Hematology, Transfusion and Cell Therapy最新文献

{"title":"Criteria for referring pediatric and adult patients with hematological diseases to palliative care: Consensus of the Brazilian Association of Hematology, hemotherapy and cell therapy (2025)","authors":"Amanda Pifano Soares Ferreira ,&nbsp;Cecília Emerick Mendes Vaz ,&nbsp;Laura Ferreira de Mesquita Ferraz ,&nbsp;Paulo de Mello Novita Teixeira ,&nbsp;Mariana Munari Magnus ,&nbsp;Clarissa de Miranda Fonseca ,&nbsp;Júlia Alvarenga Petrocchi ,&nbsp;Suzana de França Ribeiro Gonzaga ,&nbsp;Tathiana Rodrigues Peres Braz ,&nbsp;Rita de Cássia Rosário Cavalheiro ,&nbsp;Yara Andrea Pires Afonso Reina ,&nbsp;Sandra Regina Loggetto ,&nbsp;Lorena Lobo de Figueiredo Pontes ,&nbsp;Sílvia Maria Meira Magalhães ,&nbsp;Renato Sampaio Tavares ,&nbsp;Carlos Sérgio Chiattone ,&nbsp;Vânia Tietsche de Moraes Hungria ,&nbsp;Phillip Scheinberg ,&nbsp;Carmino Antônio de Souza ,&nbsp;Fernando Ferreira Costa ,&nbsp;Paula de Melo Campos","doi":"10.1016/j.htct.2026.106456","DOIUrl":"10.1016/j.htct.2026.106456","url":null,"abstract":"<div><div>Palliative care is, according to the World Health Organization (WHO), “a global ethical responsibility” and crucial to person-centered healthcare, for the relief of physical and psychological symptoms and social and spiritual suffering, impacting the improvement of the quality of life not only of pediatric and adult patients dealing with life-threatening illnesses, but also of their families. Despite the growing recognition of palliative care in the hematological setting and the increase in the number of publications on the subject, the available data are still scarce and limited. The objective of this consensus is to establish recommendations for the referral of pediatric and adult hematological patients to specialized palliative care teams and the possible integration of these two specialties.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106456"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147740008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of socioeconomic status on clinical presentation of multiple myeloma","authors":"Lívia Pessôa de Sant'Anna Coelho ,&nbsp;Renata Lyrio Rafael Baptista ,&nbsp;Gustavo de Almeida Buarque Bretas ,&nbsp;Ana Carolina Araujo ,&nbsp;Andrea Ribeiro Soares","doi":"10.1016/j.htct.2026.106256","DOIUrl":"10.1016/j.htct.2026.106256","url":null,"abstract":"<div><h3>Introduction</h3><div>The influence of socioeconomic status on cancer diagnosis, treatment, and outcomes has been studied for several decades. In multiple myeloma, many authors are investigating the impact of poverty and social inequalities, measured by indicators such as place of residence, number of residents, occupation, income and education, the incidence, stage and management of the disease, and survival, with controversial results. The aim of this study was to ambispectively analyze the association between socioeconomic status and clinical characteristics of multiple myeloma at presentation.</div></div><div><h3>Methods</h3><div>A total of 296 patients, diagnosed between 2015 and 2023 in three institutions in Rio de Janeiro, Brazil, were included. To assess the socioeconomic status, a social class questionnaire was administered to patients (or relatives, in the cases of death); information about educational level was collected from this interview and medical records and household income per capita were estimated, according to place of residence.</div></div><div><h3>Results</h3><div>Lower socioeconomic status was associated with delayed diagnosis, symptoms at presentation, advanced stage, poorer performance status, lower hemoglobin and higher calcium values.</div></div><div><h3>Conclusion</h3><div>These findings suggest a possible relationship between socioeconomic aspects and severity of multiple myeloma presentation in Brazil, and underscore the importance of shaping health policies to promote greater equity in cancer diagnosis and treatment access.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106256"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146170380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional capacity in sickle cell disease: A pilot study with 1-minute sit-to-stand test","authors":"Michele Barroso Thomaz ,&nbsp;Lucas Fernandes Suassuna ,&nbsp;Júlia Campos Fabri ,&nbsp;Isabela de Oliveira Araújo ,&nbsp;Júlia Carneiro Almeida ,&nbsp;Daniela de Oliveira Werneck Rodrigues","doi":"10.1016/j.htct.2025.106230","DOIUrl":"10.1016/j.htct.2025.106230","url":null,"abstract":"<div><h3>Background</h3><div>Sickle cell disease, the most prevalent monogenic recessive genetic disorder in the world, is characterized by two main pathogenic mechanisms: vaso-occlusion and hemolysis. These characteristics lead to reduced tolerance to physical exertion and, consequently, a reduced functional capacity which can be assessed using the one-minute sit-to-stand test. Complications from sickle cell disease result in poor quality of life, increased absenteeism from school and work, and impaired social interaction.