Hematology最新文献_第9页

BCMA CAR-T therapy as salvage therapy in patients with plasmablastic myeloma. BCMA CAR-T疗法作为髓母细胞骨髓瘤患者的补救性治疗。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-03-27 DOI: 10.1080/16078454.2025.2481555

Chengwei Jin, Jing Deng, Ying Jiang, Jun Zhu, Liqing Kang, Su Li

{"title":"BCMA CAR-T therapy as salvage therapy in patients with plasmablastic myeloma.","authors":"Chengwei Jin, Jing Deng, Ying Jiang, Jun Zhu, Liqing Kang, Su Li","doi":"10.1080/16078454.2025.2481555","DOIUrl":"10.1080/16078454.2025.2481555","url":null,"abstract":"Objectives: Plasmablastic myeloma (PBM) is a variant of multiple myeloma associated with a poor prognosis. We investigated the efficacy and safety of B-cell maturation antigen (BCMA) chimeric antigen receptor T cell (CAR-T) therapy in patients with PBM.Methods: The study comprised six patients diagnosed with PBM between January 1, 2023 and December 31, 2023. The patients received BCMA single-target CAR-T therapy or BMCA/CD19 dual-target CAR-T therapy, with some patients undergoing hematopoietic stem cell transplantation before treatment. The median patient age was 55.5 years (range, 41-63). Four patients exhibited high-risk cytogenetic abnormalities.Results: The objective response rate (ORR) was 83.3%, with four of six patients achieving a complete response or better and three of six achieving a strigent complete response. Two patients exhibited progression-free survival (PFS) of at least 6 months, one of whom succumbed to a pulmonary infection, whereas four patients died of disease progression. Cytokine release syndrome (CRS) was observed in all patients, three of whom experienced grade 3-4 CRS. Two patients experienced grade 1-2 immune effector cell-associated neurotoxicity syndrome. There were no CRS-related deaths.Conclusion: BCMA CAR-T therapy was safe and effective as a salvage treatment for PBM, and its toxicity was controllable. Future research will examine the use of CAR-T therapy as part of combination regimens.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2481555"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis and treatment of Diamond-Blackfan anemia and Pierre-Robin sequence caused by a novel mutation of RPS28 gene. 由RPS28基因突变引起的Diamond-Blackfan贫血和Pierre-Robin序列的诊断和治疗。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-03-26 DOI: 10.1080/16078454.2025.2481688

Shaofen Lin, Lele Hou, Xinyu Li, Liping Que, Xiaojuan Li, Jianpei Fang, Honggui Xu, Ke Huang

{"title":"Diagnosis and treatment of Diamond-Blackfan anemia and Pierre-Robin sequence caused by a novel mutation of RPS28 gene.","authors":"Shaofen Lin, Lele Hou, Xinyu Li, Liping Que, Xiaojuan Li, Jianpei Fang, Honggui Xu, Ke Huang","doi":"10.1080/16078454.2025.2481688","DOIUrl":"10.1080/16078454.2025.2481688","url":null,"abstract":"Background: Diamond-Blackfan anemia (DBA) is a congenital erythroid aplasia associated with physical anomalies and a predisposition to cancer. It is categorized as ribosomopathy related to heterozygous allelic variations in ribosomal protein (RP) genes. Pierre Robin sequence (PRS) is a rare and etiologically heterogeneous condition, defined by the clinical triad of micrognathia, glossoptosis, and cleft palate.Methods and results: We present a 5-year-and-2-month-old Chinese boy diagnosed with DBA combined with RPS. He was born with micrognathia, cleft palate, and airway obstruction, resulting in neonatal asphyxia and feeding difficulties, which constitute the classic triad of PRS. Low-set ears, downslanted palpebral fissures, bilateral exotropia, a short neck, hypertelorism, a thenar muscle defect, and bilateral severe sensorineural hearing loss were also observed in the boy. His motor and speech development were significantly delayed. In addition, he was found to be granulocytopenic at birth and severely anemic at 2 years and 10 months of age. Whole exome sequencing of peripheral blood revealed a heterozygous mutation in the RPS28 gene (c.2T > C, p.Met1?), a novel pathogenic mutation in RPS28. RPS28 is one of the ribosomal protein (RP) genes, which may contribute to DBA-related phenotypes. The boy underwent HSCT from 9/10 HLA-matched donor and his neutrophil and hemoglobin levels returned to normal.Conclusion: It is crucial to perform a genetic evaluation for syndromic bone marrow failure with congenital anomalies. A heterozygous mutation in the RPS28 gene (c.2T > C, p.Met1?) is a novel pathogenic mutation associated with DBA. HSCT is an effective treatment for hematological abnormalities in DBA.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2481688"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Potential prognostic value and immune landscape of lactylation and liquid-liquid phase separation related genes in acute myeloid leukemia. 急性髓系白血病中乳酸化和液-液相分离相关基因的潜在预后价值和免疫景观。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-01 DOI: 10.1080/16078454.2025.2548073

