Human Andrology最新文献_第3页

Seminal plasma clusterin as a biomarker for spermatogenesis in patients with varicocele before and after varicocelectomy 精浆聚集素作为精索静脉曲张切除术前后患者精子发生的生物标志物

Human Andrology Pub Date : 2019-12-01 DOI: 10.21608/ha.2019.6681.1037

H. Saleh, A. Afify, Walid K. M. Ahmed, M. Daruish

{"title":"Seminal plasma clusterin as a biomarker for spermatogenesis in patients with varicocele before and after varicocelectomy","authors":"H. Saleh, A. Afify, Walid K. M. Ahmed, M. Daruish","doi":"10.21608/ha.2019.6681.1037","DOIUrl":"https://doi.org/10.21608/ha.2019.6681.1037","url":null,"abstract":"Introduction: A varicoc ele is an abnormally dilated pampiniform plexus of veins. Hyperthermia, oxidative stress, and elevated apoptotic index have been described in men with varicocele and infertility. Clusterin (Clu) is a chaperone-like glycoprotein that is synthesized by Sertoli cells in high concentrations and is deposited onto the membranes of mature spermatozoa, giving rise to the possibility that it has a role in sperm development. Secreted form of Clu is a powerful anti-apoptotic agent. Aim: To explore Clu level in seminal plasma of infertile men with varicocele in comparison with normal healthy fertile patients and to compare the seminal plasma Clu level before and after varicocelectomy.Patients and methods: The study included 25 patients having varicocele with infertility (whether primary or secondary) for 12 months and 10 healthy volunteers of matched age and sex as control. For all the patients, sub-inguinal varicocelectomy was done. Semen analysis and seminal plasma Clu assay were carried out before and 3 months after varicocelectomy.Results: There was a statistically significant difference between patients and controls regarding sperm count, progressive motility, and seminal plasma Clu (P<0.01). Three months after varicocelectomy, the sperm count had a highly significant improvement in the patient’s group (mean ± SD=17.90 ± 8.86) compared with a preoperative count (mean ± SD=11.43 ± 7.56). There was a highly significant improvement in postoperative progressive motility in the patient’s group (mean ± SD=34.5 ± 20.2) compared with preoperative progressive motility (mean ± SD=22.05 ± 15.5).Clu showed a highly significant elevation in the patient group postoperatively (mean ± SD=10.73 ± 4.5) compared with preoperatively (mean ± SD=6.68 ± 3.8). Conclusion: Based on our study, we could suggest another way of contribution of varicocele to male infertility by affecting seminal plasma Clu level.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"10 1","pages":"111-114"},"PeriodicalIF":0.0,"publicationDate":"2019-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89204811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Assessment of the effect of psoriasis on male sexual function 银屑病对男性性功能影响的评价

Human Andrology Pub Date : 2019-09-01 DOI: 10.21608/HA.2018.4550.1032

Mahmoud Abd El-Mawla, A. Kandil, A. Hashim, A. Zidan

引用次数: 1

Comparing Fisch’s artery-sparing technique with the microsurgical subinguinal varicocelectomy Fisch保留动脉技术与显微外科腹股沟下精索静脉曲张切除术的比较

Human Andrology Pub Date : 2019-09-01 DOI: 10.21608/HA.2018.6103.1036

A. Elahwany

{"title":"Comparing Fisch’s artery-sparing technique with the microsurgical subinguinal varicocelectomy","authors":"A. Elahwany","doi":"10.21608/HA.2018.6103.1036","DOIUrl":"https://doi.org/10.21608/HA.2018.6103.1036","url":null,"abstract":"Objective: The aim was to evaluate the reduction of operation time using a new artery-sparing varicocelectomy technique.Patients and methods: This study compares a new surgical technique introduced by Fisch and colleagues, which elevates the testicular artery and ligates the pampiniform plexus in one or more vein groups, with subinguinal microsurgical varicocelectomy. The study was conducted retrospectively on a control group of 51 patients who had conventional microsurgical varicocelectomy (group 1) and the experimental group of 44 patients who underwent the new technique (group 2).Results: We compared the outcome measures including operative time (in minutes), postoperative complications, semen percentage improvement, and pregnancy outcome rate. Both groups had significantly improved semen count, motility, and abnormal form improvements. Group 2 had significantly greater sperm motility and 11.6% less abnormal forms. Both groups had similar pregnancy rates (40% for the microsurgical group vs. 35.7% for the Fisch technique group; P=0.3). Group 1 had an average operating time of 94±6.9 min compared with 44.5±8.4 min for group 2 (P=0.001).Conclusion: The Fisch technique dramatically reduces operative time with similar patient outcomes when compared with the traditional subinguinal microsurgical varicocelectomy.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"256 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74510385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of isotretinoin treatment on testosterone and sex hormone-binding globulin in malepatients with acne vulgaris 异维甲酸治疗对男性寻常性痤疮患者睾酮和性激素结合球蛋白的影响

