Hematology最新文献_第10页

HOTAIR promotes the progression of B-cell acute lymphoblastic leukemia by regulating the miR-326/IGF-1R axis and activating the PI3K/AKT signaling pathway. HOTAIR通过调节miR-326/IGF-1R轴和激活PI3K/AKT信号通路促进b细胞急性淋巴细胞白血病的进展。

IF 2 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-02-16 DOI: 10.1080/16078454.2026.2627664

Xue-Mei Zhao, Ya-Qin Jiang, Xin Wen, Fang-Fang Xiong, Shi-Shan Xiao, Sheng-Wen Huang, Si-Rui-Yun Ding, Qian-Qian Huang, Min-Min Jiang, Zhe Li, Hong-Qian Zhu

{"title":"HOTAIR promotes the progression of B-cell acute lymphoblastic leukemia by regulating the miR-326/IGF-1R axis and activating the PI3K/AKT signaling pathway.","authors":"Xue-Mei Zhao, Ya-Qin Jiang, Xin Wen, Fang-Fang Xiong, Shi-Shan Xiao, Sheng-Wen Huang, Si-Rui-Yun Ding, Qian-Qian Huang, Min-Min Jiang, Zhe Li, Hong-Qian Zhu","doi":"10.1080/16078454.2026.2627664","DOIUrl":"10.1080/16078454.2026.2627664","url":null,"abstract":"Background: B-cell acute lymphoblastic leukemia (B-ALL) is an aggressive hematological malignancy. Long non-coding RNAs (lncRNAs) play important roles in hematological diseases; nevertheless, their mechanistic contributions to B-ALL are still poorly defined.Purpose: This study aimed to investigate the oncogenic role of HOTAIR and the regulatory mechanism underlying the progression of B-ALL via the HOTAIR/miR-326/IGF-1R axis.Methods: The expression levels of HOTAIR and miR-326 were quantified by RT-qPCR in peripheral blood mononuclear cells (PBMCs) from B-ALL patients. CCK-8, EdU, and TUNEL assays were employed to evaluate cell viability, proliferation, and apoptosis, respectively. Dual-luciferase reporter assays were performed to verify molecular interactions, and Western blotting was performed to detect the activation of the PI3K/AKT signaling pathway.Results: HOTAIR was prominently upregulated in patient-derived PBMCs, correlating with enhanced proliferation and suppressed apoptosis. Mechanistically, HOTAIR directly targeted miR-326 binding sites and regulated the expression of IGF-1R. Experiments affirmed that overexpression of miR-326 or knockdown of IGF-1R reversed the oncogenic effects induced by HOTAIR. Furthermore, silencing of HOTAIR decreased PI3K/AKT phosphorylation, indicating pathway dependence.Conclusion: HOTAIR promotes the progression of B-ALL via the miR-326/IGF-1R axis and PI3K/AKT activation, suggesting its potential as a therapeutic target.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2627664"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146206992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phase angle as a nutritional assessment method in patients with acute myeloid leukemia: a cross-sectional study. 相位角作为急性髓性白血病患者营养评估方法的横断面研究。

IF 2 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-02-17 DOI: 10.1080/16078454.2026.2631924

