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Five-Year Trends in SSRI Consumption: A Precision Medicine Approach to Comparative Analysis Between Serbia and European Countries. SSRI消费的五年趋势:精准医学方法在塞尔维亚和欧洲国家之间的比较分析。
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-18 DOI: 10.3390/healthcare13101174
Janko Samardžić, Filip Simović, Kristina Sekanić, Milica Branković
{"title":"Five-Year Trends in SSRI Consumption: A Precision Medicine Approach to Comparative Analysis Between Serbia and European Countries.","authors":"Janko Samardžić, Filip Simović, Kristina Sekanić, Milica Branković","doi":"10.3390/healthcare13101174","DOIUrl":"https://doi.org/10.3390/healthcare13101174","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Mental diseases are one of the leading groups of health disorders worldwide, with depressive and anxiety disorders being the most prevalent. Depressive disorders can be treated with pharmacotherapy, psychotherapy, or a combination of both. In cases where these approaches prove ineffective, electroconvulsive therapy may be considered as an alternative. The drugs of choice for treating depressive disorders are selective serotonin reuptake inhibitors (SSRIs). In the Republic of Serbia, commonly prescribed SSRIs include fluoxetine, citalopram, paroxetine, sertraline, and escitalopram. <b>Methods</b>: Data on drug sales for human medicine from the Agency for Medicines and Medical Devices of Serbia (ALIMS) were used for the analysis of consumption in the period 2018-2022. Data on drug consumption in other European countries were obtained from the respective national registers. <b>Results</b>: From 2018 to 2021, sertraline was the best-selling drug in this group, but with a statistically significant decrease (R<sup>2</sup> = 0.7948, <i>p</i> = 0.042), while escitalopram showed a statistically significant increase (<i>p</i> = 0.006) and became the best-selling drug in the SSRI group in 2022. Overall, SSRI group consumption fluctuated from 2018 to 2022, with the highest values in 2020. However, these variations were not statistically significant (<i>p</i> = 0.6223). Compared to Serbia, out of 12 European countries, 8 had higher and 4 had lower consumption in 2019 and 2020. A positive correlation was found between antidepressant consumption and GDP per capita. <b>Conclusions</b>: Sertraline was the most commonly prescribed SSRI drug in Serbia from 2018 to 2021. However, in 2022, escitalopram became the most commonly used drug in this group both in Serbia and worldwide, with a consistent increase in consumption.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Care Providers' and Parents' Experiences with Implementing the Conversational Health Literacy Assessment Tool (CHAT)-Maternity-Care in the Netherlands: A Mixed Methods Study. 护理提供者和父母实施会话健康素养评估工具(CHAT)的经验-荷兰的孕产妇保健:一项混合方法研究。
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-17 DOI: 10.3390/healthcare13101173
Evi M E Vlassak, Judit K J Keulen, Elina Miteniece, Rianneke de Ritter, Marijke J C Hendrix, Marianne J Nieuwenhuijze
{"title":"Care Providers' and Parents' Experiences with Implementing the Conversational Health Literacy Assessment Tool (CHAT)-Maternity-Care in the Netherlands: A Mixed Methods Study.","authors":"Evi M E Vlassak, Judit K J Keulen, Elina Miteniece, Rianneke de Ritter, Marijke J C Hendrix, Marianne J Nieuwenhuijze","doi":"10.3390/healthcare13101173","DOIUrl":"https://doi.org/10.3390/healthcare13101173","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Care providers' understanding of patients' health literacy is crucial to tailoring care and reducing health inequalities. This study explores the experiences, facilitators, and barriers encountered by maternity care providers when implementing CHAT-maternity-care: a conversational tool that supports care providers in estimating (expectant) parents' health literacy. As a secondary objective, the study also examines the experiences of (expectant) parents. <b>Methods:</b> Maternity care providers used CHAT-maternity-care after finalizing an e-learning. Implementation was evaluated among maternity care providers with a questionnaire and in-depth focus group meetings and among (expectant) parents with semi-structured interviews. <b>Results:</b> Providers experienced that using CHAT-maternity-care enhanced their health literacy insight, improved health literacy awareness, and fostered easier, more comprehensive and structured estimation of