Hematology最新文献_第10页

Association between ABCB1 C3435 T polymorphism- and methotrexate-related toxicity in pediatric acute lymphoblastic leukemia: a meta-analysis. 小儿急性淋巴细胞白血病中 ABCB1 C3435 T 多态性与甲氨蝶呤相关毒性的关系：一项荟萃分析。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-03-03 DOI: 10.1080/16078454.2025.2469373

Xuefen Yan, Nana Zhang, Gang Wang, Jiaheng Wang

{"title":"Association between ABCB1 C3435 T polymorphism- and methotrexate-related toxicity in pediatric acute lymphoblastic leukemia: a meta-analysis.","authors":"Xuefen Yan, Nana Zhang, Gang Wang, Jiaheng Wang","doi":"10.1080/16078454.2025.2469373","DOIUrl":"10.1080/16078454.2025.2469373","url":null,"abstract":"Background: The effect of methotrexate (MTX)-related toxicity on childhood acute lymphoblastic leukemia (ALL) is controversial. Hence, this meta-analysis aimed to investigate the association between ABCB1 C3435 T polymorphism- and methotrexate-related toxicity in pediatric acute lymphoblastic leukemia.Methods: Relevant studies were systematically searched and extracted from multiple databases including PubMed, EMBASE, Web of Science, Cochrane Library, China National Knowledge Infrastructure (CNKI), and Wanfang databases up to 1 June, 2024.Results: A total of 13 articles met the criteria, including 1506 patients. The results showed that ABCB1 C3435 T polymorphism was significantly associated with MTX-induced hepatotoxicity (CT/TT vs. CC: OR: 2.15, 95% CI: 1.40-3.32). There was no significant difference between ABCB1 C3435 T polymorphism and mucositis, myelosuppression, nephrotoxicity, gastrointestinal toxicity in pediatric ALL treated with MTX.Conclusions: Our meta-analysis suggests that the ABCB1 C3435 T mutation may enhance the MTX-induced hepatotoxicity in childhood acute lymphoblastic leukemia.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2469373"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143541758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship of prognostic nutritional index with anemia and all-cause mortality: a NHANES study. 预后营养指数与贫血和全因死亡率的关系：一项NHANES研究。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-07-22 DOI: 10.1080/16078454.2025.2536402

Yongjin Zhi, Shuojing Bao, Jingcheng Mao, Hui Zhu, Jianfeng Zhu

{"title":"Relationship of prognostic nutritional index with anemia and all-cause mortality: a NHANES study.","authors":"Yongjin Zhi, Shuojing Bao, Jingcheng Mao, Hui Zhu, Jianfeng Zhu","doi":"10.1080/16078454.2025.2536402","DOIUrl":"https://doi.org/10.1080/16078454.2025.2536402","url":null,"abstract":"Background: The present study systematically explores the correlation between the Prognostic Nutritional Index (PNI) and anemia, and further analysis of its association with all-cause mortality among populations affected by anemia.Methods: Data were taken from the National Health and Nutrition Examination Survey (NHANES) from 2005 to 2018. We utilized multiple logistic regression models, Cox proportional hazards models, restricted cubic spline (RCS) analysis, and time-dependent receiver operating characteristic (ROC) analysis. As for the verification of the result robustness, subgroup and sensitivity analyses were implemented.Results: A cohort of 28,511 participants was examined, of whom 2647 (9.28%) had anemia. An inverse relationship of PNI with anemia was detected in the fully adjusted model (OR = 0.82, 95%CI: 0.80-0.84). Cox regression showed that lower PNI levels were linked to higher all-cause mortality in people with anemia (HR = 0.91, 95%CI: 0.88-0.95). A non-linear correlation between PNI and mortality was detected through RCS analysis (P < 0.001). Significant interaction effects of PNI with mortality were observed across diabetes and BMI subgroups (P < 0.05). The predictive power of PNI for all-cause mortality among anemia individuals showed areas under the curve (AUC) values of 0.702, 0.806, and 0.813 for 3-, 5-, and 10-year predictions, respectively.Conclusion: PNI demonstrates a negative association with anemia and a similar negative relationship with all-cause mortality in individuals with anemia. Future studies are warranted to substantiate these findings.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2536402"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study. 探索循环炎症蛋白对血液恶性肿瘤的潜在因果影响，并确定跨癌症药物靶点：一项孟德尔随机化研究。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-07-30 DOI: 10.1080/16078454.2025.2538327

