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Asian Journal of Organic Chemistry最新文献

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Amino‐Terephthalonitrile Based Single Benzene Fluorophores Bearing Amino Esters and Lipids for Selective Biothiol Sensing and Bioimaging 用于选择性生物硫醇传感和生物成像的氨基对苯二甲酸基单苯荧光团含氨基酯和脂类
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202500040
Ankita Sinha , Subhadeep Banerjee , Arka Bagchi , Sumiran Kasturi , Arnab Banerjee
{"title":"Amino‐Terephthalonitrile Based Single Benzene Fluorophores Bearing Amino Esters and Lipids for Selective Biothiol Sensing and Bioimaging","authors":"Ankita Sinha ,&nbsp;Subhadeep Banerjee ,&nbsp;Arka Bagchi ,&nbsp;Sumiran Kasturi ,&nbsp;Arnab Banerjee","doi":"10.1002/ajoc.202500040","DOIUrl":"10.1002/ajoc.202500040","url":null,"abstract":"<div><div>We report here the preparation of eight new AmTN SBFs which feature amino esters with an N‐terminal fluorophore and also lipophilic dyes, consisting of a push‐pull AmTN moiety. Spectrofluorimetric and NMR titration investigations reveal the preference of the terephthalonitirle ring in mono AmTNs towards rapid sensing of N‐acetyl cysteine, as opposed to the dipeptide carnosine. This has significance in the field of bioanalysis whereby the AmTNs could show their potential as thiol sensing platforms. Also, one of the lipophilic green emissive AmTNs featuring two cyclohexyl units proved its worth in fluorescence imaging using C2 C12 cells, where it localized electively inside the cell cytoplasm at concentration of 1 μM.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500040"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient Et3N‐Catalyzed three‐Component Synthesis of 4,5,6,7‐Tetrahydro‐3‐Cyanoindoles and its Conversion to 3‐Cyanoindoles 高效Et3N催化三组分合成4,5,6,7‐四氢‐3‐氰吲哚及其转化为3‐氰吲哚
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202500107
Mengxin Xia , Ahmad Farhan , Zaher M. A. Judeh
{"title":"Efficient Et3N‐Catalyzed three‐Component Synthesis of 4,5,6,7‐Tetrahydro‐3‐Cyanoindoles and its Conversion to 3‐Cyanoindoles","authors":"Mengxin Xia ,&nbsp;Ahmad Farhan ,&nbsp;Zaher M. A. Judeh","doi":"10.1002/ajoc.202500107","DOIUrl":"10.1002/ajoc.202500107","url":null,"abstract":"<div><div>We report a highly efficient and scalable one‐pot Et<sub>3</sub>N‐catalyzed cascade reaction for synthesizing 4,5,6,7‐tetrahydro‐3‐cyanoindoles from hydroxycyclohexanone dimers, oxoacetonitriles, and primary amines in up to 91 % yield. This reaction proceeds through aldol condensation, cyclization <em>via</em> Paal‐Knorr synthesis, and subsequent aromatization under mild, cyanide‐free and metal‐free conditions. The reaction uses readily available starting materials and accommodates a broad substrate scope, including diverse oxoacetonitriles and aliphatic or aromatic amines, without significant variations in yield. Gram‐scale synthesis demonstrates its practical applicability, producing the target compounds with consistent efficiency. Additionally, the 4,5,6,7‐tetrahydro‐3‐cyanoindoles were successfully converted to their corresponding 3‐cyanoindoles, emphasizing the synthetic versatility of this approach and offering a practical and more environmentally friendly alternative for generating these compounds.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500107"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Computational Study of Naphthalene Peri‐Diselenide as Glutathione Peroxidase Mimics: Mechanistic Insights and Substitution Effects 萘环二硒作为谷胱甘肽过氧化物酶模拟物的计算研究：机理和取代效应
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202400717
Shubham Bajpai , Raghu Nath Behera
{"title":"Computational Study of Naphthalene Peri‐Diselenide as Glutathione Peroxidase Mimics: Mechanistic Insights and Substitution Effects","authors":"Shubham Bajpai ,&nbsp;Raghu Nath Behera","doi":"10.1002/ajoc.202400717","DOIUrl":"10.1002/ajoc.202400717","url":null,"abstract":"<div><div>The full catalytic cycle of naphtho[1,8‐c,d]‐1,2‐diselenole, a potential glutathione peroxidase mimic, has been investigated using the density functional theory and the energetic span model. The effects of substitutions and solvent on the catalytic cycle have also been investigated. Among the four steps of the catalytic cycle, the step involving the regeneration of the catalyst exhibits the highest activation energy. Polar solvent (methanol) enhances the overall catalytic activity by decreasing the activation barrier for most of the steps. The ortho position (to selenium) of the naphthalene ring is found most suitable for the substitution, showing the highest turnover frequency (TOF) for both nitro and methoxy substituents. Meta substitution leads to a decline in catalytic efficiency, showing lower TOF than the unsubstituted molecule. Substitution at the para position enhances the activity for the methoxy group, while the nitro group reduces it.