Head & Face Medicine最新文献

{"title":"Development of a machine learning-based predictive model for maxillary sinus cysts and exploration of clustering patterns.","authors":"Haoran Yang, Yuxiang Chen, Anna Zhao, Xianqi Rao, Lin Li, Ziliang Li","doi":"10.1186/s13005-025-00492-y","DOIUrl":"10.1186/s13005-025-00492-y","url":null,"abstract":"<p><strong>Background and objective: </strong>There are still many controversies about the factors influencing maxillary sinus cysts and their clinical management. This study aims to construct a prediction model of maxillary sinus cyst and explore its clustering pattern by cone beam computerized tomography (CBCT) technique and machine learning (ML) method to provide a theoretical basis for the prevention and clinical management of maxillary sinus cyst.</p><p><strong>Methods: </strong>In this study, 6000 CBCT images of maxillary sinus from 3093 patients were evaluated to document the possible influencing factors of maxillary sinus cysts, including gender, age, odontogenic factors, and anatomical factors. First, the characteristic variables were screened by multiple statistical methods, and ML methods were applied to construct a prediction model for maxillary sinus cysts. Second, the model was interpreted based on the SHapley Additive exPlanations (SHAP) values, and the risk of maxillary sinus cysts was predicted by generating a web page calculator. Finally, the K-mean clustering algorithm further identified risk factors for maxillary sinus cysts.</p><p><strong>Results: </strong>By comparing the various metrics in the training and test sets of multiple ML models, eXtreme Gradient Boosting (XGBoost) is the best model. The average area under curve (AUC) values of the XGBoost model in the training, validation, and test sets, respectively, are 0.939, 0.923, and 0.921, which indicates its excellent classification and discrimination ability. The cluster analysis model further categorized maxillary sinus cysts into high-risk and low-risk groups, with apical lesions, severe periodontitis, and age ≥ 53 as high-risk factors for maxillary sinus cysts.</p><p><strong>Conclusion: </strong>These findings provide valuable insights into the etiology and risk stratification of maxillary sinus cysts, offering a theoretical basis for their prevention and clinical management. The integration of CBCT imaging and ML techniques holds the potential for prevention and personalized treatment strategies of maxillary sinus cysts.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"17"},"PeriodicalIF":2.4,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11900490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of acidic solutions on surface roughness of polished and glazed CAD-CAM restorative materials.","authors":"Kübra Nur Tad, Ayhan Gürbüz, Perihan Oyar","doi":"10.1186/s13005-025-00486-w","DOIUrl":"10.1186/s13005-025-00486-w","url":null,"abstract":"<p><strong>Background: </strong>The purpose of this in vitro study was to compare the surface roughness (Ra) changes of different dental ceramic materials with different compositions, which were applied two different surface treatments after exposure to acidic pH. The purpose of this in vitro study was to compare the Ra changes of different CAD-CAM materials with different compositions, which were applied two different surface treatments, after exposure to acidic pH.</p><p><strong>Methods: </strong>A total of the 168 samples (12 × 14 × 2 mm) were obtained from ceramic blocks (IPS e.max CAD (LDS)), GC Cerasmart (RNC-C), Lava Ultimate (RNC-L), and Vita Enamic (PIC). Half of each group was subjected to mechanical polishing, and the other half was glazed. After the initial Ra evaluations were made, the samples classified with 7 in each subgroup were kept in three different solutions (citric acid, Coca-Cola, and artificial saliva-control group). After 168 h, surface roughness values of the specimens were measured again.</p><p><strong>Results: </strong>In the RNC-C samples, varying surface treatments and exposure to various solutions did not produce a statistically significant difference. Different acidic solutions did not affect the Ra values of LDS and RNC-C ceramics. The percentage change in Ra values in the glazed samples of PIC exposed to Coca-Cola and RNC-L exposed to artificial saliva were higher than those applied mechanical polishing.</p><p><strong>Conclusion: </strong>The Ra values of RNC-C ceramics were not affected by both surface treatment and acid exposure. The percentage change in Ra values was highest in PIC ceramics. In general, glazed samples had larger Ra change values and higher percentage change in Ra values than manually polished ones.