Chaoqun Lu, Minghui Wang, Jiang Li, Huajian Xian, Zixuan Huang, Yixin Wang, Shufeng Xie, Wenjie Zhang, YaoYifu Yu, Huijian Zheng, Dan Li, Yuling Zheng, Han Liu, Chunjun Zhao

{"title":"Exploring potential causal effects of circulating inflammatory proteins on hematologic malignancies and identifying cross-cancer drug targets: a Mendelian randomization study.","authors":"Chaoqun Lu, Minghui Wang, Jiang Li, Huajian Xian, Zixuan Huang, Yixin Wang, Shufeng Xie, Wenjie Zhang, YaoYifu Yu, Huijian Zheng, Dan Li, Yuling Zheng, Han Liu, Chunjun Zhao","doi":"10.1080/16078454.2025.2538327","DOIUrl":"https://doi.org/10.1080/16078454.2025.2538327","url":null,"abstract":"Background: Although a substantial body of research has underscored the pivotal role of inflammatory proteins in hematologic malignancies, precise understanding of the underlying mechanisms is limited. Therefore, it's necessary to explore the possible causal relationships between specific circulating inflammatory proteins and these malignancies by using a genome-wide association approach.Methods: To evaluate the possible causal effects, we performed a two-sample Mendelian randomization (MR) study. Summary statistics for 91 proteins, sourced from large-scale genome-wide association studies, were integrated with data on 11 hematologic malignancies from the FinnGen consortium. Inverse variance weighting was applied as the primary method for MR analysis, with detailed sensitivity analyses conducted to ensure robustness. Furthermore, protein-protein interaction analysis and cross-cancer effect assessments were performed to identify potential common drug targets.Results: Our analysis demonstrated both positive and negative associations of circulating inflammatory proteins on the development of 11 hematologic malignancies. Nine proteins exhibited cross-cancer effects. MCP-1, CXCL8, IL-1α, and SCF were associated with an increased risk of hematologic malignancies, while IFN-γ, IL-10, CD40, SULT1A1, and CXCL5 were associated with a reduced risk.Conclusions: The results of the study provided possible causal evidence for the involvement of circulating inflammatory proteins in the pathogenesis of eleven hematologic malignancies. Nine proteins with cross-cancer effects were of special interest, and their potential as targets in the therapeutic intervention of blood malignancies was highlighted.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2538327"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144753168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond ISS staging: the prognostic value of the Inflammation Prognostic Score Index (IPSI) in multiple myeloma. 超过ISS分期：炎症预后评分指数（IPSI）在多发性骨髓瘤中的预后价值。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-01 DOI: 10.1080/16078454.2025.2549959

Xiaomei Huang, Jing Wu, Shiying Li, Qinglan Lu, Xunjun Huang, Ruolin Li

{"title":"Beyond ISS staging: the prognostic value of the Inflammation Prognostic Score Index (IPSI) in multiple myeloma.","authors":"Xiaomei Huang, Jing Wu, Shiying Li, Qinglan Lu, Xunjun Huang, Ruolin Li","doi":"10.1080/16078454.2025.2549959","DOIUrl":"https://doi.org/10.1080/16078454.2025.2549959","url":null,"abstract":"Objectives: To establish a novel Inflammation Prognostic Score Index (IPSI) and evaluate its prognostic value and complementary role to the International Staging System (ISS) in newly diagnosed multiple myeloma (MM).Methods: This retrospective study analyzed 98 newly diagnosed MM patients. ROC-derived cutoffs stratified patients by RDW, PLT, NMLR, SII, and SIRI. The IPSI was constructed by assigning 1 point each to elevated RDW, low PLT, and high NMLR, defining three risk groups: 0-1, 2, and 3 risk factor groups. Survival and ISS correlations were evaluated using Kaplan-Meier, Cox, and Spearman's tests.Results: Multivariate analysis confirmed RDW, PLT, and NMLR as independent predictors of overall survival (OS) (all P < 0.05). Based on these, IPSI stratified patients into three risk groups: 0-1, 2, and 3 risk factor groups, with median OS of 24, 21.5, and 14 months, respectively (log-rank P < 0.001). IPSI was an independent prognostic factor (2-risk-factors group: HR = 8.74; 3-risk-factors group: HR = 18.98 vs 0-1-risk-factors group; both P < 0.001) and correlated with ISS stage (rs = 0.35, P < 0.001). Critically, IPSI refined risk stratification within all ISS subgroups (P < 0.001). SII and SIRI correlated with ISS but were not independent prognostic factors.Conclusions: As an independent prognostic index that integrates RDW, PLT, and NMLR, IPSI optimizes ISS staging and provides a cost-effective risk stratification tool. It may be a good measure indice of identifying high-risk MM patients in resource constraint setting where access to molecular testing is not available.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2549959"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Distribution for platelet antibody in patients with immune-mediated platelet transfusion refractoriness. 免疫介导的血小板输注难治性患者血小板抗体的分布。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-01 DOI: 10.1080/16078454.2025.2549969