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202400717"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synthesis of Mg−Al Hydrotalcites with Various Surfactants as Solid Base Catalyst for the Knoevenagel Condensation Reaction 以各种表面活性剂为固体碱催化剂合成Mg−Al水滑石的Knoevenagel缩合反应
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202500015
Shun Nishimura , Huyen Nam Nguyen , Souta Yuuki , Khoki Ebitani
{"title":"Synthesis of Mg−Al Hydrotalcites with Various Surfactants as Solid Base Catalyst for the Knoevenagel Condensation Reaction","authors":"Shun Nishimura ,&nbsp;Huyen Nam Nguyen ,&nbsp;Souta Yuuki ,&nbsp;Khoki Ebitani","doi":"10.1002/ajoc.202500015","DOIUrl":"10.1002/ajoc.202500015","url":null,"abstract":"<div><div>Mg−Al layer double hydroxide (Mg/Al=3.0), commonly designed as hydrotalcite (HT), has been prepared in the presence of surfactant reagents of various types to control its genesis during co‐precipitation. Among cationic, anionic, noninonic, and amphoteric surfactants, the cationic surfactant of benzyldimethyltetradecylammonium chloride (denoted as HT‐<em>a</em>, here) served a highly‐active Mg−Al HT for the Knoevenagel condensation reaction of furfural and diethyl malonate to diethyl 2‐furfurylidenemalonate, which was selected as a model base‐catalyzed reaction for this study. It was found that crystalline sizes of (003) had a linear relation to the product yield. Based on FE‐SEM observations and N<sub>2</sub> adsorption isotherm analysis, aggregation and growth of HT crystals are expected to be prohibited in the presence of benzyldimethyltetradecylammonium chloride, affording the smaller size domains (secondary particles). These results are associated with enhanced reactivity for the base‐catalyzed reaction.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500015"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient N‐Nitrosation of Sulfonamides with tert‐Butyl Nitrite at Room Temperature 磺胺类与亚硝酸盐叔丁酯在室温下的高效N -亚硝化反应
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202500276
Vimlesh Kumar Kanaujiya , Jeyakumar Kandasamy , Subhasis Samai , Maya Shankar Singh
{"title":"Efficient N‐Nitrosation of Sulfonamides with tert‐Butyl Nitrite at Room Temperature","authors":"Vimlesh Kumar Kanaujiya ,&nbsp;Jeyakumar Kandasamy ,&nbsp;Subhasis Samai ,&nbsp;Maya Shankar Singh","doi":"10.1002/ajoc.202500276","DOIUrl":"10.1002/ajoc.202500276","url":null,"abstract":"<div><div>Sulfonamide is one of the most important structures in organic chemistry due to its presence in natural products and pharmaceuticals. Herein, we disclose a simple, highly efficient, and direct one‐step synthesis of <em>N</em>‐nitroso sulfonamides in excellent yields within 30 minutes employing sulfonamides and <em>tert</em>‐butyl nitrite at room temperature in open air. This method could be used effectively to produce a variety of value‐added <em>N</em>‐nitroso sulfonamides.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500276"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Typical Cases of Continuous Flow Chemistry in Pharmaceutical Synthesis in 2023–2024 2023-2024年药物合成连续流化学典型案例分析
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202500132
Kang‐Bo Feng , Yuan‐Yuan Zhu , Shuang‐Xi Gu , Jiao Long , Hai‐Feng Wang
{"title":"Typical Cases of Continuous Flow Chemistry in Pharmaceutical Synthesis in 2023–2024","authors":"Kang‐Bo Feng ,&nbsp;Yuan‐Yuan Zhu ,&nbsp;Shuang‐Xi Gu ,&nbsp;Jiao Long ,&nbsp;Hai‐Feng Wang","doi":"10.1002/ajoc.202500132","DOIUrl":"10.1002/ajoc.202500132","url":null,"abstract":"<div><div>Continuous flow chemistry, as an emerging technology and a significant trend in the field of pharmaceutical synthesis, has been increasingly employed in both academic laboratories and miniature industrial workshops to produce various compounds and intermediates. Compared to traditional batch production methods, this technology enhances the heat and mass transfer effects during the reaction process, thereby