parents' health literacy. Key facilitators for implementing CHAT-maternity-care as perceived by providers were the perceived value of health literacy insights; the tool's relevance, user-friendliness, and familiarity; and social factors. The main barriers were time constraints, the tool's novelty, and social factors. (Expectant) parents were positive and open to having conversations based on CHAT-maternity-care. Questions based on CHAT-maternity-care were perceived as beneficial by parents in uncovering previously unaddressed concerns. <b>Conclusions:</b> CHAT-maternity-care is mostly well received and assessed as helpful to improving health literacy insights. The findings underscore the importance of education, peer support, and organizational alignment for broader adoption and implementation of CHAT-maternity-care.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cameroonian Physiotherapists' Practice, Confidence, and Perception of Health Promotion for People at Risk or with Cardiovascular Diseases: A Qualitative Study. 喀麦隆物理治疗师的实践,信心和感知的健康促进风险或心血管疾病患者:一项定性研究。
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-17 DOI: 10.3390/healthcare13101172
Etienne Ngeh Ngeh, Rachel Young, Christopher Kuaban, Sionnadh McLean, Ben W Strafford, Joanne Lidster
{"title":"Cameroonian Physiotherapists' Practice, Confidence, and Perception of Health Promotion for People at Risk or with Cardiovascular Diseases: A Qualitative Study.","authors":"Etienne Ngeh Ngeh, Rachel Young, Christopher Kuaban, Sionnadh McLean, Ben W Strafford, Joanne Lidster","doi":"10.3390/healthcare13101172","DOIUrl":"https://doi.org/10.3390/healthcare13101172","url":null,"abstract":"<p><p><b>Background:</b> Cardiovascular diseases (CVDs) and their risk factors are increasing with associated disability and mortality burden globally, especially in low- and middle-income countries, including Cameroon. Physiotherapist-led health promotion (PLHP) interventions provide opportunities to improve health and reduce this burden. Understanding physiotherapists' practice, confidence, and perception is crucial for designing effective, context-specific PLHP interventions. <b>Methods:</b> This qualitative study explored physiotherapists' practice, perceptions, and confidence in delivering PLHP to pwCVDs in Cameroon. <b>Results:</b> Sixteen participants completed the interviews, and analyses of the transcripts generated three main themes, which included (1) the perception of physiotherapists' roles in health promotion (HP), (2) current practice of PLHP, and (3) competence in the delivery of PLHP. Physiotherapists believe that delivering HP interventions in practice is within their professional role. Current HP practice was limited to exercise, physical activity, and dietary/nutritional interventions. Participants reported a lack of knowledge and formal training in PLHP delivery. <b>Conclusions:</b> Despite intense interest in HP, HP practice among physiotherapists is limited in scope, is under-resourced, and is limited by a lack of confidence in delivering behavioural change interventions. These findings are relevant for the design of appropriate clinical training and policies for the care of pwCVDs.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Quality of Life in European Adults and Older with All-Over Pain: Relationship with Frequency of Moderate and Vigorous Physical Activity and Decision Prediction Models with Cross-Sectional Data. 欧洲成年人和老年人全身疼痛患者的生活质量:与中度和剧烈体育活动频率的关系以及具有横截面数据的决策预测模型。
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-17 DOI: 10.3390/healthcare13101171
Angel Denche-Zamorano, Daniel Collado-Mateo, Juan Manuel Franco-Garcia, José Carmelo Adsuar, Diana Salas-Gómez
{"title":"Quality of Life in European Adults and Older with All-Over Pain: Relationship with Frequency of Moderate and Vigorous Physical Activity and Decision Prediction Models with Cross-Sectional Data.","authors":"Angel Denche-Zamorano, Daniel Collado-Mateo, Juan Manuel Franco-Garcia, José Carmelo Adsuar, Diana Salas-Gómez","doi":"10.3390/healthcare13101171","DOIUrl":"https://doi.org/10.3390/healthcare13101171","url":null,"abstract":"<p><strong>Background/objectives: </strong>Quality of life (QoL) is negatively affected in people with all-over pain. Widespread pain has a negative impact on physical function, cognitive function, mental health and mood. Physical activity (PA) may help to improve the QoL in these people. This study aimed to assess the relationships between PA frequency (PAF) and QoL in middle-aged and older European people with all-over pain, in addition to developing and analyzing the performance of a classification and regression tree model (CRT) to predict QoL in this population.