Bing Zhang, Kairong Ma, Xinyu Huang, Xiaozhen Hong, Ying Liu, Zhipan Wu, Xianguo Xu, Faming Zhu

{"title":"Distribution for platelet antibody in patients with immune-mediated platelet transfusion refractoriness.","authors":"Bing Zhang, Kairong Ma, Xinyu Huang, Xiaozhen Hong, Ying Liu, Zhipan Wu, Xianguo Xu, Faming Zhu","doi":"10.1080/16078454.2025.2549969","DOIUrl":"https://doi.org/10.1080/16078454.2025.2549969","url":null,"abstract":"Objectives: HLA Class I, HPA (Human platelet antigen), CD36 allo/isoantibodies, and platelet glycoprotein autoantibodies are the primary causes of immune-mediated platelet transfusion refractoriness (iPTR). Detecting these antibodies and selecting antigen-negative platelets for transfusion effectively manages iPTR, but large-scale data on platelet antibody distribution in the Chinese population are scarce.Methods: From Jan 2021 to Dec 2023, 2073 patients with suspected iPTR underwent platelet cross-matching via solid-phase red blood cell adherence. Sera from those with positive cross-matching (≥1 donor) were analyzed for platelet antibodies using Luminex. Correlations between antibody prevalence, age, gender, and diseases were statistically analyzed.Results: 621 patients, 30.0% (621/2073) had positive cross-matching with ≥1 donor. Furthermore, 374 (60.2%) patients had platelet antibodies. Moreover, 429 antibodies were detected in these patients, and the constituent ratios of HLA Class I alloantibodies, HPA alloantibodies, autoantibodies (GPIIb/IIIa, etc), and CD36 isoantibodies were 78.09%, 4.65%, 17.01%, and 0.23%, respectively. Abs ranked as follows: HLA Class I > GPIIb/IIIa > GPIa/IIa > HPA-5b, GPIb/IX > HPA-3a > HPA-1b, 2b > HPA-3b, 4b, CD36. Lastly, positive platelet antibodies prevalence correlated with age and sex in leukemia and solid tumor patient groups.Discussion: This study clarified platelet antibody distribution in Chinese iPTR patients. Besides HLA Class I antibodies, autoantibodies against platelet glycoproteins play a key role. Among HPA antibodies, HPA-5b may predominate in the Chinese population instead of HPA-1a.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2549969"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of hematopoietic stem cell transplantation vs. immunosuppressive therapy in patients with hepatitis-associated aplastic anemia: a systematic review and meta-analysis. 造血干细胞移植与免疫抑制治疗在肝炎相关性再生障碍性贫血患者中的疗效和安全性：一项系统综述和荟萃分析

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-08-26 DOI: 10.1080/16078454.2025.2548990

Yaonan Hong, Qi Liu, Zhuonan Sun, Peicheng Wang, Xu Wang, Ziying Su, Yuzhu Li, Wenbin Liu, Huijin Hu, Yingying Shen, Baodong Ye, Yuhong Zhou, Shan Liu, Dijiong Wu

