Histology and histopathology最新文献

RHCG inhibition promotes the sensitivity of PIK3CA-mutant non-small lung cancer to PI3K inhibitor. RHCG抑制促进pik3ca突变型非小肺癌对PI3K抑制剂的敏感性。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-06 DOI: 10.14670/HH-18-946

Haitao Liu, Muqun Wang, Yingying Pang

引用次数: 0

Recent progress in macrophage-mediated tendon injury and healing. 巨噬细胞介导的肌腱损伤和愈合的最新进展。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-04 DOI: 10.14670/HH-18-945

Weijie Zhou, Yining Zhang, Yanzhao Dong, Xiaodi Zou, Ahmad Alhaskawi, Fangyu Yi, Sohaib Hasan Abdullah Ezzi, Vishnu Goutham Kota, Mohamed Hasan Abdulla Hasan Abdulla, Haiying Zhou, Alenikova Olga, Sahar Ahmed Abdalbary, Jinhui Liang, Hui Lu

引用次数: 0

Preferentially Expressed Antigen in Melanoma (PRAME) as a diagnostic and predictive marker in melanocytic tumors: An updated narrative review. 黑色素瘤中优先表达抗原（PRAME）作为黑色素细胞肿瘤的诊断和预测标志物：最新的叙述综述。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-03 DOI: 10.14670/HH-18-944

Serena Salzano, Rosario Caltabiano, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Ioannis Boutas, Nektarios Koufopoulos, Giuseppe Broggi

{"title":"Preferentially Expressed Antigen in Melanoma (PRAME) as a diagnostic and predictive marker in melanocytic tumors: An updated narrative review.","authors":"Serena Salzano, Rosario Caltabiano, Magda Zanelli, Andrea Palicelli, Maurizio Zizzo, Ioannis Boutas, Nektarios Koufopoulos, Giuseppe Broggi","doi":"10.14670/HH-18-944","DOIUrl":"https://doi.org/10.14670/HH-18-944","url":null,"abstract":"Melanocytic neoplasms range from benign nevi to malignant melanomas, and accurate differentiation between these lesions is crucial for effective treatment. Among the various immunohistochemical markers available, PRAME (Preferentially Expressed Antigen in Melanoma) has emerged as a significant diagnostic tool in the evaluation of melanocytic lesions due to its high sensitivity and specificity, particularly in distinguishing malignant melanomas from benign nevi. PRAME is strongly expressed in malignant melanomas, including cutaneous, uveal, and mucosal variants, while its expression is minimal or absent in benign and dysplastic nevi. Its utility extends to identifying metastases, especially in difficult-to-diagnose cases such as metastatic melanoma, where it aids in differentiating melanoma from other malignancies. Additionally, the presence of PRAME is associated with poor prognosis, as higher expression levels correlate with increased metastatic risk. Despite its effectiveness, the use of PRAME in immunohistochemistry is not without limitations. It is not exclusive to melanoma, as its expression can be seen in some non-melanocytic tumors, which may reduce its specificity in certain cases. Nevertheless, PRAME remains a valuable tool in the diagnostic and prognostic evaluation of melanocytic lesions, particularly when histological features are unclear or ambiguous. Further research is needed to refine its role in different melanoma subtypes and to explore its potential as a target for immunotherapy.","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"18944"},"PeriodicalIF":2.5,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144266053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intratumoral T cells are associated with prognosis and chemotherapy benefit in gastric cancer. 瘤内T细胞与胃癌的预后和化疗疗效有关。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-01 Epub Date: 2024-09-30 DOI: 10.14670/HH-18-824

Lu Liu, Qianwen Chen, Chen He, Feilan Xie, Shengyuan Su, Lijun Wang, Jintao Liu

引用次数: 0

BATF is involved in the malignant phenotype and epithelial-mesenchymal transition of colon cancer cells via ERK/PD-L1 signaling. BATF 通过 ERK/PD-L1 信号转导参与结肠癌细胞的恶性表型和上皮-间质转化。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-01 Epub Date: 2024-09-27 DOI: 10.14670/HH-18-823