</p><p><strong>Methods: </strong>A cross-sectional study of 1025 middle-aged and older European individuals with all-over pain. Relationships between moderate and vigorous PAF and QoL were assessed. A predictive algorithm for QoL was developed using CRT analysis. A cross-validation study was conducted to assess the performance of the model. In addition, a multivariate linear regression model was developed to predict QoL and compare its performance with the CRT model.</p><p><strong>Results: </strong>Higher PAF and higher QoL were found to be related (<i>p</i> < 0.001). Specifically, the CRT found that depression, poor perceived health, and moderate physical activity once a week, rarely or never were the combinations of variables that predicted lower quality of life scores. Conversely, not having depression and performing moderate physical activity more than once a week predicted higher quality of life scores. The linear regression model performed better than the CRT model (R<sup>2</sup> = 38% vs. R<sup>2</sup> = 30%), and both identified depression, SPH, moderate PAF and education level as main predictors of QoL.</p><p><strong>Conclusions: </strong>PA on a regular basis could improve the QoL of people with all-over pain. Depressive symptoms, self-perceived health, PAF and educational level are predictors of QoL in this population. Our findings provide useful information for assessing QoL in people with all-over pain, offering an easy-to-interpret visual model with similar accuracy to traditional models.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Physical Activity Influences Negative Emotion Among College Students in China: The Mediating and Moderating Role of Psychological Resilience. 体育活动对大学生负性情绪的影响:心理弹性的中介与调节作用
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-17 DOI: 10.3390/healthcare13101170
Lijun Zuo, Yao Wang, Jinfu Wang, Yidi Yao, Guan Yang
{"title":"Physical Activity Influences Negative Emotion Among College Students in China: The Mediating and Moderating Role of Psychological Resilience.","authors":"Lijun Zuo, Yao Wang, Jinfu Wang, Yidi Yao, Guan Yang","doi":"10.3390/healthcare13101170","DOIUrl":"https://doi.org/10.3390/healthcare13101170","url":null,"abstract":"<p><p><b>Background/objective</b>: Negative emotion, such as anxiety and depression, significantly impacts college students' academic performance, social relationships, and overall well-being. Given that, this study aims to explore the effect of physical activity on alleviating negative emotion among Chinese college students and to examine the mediating and moderating mechanisms of psychological resilience including individual power and supportive power. <b>Methods</b>: A cross-sectional survey was conducted with 596 college students from 10 universities in Guangdong Province (M<i><sub>age</sub></i> = 20.32, SD = 1.47). Data were collected using the Physical Activity Rating Scale (PARS-3), Adolescent Psychological Resilience Scale (APRS), and Depression-Anxiety-Stress Scale (DASS-21). Descriptive and correlation analysis, hierarchical regression analysis, and PROCESS macro models were used to test the mediating and moderating effects. <b>Results</b>: (1) Physical activity (<i>β</i> = -0.312, <i>p</i> < 0.001) and supportive power (<i>β</i> = -0.391, <i>p</i> < 0.001) both significantly negatively predicted negative emotion; (2) Individual power played a partial mediating role between physical activity and negative emotion (indirect effect accounted for 31.4%, 95% CI [-0.395, -0.242]); (3) Supportive power moderated the relationship between physical activity and negative emotion (interaction effect <i>β</i> = 0.089, <i>p</i> < 0.01), with a stronger effect of physical exercise on reducing negative emotion under low supportive conditions (<i>b</i> = -0.401 vs. <i>b</i> = -0.224). <b>Conclusions</b>: Physical activity not only directly affects negative emotion but also indirectly influences negative emotion by enhancing psychological resilience (individual power), and supportive power could moderate this effect through a resource substitution mechanism. The present study provides a theoretical basis for designing targeted mental health interventions and emphasizes the synergistic effect of integrating physical activity and social support on college students' mental health.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Association Between Financial Support and Physical Health in Older People: Evidence from CHARLS Data. 老年人经济支持与身体健康之间的关系:来自CHARLS数据的证据