Wei Li, Jing Zhang, Jing Liu, Fang Xu, Chao Hua, Qiong Qiu, Hua Xie

{"title":"Phase angle as a nutritional assessment method in patients with acute myeloid leukemia: a cross-sectional study.","authors":"Wei Li, Jing Zhang, Jing Liu, Fang Xu, Chao Hua, Qiong Qiu, Hua Xie","doi":"10.1080/16078454.2026.2631924","DOIUrl":"10.1080/16078454.2026.2631924","url":null,"abstract":"Background and objectives: The phase angle, which is associated with cellular health, has garnered increasing attention as a noninvasive and objective method for nutritional assessment. However, the association between malnutrition and phase angle in patients with acute myeloid leukemia remains unreported. Therefore, this study investigated this association in patients with acute myeloid leukemia and established a cut-off phase angle for identifying malnutrition.Methods and study design: This cross-sectional study retrospectively analysed the data of 74 inpatients with acute myeloid leukemia (66.21% male; mean age, 52.68 ± 16.31 years). Nutritional status was assessed via the Patient-Generated Subjective Global Assessment (PG-SGA). Bioelectrical impedance analysis was employed to measure phase angles.Results: The phase angle was negatively associated with malnutrition (B = -0.436; p < 0.001). Logistic regression analysis revealed that a low skeletal muscle index (SMI) (p = 0.016, OR = 5.021, 95% CI 1.347-18.716) and hemoglobin deficiency (p = 0.009, OR = 6.133, 95% CI 1.582-23.770) were risk factors for a low phase angle (PA) in acute myeloid leukemia inpatients. The area under the receiver operating characteristic (ROC) curve was 0.705. The cut-off phase angle for identifying malnutrition was 3.65° (sensitivity, 0.926; specificity, 0.553).Conclusions: The phase angle may serve as a supplementary indicator of malnutrition in inpatients with acute myeloid leukemia, particularly when the Nutritional Risk Screening 2002 (NRS-2002) is not feasible. These findings may aid in the formulation of nutritional strategies for these patients.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2631924"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146212935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeted therapy in KMT2Ar AML. 靶向治疗KMT2Ar AML。

IF 1.6 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2025-12-09 DOI: 10.1080/16078454.2025.2599585

Ying Zhang, Yankun Yang, Yiwen Du, Yuqian Tang, Yuping Gong

{"title":"Targeted therapy in KMT2Ar AML.","authors":"Ying Zhang, Yankun Yang, Yiwen Du, Yuqian Tang, Yuping Gong","doi":"10.1080/16078454.2025.2599585","DOIUrl":"https://doi.org/10.1080/16078454.2025.2599585","url":null,"abstract":"Objective: This review aims to summarize current progress in targeted therapy for acute myeloid leukemia (AML) with KMT2A rearrangement (KMT2Ar). This subtype of AML often shows resistance to chemotherapy and has a poor prognosis. The purpose is to emphasize potential therapeutic strategies and explore drugs currently under clinical development. Methods: We reviewed studies on the molecular characteristics of KMT2Ar AML and examined targeted drugs that can block key genetic and epigenetic mechanisms. Information on drug mechanisms, preclinical findings, and clinical trials was collected and analyzed.Results: Several new agents targeting KMT2A-related pathways are being explored. Menin inhibitors show encouraging clinical activity, while other inhibitors, such as those targeting DOT1L, BET, and EZH2, have produced promising preclinical results. Early data suggest that combination therapy may be more effective in overcoming drug resistance than monotherapy.Discussion: Providing a new therapeutic direction for the abnormal molecular networks in KMT2Ar AML offers a promising approach. However, most therapies are still in the early stages and clinical translation is limited. Further research is needed to improve the safety and long-term efficacy of the treatment.Conclusion: There is an urgent need for effective targeted drugs for KMT2Ar AML. Continuous research and clinical trials will be key to improving patient prognosis and advancing precise treatment for this challenging leukemia subtype.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2599585"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145714161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fluorescence in situ hybridization supplements to conventional karyotype for detecting aberration of chromosome 5, 7, or 17 in newly diagnosed acute myeloid leukemia. 荧光原位杂交补充常规核型检测5、7或17号染色体畸变在新诊断的急性髓性白血病。

IF 1.6 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2025-12-15 DOI: 10.1080/16078454.2025.2600812

Qiuyun Fang, Kunpeng Luo, Miao Yang, Shaowei Qiu, Ying Wang, Bingcheng Liu, Yingchang Mi, Jianxiang Wang, Hui Wei

