The Pan African Medical Journal最新文献

{"title":"[Predictors of hepatic encephalopathy in patients with severe acute liver injury].","authors":"Amal Khsiba,&nbsp;Samir Bradai,&nbsp;Moufida Mahmoudi,&nbsp;Asma Ben Mohamed,&nbsp;Mouna Medhioub,&nbsp;Lamine Hamzaoui,&nbsp;Mohamed Mousadek Azouz","doi":"10.11604/pamj.2022.42.323.30089","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.323.30089","url":null,"abstract":"<p><strong>Introduction: </strong>severe acute liver injury (SALI) formerly known as severe acute hepatitis is an acute inflammation of the liver with markers of liver injury (elevated transaminases) and signs of hepatocellular failure (jaundice and INR greater than 1.5) according to the latest definition of the European Association for the Study of the Liver (EASL). An important prognostic factor in SALI is the development of hepatic encephalopathy (HE) and thus its progression to acute liver failure (ALF), formerly known as acute severe hepatitis. The purpose of this study is to investigate factors predicting the development of hepatic encephalopathy during SALI.</p><p><strong>Methods: </strong>we conducted a retrospective study of patients treated for SALI between January 2000 and December 2019. We divided patients into two groups depending on whether hepatic encephalopathy occurred. We performed an analytical study comparing the two groups according to their epidemiological, biological and evolutionary data.</p><p><strong>Results: </strong>data from the medical records of fifty-nine patients were collected. A virus was the most frequent cause (63%). Hepatic encephalopathy occurred in 15 patients (25.4%). Factors predicting the development of HE in univariate analysis were a delay in consultation of more than 9 days, an INR level of more than 2.45, a bilirubin level of more than 230 μmol/l, creatinine greater than 60.5 μmol/l, urea greater than 5.5 mmol/l and MELD score greater than 26.5 (p=0.023, p=0.017, p=0.0001, p=0.049, p=0.0001, p=0.0001 respectively). Autoimmune hepatitis and an undetermined cause were associated with the development of HE (p=0,003 and p=0,044, respectively). In multivariate analysis, autoimmune aetiology and a urea level above 5.5 mmol/l were significantly associated with the occurrence of HE. No statistically significant differences were found between the two groups with regard to age, sex and diabetes.</p><p><strong>Conclusion: </strong>SALI is a rare disease, mainly due to a virus in our country. Predictive factors of HE are important for early identification of patients at risk of adverse outcomes.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"323"},"PeriodicalIF":1.2,"publicationDate":"2022-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40723191","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medicinal plants used in the traditional treatment of diabetes in Ksar Elkebir Region (North-Western Morocco).","authors":"Ibrahim Hinad,&nbsp;Youssef S'hih,&nbsp;Aboubaker Elhessni,&nbsp;Abdelhalim Mesfioui,&nbsp;Moulay Laarbi Ouahidi","doi":"10.11604/pamj.2022.42.319.32572","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.319.32572","url":null,"abstract":"<p><strong>Introduction: </strong>the number of people with diabetes continues to increase worldwide. In Morocco, two million adults are estimated to be diabetic in 2018. The Moroccan population is known for the use of medicinal plants and natural recipes for the treatment of chronic diseases including diabetes. The present study aimed to make an inventory of plant species used in folk medicine for the treatment of diabetes mellitus by diabetic patients in Ksar Elkebir City (North-west, Morocco).</p><p><strong>Methods: </strong>an ethnobotanical study was carried out among 250 diabetic patients by means of a semi-structured questionnaire by direct interviews.</p><p><strong>Results: </strong>a total of 29 species of plants belonging to 23 families were identified. The most represented families were Lamiaceae, Apiaceae, Asteraceae, fabaceae, and Lauraceae. While the most frequently cited plant species were Olea europaea l, Trigonella foenum graecum l, Origanum compactum benth l and salvia officinalis l. Leaves were the most used part of plants and the decoction was the most cited mode of preparation used by the population included in the study.</p><p><strong>Conclusion: </strong>people with diabetes in Ksar Elkebir Region use a variety of herbal remedies in several ways to treat diabetes. This result can be an important database for the following studies to confirm the efficiency of these plants in vitro and in vivo.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"319"},"PeriodicalIF":1.2,"publicationDate":"2022-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does the experience of the medical encounter with Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome impact women in Africa?","authors":"Rose-Danielle Ngoumou","doi":"10.11604/pamj.2022.42.314.32830","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.314.32830","url":null,"abstract":"<p><strong>Introduction: </strong>the MRKH syndrome is a rare congenital malformation in women. As most rare conditions, this syndrome usually causes confusion in patients and even in physicians. The medical encounter of young girls with the syndrome is intertwined in a complex matrix of social, economic and cultural factors that only contribute in creating more confusion in the young girl.