Sechenov Medical Journal最新文献

{"title":"Primary operable breast cancer: molecular subtypes and morphological prognostic factors","authors":"V. Ponomarev, S. Polikarpova, N. I. Mehtieva, N. U. Shagina, Y. Vishnevskaja, V. V. Selivanova","doi":"10.47093/22187332.2019.2.5-13","DOIUrl":"https://doi.org/10.47093/22187332.2019.2.5-13","url":null,"abstract":"Aim. To study the immediate and long - term results of treatment of patients with a primary operable breast cancer, depending on the morphological and biological characteristics of the tumor. Materials and methods. The retrospective study included 974 patients aged from 30 to 82 years (a mean age of54.5 years) with a primary operable breast cancer (T1-2N0-1M0) observed from 2005 to 2012. The overall survival (OS) and disease - free survival (DFS) were studied depending on the histological type, molecular - biological subtype of breast cancer, axillary status, lymphovascular invasion, tumor histologic grade, proliferation index (by Ki-67 staining) and HER2 protein expression. Statistical data processing included a comparison of the frequencies of the studied traits, analysis of survival curves by the Kaplan-Meier method.Results. Indicators of a 5-year OS and 5 and 10-year OS and DFS were lower in carcinomas of mixed type compared with invasive carcinoma of no special type ( p =0.03) and invasive lobular carcinoma ( p =0.01). In the absence of metastases in regional lymph nodes, indicators of 5 and 10-year OS were higher compared with the macrometastatic involvement of one ( p =0.02) or two or more lymph nodes ( p =0.004): 96.0% and 89.3%; 95.4% and 79.0%; 88.9% and 79.3%, respectively. A similar trend has been noted for indicators of 5 and 10-year DFS. The OS in the absence of metastases in the lymph nodes was greater with the luminal B HER2-positive subtype and triple - negative breast cancer. The degree of malignancy of the tumor had no effect on OS. The probability of disease recurrence was significantly higher in patients with a degree of G3 compared with G1 ( p =0.00001) and G2 ( p =0.002): the rates of 5 and 10-year - old DFS were: 84.8 and 55.0%; 94.1 and 86.0%; 88.9 and 72.2%, respectively. The expression of HER2 and Ki-67 proliferation index influenced the DFS without affecting the OS.Conclusions. The morphological factors deteriorating the OS and DFS of patients with primary operable breast cancer are the presence of macrometastases in regional lymph nodes, the defeat of two or more lymph nodes, the presence of lymphovascular invasion, mixed histological form of breast cancer. The subtypes with a more aggressive course include: HER2-positive tumors, triple negative breast cancer.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115285793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of morbidity with poisonings with ethanol and surrogate alcohols in irkutsk region between 2010 and 2017","authors":"E. I. Loskutnikova, A. Gil, I. N. Alekhin, R. Khalfin","doi":"10.47093/22187332.2019.2.36-44","DOIUrl":"https://doi.org/10.47093/22187332.2019.2.36-44","url":null,"abstract":"Aim. Poisonings with ethanol and surrogate alcohols are preventable causes of morbidity and mortality posing a serious threat to population health. The aim of the study was to analyze the dynamics of the incidence of acute poisoning with ethyl and surrogate alcohols in the Irkutsk region for the period from 2010 to 2017, and to discuss it in the context of the regional and federal policy aimed at regulation of the alcohol - containing products. Materials and methods. The data of the statistical reporting form No. 12-15 “Information on the results of toxicological monitoring” in the Irkutsk region for the period from 2010 to 2017, the data of the Federal State Statistics Service RosStat on the incidence of acute chemical poisoning, and on incidence of acute poisoning with ethyl alcohol and surrogate alcohols were analyzed. Subsequent interpretation of the results in the context of the regional and federal alcohol control policy has been performed. Results. In the Irkutsk region, during the analyzed period of time there was observed a high incidence of acute poisonings with ethanol and surrogate alcohols with territorial differences within the region, and with positive dynamics of reduction of incidence by 38.7% in 2017 in comparison to 2010. Poisonings with ethanol occupy a leading place in the structure of the incidence in comparison with poisoning with other alcohols. The Irkutsk region was ranked 9th among all other subjects of the Russian Federation in 2017 by level of morbidity with alcohol poisonings. Among all cases of poisonings the proportion of the adult working age population was 89.1%, males - 77%, and unemployed population - 57.8%, which suggests that these categories of population are under the highest risk of acute poisoning with ethanol and surrogate alcohols. Conclusion. Strengthening control over the illegal distribution of ethyl alcohol and alcohol - containing products, especially in the territories situated along the Federal highways is seen as a priority area for action. Control of distribution of alcohols between 2010 and 2017 on the territory of the Irkutsk region allowed reducing incidence of poisonings by 38.7%. To maintain the positive dynamics of reducing morbidity and mortality from acute poisoning of alcohol etiology, to preserve the labor potential of the population of the Irkutsk region, it is necessary to further strengthen and reinforce control measures at the regional level.