lipopolysaccharide-Challenged RAW 264.7 Macrophages In Vitro Compared to a Pharmacological Dose of Aspirin.","authors":"Adalberto C von Ancken, Nathalia Salles S de Medeiros, Sandra Kalil Perdomo, Mario Costa Cruz, Anuska M Alvares-Saraiva, Elizabeth C Perez, Rodrigo Augusto da Silva, Francisco Xavier Eizayaga, Leoni Villano Bonamin","doi":"10.1055/s-0043-1769105","DOIUrl":"10.1055/s-0043-1769105","url":null,"abstract":"<p><strong>Introduction: </strong>Aspirin is one of the most commonly used drugs worldwide. It is known to present antipyretic, anti-inflammatory and anti-thrombotic actions, making it extremely useful in a wide range of clinical contexts. Interestingly, homeopathically prepared <i>Aspirin</i> 15cH has been found to have a pro-thrombotic effect in rats, raising the hypothesis that <i>Aspirin</i> 15cH could also modulate the activity of inflammatory cells in different pathological processes.</p><p><strong>Objective: </strong>Our objective was to assess what effect <i>Aspirin</i> 15cH has on RAW 264.7 macrophages <i>in vitro</i>.</p><p><strong>Methods: </strong>The effects of <i>Aspirin</i> 15cH on biochemical and morphological activities of lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages were evaluated. These effects were compared with unchallenged macrophages (negative control), untreated LPS-stimulated macrophages, macrophages treated with succussed water (vehicle control), or aspirin 200 µg/mL (pharmacological inhibitor of LPS activity). Cell morphology (adhered cell area and cytoskeleton arrangements), cell viability, toll-like receptor-4 (TLR-4) expression, and the production of nitric oxide, cytokines and intracellular reactive oxygen species were assessed.</p><p><strong>Results: </strong><i>Aspirin</i> 15cH reduced the number of cells expressing TLR-4 on the surface (<i>p</i> = 0.03) and induced a \"columnar\" morphology of macrophage pseudopods, indicating changes in cytoskeleton arrangement. When cells were treated with both <i>Aspirin</i> 15cH and LPS, cell morphology became heterogeneous, suggesting that sub-populations of cells had differing sensitivities to LPS or <i>Aspirin</i> 15cH. Exposure of the cells to LPS alone, succussed water or aspirin 200 µg/mL produced effects consistent with the literature.</p><p><strong>Conclusion: </strong><i>Aspirin</i> 15cH, aspirin 200 µg/mL, LPS and succussed water appear to act as independent stimuli able to induce different patterns of macrophage response. <i>Aspirin</i> 15cH induced changes suggestive of M2 polarization of the macrophages (i.e., toward a wound healing or tissue repair, rather than inflammatory, phenotype). These preliminary findings need to be confirmed in further specific studies.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"4-15"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9897030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacy Students' Knowledge and Attitudes about Homeopathy: A Descriptive Survey Conducted in Turkey.","authors":"Gülin Renda, İçim Gökkaya, Gamze Kandemir, Tuğçe Özyiğit, Tuğba Kurt","doi":"10.1055/s-0043-1761267","DOIUrl":"10.1055/s-0043-1761267","url":null,"abstract":"<p><strong>Background: </strong>Homeopathy belongs to \"Traditional and Complementary Medicine\" (TCM) and is defined in the TCM regulation in Turkey as a holistic practice method that aims to improve health status with personalized medicines. The international and national literature includes a limited number of studies that examine individuals' knowledge, attitudes and behaviors toward homeopathy. Although in Turkey the Regulation on Pharmacists and Pharmacies states that the sale of homeopathic medicines is allowed only in pharmacies, no study was found that evaluated awareness about homeopathy among pharmacy students.</p><p><strong>Objective: </strong>The present study aims to assess pharmacy students' knowledge and attitudes toward homeopathy and to identify the factors that influence them.</p><p><strong>Methods: </strong>This descriptive study was conducted between December 1, 2021 and February 1, 2022 among the students of the Faculty of Pharmacy, Karadeniz Technical University (KTU), through a face-to-face survey. In total, 418 questionnaires suitable for data quality were included in the study. The SPSS 23.0 statistical program was used to analyze the data and the statistical significance level was taken as <i>p</i> < 0.05.</p><p><strong>Results: </strong>It was determined that 73% of the participants had heard about TCM practices and 55% had heard of homeopathy. Students in the fifth grade (<i>p</i> = 0.0001) and those working in an income-generating job (<i>p</i> = 0.026) were found to be those most aware of homeopathy. The students of the Faculty of Pharmacy correctly knew the basic working principles of homeopathy (<i>p</i> = 0.002). The source from which students obtained the most information about homeopathy was undergraduate courses. 80.4% of the participants thought that homeopathy should be applied by pharmacists. 47.0% of the students wanted to learn more about homeopathy or to carry out studies in the field of homeopathy in their careers.</p><p><strong>Conclusion: </strong>The results of this research revealed a high awareness amongst KTU pharmacy students about the practice of homeopathy.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"41-48"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9726324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contributing Reviewers in 2023.","authors":"","doi":"10.1055/s-0044-1779014","DOIUrl":"10.1055/s-0044-1779014","url":null,"abstract":"","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"113 1","pages":"i-ii"},"PeriodicalIF":1.7,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575632","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antiviral Activity of Cinchona officinalis, a Homeopathic Medicine, against COVID-19.","authors":"Somasundaram Arumugam, Kumaravel Vadivel, Devendra Kumar Dhaked, Vani Sai Prasanna, Manoj Limbraj Yellurkar, Pamelika Das, Raja Manoharan, Austin Jose Thomas, Lalith Singh, Subhas Singh, Ravichandiran Velayutham","doi":"10.1055/s-0043-1770339","DOIUrl":"10.1055/s-0043-1770339","url":null,"abstract":"<p><strong>Background: </strong>Coronavirus disease 2019 (COVID-19) is a potentially fatal disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several studies have shown that hydroxychloroquine (HCQ) significantly inhibits SARS-CoV-2 infections <i>in vitro</i>.