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-16 DOI: 10.3390/healthcare13101163
Enkai Guo, Jing Li, Yiyuan Sun, Lan Zheng
{"title":"Association Between Financial Support and Physical Health in Older People: Evidence from CHARLS Data.","authors":"Enkai Guo, Jing Li, Yiyuan Sun, Lan Zheng","doi":"10.3390/healthcare13101163","DOIUrl":"https://doi.org/10.3390/healthcare13101163","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Prior research has established the significant role of financial support in shaping older adults' physical health but often overlooks the heterogeneous effects of distinct financial support types and their underlying mechanisms. This study addresses these gaps by investigating how property-based support and children's financial support differentially influence the health of older people, aiming to inform targeted interventions for healthy aging. <b>Methods</b>: Based on 2020 microdata from the China Health and Retirement Longitudinal Study (CHARLS), the analysis was conducted using the ordered logistic regression model and the mediation effect model. <b>Results</b>: Property ownership demonstrated a significant positive association with older adults' physical health (β = 0.21, <i>p</i> < 0.01), while children's financial support showed an adverse effect (β = -0.14, <i>p</i> < 0.05). These relationships were mediated by two key pathways: enhanced social participation (accounting for 32%) and increased engagement in sports activities (accounting for 28%). <b>Conclusions</b>: The study underscores the need to differentiate between financial support sources when designing aging policies. Recommendations include incentivizing asset accumulation among older adults, promoting delayed retirement for capable individuals, and fostering community-based initiatives to boost social and physical activity participation. These findings advocate for integrated policy frameworks that combine financial empowerment with social engagement opportunities to address aging challenges in China.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Improved Prediction Accuracy for Late-Onset Preeclampsia Using cfRNA Profiles: A Comparative Study of Marker Selection Strategies. 使用cfRNA谱提高迟发性子痫前期预测准确性:标记选择策略的比较研究
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-16 DOI: 10.3390/healthcare13101162
Akiha Nakano, Kohei Uno, Yusuke Matsui
{"title":"Improved Prediction Accuracy for Late-Onset Preeclampsia Using cfRNA Profiles: A Comparative Study of Marker Selection Strategies.","authors":"Akiha Nakano, Kohei Uno, Yusuke Matsui","doi":"10.3390/healthcare13101162","DOIUrl":"https://doi.org/10.3390/healthcare13101162","url":null,"abstract":"<p><p><b>Background</b>: Late-onset pre-eclampsia (LO-PE) remains difficult to predict because placental angiogenic markers perform poorly once maternal cardiometabolic factors dominate. <b>Methods</b>: We reanalyzed a publicly available cell-free RNA (cfRNA) cohort (12 EO-PE, 12 LO-PE, and 24 matched controls). After RNA-seq normalization, we derived LO-PE candidate genes using (i) differential expression and (ii) elastic-net feature selection. Predictive accuracy was assessed with nested Monte-Carlo cross-validation (10 × 70/30 outer splits; 5-fold inner grid-search for λ). <b>Results</b>: The best LO-PE elastic-net model achieved a mean ± SD AUROC of 0.88 ± 0.08 and F1 of 0.73 ± 0.17-substantially higher than an EO-derived baseline applied to the same samples (AUROC ≈ 0.69). Enrichment analysis highlighted immune-tolerance and metabolic pathways; three genes (HLA-G, IL17RB, and KLRC4) recurred across >50% of cross-validation repeats. <b>Conclusions</b>: Plasma cfRNA signatures can outperform existing EO-based screens for LO-PE and nominate biologically plausible markers of immune and metabolic dysregulation. Because the present dataset is small (n = 48) and underpowered for single-gene claims, external validation in larger, multicenter cohorts is essential before clinical translation.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Determinants of Health-Related Quality of Life in Patients with Chronic Kidney Disease: A Cross-Sectional Study. 慢性肾病患者健康相关生活质量的决定因素:一项横断面研究