{"title":"Fluorescence in situ hybridization supplements to conventional karyotype for detecting aberration of chromosome 5, 7, or 17 in newly diagnosed acute myeloid leukemia.","authors":"Qiuyun Fang, Kunpeng Luo, Miao Yang, Shaowei Qiu, Ying Wang, Bingcheng Liu, Yingchang Mi, Jianxiang Wang, Hui Wei","doi":"10.1080/16078454.2025.2600812","DOIUrl":"https://doi.org/10.1080/16078454.2025.2600812","url":null,"abstract":"Objectives: To investigate the clinical significance of Fluorescence in situ hybridization (FISH) in detecting aberration of chromosome 5, 7, or 17 in newly diagnosed acute myeloid leukemia (AML) patients.Methods: We retrospectively evaluated the clinical features and outcomes of 77 adult newly diagnosed AML patients with 5/5q, 7/7q, or 17/17p loss detected by either FISH or conventional karyotype.Results: Among 77 patients, all (100%) were identified by FISH, while only 47 (61%) were positive with conventional karyotype. Patients with FISH-positive displayed similar age at onset, gender, WBC, and gene mutation spectrum with those identified by karyotype. In FISH-positive but karyotype-negative group, the 3-year OS and EFS were 28.9% and 23.9%, respectively, which were similar to 29.1% and 21% with FISH-positive and karyotype-positive (P = 0.59 and 0.48). When comparing the outcomes of patients with or without hematopoietic stem cell transplantation (HSCT), both groups of patients with and without HSCT showed similar outcomes. Patients underwent HSCT with 3-year OS at 76.2% in FISH and 64.3% in FISH-positive and karyotype-positive group (P = 0.66), while patients without HSCT had 3-year OS at 33.3% and 39% (P = 0.63), respectively.Conclusion: Overall, patients with 5, 7, or 17 chromosomal abnormalities identified by either FISH or karyotype have similar clinical characteristics and outcomes. FISH could supplement to conventional karyotype for detecting aberration of chromosome 5, 7, or 17 in newly diagnosed AML.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2600812"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145762579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of immune cells in multiple myeloma: a bidirectional Mendelian randomization study. 免疫细胞在多发性骨髓瘤中的作用：一项双向孟德尔随机研究

IF 1.6 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-01-05 DOI: 10.1080/16078454.2025.2611692

Peng Xu, Yanxia Wang, Yongjun Hu, Zhenyu Li

{"title":"The role of immune cells in multiple myeloma: a bidirectional Mendelian randomization study.","authors":"Peng Xu, Yanxia Wang, Yongjun Hu, Zhenyu Li","doi":"10.1080/16078454.2025.2611692","DOIUrl":"10.1080/16078454.2025.2611692","url":null,"abstract":"Objectives: Prior research has highlighted immune cells' critical role in multiple myeloma (MM) pathogenesis, yet the causal relationships between them have remained obscure.Methods: We utilized data from genome-wide association studies (GWAS) of European cohorts to conduct a Mendelian Randomization (MR) analysis, aiming to establish causal links between immune cell phenotypes and MM. We selected single nucleotide polymorphisms (SNPs) associated with immune cell traits at a suggestive significance threshold (P < 1 × 10-5) to ensure sufficient instrumental variables, with F-statistics (>10) calculated to assess instrument strength. Multiple MR methods were applied to 731 immune phenotypes and MM.Results: Eight immunophenotypes showed nominal associations with MM risk (P < 0.05). However, no associations survived the strict Bonferroni correction for multiple testing. Suggestive causal effects of MM on immunophenotypic traits are predominantly negative, implying that MM may impair the functionality of immune cells.Discussion: This study uses GWAS data to elucidate the genetic impact of immune cells on the initiation and progression of MM. It presents genetic evidence suggesting that immune cells could alter MM risk based on a thorough genetic analysis. Bidirectional two-sample MR identified eight distinct immunophenotypes (encompassing four immune signatures: MFI, RC, AC, MP) with causal effects on MM.Conclusion: Our study provides preliminary evidence for potential causal links between specific immune traits and MM risk. Independent replication in larger cohorts and functional validation are warranted given the nominal significance of these associations, which may inform future immunotherapeutic investigations. These findings contribute to a better understanding of the complex immune - MM interplay and may guide future investigations into immunotherapeutic approaches.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2611692"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145905871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Knowledge, attitude and practices regarding blood donation and its determinants among pre-service trainees at Finote Selam College of Education, Northwest Ethiopia. 埃塞俄比亚西北部菲诺特·塞拉姆教育学院职前受训人员关于献血及其决定因素的知识、态度和做法。

