Hematology最新文献_第10页

Endothelial activation and stress index (EASIX) as a predictive biomarker for survival in patients with T-cell lymphoma. 内皮活化和应激指数（EASIX）作为t细胞淋巴瘤患者生存的预测性生物标志物。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-06-23 DOI: 10.1080/16078454.2025.2519974

Miao Li, Huimin Chen, Ling Gao, Fei Li, Qi Zhang, Xinyue Zhou, Zhiqin Yang, Wenxia Gao, Huanhuan Zhao, Yuhan Ma, Zhenyu Li, Yongshuang Xiao, Kailin Xu, Wei Chen

{"title":"Endothelial activation and stress index (EASIX) as a predictive biomarker for survival in patients with T-cell lymphoma.","authors":"Miao Li, Huimin Chen, Ling Gao, Fei Li, Qi Zhang, Xinyue Zhou, Zhiqin Yang, Wenxia Gao, Huanhuan Zhao, Yuhan Ma, Zhenyu Li, Yongshuang Xiao, Kailin Xu, Wei Chen","doi":"10.1080/16078454.2025.2519974","DOIUrl":"https://doi.org/10.1080/16078454.2025.2519974","url":null,"abstract":"Background: The Endothelial Activation and Stress Index (EASIX) has emerged as a significant prognostic indicator in various hematological malignancies. However, its role as a predictive biomarker in T-Cell Lymphoma remains unestablished. The purpose of this study is to assess the clinical relevance of EASIX in predicting Overall Survival (OS) and Progression-Free Survival (PFS) among T-cell lymphomas patients.Methods: A retrospective analysis was conducted on 117T-cell lymphomas patients diagnosed between January 2010 and September 2021 at the Affiliated Hospital of Xuzhou Medical University. The study included measurements of Lactate Dehydrogenase (LDH), Creatinine, and Platelet counts. The EASIX score was calculated using the formula: LDH [U/L] × Creatinine [mg/dL] / Platelets [109 cells/L].Results: The median age of the patient cohort was 52 years, with a range of 12 to 85 years. The optimal threshold for EASIX, determined by the Receiver Operating Characteristic (ROC) analysis for OS, was identified as 1.66. Patients with a high EASIX score exhibited significantly reduced median OS and PFS compared to those with a low EASIX score (9.3 months versus not reached, P < 0.001; and 5.7 months versus 24.1 months, P < 0.001). Multivariate Cox regression analysis revealed that a high EASIX score is an independent adverse prognostic factor for OS, with a hazard ratio of 3.033 (95% Confidence Interval, 1.442-6.379; P = 0.003).Conclusions: The findings of this study suggest that the EASIX score may serve as a prognostic biomarker for poor OS in T-cell lymphomas, warranting further investigation.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2519974"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gene prediction of the relationship between iron deficiency anemia and immune cells. 缺铁性贫血与免疫细胞关系的基因预测。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-02-16 DOI: 10.1080/16078454.2025.2462857

Xuanxuan Xu, Zhixia Li, Huimin Liu, Zhiping Huang, Tao Xiong, Yuanyan Tang

{"title":"Gene prediction of the relationship between iron deficiency anemia and immune cells.","authors":"Xuanxuan Xu, Zhixia Li, Huimin Liu, Zhiping Huang, Tao Xiong, Yuanyan Tang","doi":"10.1080/16078454.2025.2462857","DOIUrl":"10.1080/16078454.2025.2462857","url":null,"abstract":"Background: Observational studies have shown a potential link between immune factors and the risk of iron deficiency anemia (IDA), yet the causal relationship between immune cells and IDA remains enigmatic. Herein, we used Mendelian randomization (MR) to assess whether this association is causal.Methods: We selected IDA genetic variants, including 8376 samples and 9810691 single nucleotide polymorphisms, and immune cells from a large open genome-wide association study (GWAS) for a bidirectional MR study. The primary method was inverse variance weighting (IVW), and auxiliary analyses were MR-Egger, weighted median, simple mode and weighted mode. The reliability of the results was subsequently verified by heterogeneity and sensitivity analysis.Results: IVW method showed that 19 types of immune cells may be the risk factors of IDA, whereas 15 types of immune cells are the protective factors of IDA. Reverse MR analysis suggested that immune cells from upstream etiology of IDA are not involved in follow-up immune activities. Next, we selected 731 immune cell types as the results. The research revealed that IDA may result in a rise in 23 kinds of immune cells and a reduction in 12 kinds of immune cells. In addition, sensitivity analysis demonstrated no evidence of heterogeneity or horizontal pleiotropy.Conclusions: From a genetic standpoint, our study suggests that specific immune cells may be involved in the occurrence of IDA. Inversely, IDA may also contribute to immune dysfunction, thus guiding future clinical investigations.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2462857"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143433175","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influencing factors of cognitive impairment in patients with thalassemia: a comprehensive review. 地中海贫血患者认知功能障碍的影响因素综述