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-16 DOI: 10.3390/healthcare13101167
Geetha Kandasamy, Thangamani Subramani, Mona Almanasef, Khalid Orayj, Eman Shorog, Asma M Alshahrani, Tahani S Alanazi, Sangeetha Balasubramanian
{"title":"Determinants of Health-Related Quality of Life in Patients with Chronic Kidney Disease: A Cross-Sectional Study.","authors":"Geetha Kandasamy, Thangamani Subramani, Mona Almanasef, Khalid Orayj, Eman Shorog, Asma M Alshahrani, Tahani S Alanazi, Sangeetha Balasubramanian","doi":"10.3390/healthcare13101167","DOIUrl":"https://doi.org/10.3390/healthcare13101167","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;b&gt;Background:&lt;/b&gt; Chronic kidney disease (CKD) significantly affects health-related quality of life (HRQoL), impacting physical and mental well-being. This study aimed to identify the key determinants influencing HRQoL among patients with CKD. &lt;b&gt;Methods:&lt;/b&gt; A cross-sectional observational study was conducted from July 2022 to March 2023 at the Rajiv Gandhi Cooperative Multi-Specialty Hospital, Palakkad, Kerala, South India, including 154 patients diagnosed with CKD stages 3 to 5. Eligible participants were required to be at least 18 years of age and have a confirmed diagnosis of CKD, specifically stages 3 to 5, with prior treatment. CKD stages were defined according to the Kidney Disease: Improving Global Outcomes (KDIGO) 2012 guidelines, based on estimated glomerular filtration rate (eGFR) thresholds as follows: Stage 3 (eGFR 30-59 mL/min/1.73 m&lt;sup&gt;2&lt;/sup&gt;), Stage 4 (eGFR 15-29 mL/min/1.73 m&lt;sup&gt;2&lt;/sup&gt;), and Stage 5 (eGFR &lt; 15 mL/min/1.73 m&lt;sup&gt;2&lt;/sup&gt;). Participants were classified into stages based on their most recent stable eGFR value at the time of recruitment. HRQoL was assessed using the European Quality of Life-5 Dimensions-3 Levels (EQ-5D-3L) questionnaire. Chi-square, ANOVA, and multivariate regression were used to analyze associations with EQ-5D-3L domains. &lt;b&gt;Results:&lt;/b&gt; Out of 154 participants, 68.8% were male, 91.6% were aged over 50 years, and 63.6% were from rural areas. Most had primary education (55.2%) and were unemployed, retired, or housewives (66.2%). As CKD progressed, comorbidities, particularly diabetes mellitus and coronary artery disease (CAD), increased, with Stage 5 showing the highest prevalence. Clinical markers showed significant declines in the glomerular filtration rate (GFR) (Stage 3: 49.16 ± 7.59, Stage 4: 22.37 ± 3.88, Stage 5: 8.79 ± 1.68) and hemoglobin (Stage 3: 10.45 ± 0.84, Stage 4: 8.88 ± 0.60, Stage 5: 7.12 ± 0.53) and an increase in serum creatinine (Stage 3: 1.72 ± 0.40, Stage 4: 3.21 ± 0.44, Stage 5: 7.05 ± 1.46). HRQoL assessments showed significant declines in mobility, self-care, usual activities, pain, and anxiety/depression with advancing CKD. Mobility issues increased from 61.2% in Stage 3 to 62.0% in Stage 5, with greater difficulties in self-care and usual activities at Stage 5. Pain and anxiety/depression worsened across stages. Multivariate analysis identified female gender, older age (≥50 years), lower education, unemployment, multiple comorbidities, smoking, lack of social support, and advanced CKD stages as significant factors linked to impaired HRQoL. CKD stage 5 (GFR &lt; 29 mL/min/1.73 m&lt;sup&gt;2&lt;/sup&gt;) and high serum creatinine (&gt;1.2 mg/dL) were associated with significantly higher odds of impairment in all HRQoL domains. &lt;b&gt;Conclusions:&lt;/b&gt; This study highlights that factors such as female gender, older age, lower education, unemployment, multiple comorbidities, smoking, advanced CKD stages, and high serum creatinine levels are associated with reduced quality of life in CKD p","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Central Venous Access: An Update on Modern Techniques to Avoid Complications. 中心静脉通路:现代避免并发症技术的最新进展。
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-16 DOI: 10.3390/healthcare13101168
Kai Woodfall, André van Zundert