reducing reaction times and yielding purer products with greater consistency in quality. Furthermore, continuous flow technology enables precise control of reaction parameters, minimizes the need for intermediate separation and purification steps, and offers a safer, more efficient and environmentally friendly platform for synthesis and production of chemical drugs. In this brief review, we present and evaluate typical cases from 2023 to 2024 that demonstrate the advancements in pharmaceutical synthetic processes achieved through flow chemistry, emphasizing the significant advantages of producing active pharmaceutical ingredients (APIs) in a continuous flow manner. This review is aimed to afford a conducive reference for efficient and sustainable production of pharmaceuticals, thereby reinvigorating the field with the aid of flow chemistry.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500132"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optically Active Triangle‐shaped Macrocycles Based on Planar Chiral [2.2]Paracyclophane 基于平面手性的光学活性三角形大环[2.2]
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202500155
Yuki Fujita , Dr. Ryo Inoue , Prof. Yasuhiro Morisaki
{"title":"Optically Active Triangle‐shaped Macrocycles Based on Planar Chiral [2.2]Paracyclophane","authors":"Yuki Fujita ,&nbsp;Dr. Ryo Inoue ,&nbsp;Prof. Yasuhiro Morisaki","doi":"10.1002/ajoc.202500155","DOIUrl":"10.1002/ajoc.202500155","url":null,"abstract":"<div><div>An optically active macrocycle containing an enantiopure pseudo‐<em>ortho</em>‐linked [2.2]paracyclophane skeleton was synthesized. This molecule consisted of a phenylene‐ethynylene‐typed π‐conjugation system, which was folded to construct a triangle‐shaped (one‐handed helical) structure. The extended π‐conjugation length derived from the single π‐conjugation system resulted in a large molar absorption coefficient and a good photoluminescence quantum efficiency. Intense circularly polarized luminescence (CPL) signals were observed, and the chiroptical properties were reproduced by the molecular simulations. The macrocycle was found to be a good CPL emitter with a high anisotropy factor and high CPL brightness values.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500155"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Naphthoquinone‐Triazole Hybrids as Potential FGFR1 Tyrosine Kinase Inhibitors 新型萘醌-三唑复合物作为FGFR1酪氨酸激酶抑制剂的设计、合成、生物学评价和分子模型研究
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202400813
Ronnakorn Leechaisit , Panupong Mahalapbutr , Utid Suriya , Pattamaporn Sukonthasakorn , Veda Prachayasittikul , Prasit Mandi , Supaluk Prachayasittikul , Somsak Ruchirawat , Virapong Prachayasittikul , Ratchanok Pingaew
{"title":"Design, Synthesis, Biological Evaluation and Molecular Modeling Studies of Novel Naphthoquinone‐Triazole Hybrids as Potential FGFR1 Tyrosine Kinase Inhibitors","authors":"Ronnakorn Leechaisit ,&nbsp;Panupong Mahalapbutr ,&nbsp;Utid Suriya ,&nbsp;Pattamaporn Sukonthasakorn ,&nbsp;Veda Prachayasittikul ,&nbsp;Prasit Mandi ,&nbsp;Supaluk Prachayasittikul ,&nbsp;Somsak Ruchirawat ,&nbsp;Virapong Prachayasittikul ,&nbsp;Ratchanok Pingaew","doi":"10.1002/ajoc.202400813","DOIUrl":"10.1002/ajoc.202400813","url":null,"abstract":"<div><div>A new series of 1,4‐naphthoquinone‐triazole derivatives <strong>5</strong>–<strong>21</strong> were synthesized using nucleophilic substitution and CuAAC reactions. The compounds were investigated for their cytotoxic activities against four cancer cell lines (i. e., HuCCA‐1, T47D, MOLT‐3, and HepG2) as well as a normal cell line (Vero). Most of the compounds showed active cytotoxic effects on all tested cancer cells without cytotoxicity to the normal cells. Particularly, compound <strong>20</strong> showed promising activity against the T47D with comparable effect to that of the known drug, doxorubicin. Compounds <strong>16</strong> and <strong>21</strong> exhibited the greatest FGFR1 inhibitory potency with nanomolar IC<sub>50</sub> values of 1.31±0.51 and 3.17±0.33 nM, respectively. Interestingly, the derivative <strong>16</strong> showed comparable inhibitory potency with the known FGFR1 inhibitor, AZD4547. Molecular docking and molecular dynamics simulations were conducted and revealed that both compounds could occupy within the ATP‐binding pocket of the target FGFR1 and shared common interacting key amino acids residues (i. e., Leu484, Val492, and Leu630) with those of inhibitor, AZD4547. The simulations also suggested that the naphthoquinone‐triazole skeleton was found to be a promising structural characteristic essential for effective inhibition of FGFR1. Additionally, the drug‐likeness prediction displayed that these compounds (<strong>16</strong> and <strong>21</strong>) are drug‐like molecules with possibility for further development.