Hautarzt最新文献_第4页

Swarm learning for decentralized healthcare. 用于分散式医疗保健的蜂群学习。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2022-01-14 DOI: 10.1007/s00105-021-04940-z

Matthias Becker

引用次数: 0

[Sun protection of human skin: from A to Z]. 【人体皮肤的防晒:从A到Z】。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2022-02-10 DOI: 10.1007/s00105-022-04953-2

B Kurz, M Berneburg, S Singer

引用次数: 1

[Nano is big! : Facts and myths about nanoparticulate UV filters]. 纳米是大的!:关于纳米颗粒紫外线过滤器的事实和神话]。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2022-02-21 DOI: 10.1007/s00105-022-04954-1

Christian Surber, James Plautz, Uli Osterwalder

{"title":"[Nano is big! : Facts and myths about nanoparticulate UV filters].","authors":"Christian Surber, James Plautz, Uli Osterwalder","doi":"10.1007/s00105-022-04954-1","DOIUrl":"https://doi.org/10.1007/s00105-022-04954-1","url":null,"abstract":"Sunscreen products containing inorganic micronized titanium dioxide (TiO2) and zinc oxide (ZnO) have been available since the 1950s. Their cosmetic acceptance remained limited as they persist as a white paste on the skin. By reducing the size of the particles into the nano-range below 100 nm, their optical property of reflecting visible light is reduced. After the year 2000, organic filters of this size range were developed. The enthusiasm for nanotechnology that prevailed at the time did not transfer to sunscreen products with nanoparticulate filters. Consumers suspect that the particles permeate the skin, are absorbed by the blood, and spread throughout the body causing illness. Not least due to public pressure, cosmetics-which include sunscreen products-became the first product segment in which accordingly manufactured substances were subjected to strict regulations. Despite advanced regulation and strict approval procedures for nanoparticulate filters, public reservations remained. Possible reasons for this are lack of knowledge or mistrust of the applicable legislation, unclear perception of the behavior of nanoparticles in sunscreen products and as a result unclear perceptions of hazard, risk, and exposure. Against this background, the nature and behavior of nanoparticulate filters in sunscreens on the skin and potentially in the skin, as well as the regulatory framework that ensure that nanoparticulate filters and the products containing them are safe to use are discussed.","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"73 4","pages":"266-274"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39818073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

[Livid nodule on the nose of a patient with bronchial carcinoma]. 支气管癌患者鼻部的青色结节。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2021-07-24 DOI: 10.1007/s00105-021-04867-5

Julia K Winkler, Holger A Haenssle, Ines Bertlich, Alexander H Enk, Ferdinand Toberer

引用次数: 0

[Immunohistochemical analysis of a hypoxia-associated signature in melanomas with positive and negative sentinel lymph nodes : Hypoxia-associated signature of primary cutaneous melanomas]. 【前哨淋巴结阳性和阴性黑色素瘤缺氧相关特征的免疫组织化学分析:原发性皮肤黑色素瘤缺氧相关特征】。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2022-01-07 DOI: 10.1007/s00105-021-04934-x

Ferdinand Toberer, Julia K Winkler, Holger A Haenssle, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold, Heinz Kutzner

{"title":"[Immunohistochemical analysis of a hypoxia-associated signature in melanomas with positive and negative sentinel lymph nodes : Hypoxia-associated signature of primary cutaneous melanomas].","authors":"Ferdinand Toberer, Julia K Winkler, Holger A Haenssle, Monika Heinzel-Gutenbrunner, Alexander Enk, Wolfgang Hartschuh, Peter Helmbold, Heinz Kutzner","doi":"10.1007/s00105-021-04934-x","DOIUrl":"https://doi.org/10.1007/s00105-021-04934-x","url":null,"abstract":"Metabolic reprogramming mediated by hypoxia-inducible factors and its downstream targets plays a crucial role in many human malignancies. Excessive proliferation of tumor cells under hypoxic conditions leads to metabolic reprogramming and altered gene expression enabling tumors to adapt to their hypoxic environment. Here we analyzed the metabolic signatures of primary cutaneous melanomas with positive and negative sentinel node status in order to evaluate potential differences in their metabolic signature. We found a positive correlation of the expression of glucose transporter 1 (GLUT-1) with tumor thickness and ulceration in all melanomas with subgroup analyses as well as in the subgroup with a negative sentinel node. Furthermore, the expression of vascular endothelial growth factor (VEGF) was positively correlated with the presence of ulceration in melanomas with positive sentinel node.","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":"73 4","pages":"283-290"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39672218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