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"16"},"PeriodicalIF":2.4,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871831/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of restorative material and connector cross-section area on the stress distribution of fixed partial denture: a finite element analysis.","authors":"Jingyi Chen, Tong Zhu, Ruyi Li, Zhou Zhu, Xibo Pei, Yichen Xu, Qianbing Wan","doi":"10.1186/s13005-025-00484-y","DOIUrl":"10.1186/s13005-025-00484-y","url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the effects of restorative materials and connector cross-section areas (CSAs) on the stress distribution of monolithic fixed partial dentures (FPDs).</p><p><strong>Methods: </strong>FPDs, abutment teeth, periodontal ligament (PDL), and alveolar bone were modeled by computer-aided design. Four materials with varied elastic modulus (3 mol% yttria-stabilized tetragonal zirconia polycrystals [Zr], lithium disilicate [LD], polymer-infiltrated ceramic network [PICN], and resin composite [RC]) and five CSA of connectors (4, 6, 8, 10, and 12 mm²) were set as FPD variables for finite element analysis (FEA). The stress distribution on FPDs, abutment teeth, PDL, and alveolar bone was analyzed under two different loading modes (three-point loading and pontic loading). The results of FEA were further verified by photoelastic test.</p><p><strong>Results: </strong>Both FPD material and CSA influenced the stress distribution of the FPD-tooth-bone complex. At a constant CSA of 8 mm², Zr, with the highest elastic modulus, exhibited the lowest stress on abutment teeth (2.4177 MPa). As the materials' elastic modulus decreased, the stress increased by 2.37%, 7.67%, and 13.16% for LD, PICN, and RC, respectively. Increasing the CSA from 4 mm² to 12 mm² reduced stress on abutments by 1.65% and 1.54% in the Zr and PICN groups, respectively. However, in the RC group, the stress increased significantly by 115.63%.</p><p><strong>Conclusion: </strong>Materials with a higher elastic modulus tend to confine stress within the FPDs, reducing the downward transmission of stress. As the CSA increases, stress might be more evenly distributed from FPD to the periodontium, potentially reducing stress concentration.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"15"},"PeriodicalIF":2.4,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11869690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143531372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schneiderian membrane perforation repair using a crosslinked collagen membrane: a retrospective cohort study.","authors":"Daya Masri, Ehud Jonas, Omar Ghanaiem, Liat Chaushu","doi":"10.1186/s13005-025-00487-9","DOIUrl":"10.1186/s13005-025-00487-9","url":null,"abstract":"<p><strong>Objectives: </strong>Perforation of the Schneiderian membrane (SM) is a common intraoperative complication of sinus augmentation. This study aimed to evaluate risk factors for SM perforation, and to compare clinical outcomes between patients with SM perforation repaired using crosslinked collagen membranes (CLM) compared to those with an intact SM.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a single tertiary medical center. Data was collected on patients requiring sinus augmentation via lateral approach prior to implant placement. The collected data included demographics, surgical details, implant outcomes, radiographic analysis, and presence of SM perforation. In cases of perforation a CLM was used to repair the SM. Statistical analysis was performed to evaluate risk factors for perforation and whether SM perforation repair using CLM influenced early implant failure (EIF). A p-value < 0.05 was considered significant.</p><p><strong>Results: </strong>Data on 194 individuals who underwent 278 lateral approach sinus augmentation procedures was collected. SM perforation occurred in 66 (23.74%) sinuses. Treatment of SM perforation using CLM yielded similar results to sinuses without perforations: EIF and the augmented gained bone did not correlate with SM perforation. Younger patients, and thick SMs (> 3 mm) had significantly lower risk of perforation.</p><p><strong>Conclusions: </strong>Older age and thinner SMs are risk factors for sinus membrane perforations. No significant differences in bone gain and EIF were found between perforated and intact membranes.</p><p><strong>Clinical relevance: </strong>Schneiderian membrane perforation repair using crosslinked collagen membrane provides comparable results to sinus augmentations without perforations, demonstrating its effectiveness in preventing complications.