</div></div><div><h3>Method</h3><div>Between January 2023 and April 2024, a pilot cross-sectional study was conducted with sickle cell disease patients aged from 18 to 60 years. The one-minute sit-to-stand test, Borg's perceived exertion scale, and the SF-36 quality of life questionnaire were utilized. Patients were monitored during the test. The sample was dichotomized based on test performance and SF-36 scores. Furthermore, clinical and demographic variables were analyzed.</div></div><div><h3>Main results</h3><div>Fifty-eight individuals participated in the final analysis. The mean age was 29.84 ± 11.20 years; 55.1 % were men, and 79.3 % identified themselves as Black or mixed race. The most prevalent genotype was hemoglobin SS (67.2 %), and 77.5 % were taking Hydroxyurea. The group with a better performance in the one-minute sit-to-stand test showed better quality of life as assessed using the SF-36 questionnaire.</div></div><div><h3>Conclusion</h3><div>Functional capacity is a significant factor in the autonomy and quality of life of patients with sickle cell disease. The one-minute sit-to-stand test is a low-cost and easily applicable test, which can contribute to the assessment of functional capacity in the routine follow-up of these patients.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106230"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-world data of autologous stem cell transplantation for patients with mantle cell lymphoma in Argentina","authors":"Martín Milanesio ,&nbsp;Mariano Berro ,&nbsp;Adriana Vitriu ,&nbsp;María Sol Jarchum ,&nbsp;Silvina Palmer ,&nbsp;Amalia Cerutti ,&nbsp;Evelyn Colombo ,&nbsp;Malena Rocca ,&nbsp;Lautaro Sardu ,&nbsp;Ana Laura Romero ,&nbsp;Micaela Quarchioni ,&nbsp;Fernando Warley ,&nbsp;Alejandra Banchieri ,&nbsp;Germán Wernicke ,&nbsp;María Marta Rivas ,&nbsp;José Trucco ,&nbsp;Leandro Castellanos ,&nbsp;Luciana Guanchiale ,&nbsp;Ana Romina Montivero ,&nbsp;Cecilia Foncuberta ,&nbsp;Ana Lisa Basquiera","doi":"10.1016/j.htct.2026.106449","DOIUrl":"10.1016/j.htct.2026.106449","url":null,"abstract":"<div><h3>Background</h3><div>For eligible patients with mantle cell lymphoma who respond to induction therapy, first-line consolidation with autologous hematopoietic progenitor cell transplantation remains a standard treatment. However, outcomes for these patients in Argentina have not been fully characterized. This paper aims to describe the factors linked to improved survival of patients with mantle cell lymphoma after transplantation in Argentina. In addition, the association between relapse within the first 24 months after transplant and overall survival was evaluated.</div></div><div><h3>Methods</h3><div>A retrospective, multicenter study was carried out. Patients over 18 years of age with a diagnosis of mantle cell lymphoma who received autologous hematopoietic progenitor cell transplantation from 2007–2023 at centers affiliated with the Argentine Group for Bone Marrow Transplantation and Cellular Therapy (GATMO-TC) were included. For the survival analysis, a landmark approach was utilized: overall survival was calculated from the date of progression for the group that relapsed within 24 months, and from the 24-month post-transplantation landmark for those who did not.</div></div><div><h3>Results</h3><div>One hundred and sixty-six patients from nine Argentine centers were included, 128 of whom were men (77%). The median age at transplantation was 58 years. Eighteen (11%) had blastoid morphology. The pretransplant status was complete response in 145 (87%) patients. With a median follow-up of 38.4 months, the median overall survival and progression-free survival were 102 and 48.8 months, respectively. In the multivariate analysis, the blastoid variant, an age ≥55 years, and a transplant comorbidity index ≥2 were independent predictors of survival.</div></div><div><h3>Conclusions</h3><div>&gt;70% achieved prolonged survival. Blastoid morphology, age older than 55 years, and comorbidities diminished outcomes after transplantation.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106449"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147600118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myeloid neoplasm with eosinophilia associated with FIP1L1–PDGFRA presenting as femoral avascular necrosis: a rare case report","authors":"Katia Gleicielly Frigotto ,&nbsp;Ingrid Caroline Rosa Diogo ,&nbsp;Pedro Guilherme Mol da Fonseca ,&nbsp;Victor Lopes de Abreu ,&nbsp;Júlia Rosa Dantas ,&nbsp;Paula Santos Barroso ,&nbsp;Juliana Bastos Torres ,&nbsp;Natália Laso Fonseca ,&nbsp;Vitor Ribeiro Gomes de Almeida Valviesse","doi":"10.1016/j.htct.2026.106258","DOIUrl":"10.1016/j.htct.2026.106258","url":null,"abstract":"","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106258"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146145089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of vaccine-induced antibody responses against SARS-CoV-2 in multiple myeloma patients from the northeastern region of Mexico","authors":"Rosario Salazar-Riojas ,&nbsp;Dalila M. Alvarado-Navarro ,&nbsp;María L. Ruiz-de la Cruz ,&nbsp;Lorena Nefertiti Castro-Fuentes ,&nbsp;Karina E. Vazquez-Hernandez ,&nbsp;David Gomez-Almaguer ,&nbsp;Adrian G. Rosas-Taraco","doi":"10.1016/j.htct.2026.106448","DOIUrl":"10.1016/j.htct.2026.106448","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate immunoglobulin G antibody responses against Severe Acute Respiratory Syndrome Coronavirus 2 in multiple myeloma patients in the northeastern region of Mexico following different COVID-19 vaccination regimens.