Tingxiu Jiang, Hong Chen, Chunjie Qin, Guoran Xie, Qiumei Huang, Shaomei Chen, Yongrong Lai

{"title":"Potential prognostic value and immune landscape of lactylation and liquid-liquid phase separation related genes in acute myeloid leukemia.","authors":"Tingxiu Jiang, Hong Chen, Chunjie Qin, Guoran Xie, Qiumei Huang, Shaomei Chen, Yongrong Lai","doi":"10.1080/16078454.2025.2548073","DOIUrl":"https://doi.org/10.1080/16078454.2025.2548073","url":null,"abstract":"Objectives: Lactylation- and liquid-liquid phase separation-related differentially expressed genes (LLRDEGs) have been implicated in cancer. However, their role in acute myeloid leukemia (AML) remains largely unexplored.Methods: LLRDEGs associated with AML prognosis were identified using Cox regression and LASSO analyzes. A prognostic model based on three LLRDEGs was constructed for AML, and its associated biological functions were investigated. Furthermore, we evaluated differences in the tumor immune microenvironment based on this prognostic signature.Results: This study represents the first comprehensive analysis of the prognostic value of LLRDEGs in AML patients, identifying three LLRDEGs with prognostic significance. A prognostic risk model was constructed using these three LLRDEGs, and its prognostic value was validated in an independent external AML dataset. This model was associated with the immune microenvironment of AML. Finally, we observed that chaperonin containing TCP1 subunit 5 (CCT5) was highly expressed in AML. In vitro experiments demonstrated that inhibition of CCT5 induces HL-60 cell cycle arrest and apoptosis.Conclusion: This research provides a theoretical basis relevant to AML treatment strategies.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2548073"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between monocyte-to-lymphocyte ratio and anemia: a NHANES analysis. 单核细胞与淋巴细胞比例与贫血的关系：一项NHANES分析。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-07-23 DOI: 10.1080/16078454.2025.2535817

Yongjin Zhi, Shuojing Bao, Jingcheng Mao, Hui Zhu, Jianfeng Zhu

{"title":"Relationship between monocyte-to-lymphocyte ratio and anemia: a NHANES analysis.","authors":"Yongjin Zhi, Shuojing Bao, Jingcheng Mao, Hui Zhu, Jianfeng Zhu","doi":"10.1080/16078454.2025.2535817","DOIUrl":"https://doi.org/10.1080/16078454.2025.2535817","url":null,"abstract":"Background: Growing evidence supports the significant role of inflammatory factors in anemia. This paper intends to ascertain the potential link between MLR and anemia and explore potential mediators.Methods: Our analysis employed comprehensive data recourse from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018 utilizing weighted logistic regression models to assess the link between MLR and anemia. Restricted cubic spline analyses were implemented to evaluate MLR-anemia nonlinear relationship. Threshold effect analysis identified a critical inflection point. To ensure robustness, we conducted extensive subgroup analyses stratified by demographic and clinical factors. The mediating role of serum albumin on the link between MLR and anemia was investigated through mediation analysis.Results: 28,616 participants were enrolled, with 2655 (9.28%) with anemia. After adjustment for all covariates, log2-transformed MLR (log2MLR) was linked with an enhanced risk of anemia (OR:1.49, 95%CI:1.33-1.65, P < 0.001). When log2MLR was categorized into quartiles, the trend remained consistent (P < 0.001). A nonlinear positive link was noted between log2MLR and anemia, with an inflection point at -2.812. No statistical interactions were unveiled in any subgroup analyses except for gender and diabetes (interaction P < 0.05). Interestingly, serum albumin partially mediated this association, accounting for 15.39% of the total effect.Conclusion: This study presents groundbreaking findings on the role of MLR in anemia and the mediating effect of serum albumin, offering new perspectives on potential inflammatory pathways underlying hematological disorders.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2535817"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Splenectomy following rituximab and cyclophosphamide for severe autoimmune hemolytic anemia in pregnancy. 利妥昔单抗和环磷酰胺治疗妊娠期严重自身免疫性溶血性贫血后脾切除术。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-06-16 DOI: 10.1080/16078454.2025.2516885

Tao Wang, Juan Yang, Bing Peng, Yongqian Jia, Hongbing Ma

引用次数: 0

Research progress on Anoikis in hematological diseases: a literature review. 血液病中Anoikis的研究进展

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-08-03 DOI: 10.1080/16078454.2025.2538320