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"14"},"PeriodicalIF":2.4,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11866630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of double-sleeve endotracheal tube in infection control for icu patients: a randomized controlled trial.","authors":"Han Sheng, Linyan Wang, Yeping Fei, Zhihong Zhu, Ping Wang","doi":"10.1186/s13005-025-00488-8","DOIUrl":"10.1186/s13005-025-00488-8","url":null,"abstract":"<p><strong>Background: </strong>Poor oral hygiene in patients with tracheal intubation will increase the occurrence of dental plaque and mucosal inflammation, resulting in oral barrier dysfunction. This study aimed to design and evaluate a novel double-lumen endotracheal tube (DETT) and explore its role in infection control, particularly its effects on the oral microenvironment and ventilator-associated pneumonia (VAP).</p><p><strong>Methods: </strong>This was a prospective, non-blinded, randomized parallel-controlled trial conducted from July 2024 to September 2024. A total of 115 patients who had been intubated for more than 3 days in a tertiary hospital ICU were enrolled and randomly assigned to either the DETT group (n = 58) or the conventional endotracheal tube (ETT) group (n = 57). Both groups received the same oral care protocols. The DETT group was intubated with the double-lumen endotracheal tube, which included a built-in bite block, while the ETT group used a standard endotracheal tube with a bite block. The primary outcome was the incidence of VAP, while secondary outcomes included oral bacterial colony counts, biofilm formation, BOAS oral health scores, and plaque index.</p><p><strong>Results: </strong>Compared to the ETT group, the DETT group showed a significant reduction in VAP incidence (χ²=4.382, p < 0.05). The DETT group also had significantly lower oral bacterial colony counts (Z=-7.362, P < 0.05) and biofilm formation (χ²=5.472, p < 0.05), as well as better BOAS scores (Z=-2.774, p < 0.05). However, there were no significant differences between the two groups in pathogenic bacterial presence or plaque index (p > 0.05).</p><p><strong>Conclusions: </strong>The novel double-lumen endotracheal tube effectively reduces the total bacterial load in the oral cavity, inhibits biofilm formation, and lowers the incidence of VAP. It also improves oral function and hygiene, contributing to infection control, and holds significant clinical value.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"12"},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporomandibular disorder prevalence in malocclusion patients: a meta-analysis.","authors":"Lijun Huang, Yafen Xu, Ziyi Xiao, Yunfeng Liu, Fen Luo","doi":"10.1186/s13005-025-00490-0","DOIUrl":"10.1186/s13005-025-00490-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the prevalence of temporomandibular disorders (TMD) in patients with malocclusion through a systematic review and meta-analysis.</p><p><strong>Materials and methods: </strong>A comprehensive literature search was conducted up to November 15, 2024. Cross-sectional studies providing data on TMD prevalence among malocclusion patients were included. Study quality was assessed using the Joanna Briggs Institute (JBI) checklist. A random-effects model was used for meta-analysis, with subgroup and meta-regression analyses to explore heterogeneity. Sensitivity analyses were performed to evaluate result robustness.</p><p><strong>Results: </strong>Thirty-two studies were included, showing an overall TMD prevalence of 43% (95% CI: 35%-50%; I² = 97.9%). Prevalence was higher in females (44%) than males (33%) and in adults (42%) than adolescents (39%). Among malocclusion types, Class II (40%) and posterior unilateral crossbite (59%) had the highest TMD prevalence. Sensitivity analysis confirmed the robustness of findings, though diagnostic criteria variations contributed to heterogeneity.</p><p><strong>Conclusions: </strong>The prevalence of TMD in malocclusion patients was 43%, with higher rates in females, adults, and specific malocclusion types such as Class II, open bite, overjet, and crossbite. Variations in diagnostic criteria and malocclusion classification contributed to heterogeneity, emphasizing the need to consider individual patient characteristics when assessing TMD risk. Standardized diagnostic criteria, representative sampling, and multilingual search strategies are essential for future research to minimize bias and improve data reliability.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"13"},"PeriodicalIF":2.4,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143515378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of the Covid-19 pandemic on odontogenic infections in maxillofacial surgery.","authors":"Florian Dudde, Oliver Schuck, Sven Duda, Manfred Giese","doi":"10.1186/s13005-025-00489-7","DOIUrl":"10.1186/s13005-025-00489-7","url":null,"abstract":"<p><strong>Background: </strong>This study investigates the impact of the COVID-19 pandemic on the distribution, characteristics, and treatment of odontogenic infections (OI) in a cranio-maxillofacial hospital, comparing data from pre-covid (PC) and intra-covid (IC) periods.