IF 2 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-01-20 DOI: 10.1080/16078454.2026.2618413

Solomon Tsehay Mengistie

{"title":"Knowledge, attitude and practices regarding blood donation and its determinants among pre-service trainees at Finote Selam College of Education, Northwest Ethiopia.","authors":"Solomon Tsehay Mengistie","doi":"10.1080/16078454.2026.2618413","DOIUrl":"10.1080/16078454.2026.2618413","url":null,"abstract":"Introduction: Blood is vital for life, but ensuring a safe and sufficient supply remains a public health challenge, particularly in low-resource settings. This study explores the knowledge, attitudes, practices, and factors influencing blood donation among pre-service teacher trainees at Finote Selam College of Education, Northwest Ethiopia.Methods: A cross-sectional survey was conducted using proportionate sampling. Data were collected through questionnaires completed by the participants themselves and analyzed using SPSS version 27, with results presented in descriptive narratives and tables.Results: Of 277 participants, 27.8% were male and 72.2% female. While 55.6% demonstrated adequate knowledge of blood donation and 42.2% had a positive attitude, only 28.2% had ever donated blood. Key factors influencing donation practices included knowledge, attitude, academic department, and religious affiliation.Conclusion: Although participants had reasonable knowledge of blood donation, positive attitudes and actual donation rates were low. Department-specific awareness programs and regular donation drives, in partnership with health institutions, could enhance donation rates and foster social responsibility among future educators.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2618413"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic factors and clinical outcomes in pediatric Langerhans Cell Histiocytosis: a retrospective cohort study on event-free survival. 儿童朗格汉斯细胞组织细胞增多症的预后因素和临床结果：无事件生存的回顾性队列研究。

IF 1.6 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-03-08 DOI: 10.1080/16078454.2026.2641933

Kang Wang, Chen Wang, Hua Zhu, Yan Zou, Yiren Tian, Meijie Quan, Yi Qu, Weili Xu

{"title":"Prognostic factors and clinical outcomes in pediatric Langerhans Cell Histiocytosis: a retrospective cohort study on event-free survival.","authors":"Kang Wang, Chen Wang, Hua Zhu, Yan Zou, Yiren Tian, Meijie Quan, Yi Qu, Weili Xu","doi":"10.1080/16078454.2026.2641933","DOIUrl":"10.1080/16078454.2026.2641933","url":null,"abstract":"Objectives: Langerhans Cell Histiocytosis (LCH) is an inflammatory myeloid neoplasm with heterogeneous outcomes. This study aimed to identify independent risk factors influencing event-free survival (EFS) in pediatric LCH, focusing on initial white blood cell (WBC) counts and disease extent.Methods: We retrospectively analyzed 67 pediatric LCH patients with bone involvement treated at Hebei Children's Hospital, Hebei Clinical Medicine Research Center for Children's Health and Diseases between 2013 and 2022. The primary endpoint was EFS. Cox proportional hazards regression models determined predictors of adverse outcomes.Results: The 3-year EFS rate was 76.1% (median follow-up: 48 months). Univariate analysis linked multiple disease sites, risk-organ involvement, CNS risk site involvement, diabetes insipidus, and elevated WBC count to poor EFS. In multivariate analysis, only multiple site involvement (Hazard Ratio [HR] = 3.12, p = 0.025) and an elevated initial WBC count (>10 × 10⁹/L) (HR = 2.89, p = 0.034) remained independent predictors.Discussion: While risk-organ involvement is a traditional stratifier, systemic inflammatory burden, reflected by leukocytosis, offers independent prognostic value. Patients with elevated WBC counts or multisite disease warrant intensive monitoring.Conclusion: Elevated initial WBC count and multiple site involvement independently predict shorter EFS in pediatric LCH. Integrating these markers into risk stratification could optimize therapies.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2641933"},"PeriodicalIF":1.6,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of frailty tools on outcomes in myeloma: MRP and simplified index predict survival but differ in infection risk stratification. 虚弱工具对骨髓瘤预后的影响：MRP和简化指数预测生存，但感染风险分层不同。