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-08-14 DOI: 10.1080/16078454.2025.2543107

Zhihao Wu, Yinan Zhang, Jiaxu Fang, Xiaohong Yang, Ying Guan, Yuefu Zhan, Jianqiang Chen

{"title":"Influencing factors of cognitive impairment in patients with thalassemia: a comprehensive review.","authors":"Zhihao Wu, Yinan Zhang, Jiaxu Fang, Xiaohong Yang, Ying Guan, Yuefu Zhan, Jianqiang Chen","doi":"10.1080/16078454.2025.2543107","DOIUrl":"10.1080/16078454.2025.2543107","url":null,"abstract":"Introduction: Thalassemia is an endemic genetic disease. The main clinical manifestation of this condition is long-term chronic anemia. In addition, patients may present with jaundice, heart failure, hepatosplenomegaly, skeletal deformities, growth retardation, and cognitive impairment. Hematopoietic stem cell transplantation (HSCT) is the only curative treatment.Areas covered: Cognitive impairment in patients with thalassemia has received increasing attention, and related studies have confirmed that patients with thalassemia have varying degrees of cognitive dysfunction. Potential contributing factors include white matter damage, ischemia, hypoxia, and systemic iron overload. However, the specific underlying mechanisms remain unclear and require further investigation. This study aimed to systematically integrate the currently fragmented mechanisms of cognitive impairment in patients with thalassemia.Methods: PubMed, Web of Science, China National Knowledge Infrastructure, and Wanfang databases were used to search for related literature. The main contents of this review include the latest progress in the diagnosis and treatment of thalassemia and the mechanism of cognitive impairment in patients.Conclusion: Cognitive impairment in patients with thalassemia includes deficits in spatial memory, computing power, executive operation, emotional communication, and other domains. Several contributing factors have been identified, including white matter damage, ischemia, hypoxia, iron deposition in the brain, and accelerated aging. Iron overload has recently emerged as a research hotspot. However, the exact location, extent, and mechanism of cerebral iron deposition remain unclear. Despite many challenges in the current research, greater breakthroughs are expected in the diagnosis and treatment of cognitive dysfunction in thalassemia, ultimately improving patients' quality of life.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2543107"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

RUNX1::MECOM rearrangement in myeloid neoplasm post cytotoxic therapy following sarcoma treatment: a case presentation and review of the literature. RUNX1::MECOM重排在骨髓肿瘤肉瘤治疗后的细胞毒性治疗：一个病例报告和文献复习。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-04-09 DOI: 10.1080/16078454.2025.2483094

Miriam Sandnes, Øystein Sefland, Irini Ktoridou-Valen, Rakel Brendsdal Forthun, Hilde Kollsete Gjelberg, Lars Henrik Dahl Hamnvik, Håkon Reikvam, Tor Henrik Andersson Tvedt