</div></div><div><h3>Methods</h3><div>This retrospective study included 33 multiple myeloma patients, and 28 healthy controls vaccinated with mRNA (BNT162b2, mRNA-1273) or adenovector (AZD1222) vaccines. Anti-spike receptor-binding domain (RBD) and anti-nucleocapsid immunoglobulin G levels were measured. Laboratory parameters, including monocyte and lymphocyte counts and serum-free light chains, were analyzed. Statistical comparisons used ANOVA, Kruskal-Wallis, and logistic regression.</div></div><div><h3>Results</h3><div>No significant differences in anti-spike receptor-binding domain immunoglobulin G levels were observed between multiple myeloma patients and healthy controls after one vaccine dose. Multiple myeloma patients who received ≥3 doses showed higher anti-spike receptor-binding domain immunoglobulin G levels compared to single-dose recipients. Anti-nucleocapsid antibodies (indicative of prior subclinical infection) were detected in 51.5% of multiple myeloma patients and correlated with elevated anti-spike receptor-binding domain levels. Patients in the third anti-spike immunoglobulin G quartile (10,427.9–23,954.0 AU/mL) had higher monocyte counts compared with patients in the lower quartiles. No correlations were found between anti-spike immunoglobulin G and lymphocyte counts, serum proteins, or gamma globulins. Abnormal kappa/lambda light chain ratios did not impair antibody responses in nucleocapsid-positive patients.</div></div><div><h3>Conclusion</h3><div>Multiple myeloma patients achieved comparable immunoglobulin G responses to healthy controls after one vaccine dose, with enhanced responses following ≥3 doses. Subclinical infections may augment humoral immunity. Elevated monocyte counts are indicative of innate immune activation following the administration of the vaccine. These findings support prioritizing booster doses for multiple myeloma patients despite immunosuppressive therapies.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106448"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147640997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute fibrinous and organizing pneumonia after bone marrow transplantation, an underrecognized, severe condition","authors":"Anita Cassoli Cortez ,&nbsp;Maria Cristina Nunez Seiwald ,&nbsp;Ana Rita Brito Medeiros da Fonseca ,&nbsp;Aliana Meneses Ferreira ,&nbsp;Gabriella Pogorzelski ,&nbsp;Leonardo de Abreu Testagrossa ,&nbsp;Yana Novis ,&nbsp;André Nathan Costa","doi":"10.1016/j.htct.2025.106238","DOIUrl":"10.1016/j.htct.2025.106238","url":null,"abstract":"<div><h3>Introduction</h3><div>Allogeneic bone marrow transplantation can lead to various pulmonary complications, including acute fibrinous organizing pneumonia. This condition is rare and presents with aggressive clinical features, distinct from other forms of organizing pneumonia, such as cryptogenic organizing pneumonia.</div></div><div><h3>Method</h3><div>A literature review using the PubMed, Embase, Lilacs, and Cochrane databases was conducted to analyze cases of acute fibrinous organizing pneumonia following transplantation focusing on clinical features, therapeutic approaches, and outcomes.</div></div><div><h3>Case Report</h3><div>The case of a 62-year-old female who developed acute fibrinous organizing pneumonia after transplantation for acute myeloid leukemia is presented. Despite an initial absence of infectious agents, parainfluenza virus was later identified in a bronchoalveolar lavage. The patient progressed to severe hypoxemic respiratory failure and was unresponsive to corticosteroids and rituximab, ultimately dying seven months post-transplant.</div></div><div><h3>Conclusion</h3><div>This is a rare and severe complication following allogeneic bone marrow transplantation. Early diagnosis, histopathological confirmation, and prompt initiation of corticosteroid therapy are critical for improving outcomes. Patients diagnosed before Day +100 generally have a better response to treatment and more favorable clinical outcomes. The need for a more effective and targeted treatment strategy remains an unmet challenge in managing this condition.