Wencong Luo, Yundong Chen, Xiaoyu Yao, Yi Huang, Jishi Wang

{"title":"Research progress on Anoikis in hematological diseases: a literature review.","authors":"Wencong Luo, Yundong Chen, Xiaoyu Yao, Yi Huang, Jishi Wang","doi":"10.1080/16078454.2025.2538320","DOIUrl":"https://doi.org/10.1080/16078454.2025.2538320","url":null,"abstract":"Anoikis, a specialized form of programed cell death, is triggered by the detachment of cells from the extracellular matrix (ECM). It highlights the pivotal role of the cell-ECM interaction, a feature that distinguishes it from the more common apoptotic pathways. However, the severance of this vital link can precipitate the disassociation of cells from their native microenvironment, thereby potentially fueling the genesis and escalation of neoplastic growths. In the context of hematological malignancies, these aberrant blood cells frequently develop a resistance to Anoikis, thereby enhancing their survival and metastatic capabilities. Current studies have unveiled the complex interplay between the ECM and hematological cancers, an understanding of which is fundamental to deciphering the pathophysiology, the cell's evasion tactics, and the identification of novel therapeutic targets. This manuscript delves into the recent insights into the role of Anoikis in hematological disorders, elucidating its intricate mechanisms and cellular underpinnings. While existing studies have explored anoikis in isolated hematological disorders, a comprehensive synthesis of its role across diseases-particularly the shared and distinct mechanisms of resistance, ECM crosstalk, and therapeutic opportunities-remains underexplored. This review addresses this gap by integrating recent findings to inform novel therapeutic strategies.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2538320"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144775309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ponatinib/blinatumomab for relapsed Philadelphia chromosome-positive leukemia as a bridge to allogeneic transplantation. Ponatinib/ blinatumumab治疗复发性费城染色体阳性白血病作为异基因移植的桥梁。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-07-29 DOI: 10.1080/16078454.2025.2539550

Yasutaka Sadaga, Daisuke Watanabe, Yuho Najima, Daichi Sadato, Chizuko Hirama, Kana Kato, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasuhiro Kambara, Masashi Shimabukuro, Atsushi Jinguji, Naoki Shingai, Kyoko Haraguchi, Takashi Toya, Hiroaki Shimizu, Takeshi Kobayashi, Yoshiki Okuyama, Yuka Harada, Daisuke Mizuchi, Noriko Doki

{"title":"Ponatinib/blinatumomab for relapsed Philadelphia chromosome-positive leukemia as a bridge to allogeneic transplantation.","authors":"Yasutaka Sadaga, Daisuke Watanabe, Yuho Najima, Daichi Sadato, Chizuko Hirama, Kana Kato, Kaori Kondo, Chika Kato, Satoshi Sakai, Yasuhiro Kambara, Masashi Shimabukuro, Atsushi Jinguji, Naoki Shingai, Kyoko Haraguchi, Takashi Toya, Hiroaki Shimizu, Takeshi Kobayashi, Yoshiki Okuyama, Yuka Harada, Daisuke Mizuchi, Noriko Doki","doi":"10.1080/16078454.2025.2539550","DOIUrl":"10.1080/16078454.2025.2539550","url":null,"abstract":"We report three cases of ponatinib/blinatumomab (Pona/BLIN) combination therapy as a bridge to allogeneic hematopoietic cell transplantation (allo-HCT) in patients with relapsed/refractory Philadelphia chromosome-positive acute lymphoblastic leukemia (r/r-Ph + ALL) or lymphoid chronic myeloid leukemia blast crisis (CML-BC). Case 1: A 60-year-old man with Ph + ALL achieved molecular complete remission (mCR) with Pona/BLIN after relapse following initial dasatinib-based treatment and subsequently underwent allo-HCT. Case 2: A 39-year-old man with Ph + ALL achieved hematological CR (hCR) with one cycle of inotuzumab ozogamicin and mCR with Pona/BLIN after post-transplant relapse but developed extramedullary relapse with BCR::ABL-negative clone and underwent a second allo-HCT in non-remission. He subsequently developed hematological relapse. Case 3: A 57-year-old woman initially diagnosed with myeloid CML-BC achieved mCR with chemotherapy regimens and dasatinib maintenance but relapsed as lymphoid CML-BC. She achieved hCR with Pona/BLIN and proceeded to allo-HCT. None of the cases developed grade 3 or higher adverse events during treatment. These cases suggest that Pona/BLIN combination therapy is safe and effective as a bridging strategy to allo-HCT, but extramedullary relapse caused by BCR::ABL-negative blasts can occur.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2539550"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144742039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful switch from pegcetacoplan to iptacopan after repeated severe breakthrough hemolysis events - case report. 反复发生严重突破性溶血事件后，成功地从pegcetacoplan切换到iptacopan - 1例报告。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-20 DOI: 10.1080/16078454.2025.2559333