{"title":"RUNX1::MECOM rearrangement in myeloid neoplasm post cytotoxic therapy following sarcoma treatment: a case presentation and review of the literature.","authors":"Miriam Sandnes, Øystein Sefland, Irini Ktoridou-Valen, Rakel Brendsdal Forthun, Hilde Kollsete Gjelberg, Lars Henrik Dahl Hamnvik, Håkon Reikvam, Tor Henrik Andersson Tvedt","doi":"10.1080/16078454.2025.2483094","DOIUrl":"https://doi.org/10.1080/16078454.2025.2483094","url":null,"abstract":"Objectives: Myeloid neoplasms occurring after cytotoxic therapy (MN-pCT), previously termed therapy-related myelodysplastic neoplasia (MDS) or therapy-related acute myelogenous leukemia (AML), pose significant treatment challenges due to high resistance, poor chemotherapy tolerance, and relapse.Methods: We present a 73-year-old woman with therapy-related AML following treatment for myxofibrosarcoma, characterized by the rare RUNX1::MECOM fusion resulting from a t(3;21)(q26;q22) chromosomal translocation. We also review the current literature regarding cases of this rare translocation.Results: The patient, previously treated with chemotherapy and radiotherapy for sarcoma, was diagnosed with pancytopenia and hypoplastic bone marrow with increased blasts. Cytogenetic analysis confirmed RUNX1::MECOM fusion. Furthermore, we discuss the molecular mechanisms underlying MECOM rearrangements, specifically the role of the EVI1 oncogene. AML associated with MECOM rearrangements is associated with poor prognosis and resistance to conventional therapies. While allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the only potential curative treatment, the high relapse rate limits its efficacy. Recent advancements in understanding the molecular drivers of MECOM-related AML suggest potential therapeutic strategies, including hypomethylating agents and novel combinations such as lenalidomide.Conclusion: this case and literature review emphasizes the importance of long-term monitoring of cancer survivors treated with cytotoxic therapies, as well as awareness of rare translocations in MN-pCT.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2483094"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epstein-Barr virus infection plays a crucial role in triggering hemophagocytic lymphohistiocytosis in patients with X-linked inhibitor of apoptosis protein deficiency. Epstein-Barr病毒感染在X-linked inhibitor of apoptosis protein缺乏症患者的噬血细胞性淋巴组织细胞增多症中起着至关重要的作用。

IF 2 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-05-13 DOI: 10.1080/16078454.2025.2503745

Lin Shi, Liurui Dou, Jingshi Wang, Zhao Wang

{"title":"Epstein-Barr virus infection plays a crucial role in triggering hemophagocytic lymphohistiocytosis in patients with X-linked inhibitor of apoptosis protein deficiency.","authors":"Lin Shi, Liurui Dou, Jingshi Wang, Zhao Wang","doi":"10.1080/16078454.2025.2503745","DOIUrl":"https://doi.org/10.1080/16078454.2025.2503745","url":null,"abstract":"Background: X-linked inhibitor of apoptosis protein (XIAP) deficiency is a congenital immunodeficiency disorder characterized by increased susceptibility to Epstein-Barr virus (EBV) infection and is frequently associated with hemophagocytic lymphohistiocytosis (HLH).Objective: To investigate the correlation between EBV and XIAP deficiency-related HLH, including EBV infection status, XIAP genetic mutation sites, and the efficacy of different treatment regimens in patients with EBV-positive XIAP deficiency-related HLH, and to analyse the prognosis of these patients.Methods: We retrospectively analysed patients diagnosed with EBV-positive XIAP deficiency-related HLH.Results: Data were collected from August 2017 to August 2024, and 10 patients were included in this study. All patients exhibited an elevated EBV-DNA load. EBV-DNA was detected in both plasma (2/10) and peripheral blood mononuclear cells (10/10), specifically B cells (9/9) and T cells (4/9). Treatment regimens containing rituximab, HLH-2004, and dexamethasone with or without ruxolitinib achieved complete remission. However, only the regimen containing rituximab successfully eradicated EBV from plasma and peripheral blood mononuclear cells in all patients. None of the patients underwent allogeneic haematopoietic stem cell transplantation. No cases of HLH recurrence or EBV reactivation were observed during a median follow-up of 28 months.Conclusions: EBV infection plays a crucial role in triggering HLH in patients with XIAP deficiency. XIAP deficiency-related HLH is frequently associated with EBV infection, which predominantly affects B cells. Treatment regimens containing rituximab can effectively control HLH and eliminate EBV infection. Allogeneic haematopoietic stem cell transplantation may be avoidable in paediatric patients achieving EBV eradication through rituximab-containing regimens.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2503745"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143995466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the prognostic value of TP53 mutations in acute leukemia: a comprehensive retrospective study from a tertiary care hospital. 评估急性白血病TP53突变的预后价值：一项来自三级医院的综合回顾性研究。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-24 DOI: 10.1080/16078454.2025.2552428