</p><p><strong>Methods: </strong>the study is qualitative and designed to describe the first encounter of women with the MRKH syndrome at the physician. To that effect, an interview guide was designed for in-depth interviews with 05 MRKH women from varied African countries (Cameroon, Côte-d'Ivoire, and Senegal) selected using the snowball technique.</p><p><strong>Results: </strong>findings from this study revealed that most women go to the hospital and return more confused as no clear information is given to them on their condition. Also, cultural, social and religious beliefs on the one hand seems to blur the physician's judgment to provide appropriate remedies like instrumental dilatation for rudimentary vagina, surrogacy for uterine infertility factor, adoption, etc. and on the other hand, these beliefs also act as a barrier for these young girls who are not strangers to the culture.</p><p><strong>Conclusion: </strong>the study suggests that, physicians give to the patients all necessary information for them to take elective decisions on their health. It also suggests that awareness should be raised on this condition.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"314"},"PeriodicalIF":1.2,"publicationDate":"2022-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40712909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human African trypanosomiasis (HAT) in the Republic of Congo: why the Congolese population is reluctant to screening?","authors":"Viny Andzi Elenga,&nbsp;Abel Lissom,&nbsp;Christevy Vouvoungui,&nbsp;Tsengue-Tsengue,&nbsp;Gabriel Ahombo,&nbsp;Francine Ntoumi","doi":"10.11604/pamj.2022.42.309.34830","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.309.34830","url":null,"abstract":"<p><strong>Introduction: </strong>human African trypanosomiasis (HAT) is a neglected tropical infection, and surveillance of the disease relies on community participation in screening. This study aimed to identify the main factors associated with low community uptake of the HAT screening in endemic districts in the Republic of Congo.</p><p><strong>Methods: </strong>a cross-sectional survey was carried out during a sensitisation campaign about HAT in the districts of Mpouya, Ngabé and Loudima, which are endemic for the disease. After signing the informed consent form, participants were organized into groups of 10 for focus group discussions (FGDs). A list of questions was used for guiding the discussion, addressing understanding of the disease and reasons for refusing screening.</p><p><strong>Results: </strong>out of 220 recruited individuals (corresponding to 22 FGDs), 58.6% were men. The majority of the respondents described HAT as a rural disease (48.2%) or as a witchcraft (22.3%). Among the clinical signs cited by the participants, sleep disorder (40%) was the most common answer, followed by prolonged fever (19.5%) and madness (14.1%). The main reasons for non-adherence to HAT screening was the fear of lumbar puncture (45.9%) and stigmatisation (22.3%).</p><p><strong>Conclusion: </strong>the findings of this study suggest that more effort should be put into raising awareness of HAT and the benefits of screening amongst the Congolese population, in order to strengthen the national disease control program.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"309"},"PeriodicalIF":1.2,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40704972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective analysis of the role of retrobulbar amphotericin-B injection in the management of COVID-19 associated rhino-orbito-cerebral-mucormycosis.","authors":"Rekha Yadav,&nbsp;Siddharth Madan,&nbsp;Jolly Rohatgi,&nbsp;Anam Ansari,&nbsp;Rahul Sharma,&nbsp;Priyanka Gautam,&nbsp;Puja Rai,&nbsp;Gopal Krushna Das,&nbsp;Pramod Kumar Sahu,&nbsp;Vipin Arora","doi":"10.11604/pamj.2022.42.312.34757","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.312.34757","url":null,"abstract":"<p><strong>Introduction: </strong>Rhino-orbito-cerebral-mucormycosis (ROCM) is the most common form of mucormycosis observed during the second wave of COVID-19 where a steep rise in the number of cases was seen. The orbital form is almost always associated with fungal sinusitis. Among the various treatment modalities available, the role of retrobulbar Amphotericin-B injections is under-reported. This study is conducted to determine the role of transcutaneous retrobulbar amphotericin-B (TRAMB) in the management of COVID-19 associated ROCM.</p><p><strong>Methods: </strong>a retrospective analysis of 61 patients of COVID-19 associated ROCM was done, who met the inclusion criteria and presented to a tertiary care center, between May to August 2021. These patients were administered TRAMB (deoxycholate/emulsion form) along-with systemic amphotericin B. All the patients were evaluated for clinical improvement.</p><p><strong>Results: </strong>out of 61 patients, 58 (95.08%) showed overall improvement. 40 patients (65.57%) stabilized or improved clinically and 3 patients succumbed to the illness due to advanced systemic mucormycosis and acute kidney failure. Sixteen out of 58 patients underwent orbital exenteration. Out of remaining 43 patients, 35 showed complete recovery of orbital and ocular disease and the disease stabilized in eight patients. Seven patients demonstrated TRAMB associated ocular complications which however completely resolved in six patients.