Human Andrology Pub Date : 2019-09-01 DOI: 10.21608/ha.2020.15139.1048

Y. Nasrallah, Halim Maher, Maha M Anani, M. Eyada

{"title":"Impact of isotretinoin treatment on testosterone and sex hormone-binding globulin in malepatients with acne vulgaris","authors":"Y. Nasrallah, Halim Maher, Maha M Anani, M. Eyada","doi":"10.21608/ha.2020.15139.1048","DOIUrl":"https://doi.org/10.21608/ha.2020.15139.1048","url":null,"abstract":"Background: Acne vulgaris is primarily a disease of the pilosebaceous unit. Four main pathogenic factors are known to lead to its development: follicular epidermal hyperproliferation, excess sebum production, inflammation, and the activity of propionibacterium acnes. Isotretinoin (ISO) is a 13-cis-retinoic acid derivative of vitamin A. It is a highly effective therapy for severe nodulocystic acne. Objective: The aim was to measure serum total, free testosterone, and sex hormone-binding globulin (SHBG) levels, before and after treatment, in male patients suffering from acne vulgaris and taking ISO as a treatment for their acne. Patients and Methods: The authors included 113 male patients with acne vulgaris. The patients received 0.5░mg/kg/day ISO treatment. Blood samples were collected from the patients for analysis of total, free testosterone, and SHBG levels before and after 6 months of treatment. Results: After 6 months of treatment with ISO, the total lesion count was significantly lower after treatment (88.70±35.04 and 27.80±17.94, respectively, P<0.05).There was significant reduction in mean total testosterone serum levels after treatment (5.553±2.614 and3.329±2.276, respectively, P<0.05).The mean free testosterone serum level was insignificantly lower after treatment (31.237±11.994 and 24.526±14.917, respectively, P>0.05), and the mean SHBG serum level was insignificantly higher after treatment (104.367±14.689 and105.533±16.362, respectively, P>0.05). Conclusion: This study showed that ISO treatment led to significant reduction in serum total testosterone levels, which may be beneficial for tackling the pathogenesis of acne.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80900928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Role of serum androgens and prostate-specific antigen levels in males with androgenetic alopecia 血清雄激素和前列腺特异性抗原水平在男性雄激素性脱发中的作用

Human Andrology Pub Date : 2019-09-01 DOI: 10.21608/ha.2020.19072.1050

H. Khaled, A. A. Abdu Allah, Ahmad Abdelhameed, W. Shehata

{"title":"Role of serum androgens and prostate-specific antigen levels in males with androgenetic alopecia","authors":"H. Khaled, A. A. Abdu Allah, Ahmad Abdelhameed, W. Shehata","doi":"10.21608/ha.2020.19072.1050","DOIUrl":"https://doi.org/10.21608/ha.2020.19072.1050","url":null,"abstract":"Background: Androgenetic alopecia (AGA) is the most common form of hair loss. It is caused by the continuous miniaturization of affected hair follicles. Genetic factors and androgenic factors especially dihydrotestosterone (DHT), which is a testosterone tissue metabolite, play major roles in the pathogenesis of AGA. Many studies suggest that AGA may be a marker of increased risk of prostate cancer. Objective: The study aimed to examine the role of serum androgens and prostate-specific antigen (PSA) in males with AGA. Patients and Methods: The study included 80 participants: 40 men diagnosed with AGA and 40 age-matched healthy male volunteers as a control group. The authors also divided the patient group into two subgroups: frontal AGA group and vertical AGA group. All participants were subjected to measurement of serum level of testosterone, DHT, and PSA by enzyme-linked immunosorbent assay. Results: The study revealed that the mean serum level of testosterone and DHT in patients with AGA was higher than that in the control group, and the mean serum level of testosterone in vertical AGA group was higher than that in frontal AGA group. There was no significant difference between patients and controls regarding the mean serum level of PSA. Conclusion: This study showed that serum androgens play an important role in the development of AGA, and there is a strong association between serum level of androgens and staging of AGA, whether frontal or vertical.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"2 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90643745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bisphenol A as a potential hazardous compound on male reproductive function : A mini-review 双酚A对男性生殖功能的潜在危害:综述