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114321316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of programs for ensuring active longevity of persons of older age groups in the moscow region","authors":"N. Burdaev, S. Sboeva, S. Krivosheev","doi":"10.47093/22187332.2019.2.45-53","DOIUrl":"https://doi.org/10.47093/22187332.2019.2.45-53","url":null,"abstract":"Aim. To study non - stationary and semi - stationary forms of health - improving services of multifunctional regional social welfare centers and determine satisfaction with their quality. Material and methods. The annual reports of state budgetary institutions of Territorial Centers for Social Welfare for 2017, projects to ensure healthy longevity. A survey of 210 respondents was conducted (average age - 71 years) of the participants in the Moscow Longevity project about satisfaction with the provision of recreational services of Territorial Centers for Social Welfare. Statistical analysis included the study of the absolute and relative values of the indicators obtained. Results. An analysis of the activities of 6 organizations of the Moscow Territorial Centers for Social Welfare revealed the implementation of all federal and regional programs, as well as two of them - local projects to stimulate active longevity. Women (68%) and persons with a higher education (48%) prevailed among the surveyed participants in the Moscow Longevity project. The frequency of chronic diseases and the attendance of medical care increased with age of the respondents. The average cost of purchasing drugs amounted to 25% of the monthly pension. Within one to three years, 54% of respondents used the services of Territorial Centers for Social Welfare. The analysis of satisfaction with the quality of social and health services showed high rates (4.7-4.9 points out of 5) for the criteria “Goodwill and competence of employees”, “Organization of educational, physical, leisure and social and cultural activity”. Average values (4.5-4.6 points) were obtained for the criteria “Openness and availability of information about the services provided” and “Comfort of conditions for the provision of services”. The lowest number of points - 4.2 - was obtained according to the criterion \"Organization of medical and pharmaceutical care\". Conclusions. In addition to federal and regional programs, organizations of the Moscow Territorial Centers for Social Welfare also implement local projects to stimulate active longevity. The majority of respondents use the services of Territorial Centers for Social Welfare for more than one year and positively evaluate their activities, but consider it expedient to increase the semi - stationary and non - stationary bases of the Territorial Centers for Social Welfare, create conditions for the provision of medical and medicinal care.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131649012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cellular composition and microanatomy of lymphoid formations of the vestibule of the vagina in postnatal ontogenesis","authors":"S. Shadlinskaya","doi":"10.47093/22187332.2019.1.57-62","DOIUrl":"https://doi.org/10.47093/22187332.2019.1.57-62","url":null,"abstract":"Aim - presents data on the number of cells of the lymphoid series and the cellular composition of the lymphoid tissue in the mucosa of the vaginal vestibule at different age periods of ontogenesis. Materials and methods. The study material was preparations of the vaginal vestibule taken from 45 women of different ages (from newborns to 75 years). By age periods, the material was subdivided according to the standard scheme of age periodization. Cross sections of the organ wall were stained with hematoxylin - eosin and according to Van Gieson. In a number of cases, the silvering of Grimelius was performed. Obtained during the study of digital data were subjected to statistical processing. Results. Analysis of the results showed that lymphoid formations are located mainly near the glands. Glandular - lymphoid relationships are less impressed in newborns, to the maximum extent from early childhood to the 1st period of adulthood, in the elderly and senile age of cells. There are fewer lymphoid rows near the initial divisions and in the stroma of the glands. The lymphoid apparatus of the vaginal vestibule is represented by all the morphogenetic forms of the lymphoid tissue. The qualitative composition of lymphoid tissue is of the same type in all its morphogenetic forms, regardless of age. It has been established that there are close microsynthopic connections between immune structures and small glands of the vestibule. The intensity of these relationships has ontogenetic features. They are relatively weak in new - borns, are maximal in early childhood and weaken after the 1st period of adulthood. Conclusion. The study allowed us to identify previously unknown patterns of morphogenesis of lymphoid structures of the vaginal vestibule.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"2010 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127345323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the seasonal dynamics of ambulance calls for patients with angina pectoris","authors":"V. A. Belyaeva","doi":"10.47093/22187332.2019.1.5-10","DOIUrl":"https://doi.org/10.47093/22187332.2019.1.5-10","url":null,"abstract":"Angina pectoris is a chronic disabling heart disease that leads to myocardial infarction and death without proper treatment. Aim - to study the dynamics of frequency of ambulance сalls for patients with stable angina in different seasons of the year, depending on the current meteorological factors.Materials and methods. 