Li-Ping Peng, Wei-Zhou Li, Fang Liu, Ting Hu

{"title":"Evaluating the prognostic value of TP53 mutations in acute leukemia: a comprehensive retrospective study from a tertiary care hospital.","authors":"Li-Ping Peng, Wei-Zhou Li, Fang Liu, Ting Hu","doi":"10.1080/16078454.2025.2552428","DOIUrl":"https://doi.org/10.1080/16078454.2025.2552428","url":null,"abstract":"Background: Acute leukemia with gene mutations, particularly TP53, is associated with poor prognosis, yet their impact in middle-aged and elderly patients remains insufficiently explored. This study evaluated the prevalence and prognostic significance of TP53 mutations in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).Methods: This retrospective cohort study included 93 adult patients diagnosed with AML (n = 50) or ALL (n = 43) between January 2013 and December 2023. Clinical, laboratory, and molecular data were collected. Kaplan-Meier survival analysis, Cox proportional hazards regression, and comparative descriptive statistics were used to analyze the impact of TP53 mutations on patient prognosis.Results: TP53 mutations were detected in 16 patients (17.2%). The median age was 56.50 years for TP53mut patients and 56.00 years for TP53wt patients. TP53 mutations were associated with significantly poorer overall survival (OS), with a median OS of 16.50 months in TP53mut patients compared to 39 months in TP53wt patients (P = 0.001). In AML patients, TP53 mutations were linked to a median OS of 14.50 months versus 34.50 months in TP53wt patients (P = 0.015). In ALL patients, the median OS was 22 months for TP53mut patients compared to 46 months for TP53wt patients (P = 0.042). Multivariate analyses identified age ≥ 60 years as a significant predictor of poor OS (P < 0.05).Conclusion: This study shows that TP53 mutations significantly worsen the prognosis of acute leukemia. Routine TP53 mutation screening should be integrated into clinical practice to refine risk stratification and guide treatment, while prospective studies are needed to validate these findings and explore targeted therapies.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2552428"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145137348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The disease burden of β-thalassaemia revisited. 重新审视β-地中海贫血的疾病负担。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-09-08 DOI: 10.1080/16078454.2025.2551450

Elpidoforos S Soteriades, Michael Angastiniotis, Eleftheria C Economidou, Dimitrios Farmakis, Demetris Avraam, Androulla Eleftheriou

{"title":"The disease burden of β-thalassaemia revisited.","authors":"Elpidoforos S Soteriades, Michael Angastiniotis, Eleftheria C Economidou, Dimitrios Farmakis, Demetris Avraam, Androulla Eleftheriou","doi":"10.1080/16078454.2025.2551450","DOIUrl":"https://doi.org/10.1080/16078454.2025.2551450","url":null,"abstract":"Objective: The complexity of β-thalassaemia with associated morbidity, lifelong daily expensive treatment, and multidisciplinary care results in a considerable disease burden. Our study aimed to revisit the β-thalassaemia burden using epidemiological, clinical, and financial indicators related to patients, families, and healthcare systems.Methods: Patient density measures, transfusion indices, complication rates, universal health coverage, and other indicators were tabulated by country and region. Original English language studies, systematic reviews, the global burden of disease project, the International Thalassaemia Collaborative Study, and other databases were reviewed.Results: Our spherical approach revealed existing and continuing stark discrepancies between countries and regions in most published reports concerning β-thalassaemia. Our study provides new insights into the difficult task of quantifying such a complex disease burden in the absence of national registries, electronic health records, and updated epidemiological monitoring worldwide.Conclusion: Disease burden evaluation constitutes a complex and difficult task, especially for hereditary diseases such as β-thalassaemia. Our study revealed stark discrepancies between world regions and countries in most β-thalassaemia indicators examined, including epidemiological, clinical, and psychosocial parameters.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2551450"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145015085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical analysis of eight patients with lung biopsy-proven pulmonary intravascular large B-cell lymphoma in a single center. 单中心肺活检证实肺血管内大b细胞淋巴瘤8例临床分析。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-10-03 DOI: 10.1080/16078454.2025.2566576