Human Andrology Pub Date : 2019-09-01 DOI: 10.21608/ha.2020.21245.1052

M. A. Abd El Salam, Nada El Sayed Selim

引用次数: 1

Efficacy of sildenafil citrate in the treatment of female sexual dysfunction 枸橼酸西地那非治疗女性性功能障碍的疗效观察

Human Andrology Pub Date : 2019-09-01 DOI: 10.21608/HA.2018.4085.1029

E. Nada, M. El-Taieb, H. Ibrahim

{"title":"Efficacy of sildenafil citrate in the treatment of female sexual dysfunction","authors":"E. Nada, M. El-Taieb, H. Ibrahim","doi":"10.21608/HA.2018.4085.1029","DOIUrl":"https://doi.org/10.21608/HA.2018.4085.1029","url":null,"abstract":"Introduction: Female sexual dysfunction (FSD) defines as disturbances in the female sexual response cycle resulting in marked distress and interpersonal difficulties. Sildenafil citrate was effective in treatment of FSD through increasing blood flow to corpus cavernosum of clitoris, vagina and labia minor.Aim:To evaluate the effect of sildenafil citrate in treatment of female sexual dysfunction.Patients and Methods: An observational study had been done on 43 females complaining of FSD who were fulfilling the inclusion criteria. They were taken oral sildenafil citrate 25mg daily for 6 weeks and were evaluated by 19–items Female Sexual Function Index (FSFI) questionnaire before and after treatment.Results: Our results showed that 34.4% became normal with score of FSFI>26.5; while 65.6% showed some improvement but still have FSD (FSFI<26.5). There was significant improvement in all female sexual domains in FSFI ranged from 21% to 69%. There was significant improvement of total score in both 1st degree circumcision more than 2nd degree circumcisions with 41%- 35%, respectively.Conclusion: We concluded that the treatment of patients with FSD by sildenafil citrate 25mg daily for 6 weeks had significant improvement effect on all domains of FSD with no improvement in pain score and effective in1st degree circumcised female more than 2nd degree according to FSFI questionnaire.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"108 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83557829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fake it: women pretending orgasms 假装:女人假装高潮

Human Andrology Pub Date : 2019-09-01 DOI: 10.21608/HA.2018.5339.1035

I. Younis, Hala Mostaf, R. Salem, O. Hamed

{"title":"Fake it: women pretending orgasms","authors":"I. Younis, Hala Mostaf, R. Salem, O. Hamed","doi":"10.21608/HA.2018.5339.1035","DOIUrl":"https://doi.org/10.21608/HA.2018.5339.1035","url":null,"abstract":"Introduction: During intercourse, a man and a woman send each other signals about their true state of pleasure. Some of these signals may be deceptive. For example, if one of the partners is not in ecstasy, then he or she may decide to fake it.Aim: The current study was carried out to evaluate the prevalence of pretending orgasm and the possible causes of this behavior in a sample of married Egyptian women.Patients and methods: A total of 403 sexually active married women participated in this work. The tool used in this cross-sectional study was a self-report questionnaire designed by the authors and guided by the Female Sexual Function Index.Results: Among our participants, 84.9% admitted that they faked orgasm with different frequencies ranging from ‘usually’ to ‘rarely.’ The most common reasons for faking were to save husband’s self-esteem, distraction by outer causes, to comply with husband’s high libido, and to hasten the end of intercourse owing to fatigue or inability to have orgasm rapidly.Conclusion: Faking orgasm is a common behavior in this sample of Egyptian women. Women do it as a method to retain the interest of their husbands or to try to hasten the end of intercourse out of being tired or in pain or unable to have timely orgasm.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"119 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88248052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Can a woman with sexual dysfunction take sildenafil citrate? 性功能障碍的女性可以服用枸橼酸西地那非吗?