{"title":"Efficacy and safety of hematopoietic stem cell transplantation vs. immunosuppressive therapy in patients with hepatitis-associated aplastic anemia: a systematic review and meta-analysis.","authors":"Yaonan Hong, Qi Liu, Zhuonan Sun, Peicheng Wang, Xu Wang, Ziying Su, Yuzhu Li, Wenbin Liu, Huijin Hu, Yingying Shen, Baodong Ye, Yuhong Zhou, Shan Liu, Dijiong Wu","doi":"10.1080/16078454.2025.2548990","DOIUrl":"10.1080/16078454.2025.2548990","url":null,"abstract":"The present study aimed to compare the efficacy and safety of hematopoietic stem cell transplantation (HSCT) and immunosuppressive therapy (IST) for hepatitis-associated aplastic anemia (HAAA). Studies comparing HSCT with IST in HAAA were retrieved from inception to July 22, 2024, including 12 studies with a total of 544 cases for meta-analysis. Meta-analysis demonstrated significantly superior outcomes in the HSCT group versus IST, which was manifested as lower overall mortality (P < 0.01), higher overall response rate (P < 0.001), and improved five-year overall survival (P < 0.05), yielding a pooled RR of 1.67 (95% CI: 1.15-2.44), 0.75 (95% CI: 0.66-0.86) and 0.88 (95% CI: 0.78-0.99), respectively. However, no benefit was observed in one-year survival (P = 0.08). Further subgroup analysis indicated that the advantage of mortality (P < 0.05, RR = 1.67, 95% CI: 1.10-2.55) and five-year overall survival (P = 0.05, RR = 0.84, 95% CI: 0.71-1.00) only achieved in patients under 20 years old. There was no significant difference in the overall response and one-year overall survival for each age group. Additionally, for the IST selection, a combination of cyclosporine (CSA) and antithymocyte globulin/antilymphocyte globulin (ATG/ALG) was preferred over the CSA-only regimen (effectiveness of 78.57% vs. 50.00%), although the difference was not statistically significant (P = 0.10, RR = 1.56, 95% CI: 0.92-2.66). This study showed that HSCT had a higher effective rate, greater long-term survival and lower mortality compared to IST, especially for patients under 20 years old, who should receive HSCT treatment as possible.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2548990"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145023155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mendelian randomization reveals causal effect of Hashimoto's thyroiditis on immune thrombocytopenic purpura. 孟德尔随机化揭示桥本甲状腺炎对免疫性血小板减少性紫癜的因果效应。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-04-02 DOI: 10.1080/16078454.2025.2484959

Zhen Yao, Mingzhu Xu, Zijin Wang, Shanglong Feng, Fuquan Zhang, Shengli Xue, Chengsen Cai

{"title":"Mendelian randomization reveals causal effect of Hashimoto's thyroiditis on immune thrombocytopenic purpura.","authors":"Zhen Yao, Mingzhu Xu, Zijin Wang, Shanglong Feng, Fuquan Zhang, Shengli Xue, Chengsen Cai","doi":"10.1080/16078454.2025.2484959","DOIUrl":"10.1080/16078454.2025.2484959","url":null,"abstract":"Introduction: Patients with immune thrombocytopenic purpura (ITP) usually express thyroid antigen-specific antibodies. The purpose of this study was to explore the causal relationship between Hashimoto's thyroiditis (HT) and ITP.Methods: A two-sample Mendelian randomization (TSMR) analysis was applied to investigate the potential causal relationship between HT and ITP in European population. Five complementary methods including inverse variance weighted (IVW), Mendelian Randomization-Egger (MR-Egger), weighted median, and weighted mode were performed in our study. Risk genes of HT and ITP were selected through Mendelian randomization (MR), and the common risk genes were further analysed by bioinformatics methods to explore the common pathogenesis of the two diseases.Results: The MR analysis revealed a potential causal relationship between HT and risk of ITP [odds ratio (OR) = 1.22; 95% confidence interval (CI) 1.01, 1.49; P = 0.046]. Gene eQTL data were obtained from the IEU database. HT and ITP were respectively treated as outcome variables for MR analysis, and a total of 32 common risk genes were selected, including 12 high-risk genes and 20 low-risk genes. Functional analysis including Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genome (KEGG) analysis revealed that risk genes were closely related to antigen processing and presentation, and played a crucial role in the process of various viral and bacterial infections.Conclusion: Our study demonstrated that HT may increase the risk of ITP, and revealed the role of their common risk genes in the development of the two diseases.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2484959"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143772153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sintilimab for treating progressive multifocal leukoencephalopathy caused by human polyomavirus 2 virus infection following allogeneic hematopoietic cell transplantation: a case report. 辛替单抗治疗异基因造血细胞移植后由人多瘤病毒2型感染引起的进行性多灶性白质脑病1例

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-02-03 DOI: 10.1080/16078454.2025.2458932

