Human toxicology最新文献_第6页

Arsenic-induced skin toxicity. 砷引起的皮肤中毒。

Human toxicology Pub Date : 1989-03-01 DOI: 10.1177/096032718900800203

R L Shannon, D S Strayer

{"title":"Arsenic-induced skin toxicity.","authors":"R L Shannon, D S Strayer","doi":"10.1177/096032718900800203","DOIUrl":"https://doi.org/10.1177/096032718900800203","url":null,"abstract":"<p><p>We reviewed available literature on the effects of inorganic arsenic on the skin to determine the potential hazards and to collate information regarding dosage and exposure to the incidence of skin cancer. Arsenic intake may result from occupational or medicinal exposure, or from drinking well water in areas with high arsenic levels in the soil. Arsenic causes a variety of benign skin lesions including hyperpigmentation and hyperkeratosis. Some hyperkeratotic lesions and squamous cell carcinomas in situ may progress to invasive carcinoma; other invasive squamous cell carcinomas will develop de novo. These cutaneous squamous cancers may metastasize; mortality is low, but has been reported. Locally invasive but non-metastasizing basal cell carcinomas may arise as well. These lesions occur in a characteristic pattern of distribution and are usually multiple. Observers reporting medicinally administered arsenic have described dose-response relationships between the amount of arsenic ingested and the frequency of various skin lesions. For arsenic found in drinking water, however, there is more controversy regarding the doses and exposure times necessary for cutaneous toxicity.</p>","PeriodicalId":13194,"journal":{"name":"Human toxicology","volume":"8 2","pages":"99-104"},"PeriodicalIF":0.0,"publicationDate":"1989-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/096032718900800203","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13806270","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 81

An evaluation of the hypothesis that females are more susceptible than males to lead-induced haematological alterations. 对女性比男性更容易受到铅引起的血液学改变的假设的评价。

Human toxicology Pub Date : 1989-03-01 DOI: 10.1177/096032718900800204

R Ken, E J Calabrese, R W Tuthill

引用次数: 2

Effects of calcium entry blockers on human platelet metabolism measured by microcalorimetry. 钙进入阻滞剂对微量热法测定血小板代谢的影响。

Human toxicology Pub Date : 1989-03-01 DOI: 10.1177/096032718900800208

L Edvinsson, J Ikomi-Kumm, M Monti

引用次数: 2

Effect of homeopathic dilutions on subcellular enzymatic activity. 顺势稀释剂对亚细胞酶活性的影响。

Human toxicology Pub Date : 1989-03-01 DOI: 10.1177/096032718900800207

C Petit, P Belon, R Got

引用次数: 11

Radionuclides in food: a neglected branch of toxicology? 食物中的放射性核素:一个被忽视的毒理学分支?

Human toxicology Pub Date : 1989-03-01 DOI: 10.1177/096032718900800201

E D Rubery

引用次数: 4

Predictors of methanol intoxication with unfavourable outcome. 甲醇中毒不良预后的预测因素。

Human toxicology Pub Date : 1989-03-01 DOI: 10.1177/096032718900800209

P Mahieu, A Hassoun, R Lauwerys

引用次数: 56

Immunotherapy for the treatment of acute paraquat poisoning. 免疫疗法治疗急性百草枯中毒。

Human toxicology Pub Date : 1989-03-01 DOI: 10.1177/096032718900800206

M Nagao, T Takatori, B Wu, K Terazawa, H Gotouda, H Akabane

引用次数: 21

Renal tubular acidosis with an elevated anion gap in a 'glue sniffer'. 肾小管酸中毒伴“胶水嗅探器”阴离子间隙升高。

Human toxicology Pub Date : 1989-03-01

J Sarmiento Martinez, J J Guardiola Sala, A Martinez Vea, E Campaña Casals

引用次数: 0

An evaluation of the safety of ranitidine during seven years daily oral administration to beagle dogs. 雷尼替丁7年每日口服比格犬的安全性评价。

Human toxicology Pub Date : 1989-01-01 DOI: 10.1177/096032718900800105

N W Spurling, S A Selway, D Poynter

{"title":"An evaluation of the safety of ranitidine during seven years daily oral administration to beagle dogs.","authors":"N W Spurling, S A Selway, D Poynter","doi":"10.1177/096032718900800105","DOIUrl":"https://doi.org/10.1177/096032718900800105","url":null,"abstract":"1 Ranitidine hydrochloride was administered orally to Beagles at doses equivalent to 50 mg once daily, or 5 mg twice daily, of ranitidine base/kg for more than 7 years. 2 Apart from looseness of faeces, seen mainly after doses of 50 mg/kg and only rarely after the first year of such treatment, there were no adverse clinical effects. There were no deaths related to treatment. 3 Periodic gastroscopy revealed nothing abnormal. 4 Peak plasma levels of ranitidine occurred within 2 h of dosing; levels were proportional to the doses administered. 5 There were no major differences in fasting plasma gastrin levels between treated and untreated dogs; the expected increase occurred in response to the provision of food and, predictably, this was greater following a dose of ranitidine. 6 A normal histamine-induced gastric secretory response was demonstrated. 7 Necropsy revealed no lesions of toxicological significance. Macroscopically the stomachs appeared normal but microscopic examination showed some gastritis in both treated and control dogs. No changes in enterochromaffin-like (ECL) cells were detected. Electron microscopy showed unimpaired secretory activity of parietal cells. 8 Thus, after more than 7 years administration to beagle dogs of doses in excess of the normal daily therapeutic dose, the stomachs showed no changes attributable to treatment and their secretory capacity was unimpaired.","PeriodicalId":13194,"journal":{"name":"Human toxicology","volume":"8 1","pages":"23-32"},"PeriodicalIF":0.0,"publicationDate":"1989-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/096032718900800105","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"13855656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Ranitidine fails to suppress the growth in vitro of haemopoietic progenitors from human peripheral blood or bone marrow. 雷尼替丁不能抑制体外人外周血或骨髓造血祖细胞的生长。

Human toxicology Pub Date : 1989-01-01 DOI: 10.1177/096032718900800104

C D Reid, A Kirk

引用次数: 3