1034 cases of calls of the emergency medical service in the city of Vladikavkaz to the patients with angina attack were analyzed. Based on the seasonal ranking of the ambulance frequency calls and the corresponding base of meteorological parameters, a correlation analysis of the relationship between these indicators was made. Results. It has been established that the seasonality factor influences the frequency of calls to the ambulance (2=9.12; KW-H=8.92). Correlations between the frequency of calls to the ambulance and meteorological factors are seasonally specific and vary with respect to annual coefficients. The most significant contribution to the increase in the incidence of angina attacks is made by the factors: average daily air temperature, inter - day variability of atmospheric pressure, relative humidity, cloudiness, pathogen indices of these factors, as well as a general index of weather pathogenicity.Conclusion. In winter, due to the negative impact of low temperatures and sharp variations in the whole complex of meteorological factors, the maximum number of ambulance calls to patients with angina is recorded. The most favorable period for patients suffering from angina pectoris is the summer season, during which emergency medical care is minimal.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128597717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE IMPACT OF CARDIOVASCULAR AND BRONCHOPULMONARY DISEASES ON COENZYME Q10 PLASMA CONCENTRATION","authors":"V. Zozina, E. Melnikov, L. M. Krasnykh, O. Goroshko, Kukes Vg","doi":"10.47093/22187332.2019.1.16-21","DOIUrl":"https://doi.org/10.47093/22187332.2019.1.16-21","url":null,"abstract":"Introduction. Coenzyme Q10 plays an important role in the human body. Its main function is not only the transfer of electrons in the mitochondrial respiratory chain for the ATP synthesis, but it is also one of the most powerful antioxidants in the body.The aim of research is to monitor the relationship between cardiovascular and pulmonary diseases, and the concentration of coenzyme Q10 in the blood plasma.Materials and methods. Coenzyme Q10 was determined using high performance liquid chromatography with mass spectrometric detection.Results and discussion. During the study, it was found that the concentration of coenzyme Q10 in plasma is affected not only by the main diseases, but also by comorbidities, as well as by the therapy. A sharp decrease in plasma coenzyme Q10 concentration was noted in patients with cardiovascular pathologies, especially in those with concomitant endocrine diseases. Also, it was recorded a decrease in the concentration of coenzyme Q10 in the plasma of patients with pneumonia. Conclusion. During the experiment, the coenzyme Q10 concentration was found to be dependent on cardiovascular and pulmonary diseases.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131863753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE STUDY OF THE PHARMACOKINETIC PROPERTIES OF 11-DEOXYMISOPROSTOL AFTER INTRAGASTRIC ADMINISTRATION","authors":"R. M. Kataeva, E. F. Agletdinov, K. V. Bulygin, V. Kataev, N. Ivanova, S. F. Gabdrakhmanova, T. Sapozhnikova","doi":"10.47093/22187332.2019.1.22-28","DOIUrl":"https://doi.org/10.47093/22187332.2019.1.22-28","url":null,"abstract":"The aim - to establish the main pharmacokinetic parameters of 11-deoxyimisoprostol after intragastric administration. Materials and methods. The experiments were performed on 410 white outbred rats - females weighing 180-220 g. 11-deoxymysoprostol was administered to rats intragastrally at a dose of 2.0 mg/kg. Blood and organs were taken for examination at 6, 12, 15, 30 minutes and hourly for 12 hours after administration. After these intervals, the concentration of the drug in the blood and tissue homogenates of laboratory animals was determined, and in the urine - every hour during the day. Chromatographic separation was carried out using a liquid chromatograph (Shimadzu, Japan LC-20 PROMI- NENCE with a diode - array detector SPD-20A).Results. 11-deoxyimisoprostol is rapidly absorbed from the gastrointestinal tract. The maximum (6.625 μg/ml) of the compound in the blood plasma is reached 15 minutes after intragastric administration. When this occurs, a simultaneous in - crease in the concentration of the metabolite - 11-deoxyimisoprostolic acid. The maximum concentration (23.547 µg/ml) of the metabolite in the blood plasma is reached 30 minutes after the administration of 11-deoxyimisoprostol. 11-deoxyimisoprostol is intensively distributed throughout the organs and tissues, while the compound has the highest affinity for myometrium and liver. The smallest quantities of the test substance were found in the lungs, the brain, and the omentum. The active metabolite of 11-deoxyimisoprostol is intensively distributed in organs and tissues, while in the greatest amounts it was detected in the myometrium and the liver and kidneys. The smallest quantities of the test substance were found in the lungs, the brain, and the omentum. In the urine, 11-deoxyimisoprostolic acid is determined during the first days of the study, with a maximum clearance of 6-8 hours after administration.Conclusion. 