Heart, Lung and Circulation最新文献

{"title":"Short- and Long-Term Outcomes of Obstructive and Non-Obstructive Hypertrophic Cardiomyopathy: A Systematic Review and Meta-Analysis","authors":"Hui Zhen Lo BMedSci, MD ,&nbsp;Chen Ee Low MBBS ,&nbsp;Chun En Yau MBBS ,&nbsp;Yao Hao Teo MBBS ,&nbsp;Yao Neng Teo MBBS ,&nbsp;Tony YW. Li MBBS ,&nbsp;Nicholas L. Syn MBBS ,&nbsp;Ping Chai MBBS ,&nbsp;Weiqin Lin MBBS ,&nbsp;Tiong-Cheng Yeo MBBS ,&nbsp;William K.F. Kong MBChB ,&nbsp;Raymond C.C. Wong MBBS ,&nbsp;Ching-Hui Sia MBBS","doi":"10.1016/j.hlc.2025.03.011","DOIUrl":"10.1016/j.hlc.2025.03.011","url":null,"abstract":"<div><h3>Background</h3><div>Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac condition, but the risk factors and outcomes of patients with obstructive (HOCM) and non-obstructive hypertrophic cardiomyopathy (NOCM) remain unclear. This systematic review and meta-analysis was conducted to investigate the risk ratio (RR), incidence, and risk factors of all-cause and HCM-specific mortality.</div></div><div><h3>Methods</h3><div>This PRISMA-adherent systematic review involved a systematic search of PubMed, SCOPUS, and Embase for studies published from 1 January 2001 to 31 August 2023 that reported outcomes of patients with HOCM and NOCM. Random effects meta-analyses and meta-regressions were used for primary analysis.</div></div><div><h3>Results</h3><div>Sixty-one observational studies with 52,020 participants were included. All-cause, HCM-related, and heart failure-related mortality had no difference in HOCM vs NOCM patients (RR 0.85, 95% CI 0.58–1.25), (RR 0.95, 95% CI 0.68–1.32), and (RR 0.95, 95% CI 0.58–1.58), respectively. Sudden cardiac death (SCD) was significantly higher in HOCM vs NOCM patients (RR 1.69, 95% CI 1.19–2.42). Incidence of all-cause mortality (NOCM 95.47, 95% CI 63.96–140.18 vs HOCM 65.75, 95% CI 48.04–89.37) per 1,000 observations, HCM-related mortality (NOCM 59.72, 95% CI 41.91–84.42 vs HOCM 55.51, 95% CI 39.42–77.64), and SCD (NOCM 32.17, 95% CI 22.42–45.96 vs HOCM: 25.39 95% CI 15.24–42.01) were higher in NOCM patients, while heart failure-related mortality (HOCM 55.51, 95% CI 39.42–77.64 vs NOCM 30.04, 95% CI 14.78–60.11) was higher in HOCM patients.</div></div><div><h3>Conclusions</h3><div>The RR of SCD was significantly higher in HOCM vs NOCM patients. All-cause mortality, HCM-related mortality, and SCD were of higher incidence in NOCM patients. Only heart failure-related mortality was higher in HOCM patients.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages e104-e124"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorodeoxyglucose Positron Emission Tomography Detects Persistent Arterial Inflammation After Symptomatic COVID-19","authors":"Heidi Espedal PhD ,&nbsp;Shipra Verma MD ,&nbsp;Ambuj Roy MD ,&nbsp;Nick S.R. Lan MBBS, MClinRes, MSc ,&nbsp;Sheeraz Mohd PhD ,&nbsp;Benjamin Bartlett PhD ,&nbsp;Kamar Ali MSc ,&nbsp;Natalie C. Ward PhD ,&nbsp;Martin A. Ebert PhD ,&nbsp;Dick C. Chan MD, PhD ,&nbsp;Gerald F. Watts MD, PhD ,&nbsp;Girish Dwivedi MD, PhD ,&nbsp;Roslyn J. Francis MD, PhD","doi":"10.1016/j.hlc.2025.03.005","DOIUrl":"10.1016/j.hlc.2025.03.005","url":null,"abstract":"<div><h3>Background</h3><div>There is limited knowledge of persisting vascular and systemic inflammation in adults recovered from COVID-19. This study aimed to assess whether inflammation from symptomatic mild-to-moderate COVID-19 persists beyond the apparent clinical resolution of disease using fluorodeoxyglucose positron emission tomography (FDG-PET).</div></div><div><h3>Method</h3><div>This observational single-centre cohort study invited adults (aged &gt;40 years) who had clinically recovered from mild-to-moderate COVID-19. Whole-body FDG-PET imaging and C-reactive protein test were performed on the same day after a minimum of 30 days after COVID-19 diagnosis. COVID-19–naive adults at high-risk for cardiovascular disease (CVD) were included for comparison (n=8); thoracic FDG-PET imaging was performed for these participants.</div></div><div><h3>Results</h3><div>FDG-PET imaging was performed after a median of 97 days (interquartile range [IQR] 75–113 days) after COVID-19 diagnosis. Participants who recovered from COVID-19 showed an increased arterial inflammation (median standard uptake value [SUV]_max 3.1; IQR 2.7–3.3) compared with the high-risk participants with CVD (median SUV_max 2.5; IQR 2.2–2.8; p&lt;0.001). There was a moderate positive correlation between the total thoracic SUV_max and the bone marrow SUV_mean (Spearman r=0.58; p&lt;0.001) and the spleen mean SUV_max (Spearman r=0.62, p&lt;0.001) for participants who recovered from COVID-19.