IF 2 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-03-09 DOI: 10.1080/16078454.2026.2639783

Shaoli Zhang, Linyu Li, Weiwei Tian, Chenhuan Xiang, Qiujuan Zhu, Tao Wang, Zhilin Gao, Yunxia Xie, Shaolong He, Liangming Ma, Lifang Huang, Jie Zhao, Qiong Yao

{"title":"Impact of frailty tools on outcomes in myeloma: MRP and simplified index predict survival but differ in infection risk stratification.","authors":"Shaoli Zhang, Linyu Li, Weiwei Tian, Chenhuan Xiang, Qiujuan Zhu, Tao Wang, Zhilin Gao, Yunxia Xie, Shaolong He, Liangming Ma, Lifang Huang, Jie Zhao, Qiong Yao","doi":"10.1080/16078454.2026.2639783","DOIUrl":"10.1080/16078454.2026.2639783","url":null,"abstract":"Objective: To explore the application efficacy of the UK Myeloma Alliance Risk Stratification (MRP) and the Simplified Frailty Index (FI) in patients with newly diagnosed multiple myeloma (NDMM).Methods: 205 NDMM patients diagnosed in our hospital from 1 July 2014 to 1 July 2022; frailty was assessed using MRP and Simplified FI. The Fine-Gray competing risk model compared the cumulative incidence of early grade ≥3 infections. Kaplan-Meier method and the log-rank test were applied for analyzing OS and PFS. ROC curves, AUC values, and Youden's index were used to compare the predictive values for OS, PFS, and early grade ≥3 infections. P < 0.05 indicated statistical significance.Results: The frail groups by MRP and the Simplified FI had significantly shorter OS (36 vs. 75 months and 38 vs. 76 months) and PFS (11 vs. 21 months and 11 vs. 23 months; P < 0.001) with increased mortality risk (HR: 2.51 and 2.12). One-year mortality was significantly higher in frail patients (P < 0.005). The common frail group showed the poorest outcomes, but without significant difference from individual frailty groups (P > 0.05). Frail patients by both showed higher rates of early grade ≥3 infections, but there was no statistically significant difference (50.6% vs. 37.9% and 45.76% vs. 41.78%, P > 0.05). Regarding predictive performance, both tools effectively predicted OS and PFS (all P < 0.05). For early infections, MRP was not predictive (P = 0.237) whereas FI was (P = 0.012), though their predictive performance did not differ significantly (P > 0.05).Conclusion: Both MRP and FI are effective frailty assessment tools in NDMM patients. They significantly correlate with OS, PFS.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2639783"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Independent prognostic factors predicting survival in multiple myeloma patients post-chemotherapy: a retrospective study. 预测多发性骨髓瘤患者化疗后生存的独立预后因素：一项回顾性研究。

IF 2 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-01-20 DOI: 10.1080/16078454.2026.2613508