Human Andrology Pub Date : 2019-06-01 DOI: 10.21608/ha.2019.15084.1047

A. Esawy, A. Kandil

{"title":"Can a woman with sexual dysfunction take sildenafil citrate?","authors":"A. Esawy, A. Kandil","doi":"10.21608/ha.2019.15084.1047","DOIUrl":"https://doi.org/10.21608/ha.2019.15084.1047","url":null,"abstract":"Background: Sexual dysfunction refers to a problem that occurs during the sexual response cycle that prevents the individual from experiencing satisfaction from sexual activity. The assessment of sexual function in women is frequently confounded by many factors, including depressed mood and other comorbid medical and psychiatric disorders. Sildenafil is selective type 5 phosphodiesterase (PDE5) inhibitors, taken orally and effective for men with erectile dysfunction. Previous studies suggested that sildenafil, which acts by inhibiting cyclic GMP specific PDE5 may improve the sexual health of women affected by sexual difficulties such as arousal disorders and may indirectly improve other aspects of sexual life. Sildenafil was effective and well-tolerated in postmenopausal women with sexual arousal disorder without concomitant hypoactive sexual desire disorder or contributory emotional relationship or historical abuse issues.Objective: This study aims to evaluate the effect of sildenafil citrate on female sexual dysfunction.Patients and Methods: The study was conducted in Dermatology, Venereology, and Andrology Department, Faculty of Medicine, Zagazig University Hospitals during the period from April 2017 to August 2018. Fifty-two married female patients were included in this study. Patients were divided into two groups. Group 1 contains twenty-six patients took 50mg sildenafil on-demand and group 2 contains twenty-six patients took a placebo.Results: There were no significant differences between the studied groups regarding the demographic data and FSFI. There were significant differences between pre and post-treatment of sexual dysfunction regarding group І. There were no significant differences in post-treatment results between the two studied groups as regard sexual dysfunction except in orgasm.Conclusion: Sildenafil citrate may be effective in women who could not achieve orgasm","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72898853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Female sexual function and depressive symptoms among premenopausal females on hemodialysis 绝经前女性血液透析患者的女性性功能与抑郁症状

Human Andrology Pub Date : 2019-06-01 DOI: 10.21608/ha.2019.15151.1049

Y. Nasrallah, R. Marie, M. Eyada

{"title":"Female sexual function and depressive symptoms among premenopausal females on hemodialysis","authors":"Y. Nasrallah, R. Marie, M. Eyada","doi":"10.21608/ha.2019.15151.1049","DOIUrl":"https://doi.org/10.21608/ha.2019.15151.1049","url":null,"abstract":"Background Premenopausal female Patient treated with hemodialysis experience various physical and emotional symptoms that impair their quality of life. Studies demonstrating sexual dysfunction (SD) among those patients are limited and there is no consensus about the relation of SD with the prevalence of depressive symptoms among them.Objective: The study aims to understand the association of hemodialysis with SD as well as depression and to examine whether SD is a risk factor of depression among those patients.Patients and Methods: 82 premenopausal sexually active married females on hemodialysis were enrolled in the study. History taking, general and genital examination were performed. Sexual function was evaluated using the Female Sexual Function Index (FSFI) questionnaire. Depressive symptomswere assessed using the Center for Epidemiologic Studies-Depression (CESD) scale. SD was studied as an independent predictor of depression.Results: OF all enrolled patients, 56 (68.3%) had SD while 25 (30.5%) had depression. Patients with SD had significant higher mean age, illiteracy rate, mean duration of marriage and mean duration of dialysis. Patients with SD had significant higher depressive symptoms in comparison to patients without SD.Conclusion: SD is highly prevalent in premenopausal females undergoing hemodialysis. Age, Literacy, duration of marriage, and duration of dialysis might be risk factors of SD among them. SD might be a predictor of depression among those patients.","PeriodicalId":13018,"journal":{"name":"Human Andrology","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79261618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3