Xiaoqiong Chen, Huaqian Dong, Liping Jin

{"title":"BATF is involved in the malignant phenotype and epithelial-mesenchymal transition of colon cancer cells via ERK/PD-L1 signaling.","authors":"Xiaoqiong Chen, Huaqian Dong, Liping Jin","doi":"10.14670/HH-18-823","DOIUrl":"10.14670/HH-18-823","url":null,"abstract":"Objective: Transcription factors have emerged as primary regulators in colon cancer. Basic Leucine Zipper Transcription Factor (BATF) was found to be differentially expressed in colon cancer. This study aimed to explore the impact of BATF on the malignant phenotype and epithelial-mesenchymal transition (EMT) process.Methods: Based on The Cancer Genome Atlas (TCGA) data, the correlation between BATF and patients' overall prognosis was analyzed. BATF expression in epithelial and colon cancer cells was evaluated. By knocking down its levels in colon cancer cells, its effects on the malignant phenotype, apoptosis, EMT progression, and ERK/PD-L1 were evaluated. Cells were treated with ERK/PD-L1 agonists, and the BATF cell regulation was re-examined.Results: BATF levels were negatively correlated with patients' overall survival. BATF is upregulated in colon cancer cell lines, and BATF knockdown in HCT116 cells suppressed the malignant cellular phenotypes (proliferation, migration, and invasion) and increased apoptosis. BATF knockdown inhibited EMT and ERK/PD-L1 signaling activation, whereas upon agonist treatment, BATF potency was disrupted.Conclusion: This study revealed that BATF is involved in the malignant phenotype and EMT of colon cancer cells, and this process may be mediated by ERK/PD-L1 signaling.","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"871-879"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological and stereological insights into renal and adrenal changes in pregnant rats exposed to wood smoke-derived PM2.5. 暴露于木材烟雾衍生PM2.5的怀孕大鼠肾脏和肾上腺变化的组织学和体视学研究。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-01 Epub Date: 2024-12-23 DOI: 10.14670/HH-18-863

P Salinas, F Villarroel, C González-Torres, T Lazcano, J Silva, A Maulen, E Rojas

{"title":"Histological and stereological insights into renal and adrenal changes in pregnant rats exposed to wood smoke-derived PM2.5.","authors":"P Salinas, F Villarroel, C González-Torres, T Lazcano, J Silva, A Maulen, E Rojas","doi":"10.14670/HH-18-863","DOIUrl":"https://doi.org/10.14670/HH-18-863","url":null,"abstract":"Air pollution, particularly fine particulate matter (PM2.5), is a global health issue affecting millions. In southern Chile, firewood used for heating exacerbates pollution, especially in winter. This study examines the impact of wood smoke-derived PM2.5 on kidney and adrenal gland morphology in pregnant rats. It evaluates chronic PM2.5 exposure effects during pregestational and gestational periods in Sprague-Dawley rats. Pregnant rats were exposed to PM2.5 in Temuco, a city with high wood smoke pollution. Filtered and unfiltered air chambers simulated different exposure conditions. Histological and stereological analyses were conducted on rat kidneys and adrenal glands using systematic sampling and STEPanizer software. Findings showed significant changes in renal and adrenal morphology due to PM2.5 exposure. In the kidney, variations were observed in glomerular compaction, proximal convoluted tubules, and medullary rays. In the adrenal gland, the zona fasciculata showed decreased acidophilia and lipid content, reduced cytoplasmic homogeneity, and the appearance of empty spaces. These effects were more pronounced in rats exposed to unfiltered air during both pregestational and gestational periods. Wood smoke-derived PM2.5 exposure significantly impacts kidney and adrenal morphology in pregnant rats, emphasizing the need for strategies to reduce environmental pollutant exposure during critical developmental periods to protect maternal-fetal health.","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":"40 6","pages":"857-870"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinicopathological diagnosis of axillary signet-ring cell-like/histiocytoid carcinoma: A case report and literature review. 腋窝标志环细胞样癌/组织细胞样癌的临床病理诊断：病例报告和文献综述。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-01 Epub Date: 2024-10-04 DOI: 10.14670/HH-18-828

Ling Zhang, Li Li, Yun Wang, Xiao Ling Wang

{"title":"Clinicopathological diagnosis of axillary signet-ring cell-like/histiocytoid carcinoma: A case report and literature review.","authors":"Ling Zhang, Li Li, Yun Wang, Xiao Ling Wang","doi":"10.14670/HH-18-828","DOIUrl":"10.14670/HH-18-828","url":null,"abstract":"Objective: To explore the clinicopathological and morphological characteristics, diagnosis, differential diagnosis, treatment, and prognosis of primary signet-ring cell/histiocytoid carcinoma (SRCHC) of the axilla.Methods: The clinical manifestations, pathomorphological characteristics, and immunohistochemical staining results of a case of primary SRCHC in the axilla were retrospectively analyzed, and the relevant literature was reviewed.Results: The patient was a 69-year-old male. Subcutaneous gray-white nodules with unclear boundaries were visible. Microscopic examination: The tumor was located in the dermis and subcutaneous tissue. The tumor cells were arranged in a cord-like, soldier-like, or nest-like shape, with mild to moderate atypia. Some cells had obvious nucleoli. The tumor cytoplasm was eosinophilic, and mucoid material inside and outside the cells could be seen, showing a signet-ring-like or histiocytoid appearance. Immunohistochemical staining was positive for GCDFP-15, CK7, E-cadherin, AR, P120, GATA3 and negative for Villin, S-100, CK20, SMA, P63, CD68, TTF-1, NapsinA, ER, PR, and Ki-67 proliferation index (8%), HER2(2+) and FISH(-). The special staining AB-PAS (AB+,PAS-).Conclusion: Cutaneous axillary primary SRCHC is extremely rare and highly invasive and needs to be differentiated from a variety of metastatic tumors (breast, digestive system, lung, etc.).","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"911-917"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142545178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STAT3/p-STAT3 expression is correlated with clinicopathological characteristics and prognosis in non-small cell lung cancer. STAT3/p-STAT3的表达与非小细胞肺癌的临床病理特征和预后相关。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-01 Epub Date: 2024-10-03 DOI: 10.14670/HH-18-827