</p><p><strong>Objective: </strong>Since the phytoconstituents of <i>Cinchona officinalis</i> (CO) are similar to those of HCQ, the objective of this study was to test the antiviral potential of different homeopathic formulations of CO.</p><p><strong>Methods: </strong>An analysis of the molecular composition of CO was carried out using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry, followed by a detailed docking study. The constituents of CO were docked against various targets of SARS-CoV-2, and the binding potential of the phytoconstituents was compared and quantified. The ligand with the lowest Glide docking score is considered to have the best binding affinity. The cytotoxicity of several homeopathic formulations, including CO mother tincture (CO-MT), was also checked on VeroE6 cells. A known antiviral, remdesivir, was used as a positive control for the <i>in vitro</i> assays to evaluate the effects of CO-MT against SARS-CoV-2-infected VeroE6 cells.</p><p><strong>Results: </strong>Molecular docking studies showed that constituents of CO exhibited binding potential to various targets of SARS-CoV-2, including Mpro, PLpro, RdRp, nucleocapsid protein, ACE2 (in host) and spike protein. Quinoline, one of the constituents of CO, can potentially bind the spike protein of SARS-CoV-2. Quinic acid showed better binding capabilities with Mpro, PLpro RdRp, nucleocapsid protein and ACE2 (allosteric site) than other constituents. Quinidine exhibited better binding to ACE2. Compared to HCQ, other phytoconstituents of CO had the equivalent potential to bind the RNA-dependent RNA polymerase, nucleocapsid protein, Mpro, PLpro and spike protein of SARS-CoV-2. <i>In vitro</i> assays showed that homeopathic CO-MT was not cytotoxic and that CO-MT and remdesivir respectively caused 89% and 99% inhibition of SARS-CoV-2 infection in VeroE6 cells.</p><p><strong>Conclusion: </strong>Based on this <i>in silico</i> and <i>in vitro</i> evidence, we propose CO-MT as a promising antiviral medicine candidate for treating COVID-19. <i>In vivo</i> investigation is required to clarify the therapeutic potential of CO-MT in COVID-19.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"16-24"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10167461","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Novel Homeopathic Complex Medicine on the Management of Multiple Antibiotic-Resistant Bovine Mastitis: An Open-Label, Non-Randomized, Placebo-Controlled Trial.","authors":"Bruna de Fatima Antunes Laginestra, Thaís Camaso de Sá, Jessé Lahos Borges, Matheus Basilio Marçal, João Vitor Morais Simões, Selma Alves Rodrigues, Zilda Cristiani Gazim, Ranulfo Piau Júnior","doi":"10.1055/s-0043-1768465","DOIUrl":"10.1055/s-0043-1768465","url":null,"abstract":"<p><strong>Background: </strong>Bovine mastitis is characterized by an inflammatory process in the mammary gland and represents one of the main diseases affecting a dairy herd. Management of mastitis is most commonly via antibiotics, but the rising incidence of multiple antibiotic resistance (MAR) means that additional options are needed. Homeopathic products can be administered in dairy farming for a range of clinical reasons and may be preferential due to the absence of residues.</p><p><strong>Objectives: </strong>The aim of this study was to assess the potential of a novel homeopathic complex medicine in managing bovine mastitis.</p><p><strong>Methods: </strong>Twenty-four lactating Holstein cows with mastitis were divided into two groups: the homeopathic complex group received a homeopathic complex daily for 60 days at a dose of 20 g/d; the placebo group received the calcium carbonate vehicle without homeopathic medicines at the same dose and repetition. The main outcome measure was somatic cell count (SCC; cells/mL), with additional outcome measures including milk production (kg/d), milk constituents (percentage of protein, fat, lactose and total milk solids), and serum levels of cortisol, glucose, ammonia and lactic acid. All outcomes were measured at the beginning of the study and after 30 and 60 days. Milk samples were also collected from all animals at the beginning of the study, confirming a high (>0.2) MAR index for isolated bacterial cultures.</p><p><strong>Results: </strong>Assessment of SCC showed a statistically significant difference favoring the homeopathic complex versus placebo group at day 60. A reduction in serum cortisol levels and an increase in fat, lactose and total milk solids in animals treated with the homeopathic complex at day 60 were also seen. Other outcome measures did not show statistically significant inter-group differences.</p><p><strong>Conclusion: </strong>The results of this non-randomized, open-label, placebo-controlled trial suggest the potential for a novel homeopathic complex medicine in management of multiple antibiotic-resistant bovine mastitis, thus offering dairy farmers an additional option to antibiotics and making dairy products safer for consumer health and milk production more sustainable.</p>","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":" ","pages":"25-31"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10114382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Insights from a Decade of 'Cutting Edge Research in Homeopathy'.","authors":"E Rachel Roberts, Angelina J Mosley, Alexander L Tournier","doi":"10.1055/s-0043-1777309","DOIUrl":"10.1055/s-0043-1777309","url":null,"abstract":"","PeriodicalId":13227,"journal":{"name":"Homeopathy","volume":"113 1","pages":"1-3"},"PeriodicalIF":1.2,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139575595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}