Yujie Shi, Kai Xu, Ji Li, Ning Guo, Ruxuan Chen, Chi Shao, Mengqi Wang, Yongjian Liu, Hui Huang, Rui Zhu, Mengzhao Wang, Zuojun Xu

{"title":"Clinical analysis of eight patients with lung biopsy-proven pulmonary intravascular large B-cell lymphoma in a single center.","authors":"Yujie Shi, Kai Xu, Ji Li, Ning Guo, Ruxuan Chen, Chi Shao, Mengqi Wang, Yongjian Liu, Hui Huang, Rui Zhu, Mengzhao Wang, Zuojun Xu","doi":"10.1080/16078454.2025.2566576","DOIUrl":"https://doi.org/10.1080/16078454.2025.2566576","url":null,"abstract":"Objectives: The study aimed to describe the confirmed cases via lung biopsy to accurately reflect the characteristics and improve the prognosis of pulmonary IVLBCL patients.Methods: We retrospectively reviewed medical records of patients with pathologically confirmed IVLBCL between July 2014 and December 2023. Patients diagnosed with pulmonary IVLBCL by lung biopsy were enrolled.Results: Among 66 patients with IVLBCL, 8 patients (5 males and 3 females) were enrolled. The mean age was 54.6 ± 11.3 years old. Fever (87.5%), exertional dyspnea (75%), hypoxia (75%), and weight loss (>5 kg, 50%) were common clinical manifestations. Elevated lactate dehydrogenase (LDH, 100%), erythrocyte sedimentation rate (75%), C-reactive protein (75%), and hypoalbuminemia (75%) were common. Most patients showed diffuse ground-glass opacities (GGOs) with thickened interlobular septa on chest CT, highlighted by shadows on PET-CT. Bronchioalveolar lavage fluid analyses were usually normal; however, seven patients (87.5%) were identified as having IVLBCL via transbronchial lung biopsy. There were five patients using the regimen of R-CHOP or combined with Zanubrutinib, and one patient using Zanubrutinib-Rituximab. Finally, three patients died, four patients were in complete remission, and one was lost to follow-up. Among the three patients who died, one suffered from severe infection, and the other two suffered from lymphoma progression.Conclusions: Patients with pulmonary IVLBCL mainly suffer from fever, weight loss, dyspnea, hypoxia, hyperinflammatory cytokine levels and elevated LDH levels. Diffuse GGOs and thickening interlobular septa with high uptake of 18F-FDG were common radiological features. Bronchoscopy might be an effective tool for the diagnosis of pulmonary IVLBCL.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2566576"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between gut microbiota, plasma metabolites, and iron deficiency anemia in European populations: a three-sample Mendelian randomization analysis. 欧洲人群肠道菌群、血浆代谢物和缺铁性贫血之间的关系：三样本孟德尔随机化分析

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-10-04 DOI: 10.1080/16078454.2025.2549962