</p><p><strong>Conclusion: </strong>to the best of the author´s knowledge, regression of orbital mucormycosis with improvement in ptosis, proptosis, ocular motility and stabilization of visual acuity are scarcely reported in literature. Further TRAMB as a globe non-deforming treatment modality is an option available for ROCM.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"312"},"PeriodicalIF":1.2,"publicationDate":"2022-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9664513/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40723193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, attitude and adherence to COVID-19 prevention among community health workers in Nigeria.","authors":"Oluyemi Peter Atibioke,&nbsp;Fatimah Adepoju-Olajuwon,&nbsp;Oluwaseun Ayoola Ojomo,&nbsp;Adeyemi Olalekan Oladeji,&nbsp;Oluwakemi Bolatito Oripeloye,&nbsp;Kehinde Adesola Osinowo,&nbsp;Ademola Johnson Ajuwon,&nbsp;Oladapo Alabi Ladipo","doi":"10.11604/pamj.2022.42.307.30791","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.307.30791","url":null,"abstract":"<p><strong>Introduction: </strong>community health workers play important roles in curtailing the spread of COVID-19. This study therefore investigated the knowledge, attitude and adherence to practice of COVID-19 prevention-protocols among community health workers in selected States of Nigeria.</p><p><strong>Methods: </strong>purposive sampling method was adopted. A cohort of community health workers testing and enrolling human immunodeficiency virus (HIV) positive-clients into care were involved in the study. Questionnaire on Microsoft forms was completed by 366 participants. Data were analyzed using descriptive and inferential statistical methods.</p><p><strong>Results: </strong>key findings revealed that 87.80% have good knowledge of COVID-19; 96.10% positive attitude towards COVID-19 prevention-protocols and 97.20% adhere to the protocols. Demographics variables have significant positive effect on adherence to COVID-19 prevention-protocol among the respondents as follows: marital status (X²: 21.91; p: <0.05), gender (X²: 9.01; p: 0.003), ethnic group (X²: 17.45; p: <0.05), State of residence (X²: 32.51; p: <0.05), education status (X²: 18.44; p: 0.005). Findings revealed there is no significant relationship between knowledge of COVID-19 and the anxiety status of community health workers (p=0.90). There is positive relationship between knowledge of COVID-19 and attitude to guidelines and adherence to COVID-19 prevention-protocols. R=0.20 (<0.05) and 0.195 (<0.05) respectively.</p><p><strong>Conclusion: </strong>the high knowledge of COVID-19, positive attitude and adherence to the prevention-protocols among community health workers provides assurance of their ability to provide factual information to the community and their ability to promote good attitude and adherence to the prevention-protocols. Key sociodemographic variable like marital status, gender, ethnic groups, educational status and State of residents play significant roles in adherence to COVID-19 prevention-protocols.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"307"},"PeriodicalIF":1.2,"publicationDate":"2022-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653541/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40704971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mini-laparotomy for cholecystectomy in resourced limited settings: a 10-year retrospective hospital-based study.","authors":"Samir Ismail Bashir,&nbsp;Rayan Bakari Adam Mohamed,&nbsp;Khalid Abbas Owish,&nbsp;Abdalla Mohamed Abdalla,&nbsp;Abdullah Misbah Abdullah,&nbsp;Yasir Babiker Ali","doi":"10.11604/pamj.2022.42.304.32681","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.304.32681","url":null,"abstract":"<p><p>Cholecystectomy is a commonly performed abdominal procedure, the gold standard currently is the laparoscopic approach and, however, the facilities and expertise for laparoscopy are not available widely, especially in developing countries. A Mini-laparotomy cholecystectomy is an additional approach that is performed through an incision that is less than 5 cm thus minimizing the complications of the traditional open cholecystectomy and the postoperative hospital stay. The study aims to evaluate the outcome of mini-laparotomy cholecystectomy in terms of operative duration, complications, and hospital stay in a rural hospital. This is a retrospective study conducted in El-Dwaim Teaching Hospital, Sudan. All cases of mini-laparotomy cholecystectomy conducted from March 2009 to December 2020 were included and retrospectively studied. Descriptive statistics were applied using SPSS version 25. A total of 512 mini-laparotomy cases were involved in the study, of those 442 aged more than 40 years. The operation lasted less than 60 minutes for 486 of the participants, and the most frequent cholecystitis complication observed intraoperatively was mucocele, occurring in 70 (13.6%) participants. Intraoperative complications due to mini-laparotomy occurred in 4 (0.8%) cases, in the form of bleeding and none of the observed cases converted into open cholecystectomy. Postoperative complications occurred in the form of wound infection in 7 participants, biliary leak in 1 participant, and fistula formation in 1 participant. Post-operative hospital stay was 24 hours for 458 participants. Mini-laparotomy cholecystectomy is a safe minimally invasive approach with low rates of complications and short postoperative hospital stay, making it an optimum approach in facility-deprived countries.