</p><p><strong>Materials and methods: </strong>A retrospective analysis was conducted on 194 patients treated for OIs from February 2019 to January 2021. Patients were categorized into two cohorts: PC (02/2019 - 01/2020) and IC (02/2020 - 01/2021). Data collected included demographics, infection types, symptoms, pre-existing conditions, treatments, length of hospital stay, and time from symptom onset to treatment.</p><p><strong>Results: </strong>The IC cohort exhibited a significant increase in submandibular (13.9% to 26.7%) and floor of mouth abscesses (6.5% to 18.6%). Patients in the IC period were more likely to present with fever (69.8% vs. 36.1%, p < 0.001) and dyspnea (48.8% vs. 33.3%, p = 0.029). Additionally, there was an increase in multi-space infections (7.4% to 22.1%) and higher inflammatory markers, with leukocyte counts rising from 12.51 × 10^9/l to 15.41 × 10^9/l (p < 0.001). The mean length of stay in the hospital also increased significantly from 3.24 days to 8.01 days (p < 0.001).</p><p><strong>Conclusion: </strong>The COVID-19 pandemic has significantly altered the landscape of OIs in oral and maxillofacial surgery, leading to more severe presentations, prolonged treatment durations, and increased hospital admissions. These findings underscore the necessity for improved public health strategies to ensure timely access to dental care during health crises. Enhanced awareness and proactive management are essential to mitigate the long-term impact of the aforementioned disruptions on patient outcomes.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"11"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11852508/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic gene expression analysis of putative target genes linked to miR-31 in 83 oral squamous cell carcinoma samples.","authors":"Carolin Feldges, Susanne Jung, Nikolai Purcz, Christoph Sproll, Johannes Kleinheinz, Sonja Sielker","doi":"10.1186/s13005-024-00443-z","DOIUrl":"10.1186/s13005-024-00443-z","url":null,"abstract":"<p><strong>Background: </strong>The development of oral squamous cell carcinoma on the molecular level and the resulting prognosis for patients have remained poorly understood. While AngiomiR-31 was implicated in the progression and metastasis of OSCC. However, this connection has not yet been investigated in more detail and tested for its significance with regard to new therapies and the prognosis of patients.</p><p><strong>Methods: </strong>Through a systemic analysis of putative target genes of AngiomiR-31 in OSCC, this study aimed to highlight possible prognostic markers and genes that might improve prognostic predictability in patients with oral squamous cell carcinoma, especially regarding AngiomiR-31 as an outstanding mediator of angiogenesis. The study is based on gene data from 83 OSCC samples. Potentially relevant genes were selected and sorted by TNM, grading and UICC in these 83 OSCC whole-genome microarray datasets. Data was analysed and tested for significance.</p><p><strong>Results: </strong>Through our investigation 20 potential target genes, including tumor suppressor genes, oncogenes and genes not yet categorized, were found and their expression correlated significantly with the expression of AngiomiR-31.</p><p><strong>Conclusion: </strong>These findings contribute to a more profound understanding of the molecular mechanisms underlying OSCC progression and may have implications for the development of novel therapeutic strategies targeting AngiomiR-31 in OSCC. Further validation of these genes is needed to validate their clinical relevance and potential as prognostic markers or therapeutic targets in OSCC.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"10"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of orthodontic archwire (nickel-titanium versus copper-nickel-titanium) on pain in adult patients in the aligning phase of treatment with self-ligating brackets (two months of follow-up): a prospective observational pilot study.","authors":"Raquel Marzal, Alberto Albaladejo, Daniel Curto, Adrián Curto","doi":"10.1186/s13005-025-00483-z","DOIUrl":"10.1186/s13005-025-00483-z","url":null,"abstract":"<p><strong>Background: </strong>The aim of this pilot study was to analyze the influence of a nickel-titanium archwire (NiTi) and a copper-nickel-titanium archwire (Cu-NiTi) on pain levels in adult patients during the first two months of orthodontic treatment with self-ligating brackets.