Wolfgang Füreder, Andreas Reinisch

{"title":"Successful switch from pegcetacoplan to iptacopan after repeated severe breakthrough hemolysis events - case report.","authors":"Wolfgang Füreder, Andreas Reinisch","doi":"10.1080/16078454.2025.2559333","DOIUrl":"10.1080/16078454.2025.2559333","url":null,"abstract":"Objectives: A subset of paroxysmal nocturnal hemoglobinuria (PNH) patients develops clinically relevant extravascular hemolysis when treated with complement C5 inhibitors. These patients may benefit proximal complement inhibitors such as pegcetacoplan, danicopan or iptacopan. No studies comparing these substances are available. Breakthrough hemolysis (BTH) - defined by exacerbation of intravascular hemolysis despite complement inhibition - can be severe especially in patients treated with proximal complement inhibitors.Methods: We report on a PNH patient who had suffered repeated episodes of severe BTH with acute renal failure during 1 year of treatment with pegcetacoplan. The patient was switched to iptacopan and followed also for 1 year.Results: After switching to iptacopan, no further BTH occurred for the duration of 12 months follow up. The patient maintained stable hemoglobin and reticulocyte counts as well as lactate dehydrogenase (LDH) levels within the normal range.Discussion: Despite dose escalation of pegcetacoplan, BTH recurred in our patient. Therefore, an alternative therapy was warranted. During iptacopan therapy - chosen due to patient preference -no further BTH occurred. However, more data from a larger number of patients are needed.Conclusion: A switch to iptacopan may be an option for pegcetacoplan treated patients who experience repeated BTH in spite of dose escalation.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2559333"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acute myeloid leukemia: a brief historical perspective of AML treatment. 急性髓性白血病：AML治疗的简史回顾。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-23 DOI: 10.1080/16078454.2025.2539528

Selin Merih Urlu, Muhit Özcan

引用次数: 0

Trends and disparities in immune thrombocytopenic purpura-related mortality in the United States: a retrospective study over 24 years. 美国免疫性血小板减少性紫癜相关死亡率的趋势和差异：一项超过24年的回顾性研究

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-16 DOI: 10.1080/16078454.2025.2559334

Shahzaib Ahmed, Hamza Ashraf, Haider Ashfaq, Eeman Ahmad, Umar Akram, Ahila Ali, Shoaib Ahmad, Raheel Ahmed, Muhammad Kashif Amin, Moazzam Shahzad

{"title":"Trends and disparities in immune thrombocytopenic purpura-related mortality in the United States: a retrospective study over 24 years.","authors":"Shahzaib Ahmed, Hamza Ashraf, Haider Ashfaq, Eeman Ahmad, Umar Akram, Ahila Ali, Shoaib Ahmad, Raheel Ahmed, Muhammad Kashif Amin, Moazzam Shahzad","doi":"10.1080/16078454.2025.2559334","DOIUrl":"10.1080/16078454.2025.2559334","url":null,"abstract":"Introduction: Immune thrombocytopenic purpura (ITP) is an autoimmune disorder characterized by thrombocytopenia in the absence of another cause. Our aim is to analyze mortality trends related to ITP in the United States (US) population from 1999 to 2022.Methods: We extracted age-adjusted mortality rates (AAMR) per 100,000 population for ITP-related deaths in the United States from 1999 to 2022 using the CDC Wide-ranging Online Data for Epidemiologic Research (WONDER) database from 1999 to 2022. AAMRs were stratified by year, gender, race or ethnicity, and geographical distribution. Joinpoint regression was used to calculate annual percent change (APC) and average annual percent change (AAPC) through the Joinpoint Regression Program (V 5.1.0, National Cancer Institute).Results: From 1999 to 2022, a total of 17,069 ITP-related deaths occurred in the US. Males exhibited a higher overall AAMR (0.22) in comparison to females (0.17). NH Whites exhibited the highest overall AAMR (0.20). Stratification by geographical location revealed non-metropolitan areas to have a higher overall AAMR (0.24) than metropolitan areas (0.19). The Midwest exhibited the highest overall AAMR (0.22). Vermont (0.37), Rhode Island (0.35), and North Dakota (0.32) were among the states with the highest overall AAMR, whereas states on the other end of the spectrum included Nevada (0.13), the District of Columbia (0.14) and Louisiana (0.15).Conclusion: The disparities identified in our analysis, particularly among NH Whites, the elderly, and residents of the Midwest and rural areas, suggest underlying healthcare access issues, potential genetic predispositions, and regional differences in treatment strategies.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2559334"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0