Yuan Luo, Tao Jiang, Li Liu

{"title":"Independent prognostic factors predicting survival in multiple myeloma patients post-chemotherapy: a retrospective study.","authors":"Yuan Luo, Tao Jiang, Li Liu","doi":"10.1080/16078454.2026.2613508","DOIUrl":"10.1080/16078454.2026.2613508","url":null,"abstract":"Objective: To identify simple clinical predictors of prognosis in multiple myeloma (MM) after chemotherapy and assess their predictive value.Methods: We retrospectively analyzed 164 newly diagnosed MM patients treated with proteasome inhibitor- and/or immunomodulatory drug-based chemotherapy between 2018 and 2024. Baseline data included demographics, DS/ISS stage, haemoglobin (Hb), platelets, albumin, creatinine, calcium, lactate dehydrogenase (LDH), erythrocyte sedimentation rate, and serum β2-microglobulin (β2-MG). Treatment responses after four cycles (CR/VGPR vs ≤PR) and survival outcomes were recorded. Overall survival (OS) and progression-free survival (PFS) were estimated by Kaplan-Meier analysis. Cox models identified independent prognostic factors. Landmark 2-year ROC curves evaluated discriminative ability.Results: After four cycles, 95/164 patients (57.9%) achieved CR/VGPR and 69 (42.1%) ≤PR. During a median follow-up of 31 months, 85 deaths and 112 progression events occurred. Multivariable analysis showed that age >60 years, Hb ≤85 g/L, β2-MG>3.5 mg/L, and ≤PR were independently associated with shorter OS, whereas Hb ≤85 g/L and ≤PR predicted shorter PFS. Two-year AUCs for mortality prediction were 0.601 for age, 0.624 for Hb, 0.647 for β2-MG, and 0.731 for response; for PFS prediction, AUCs were 0.668 for Hb and 0.749 for response, indicating fair but limited standalone discrimination.Conclusion: Advanced age, severe anaemia, elevated β2-MG, and suboptimal early response are simple, readily available predictors of adverse survival in MM. Although their individual discriminative power is modest, these factors may inform pragmatic risk stratification, especially where cytogenetic and MRD testing are unavailable, and could be incorporated into future composite prognostic scores.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2613508"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146010119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-dependent clinical, molecular, and prognostic differences in patients with AML: a retrospective study. AML患者年龄依赖性临床、分子和预后差异：一项回顾性研究

IF 2 4区医学

Hematology Pub Date : 2026-12-01 Epub Date: 2026-01-27 DOI: 10.1080/16078454.2026.2622254

Hong Liu, Zhi Li, Jingjing Ma, Yuye Shi, Shandong Tao, Yue Chen, Tingting Ji, Yang Su, Qiuni Chen, Chunling Wang, Liang Yu

{"title":"Age-dependent clinical, molecular, and prognostic differences in patients with AML: a retrospective study.","authors":"Hong Liu, Zhi Li, Jingjing Ma, Yuye Shi, Shandong Tao, Yue Chen, Tingting Ji, Yang Su, Qiuni Chen, Chunling Wang, Liang Yu","doi":"10.1080/16078454.2026.2622254","DOIUrl":"10.1080/16078454.2026.2622254","url":null,"abstract":"Objectives: This study aimed to compare clinical, and molecular features between acute myeloid leukemia (AML) patients aged <50 and ≥50 years, while also assessing their respective treatment outcomes and prognostic factors.Methods: We conducted a retrospective analysis of clinical data from AML patients treated at our institution between October 2015 and June 2021, supplemented by data extracted from the SEER database spanning 2000 to 2019. Survival outcomes were evaluated using Kaplan-Meier methodology.Results: In patients aged ≥50 years, we observed higher prevalence of DNMT3A, IDH2, and TP53 mutations along with -5/del (5q) karyotype abnormalities. The treatment outcomes were suboptimal, with a complete response (CR) rate of 45.9%, relapse rate of 60.8%, and two-year overall survival (OS) rate of 33.3%. VEN-treated chemotherapy-intolerant patients showed significantly improved two-year OS (36.0% vs 12.1% in non-VEN group; P = 0.006). In contrast, patients aged <50 years exhibited a distinct molecular profile characterized by a predominance of NRAS, biallelic CEBPA, WT1, and C-KIT mutations, along with a higher incidence of RUNX1-RUNX1T1 and CBFB-MYH11 fusion genes. This group demonstrated more favorable clinical outcomes, with a CR rate of 73.1%, relapse rate of 36.8%, and two-year OS rate of 68.3%.Conclusions: This study revealed that patients aged ≥50 years displayed more complex genetic aberration profiles and experienced significantly poorer prognoses compared to their younger counterparts. These findings provided novel insights for optimizing treatment strategies for middle-aged and elderly AML patients in the Chinese population.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"31 1","pages":"2622254"},"PeriodicalIF":2.0,"publicationDate":"2026-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146051784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0