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"304"},"PeriodicalIF":1.2,"publicationDate":"2022-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9653538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40510691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Unusual localizations of subcutaneous lipomas: case report].","authors":"Yassamina Ribag,&nbsp;Abdelhafid Achbouk,&nbsp;Jalal Hamama,&nbsp;Mohamed Karim El Khatib","doi":"10.11604/pamj.2022.42.300.28318","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.300.28318","url":null,"abstract":"<p><p>Subcutaneous lipomas are very common tumors preferentially occurring in the neck and trunk. Although rare and unusual, they can occur in other parts of the body. Then they should be suspected in patients with subcutaneous swellings. We here report 3 cases of lipomas occurring in rare sites, detailing diagnosis and treatment. They occurred in the interdigital web space of the hand, toe and lateral canthus of the eye.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"300"},"PeriodicalIF":1.2,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40702227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Satisfaction in conventional acrylic complete denture patient with and without denture liners - a systematic review.","authors":"Jayesh Shinde, Tushar Mowade, Priya Gupta, Rahul Tekale, Neelam Pande, Kalyani Deshmukh, Twinkle Lokhande, Usha Radke","doi":"10.11604/pamj.2022.42.296.33035","DOIUrl":"10.11604/pamj.2022.42.296.33035","url":null,"abstract":"<p><p>To make a new complete denture, a series of steps is needed, and it is a time-consuming process. Which is not possible in every patient due to financial and medical reasons. The old denture can be relined by denture liners in less clinical and laboratory steps and can successfully increase the efficiency of ill-fitting dentures however, patient satisfaction with denture liners is doubtful. This systematic review was organized from the preferred reporting items for systematic reviews' checklist, and the methods were registered on the international prospective register of systematic reviews (PROSPERO- CRD42020210227). The main systematic review is to assess satisfaction in convectional acrylic complete denture with or without denture liners. Search engines such as PubMed, Science Direct, Cochrane, Ovid, and Google Scholar were used to extract information. The risk of bias was measured with the help of the Cochrane collaboration tool. Initially we found 1711 articles out of which 6 were finalised as per PICO criteria. Patient satisfaction was evaluated by using a visual analogue scale and questionnaire method, which shows denture liners group has more patient satisfaction. Acrylic denture liner and silicon denture liner shows better patient satisfaction compared to the conventional acrylic denture. Among denture liners, there is no significant difference.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"296"},"PeriodicalIF":0.0,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643794/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40702229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Which chemotherapy regimen in patients with metastatic phyllodes tumors of the breast? case report].","authors":"Imane Ait Kaikai,&nbsp;Mouna Bourhafour,&nbsp;Meriem Haffadi,&nbsp;Zineb Bouchbika,&nbsp;Nadia Benchakroune,&nbsp;Hassan Jouhadi,&nbsp;Nezha Tawfiq,&nbsp;Souha Sahraoui,&nbsp;Abdellatif Benider","doi":"10.11604/pamj.2022.42.293.20377","DOIUrl":"https://doi.org/10.11604/pamj.2022.42.293.20377","url":null,"abstract":"<p><p>Phyllodes tumors (PT) of the breast are rare. They can be benign, borderline or malignant. Malignant forms account for 20-30% of PTs, with distant metastases in 10-26% of cases. Chemotherapy is one of the main therapeutic weapons for metastatic phyllodes tumors (MPTs). We here report four cases of MPTs of the breast managed at The Mohammed VI Center For Cancers Treatment in Casablanca from January 2015 to December 2017. The average age of patients ranged from 25 to 45 years. The mode of revelation was represented, in the majority of cases, by the occurrence of a huge breast mass and in all patients the histological diagnosis was based on the examination of mastectomy specimen. Three patients had lung metastases, two had axillary lymph-node metastases, two had bone metastases and only one had liver metastases. All patients received chemotherapy. Doxorubicin monotherapy and doxorubicin-ifosfamide (AI) were used. Only one patient had a very favorable outcome, with radiologic complete response after 3 AI regimens. MPTs of the breast have a poor prognosis. The role of systemic chemotherapy is to be defined, especially since there are no data available on optimal chemotherapy regimen.</p>","PeriodicalId":131455,"journal":{"name":"The Pan African Medical Journal","volume":" ","pages":"293"},"PeriodicalIF":1.2,"publicationDate":"2022-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9643797/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40702308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}