</div></div><div><h3>Conclusions</h3><div>Ongoing arterial inflammation is detected by FDG-PET imaging after mild-to-moderate COVID-19. Larger prospective studies are needed to assess the implications on CVD risk.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 969-976"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rural and Remote Acute STEMI Diagnosis and Management: Current Status and Future Directions.","authors":"Ryan Gadeley, Ruth Arnold, David Amos, Stuart Moss, Alex Elder, Sameer Karve, Mark Adams, David Brieger, Harry C Lowe","doi":"10.1016/j.hlc.2025.06.1035","DOIUrl":"10.1016/j.hlc.2025.06.1035","url":null,"abstract":"<p><p>Current European, American and Australasian guidelines recommend revascularisation for acute ST elevation myocardial infarction (STEMI) by immediate or \"primary\" percutaneous coronary intervention (pPCI), or if pPCI cannot be performed within 120 minutes, by thrombolysis followed by rescue PCI. This latter approach, despite its limitations, remains a cornerstone of STEMI care in rural and remote settings, where pPCI is not immediately available, and where one-third of the Australian population live. This review evaluates the current status of thrombolysis and rescue PCI in rural and remote settings, examines the multiple changes that have occurred since its inception, and highlights persisting gaps in knowledge, to provide an up-to-date evaluation of this field, and an outlook for future directions, in this area of ongoing change.</p>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":" ","pages":""},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144952038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Symptomatic Neonates With Tetralogy of Fallot: Shunt or Primary Repair?","authors":"Xin Tao Ye MD ,&nbsp;Soichiro Henmi MD, PhD ,&nbsp;Edward Buratto MBBS, PhD ,&nbsp;Mitchell C. Haverty MS ,&nbsp;Can Yerebakan MD ,&nbsp;Tyson Fricke MBBS, PhD ,&nbsp;Christian P. Brizard MD, MS ,&nbsp;Yves d’Udekem MD, PhD ,&nbsp;Igor E. Konstantinov MD, PhD","doi":"10.1016/j.hlc.2025.01.009","DOIUrl":"10.1016/j.hlc.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>The optimal management strategy for symptomatic neonates with tetralogy of Fallot is unclear. We compared the outcomes of staged repair (SR) (shunt palliation followed by complete repair) and primary repair (PR) in two institutions that have each exclusively adopted one of these strategies.</div></div><div><h3>Method</h3><div>We retrospectively compared 65 symptomatic neonates who underwent shunt palliation between 1993 and 2021 at the Royal Children’s Hospital, Melbourne, Australia with 38 symptomatic neonates who underwent PR between 2005 and 2018 at the Children’s National Hospital, Washington, USA. Median follow-up duration was 8.0 (interquartile range 2.9–13.5) years.</div></div><div><h3>Results</h3><div>After the initial procedure, hospital mortality (shunt 4.6% vs PR 7.9%; p=0.50) and 5-year survival (shunt 94%; 95% confidence interval [CI] 84%–98% vs PR 89%; 95% CI 72%–96%; p=0.21) were not significantly different. The SR group had shorter durations of cardiopulmonary bypass and intensive care admission during the neonatal period, but a higher burden of unplanned re-interventions before discharge. Five-year freedom from re-interventions was not significantly different (shunt 63%; 95% CI 49%–74% vs PR 49%; 95% CI 29%–66%; p=0.13). Postoperative morbidity, mortality, and re-interventions were not significantly different among 13 propensity score–matched pairs balanced for operative weight. For neonates weighing &lt;3 kg, PR was associated with significantly more early re-interventions.</div></div><div><h3>Conclusions</h3><div>In symptomatic neonates with tetralogy of Fallot operated at two institutions with distinct treatment protocols, no statistically significant difference in medium-term survival and re-intervention was observed between the two strategies. SR was associated with lower neonatal morbidity but more unplanned re-interventions before discharge. PR in neonates weighing &lt;3 kg may result in more early re-interventions.