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106238"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent trade-offs among intravenous iron formulations for iron-deficiency anemia: a longitudinal systematic review and network meta-analysis","authors":"Francino Machado de Azevedo Filho,&nbsp;Mariana Millan Fachi,&nbsp;Layssa Andrade Oliveira,&nbsp;Haliton Alves de Oliveira Junior,&nbsp;Rosa Camila Lucchetta","doi":"10.1016/j.htct.2026.106435","DOIUrl":"10.1016/j.htct.2026.106435","url":null,"abstract":"<div><div>Intravenous iron formulations differ in benefits and risks that evolve across clinically relevant timepoints. A comprehensive network meta-analysis of randomized trials compared different intravenous iron formulations with oral iron and with each other. In addition to overall estimates, results are presented by predefined timepoints (4, 8, 12 and 24 weeks) for hemoglobin, ferritin, transferrin saturation, serious adverse events, and hypophosphatemia. Over 4-8 weeks, ferric carboxymaltose more consistently increased iron stores (ferritin/transferrin saturation) compared with the alternatives at the cost of a higher risk of hypophosphatemia. In 12-24 weeks, differences in iron stores attenuated and safety considerations became the main driver of choice, with ferric derisomaltose and iron sucrose generally favored when mineral safety is prioritized (e.g., for chronic kidney disease and inflammatory bowel disease). Effects on hemoglobin were broadly comparable between ferric carboxymaltose and ferric derisomaltose across most timepoints. These findings support conditional, scenario-specific decisions rather than a single ‘best’ formulation: ferric carboxymaltose when rapid repletion is critical and monitoring for hypophosphatemia is feasible; ferric derisomaltose and iron sucrose when safety predominates, or longer-term maintenance is planned. This windowed presentation facilitates pragmatic evidence translation for clinical decision-making while maintaining transparency through standard network meta-analysis diagnostics and certainty assessments.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106435"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147597374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on “Risk factors associated with the use of red blood cells in elective cardiac surgeries”","authors":"Hinpetch Daungsupawong ,&nbsp;Viroj Wiwanitkit","doi":"10.1016/j.htct.2025.106236","DOIUrl":"10.1016/j.htct.2025.106236","url":null,"abstract":"","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106236"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145924509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of the ABCB1 gene polymorphism C3435T (rs1045642) with acute myeloid leukemia: A genetic study","authors":"Roh Ullah ,&nbsp;Nazish Mazari ,&nbsp;Ghulam Mustafa ,&nbsp;Aisha Hameed ,&nbsp;Shagufta Khaliq ,&nbsp;Ali Amar ,&nbsp;Faiz Ul Haq ,&nbsp;Asif Haleem Khan ,&nbsp;Asif Naveed","doi":"10.1016/j.htct.2025.106239","DOIUrl":"10.1016/j.htct.2025.106239","url":null,"abstract":"<div><h3>Introduction</h3><div>The <em>ATP Binding Cassette Subfamily B1</em> (<em>ABCB1</em>) gene is responsible for encoding the permeability glycoprotein (P-gp), a crucial protein involved in multidrug resistance. P-gp functions as an ATP-dependent efflux pump, actively removing diverse substances, including carcinogens, from cells. However, a specific genetic variation called the <em>C3435T</em> polymorphism of the <em>ABCB1</em> gene has been linked to reduced plasma levels of P-gp substrates. This genetic variation leads to the accumulation of harmful compounds within cells, which may increase susceptibility to hematological malignancies. This study aims to determine the frequency of <em>ABCB1</em> gene polymorphism <em>C3435T</em> (rs1045642) in acute myeloid leukemia patients at tertiary care hospitals in Lahore, Pakistan.</div></div><div><h3>Methods</h3><div>A cross-sectional comparative study was conducted to investigate the association between <em>ABCB1</em> gene polymorphism (<em>C3435T</em>) and acute myeloid leukemia. A total of 100 samples (50 cases and 50 healthy controls) were genotyped using restriction fragment length polymorphism assay.</div></div><div><h3>Results</h3><div>The TT genotype of <em>ABCB1 C3435T</em> was more prevalent in cases (62%) compared to the control group (20%). In different genetic models, the TT genotype was significantly associated with acute myeloid leukemia when compared to the CC and CT genotypes.</div></div><div><h3>Conclusion</h3><div>This study suggests that the TT genotype of the <em>ABCB1 C3435T</em> gene polymorphism is more strongly associated with acute myeloid leukemia compared to controls. This specific genotype may contribute to the development or progression of this malignancy. Further research is needed to explore the functional implications of this genetic variation in the pathogenesis.</div></div>","PeriodicalId":12958,"journal":{"name":"Hematology, Transfusion and Cell Therapy","volume":"48 2","pages":"Article 106239"},"PeriodicalIF":1.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145954695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}