XuWen Zheng, WenMing Shen, JinNan Yin

{"title":"The relationship between gut microbiota, plasma metabolites, and iron deficiency anemia in European populations: a three-sample Mendelian randomization analysis.","authors":"XuWen Zheng, WenMing Shen, JinNan Yin","doi":"10.1080/16078454.2025.2549962","DOIUrl":"https://doi.org/10.1080/16078454.2025.2549962","url":null,"abstract":"Objectives: Previous research indicates that gut microbial composition significantly affects iron metabolism and absorption, potentially influencing the risk of iron deficiency anemia (IDA). This study aimed to investigate how plasma metabolites might mediate the relationship between gut microbiota and IDA.Methods: We performed MR analyses utilizing publicly available genome-wide association study (GWAS) data, comprising 5,959 individuals for gut microbiota characterization and 8,299 individuals for plasma metabolite profiling. Outcome data for IDA were sourced from large-scale cohorts including Pan-UKB, FinnGen, and GERA, collectively encompassing 28,075 IDA cases and 857,930 controls. We assessed the mediating role of identified plasma metabolites on the relationship between gut microbial taxa and IDA using the product-of-coefficients method.Results: Our analyses identified 18 gut bacterial taxa and numerous plasma metabolites with potential causal links to IDA. For example, genetically higher abundance of species Ruminococcus E sp003521625 increased IDA risk (OR  =  1.20; 95 % CI  =  1.04-1.39; P  =  0.011), whereas higher abundance of family Jiangellaceae decreased risk (OR  =  0.77; 95 % CI  =  0.61-0.98; P  =  0.035). Mediation analyses revealed that the metabolite 1-palmitoyl-2-stearoyl-glycero-3-phosphocholine (PSPC) significantly mediated the Jiangellaceae - IDA association, with an indirect effect of -0.0477 (95 % CI  =  -0.0952 to -0.0001; P  =  0.049) accounting for approximately 18.55 % of the total effect.Conclusion: Our findings validate the crucial role of gut microbiota in IDA etiology, highlighting mediation via key plasma metabolites. These insights enhance understanding of the gut microbiota-hematopoiesis axis and offer potential avenues for novel biomarkers or therapeutic interventions targeting IDA.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2549962"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145225452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effectiveness and safety of various treatments for hemophilia in China: a literature review and evidence mapping. 中国血友病各种治疗方法的有效性和安全性：文献综述和证据图谱。

IF 1.6 4区医学

Hematology Pub Date : 2025-12-01 Epub Date: 2025-10-06 DOI: 10.1080/16078454.2025.2564511

Yu Yang, Jing Zhang, Lingling Chen, Huan Dong, Ting Sun, Xinyue Dai, Mankai Ju, Wei Liu, Yunfei Chen, Xiaofan Liu, Rongfeng Fu, Lei Zhang, Feng Xue, Renchi Yang

{"title":"The effectiveness and safety of various treatments for hemophilia in China: a literature review and evidence mapping.","authors":"Yu Yang, Jing Zhang, Lingling Chen, Huan Dong, Ting Sun, Xinyue Dai, Mankai Ju, Wei Liu, Yunfei Chen, Xiaofan Liu, Rongfeng Fu, Lei Zhang, Feng Xue, Renchi Yang","doi":"10.1080/16078454.2025.2564511","DOIUrl":"https://doi.org/10.1080/16078454.2025.2564511","url":null,"abstract":"To evaluate the safety and effectiveness of treatments for hemophilia in China through a literature review and evidence mapping, we systematically searched PubMed, Web of Science, Cochrane Library, CNKI, Wanfang, and CBM. Descriptive statistics were used for data analysis in this evidence mapping and the review concluded on 21 April 2025. Results were compiled in tabular or graphical form. This review included 49 studies (two RCTs and 47 observational studies), involving 2274 patients, 41 articles focusing on hemophilia A, seven on hemophilia B, and one on both. The average (mean or median) age of subjects within the individual studies ranged from 5.77 to 34.6 years. This study revealed a decrease in both annualized bleeding rate (ABR) and annualized joint bleeding rate (AJBR) following prophylaxis treatment and immune tolerance induction (ITI) treatment. The reduction in target joint count post-treatment aligns with previous research indicating successful hemostasis in most people with hemophilia after alternative therapies; long-term follow-up studies consistently showed improved imaging scores at various dosage levels, indicating disease amelioration. Additionally, our findings suggest enhanced quality of life for people with hemophilia following treatment. Alternative therapies, encompassing prophylaxis therapy, on-demand treatment, and ITI therapy, demonstrated both efficacy and safety in the management of hemophilia among Chinese people with hemophilia.","PeriodicalId":13161,"journal":{"name":"Hematology","volume":"30 1","pages":"2564511"},"PeriodicalIF":1.6,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145232391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0