Xuelian Jin, Xushu Zhong, Qinyu Liu, Xinchuan Chen

{"title":"Sintilimab for treating progressive multifocal leukoencephalopathy caused by human polyomavirus 2 virus infection following allogeneic hematopoietic cell transplantation: a case report.","authors":"Xuelian Jin, Xushu Zhong, Qinyu Liu, Xinchuan Chen","doi":"10.1080/16078454.2025.2458932","DOIUrl":"10.1080/16078454.2025.2458932","url":null,"abstract":"Background: Progressive multifocal leukoencephalopathy (PML) is characterized by demyelination in the central nervous system. It is caused by infection with human polyomavirus 2 and has a poor prognosis. Therapeutic strategies involve restoring immune function and/or discontinuing immunosuppressive treatment. Immune checkpoint inhibitors such as those targeting programmed death receptor-1 (PD-1) can alleviate PML by restoring T cell function. There are no case reports on the use of the PD-1 inhibitor, Sintilimab, for treating PML. Here, we report a case of successful treatment of PML with sintilimab following allogeneic hematopoietic stem cell transplantation.Case presentation: A 35-year-old woman with high-risk acute myeloid leukemia underwent allogeneic hematopoietic stem cell transplantation after induced remission and developed PML 12 months after transplantation. She received five courses of 100 mg every 4 weeks with monitoring by magnetic resonance imaging (MRI) and viral load in the cerebrospinal fluid, showing clinical improvement, resolution of neurological symptoms, and reduced viral load. MRI showed initial exacerbation of lesions but significant improvement after five courses of treatment. No graft-versus-host disease occurred, but manageable immune reconstitution inflammatory syndrome was observed.Conclusion: Sintilimab, a PD-1 inhibitor, might be used to treat PML in patients with hematologic malignancies undergoing allo-HSCT, which needs further investigation.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2458932"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143079693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting NEDD8 in pediatric acute myeloid leukemia: an integrated bioinformatics and experimental approach. 靶向NEDD8治疗小儿急性髓性白血病：综合生物信息学和实验方法。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-03-18 DOI: 10.1080/16078454.2025.2478650

Jian Sun, Cui Liu, Guangli Yang, Qian Li, Yang An, Yin Zhu, Pingping Zhang, Yaning Guan, Chang Peng, Zuochen Du, Pei Huang, Yan Chen

引用次数: 0

In vitro antitumor effects of PI3K inhibitor linperlisib (YY-20394) on acute myeloid leukemia cells. PI3K抑制剂linperlisib （YY-20394）对急性髓系白血病细胞的体外抗肿瘤作用。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-10-16 DOI: 10.1080/16078454.2025.2571812

Jia-Qi Chen, Yan Lou, Li-Li Zhou, Ji Shen, Yan-Li Yang, Wen-Juan Wu, Ying-Hua Geng

{"title":"In vitro antitumor effects of PI3K inhibitor linperlisib (YY-20394) on acute myeloid leukemia cells.","authors":"Jia-Qi Chen, Yan Lou, Li-Li Zhou, Ji Shen, Yan-Li Yang, Wen-Juan Wu, Ying-Hua Geng","doi":"10.1080/16078454.2025.2571812","DOIUrl":"https://doi.org/10.1080/16078454.2025.2571812","url":null,"abstract":"Objective: To investigate the effects of the PI3 K inhibitor, linperlisib (YY20394), on proliferation, apoptosis, cell cycle and signaling pathways in acute myeloid leukemia (AML) cells.Methods: The U937 cell cultures were treated with different concentrations of YY20394 to determine the IC50 value by analyzing the cell viability using Cell Counting Kit-8(CCK8). The obtained IC50 value was used for selecting the appropriate concentrations for studies on apoptosis and cell cycle changes using AO/EB dual fluorescence staining and flow cytometry respectively. The effects of YY20394 on signaling pathways at different concentrations were detected by real-time quantitative PCR (RT-PCR) and Western blotting.Results: Compared with the control group, YY20394 significantly increased the inhibition rate of proliferation and the apoptosis rate of AML cells (P < 0.05). Treatment with 5 μM YY20394 led to cell cycle arrest predominantly in the G1phase, while 10um treatment resulted in cell cycle arrest mainly in the G2 phase. Interestingly, YY20394 did not exert its anti-leukemic effects through modulation of the PI3 K/Akt/mTOR Signaling pathway, suggesting that alternative molecular mechanisms may be involved.Conclusion: YY20394 has a favorable inhibitory effect and significant pro-apoptotic effect on the proliferation of AML cells, which suggests that it has some potential for the treatment of AML.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2571812"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145299974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0