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202400813"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cu(OAc)2.H2O used as acetoxy source for the selective C(sp2)‐H acetoxylation: Synthesis of Acetoxylated Indoles/bisindolyl 铜(OAc) 2。H2O作为选择性C（sp2）‐H乙酰氧基化的乙酰氧基源：乙酰化吲哚/双吲哚的合成
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202400763
Peramalla Edukondalu , Praveen Kumar Naikawadi , Kuruva Prabhakar , Keerthana Pradeesh , Dr. Sabbasani Rajasekhara Reddy , Dr. K. Shiva Kumar
{"title":"Cu(OAc)2.H2O used as acetoxy source for the selective C(sp2)‐H acetoxylation: Synthesis of Acetoxylated Indoles/bisindolyl","authors":"Peramalla Edukondalu ,&nbsp;Praveen Kumar Naikawadi ,&nbsp;Kuruva Prabhakar ,&nbsp;Keerthana Pradeesh ,&nbsp;Dr. Sabbasani Rajasekhara Reddy ,&nbsp;Dr. K. Shiva Kumar","doi":"10.1002/ajoc.202400763","DOIUrl":"10.1002/ajoc.202400763","url":null,"abstract":"<div><div>For the first time, Cu(OAc)<sub>2</sub>.H<sub>2</sub>O has been demonstrated as an effective source of acetoxy groups for the selective oxidative acetoxylation of Csp<sup>2</sup>‐H bonds. We present a method that selectively acetoxylation of indoles and bisindolyls with high regioselectivity, thus allowing us to specifically functionalize specific molecule positions while leaving other reactive sites unaffected. The Cu(OAc)<sub>2</sub>.H<sub>2</sub>O mediated acetoxylation method has milder reaction conditions and a greater compatibility between functional groups, allowing for the efficient synthesis of complex indoles and bisindolyl derivatives. Similar efficiency was observed on gram scales.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202400763"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent Advances in the Chemistry of 5 and 6‐Membered Selenacycles and Selenaheterocycles 5元和6元硒环和硒杂环的化学研究进展
IF 2.8 4区 化学
Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI: 10.1002/ajoc.202500093
Dr. Italo Franco Coelho Dias , Prof. Claudio Santi , Prof. Luca Sancineto
{"title":"Recent Advances in the Chemistry of 5 and 6‐Membered Selenacycles and Selenaheterocycles","authors":"Dr. Italo Franco Coelho Dias ,&nbsp;Prof. Claudio Santi ,&nbsp;Prof. Luca Sancineto","doi":"10.1002/ajoc.202500093","DOIUrl":"10.1002/ajoc.202500093","url":null,"abstract":"<div><div>In recent years, selenium and selenium‐containing compounds have attracted increasing attention due to their fascinating biological activities and synthetic versatility. This review aims to highlight the recent advances in the chemistry of cyclic structures incorporating this valuable yet rare heteroatom. Special emphasis is given to 5‐ and 6‐membered rings containing selenium, including combinations with other heteroatoms such as oxygen and nitrogen. To provide a comprehensive and up‐to‐date overview, we have summarized contributions reported between 2020 and 2024, addressing both synthetic methods and medicinal chemistry aspects where relevant. Following an introductory section, the review explores the chemistry of 5‐membered rings, including selenophenes, benzo(heteroaryl)selenophenes, and tetrahydroselenophenes. Subgroups such as 1,3‐selenazoles and 1,3‐oxaselenolanes are discussed in detail, alongside a dedicated analysis of benzisoselenazolones. Among these, ebselen—a prototypical benzisoselenazolone and one of the most extensively studied selenium‐based compounds—is given particular attention. The discussion then shifts to 6‐membered rings, encompassing among others selenomorpholines, 1,3‐selenazinanes, 1,2,4‐selenadiazinanes, and tetrahydro‐<em>2H</em>‐selenopyranes, with a focus on their unique chemical properties and potential applications. The review concludes with a summary and an outlook on future research directions in this evolving field.</div></div>","PeriodicalId":130,"journal":{"name":"Asian Journal of Organic Chemistry","volume":"14 5","pages":"Article e202500093"},"PeriodicalIF":2.8,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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