Jili Li, Yingying Zhu, Jianyue Peng, Lan Yang, Li Zhang, Lei Li

引用次数: 0

The prognostic value of H3 K27me3 in meningiomas: A review on current evidence and methodological challenges. H3 K27me3在脑膜瘤中的预后价值：对现有证据和方法学挑战的回顾。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-01 Epub Date: 2024-11-21 DOI: 10.14670/HH-18-851

Alberto Pietrantoni, Valeria Barresi

{"title":"The prognostic value of H3 K27me3 in meningiomas: A review on current evidence and methodological challenges.","authors":"Alberto Pietrantoni, Valeria Barresi","doi":"10.14670/HH-18-851","DOIUrl":"10.14670/HH-18-851","url":null,"abstract":"Meningiomas are the most common primary intracranial neoplasms. Although they mostly exhibit a benign course, some cases recur after surgery and show high morbidity and mortality rates. In addition to currently established prognostic factors, such as the extent of surgical resection and tumor grade assessed according to World Health Organization (WHO) criteria, the prognostic significance of the immunohistochemical loss of Histone 3 trimethylation in Lysine 27 (H3 K27me3) has emerged in meningiomas. This review examined original studies that analyzed the immunohistochemical expression of H3 K27me3 in meningiomas and its correlation with various features, including overall survival (OS), recurrence-free survival (RFS), and WHO grade. A literature search was conducted in PubMed for English-language publications up to July 8, 2024. Sixteen studies were included in this review. In summary, current evidence indicates that H3 K27me3 loss is more frequent in tumors exhibiting higher biological aggressiveness, as reflected by a significant association with a higher WHO grade, proliferative index, and prognostically unfavorable methylation classes. In addition, published studies consistently indicate a negative prognostic significance for progression-recurrence-free survival (PFS/RFS) in WHO grade 2 meningiomas and OS in WHO grade 3 tumors. However, the lack of a standardized definition for H3 K27me3 loss significantly hampers the incorporation of the H3 K27me3 immunohistochemical assay into routine practice to establish the prognosis of meningiomas.","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"797-803"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Iron in the migraine brain. 偏头痛大脑中的铁。

IF 2.5 4区生物学

Histology and histopathology Pub Date : 2025-06-01 Epub Date: 2024-12-16 DOI: 10.14670/HH-18-862

Nermin Tepe, Muge Yemisci, Hulya Karatas

{"title":"Iron in the migraine brain.","authors":"Nermin Tepe, Muge Yemisci, Hulya Karatas","doi":"10.14670/HH-18-862","DOIUrl":"10.14670/HH-18-862","url":null,"abstract":"Iron, a vital element for numerous peripheral and central nervous system functions, is a key player in DNA synthesis, gene expression, myelination, neurotransmission, and mitochondrial electron transport. Iron has utmost importance in various neurological functions, including neurotransmitter synthesis and brain cell metabolism. Migraine is a neurogliovascular disorder in which neuroinflammation plays a crucial role. Iron deficiency has been associated with various neurological issues and could potentially influence migraine frequency or severity. However, the relationship between iron levels and migraine is not fully clear and necessitates further research. On the other hand, iron overload could also have negative effects, as excessive iron might contribute to oxidative stress and inflammation, which may impact migraine-related pathways. The interplay between iron levels and neuroinflammation might affect migraines. While iron deficiency could exacerbate inflammation or disrupt neurotransmitter balance, iron overload might increase oxidative stress and neuroinflammation. Comprehending this balance is fundamental, as both iron deficiency and overload can have detrimental effects on brain health and migraine symptoms. In this review, we will summarize the current interconnection between migraine, iron levels, and neuroinflammation that are currently under active investigation.","PeriodicalId":13164,"journal":{"name":"Histology and histopathology","volume":" ","pages":"805-812"},"PeriodicalIF":2.5,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142921542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0