{"title":"Central Venous Access: An Update on Modern Techniques to Avoid Complications.","authors":"Kai Woodfall, André van Zundert","doi":"10.3390/healthcare13101168","DOIUrl":"https://doi.org/10.3390/healthcare13101168","url":null,"abstract":"<p><p><b>Background</b>: Central venous catheterization (CVC) is a frequently performed procedure in anesthesia and critical care settings. Modern procedures have improved significantly, particularly with increasingly sophisticated venous verification methods and ultrasound guidance. While the associated historical complication rates reflect this improvement, complications such as inadvertent arterial puncture, arterial cannulation, pneumothorax, deep vein thrombosis, and catheter-associated infection are still significant risks. <b>Methods</b>: This narrative review was constructed from a literature review using a search strategy of the MESH terms central venous access, central venous line, complications, insertion, and puncture, published between 2015 and 2025. Inclusion criteria included peer-reviewed full-text articles. Supplementary articles were included to construct the historical perspectives on central venous access and complications. <b>Results</b>: Our review offers a simple management algorithm for the mechanical complications of CVC insertion. This algorithm focuses on inadvertent arterial puncture/cannulation, with steps ranging from external compression to endovascular repair or surgical intervention. <b>Conclusions</b>: Moving forward, clinicians are encouraged to look into the future to predict what complications may arise as our modern patient cohort evolves. When complications develop, clinicians should know how to manage them to prevent further patient morbidity.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implementing mHealth Apps Through Community Engagement to Promote Cancer Screening: A Scoping Review. 通过社区参与实施移动健康应用程序以促进癌症筛查:范围审查。
IF 2.4 4区 医学
Healthcare Pub Date : 2025-05-16 DOI: 10.3390/healthcare13101161
Maria Teresa Riccardi, Aurora Heidar Alizadeh, Bianca Maria Costigliolo, Anna Nisticò, Lia Olivo, Mario Cesare Nurchis, Massimo Maurici, Elisabetta Anna Graps, Massimo Oddone Trinito, Gianfranco Damiani
{"title":"Implementing mHealth Apps Through Community Engagement to Promote Cancer Screening: A Scoping Review.","authors":"Maria Teresa Riccardi, Aurora Heidar Alizadeh, Bianca Maria Costigliolo, Anna Nisticò, Lia Olivo, Mario Cesare Nurchis, Massimo Maurici, Elisabetta Anna Graps, Massimo Oddone Trinito, Gianfranco Damiani","doi":"10.3390/healthcare13101161","DOIUrl":"https://doi.org/10.3390/healthcare13101161","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Colorectal (CRC), breast (BC), and cervical cancer (CC) pose a significant health burden, yet screening programs have been proven to reduce cancer-specific mortality and other non-lethal endpoints. Mobile health (mHealth) technologies can enhance adherence, but effectiveness varies. This scoping review aims to explore mHealth apps for cancer screening developed with community engagement, identifying research approaches and gaps. <b>Methods</b>: A scoping review following PRISMA-ScR guidelines analyzed studies on mHealth apps for cancer screening developed through community engagement. Community engagement was classified per WHO's definition. Databases were searched using a PCC-based strategy; eligible studies involved app development, excluding hypothetical apps or text messaging-/social media-only interventions. Screening and data extraction were conducted independently. <b>Results</b>: Thirteen articles were included. Findings indicate a growing but limited body of evidence, with most studies focusing on CRC and BC and involving minority populations through mHealth apps. Key engagement phases included research design, CAB establishment, and recruitment, while priority setting was never community-led. The wMammogram, Meet ALEX, and mMammogram apps improved screening knowledge, intention, and participation, while ColorApp enhanced knowledge but not attitudes. Only CBPR-based studies included dissemination, and one involved the CAB in data analysis. Some studies acknowledged community contributions, though details on ColorApp's engagement were limited. <b>Conclusions</b>: Standardized engagement frameworks combined with mHealth were associated with greater community involvement and may improve equity. No community-designed mHealth app was found for CC screening, despite its relevance. Future research should address gaps in CC programs, prioritize early community involvement, and assess the long-term impact of mHealth interventions.</p>","PeriodicalId":12977,"journal":{"name":"Healthcare","volume":"13 10","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144158384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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