磺胺类与亚硝酸盐叔丁酯在室温下的高效N -亚硝化反应

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202500276

Vimlesh Kumar Kanaujiya , Jeyakumar Kandasamy , Subhasis Samai , Maya Shankar Singh

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引用次数: 0

摘要

磺胺是有机化学中最重要的结构之一，存在于天然产物和药物中。在此，我们公开了一种简单、高效、直接的一步合成N -亚硝基磺酰胺的方法，使用磺酰胺和亚硝基叔丁基亚硝酸盐，在室温下，在30分钟内以优异的收率合成N -亚硝基磺酰胺。该方法可有效地用于生产多种高附加值N -亚硝基磺胺。

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Efficient N‐Nitrosation of Sulfonamides with tert‐Butyl Nitrite at Room Temperature

Sulfonamide is one of the most important structures in organic chemistry due to its presence in natural products and pharmaceuticals. Herein, we disclose a simple, highly efficient, and direct one‐step synthesis of N‐nitroso sulfonamides in excellent yields within 30 minutes employing sulfonamides and tert‐butyl nitrite at room temperature in open air. This method could be used effectively to produce a variety of value‐added N‐nitroso sulfonamides.

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.