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 935-950"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can Australia Tackle its Failure in Research Translation to Reduce Cardiovascular Disease, Improve Equity and Deliver Better Health and Economic Outcomes?","authors":"Clara Chow AM MBBS, PhD ,&nbsp;Jason Kovacic MBBS, PhD ,&nbsp;Bruce Neal MB ChB, PhD ,&nbsp;Geoffrey Donnan AO MBBS, PhD ,&nbsp;Alex Brown MBBS, PhD ,&nbsp;Louise Maple-Brown PhD ,&nbsp;Karen Carey BA ,&nbsp;Richard Taggart MBA ,&nbsp;Pamu Kularathna PhD ,&nbsp;Sally McNeill MPH ,&nbsp;Stephen Nicholls MBBS, PhD","doi":"10.1016/j.hlc.2025.04.095","DOIUrl":"10.1016/j.hlc.2025.04.095","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 877-882"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144717848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Shunt or Primary Repair in Symptomatic Neonates With Tetralogy of Fallot: The Time has Come for a Randomised Trial to Settle the Debate","authors":"William Foot MBBS,&nbsp;Nelson Alphonso FRACS,&nbsp;Prem Venugopal FRACS","doi":"10.1016/j.hlc.2025.08.007","DOIUrl":"10.1016/j.hlc.2025.08.007","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 873-874"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid Access, Real Impact: Reimagining Chest Pain Clinics for the Australian Healthcare System","authors":"Travis Chong MD, MMed ,&nbsp;Nick S.R. Lan MBBS, MClinRes ,&nbsp;Girish Dwivedi MD, PhD","doi":"10.1016/j.hlc.2025.08.005","DOIUrl":"10.1016/j.hlc.2025.08.005","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 869-872"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145003647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Health for Every Heart – the Heart Foundation’s 25-year vision for heart health in Australia","authors":"","doi":"10.1016/j.hlc.2025.08.004","DOIUrl":"10.1016/j.hlc.2025.08.004","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Page 984"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145005268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proteomic Effects of Colchicine on Human Macrophages Loaded With Oxidised Low-Density Lipoprotein Cholesterol","authors":"Sushma R. Rao PhD ,&nbsp;Thalia Salagaras BSc ,&nbsp;Yung-Chih Chen PhD ,&nbsp;Christina A. Bursill PhD ,&nbsp;Karlheinz Peter MD, PhD ,&nbsp;Marten F. Snel PhD ,&nbsp;Peter J. Psaltis MBBS, PhD","doi":"10.1016/j.hlc.2025.04.071","DOIUrl":"10.1016/j.hlc.2025.04.071","url":null,"abstract":"","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 980-983"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144859127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early and Midterm Outcomes of INSPIRIS RESILIA Versus AVALUS: A Propensity Score Matching Analysis","authors":"Takuya Narita MD, PhD ,&nbsp;Taisuke Nakayama MD, PhD ,&nbsp;Shuhei Nishijima MD ,&nbsp;Yoshitsugu Nakamura MD, PhD","doi":"10.1016/j.hlc.2025.02.110","DOIUrl":"10.1016/j.hlc.2025.02.110","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare the early and midterm clinical outcomes of aortic valve replacement (AVR) using the INSPIRIS RESILIA bioprosthesis (IR-B) with AVR using the AVALUS bioprosthesis (AV-B).</div></div><div><h3>Methods</h3><div>This single-centre retrospective study analysed the perioperative clinical outcomes of 256 consecutive patients who underwent AVR with either IR-B (n=156) or AV-B (n=100) at this institution between 1 August 2018 and 30 June 2023. After propensity score matching, freedom from death, freedom from major adverse cardiovascular events (MACE), and echocardiographic data were compared between the two groups during the follow-up period.</div></div><div><h3>Results</h3><div><span><span>Propensity score matching resulted in the addition of 79 patients to each group. The 1-year survival rates in the propensity score-matched cohort were 93.8% and 94.5% in the IR-B and AV-B groups, respectively, while the 3-year survival rates remained unchanged, with no statistically significant differences between groups (p=0.88). At 3 years postoperatively, freedom from MACE was 93.2% and 92.8% in the IR-B and the AV-B groups, respectively, which was not statistically significant (p=0.90). The mean </span>aortic pressure gradient after AVR remained stable in both the IR-B and AV-B groups (IR-B group, 10.7–11.3 mmHg vs AV-B group, 11.5–12.1 mmHg), and there was no significant difference observed between the two groups during the follow-up period. The absolute change from the baseline left ventricular mass index in both the IR-B and AV-B groups decreased in each group over time (IR-B group, −20.8 to −38.6 g/m</span>² vs AV-B group, −16.6 to −35.5 g/m²). However, these changes were statistically insignificant between the two groups over the 3-year follow-up.</div></div><div><h3>Conclusion</h3><div>The early and midterm clinical outcomes were comparable between the IR-B and AV-B groups.</div></div>","PeriodicalId":13000,"journal":{"name":"Heart, Lung and Circulation","volume":"34 9","pages":"Pages 908-917"},"PeriodicalIF":2.2,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144564673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}