</p><p><strong>Methods: </strong>This prospective observational pilot study was carried out at the Dental Clinic of the University of Salamanca between 2023 and 2024. This study analyzed 30 adult orthodontic patients who began treatment with self-ligating brackets. The participants were distributed into two study groups (n = 15) for treatment with initial NiTi and Cu-NiTi archwires. At the beginning, a 0.014-inch archwire was used, and a 0.016-inch archwire was used after a month. The level of pain was measured using a visual analog scale (VAS) at the beginning of treatment (T0), at one month (T1), and at two months (T2). At each time point (T0, T1, and T2), pain was measured at baseline and at 4, 24, and 48 h after archwire placement or replacement. The data were analyzed using Spearman's correlation coefficient and the Mann-Whitney test (p < 0.05).</p><p><strong>Results: </strong>The mean age of the participants (n = 30) was 31.34 (± 6.05) years. The maximum pain peak was in the first 48 h after placing the initial archwire (5.57 ± 1.72). The age and sex of the participants did not influence the pain levels in the sample studied. The composition of the orthodontic archwire only influenced the pain levels at the beginning of treatment (T0) (p < 0.05); in this case, the NiTi group (1.73 ± 1.53) described a higher level of pain than that of the Cu-NiTi group (1.07 ± 1.36); in the rest of the follow-up period, no significant differences were observed.</p><p><strong>Conclusions: </strong>Within the limitations of this study, we observed that the orthodontic archwire material (nickel-titanium versus copper-nickel-titanium) only influenced pain levels at the beginning of orthodontic treatment.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"9"},"PeriodicalIF":2.4,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the usefulness of platelet-rich fibrin (PRF) in mandibular third molar surgery with 3D facial swelling analysis: a split-mouth randomized clinical trial.","authors":"Selene Barone, Francesco Bennardo, Marianna Salviati, Alessandro Antonelli, Amerigo Giudice","doi":"10.1186/s13005-025-00482-0","DOIUrl":"10.1186/s13005-025-00482-0","url":null,"abstract":"<p><strong>Background: </strong>Third molar surgery is associated with various postoperative complications (PC). Different strategies, including the application of platelet-rich fibrin (PRF), have been implemented to reduce PC. Digital technologies have proven useful in objectively assessing postoperative facial swelling. This study aimed to evaluate the effect of PRF on reducing facial swelling after lower third molar surgery using a 3D face scanner.</p><p><strong>Methods: </strong>A randomized split-mouth clinical trial was set up and 32 patients (18 to 32 years), requiring extraction of both mandibular third molars, were recruited at the Oral Surgery Clinic of the Magna Graecia University of Catanzaro. The primary predictive variable was the application or not of PRF plugs and membranes in the post-extraction socket. Primary outcome variable was facial swelling recorded with a face scanner preoperatively (T0), after three (T1) and seven (T2) days. Qualitative and quantitative data analysis were conducted following an automated and standardized imaging analysis workflow using the 3D Slicer software. Secondary outcome variables were trismus, recorded by measuring the maximum buccal opening with a caliper, pain, recorded using a visual analogue scale (VAS), and duration of the surgery. Descriptive and bivariate analysis were performed by setting the significance level [Formula: see text] = 0.05.</p><p><strong>Results: </strong>All patients exhibited a significant increase in facial swelling at T1, followed by a subsequent reduction from day 3 to day 7, with a slight persistence of edema observed on the seventh day. No significant data emerged from the statistical analysis conducted. Linear differences in PRF group reported improved values of postoperative swelling only in the T1-T2 and T0-T2 phases of analysis. Volumetric differences favored PRF group compared with control group in all phases. VAS was lower in PRF group only at T2, compared with control group.</p><p><strong>Conclusions: </strong>Application of PRF in post-extraction sockets showed effectiveness in reducing facial swelling. Its advantages, including accessibility, cost-effectiveness, and absence of adverse reactions, make it an optimal treatment choice in reducing post-surgical sequelae.</p>","PeriodicalId":12994,"journal":{"name":"Head & Face Medicine","volume":"21 1","pages":"8"},"PeriodicalIF":2.4,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}