[Calprotectin-a key for diagnosing chronic inflammatory bowel disease in inflammatory dermatoses? : Three case reports]. 钙护蛋白是炎性皮肤病中诊断慢性炎症性肠病的关键?[3例报告]。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2021-04-21 DOI: 10.1007/s00105-021-04821-5

E Koutra, E Lusmöller, R Stadler

引用次数: 1

["Joy and friendship through research" : On the occasion of the 100th birthday of Prof. Dr. med. Dr. h.c. mult. Otto Braun-Falco]. “研究带来的快乐和友谊”:在医学博士h.c. mult博士诞辰100周年之际。奥托Braun-Falco]。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2022-02-24 DOI: 10.1007/s00105-022-04971-0

Jörg C Prinz, Lars E French

引用次数: 0

[Pregnant woman with pruritic urticarial plaques on the abdomen]. [腹部瘙痒性荨麻疹斑块的孕妇]。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2021-06-16 DOI: 10.1007/s00105-021-04838-w

Sven-Niklas Burmann, Sara Lausch, Frank Oellig, Alena-Lioba Michalowitz, Alexander Kreuter

引用次数: 0

[Laugier-Hunziker syndrome : A rare differential diagnosis of mucocutaneous hyperpigmentation]. [Laugier-Hunziker综合征:一种罕见的粘膜色素沉着的鉴别诊断]。

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2021-06-25 DOI: 10.1007/s00105-021-04845-x

Sören Korsing, Marcel Boede, Schokufe Ebrahimsade, Katharina Meier

引用次数: 2

[Characterization of sun protection performance: Quo vadis?] 【防晒性能表征:Quo vadis?】］

4区医学

Hautarzt Pub Date : 2022-04-01 Epub Date: 2022-03-25 DOI: 10.1007/s00105-022-04958-x

Uli Osterwalder, Christian Surber

{"title":"[Characterization of sun protection performance: Quo vadis?]","authors":"Uli Osterwalder, Christian Surber","doi":"10.1007/s00105-022-04958-x","DOIUrl":"https://doi.org/10.1007/s00105-022-04958-x","url":null,"abstract":"The task of the first sunscreens was to prevent the development of sunburn and, following the spirit of the 1950/1960s, to not impair the tanning of the skin. The need to quantify the protective performance soon arose. Originally with the help of natural-nowadays artificial-sunlight, a method was developed to determine a sun protection factor (SPF). It is formally defined as a ratio between minimum erythema-effective UV dose on sunscreen-protected skin and minimum erythema-effective UV dose on unprotected skin (ISO 24444:2019). Three observations question the suitability of the method. (1) Interlaboratory variability: Despite strict standardization, results of SPF determinations from different laboratories are subject to large variations. (2) Natural vs. artificial sunlight: The radiation spectrum of artificial sunlight differs from that of natural sunlight. SPFs determined with artificial sunlight (as depicted on all sunscreens currently on the market) are significantly too high compared to SPF determination with natural sunlight. (3) Erythema burden: When determining SPF, subjects are exposed to potentially harmful radiation. Against this background alternative methods-in vitro SPF, hybrid diffuse reflectance spectroscopy (HDRS) and in silico calculations-are presented. These have the potential to replace the current method. As an immediate measure, it is recommended to return to the comprehensible description of low, medium, high, and very high protection and in the future to take into account the spectrum of natural sunlight.","PeriodicalId":12970,"journal":{"name":"Hautarzt","volume":" ","pages":"276-282"},"PeriodicalIF":0.0,"publicationDate":"2022-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8964537/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40328272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2