11-deoxyimisoprostol has a short half - life after intragastric administration (T1/2=0,550 h), which indicates the absence of cumulative properties. The nature of the pharmacokinetic curve is monoexponential.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124291739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE ANALYSIS OF THE COMMUNITY-ACQUIRED PNEUMONIA COURSE IN CHILDREN OF ROSTOV-ON-DON","authors":"O. Semernik, A. Lebedenko, E. B. Tyurina, S. K. Luspikayan","doi":"10.47093/22187332.2019.1.52-56","DOIUrl":"https://doi.org/10.47093/22187332.2019.1.52-56","url":null,"abstract":"Objective - to study the clinical features of community - acquired pneumonia in children of Rostov - on - Don. Materials and methods. To achieve this goal, 261 cases of children aged 1 month to 17 years who were admitted to the hospital with suspected community - acquired pneumonia were analyzed. All patients underwent a thorough analysis of anamnestic data, the results of clinical examination of patients, laboratory diagnostics, and X-ray chest examination. Results. The study showed that the highest incidence of community - acquired pneumonia was observed in children aged 8 to 12 years. Boys get sick more often than girls. More often, pulmonary parenchyma lesions were observed, localized on the right side of 66%, while the bilateral process was registered only in 10%. According to the morphological form, segmental - 42% and focal - 34% lesions were most often registered, polysegmental were 17%, and equity - 1%. The results of X- ray examination of patients allowed to confirm the diagnosis of community - acquired pneumonia in most patients. Conclusion. The most common clinical and morphological form of pneumonia in children remains focal and segmental forms with a high prevalence of right - sided pneumonia.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115743949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the structure of the muscles acting on the hip joint of the human fetus","authors":"R. Z. Nurimanov, A. E. Strizhkov, V. Nikolenko","doi":"10.47093/22187332.2019.1.47-51","DOIUrl":"https://doi.org/10.47093/22187332.2019.1.47-51","url":null,"abstract":"Aim - to identify the features of the anatomical structure of the muscles acting on the hip joint in the fetal period of prenatal ontogenesis. Material and methods. The study was carried out on corpses of 200 fetuses aged from 12th to 38th weeks. Anatomical and morphometric research methods were used. Results. As a result of the study, it was established that the muscles of the pelvis and thigh of the fetus are different from the definitive ones: more heads are noted, a different direction of force action vector, functional indicators of the extensor and rotator muscles prevail. There are critical periods of organogenesis of functional muscle groups. Conclusions. The main trend of organogenesis of the muscles of the pelvis and thigh is the fusion of small muscle insertions into larger organs. A feature of the fetal muscles acting on the hip joint is the morpho - functional predominance of the insteps and adductor muscles that create the necessary conditions for the hip joint morphogenesis. The 20th-22th and 28th-30th weeks of intrauterine development are critical periods in human hip joint morphogenesis.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122626968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the effect of COPD on the quality of life of patients according to the results of the Cat - test in outpatient practice","authors":"T. Levina, M. D. Romanov","doi":"10.47093/22187332.2019.1.35-40","DOIUrl":"https://doi.org/10.47093/22187332.2019.1.35-40","url":null,"abstract":"The article analyzes the impact of chronic obstructive pulmonary disease (COPD) on the quality of life of patients according to the results of clinical and instrumental examination and ante - testing using the integral CAT-test.Objective. Study of the effect of COPD on the quality of life in outpatient practice based on the results of the integral CAT-test. Materials and methods. The article analyzes the impact of chronic obstructive pulmonary disease (COPD) on the quality of life of patients according to the results of clinical and instrumental examination and ante - testing using the integral CAT-test.Results. The primary treatment of patients with a long history of COPD in stages II and III recorded a greater impact of the respiratory component on the quality of life. Because of complex therapy (inhaled bronchodilators and glucocorticosteroids, antibiotics according to indications, non - pharmacological methods of pulmonary rehabilitation, respiratory gymnastics, and school for patients with COPD) during 1 year of follow - up, there were significant changes in the indicators of quality of life. In patients with the sum of scores on the SAT-test up to 20 showed a decrease in the number and severity of clinical symptoms of respiratory status, and the average value of forced expiratory volume in 1 s (FEV1) remained almost at the same level with a significant improvement in the overall quality of life. In patients with a score of 21 or higher, the FEV1 level after 1 year significantly increased by 12.2%, which is apparently due to a higher level of patient compliance and the effect of pulmonary rehabilitation measures.Conclusion. The results of assessing the impact of different stages of COPD on the quality of life of patients in outpatient practice will improve the monitoring of the course of the disease and optimize the prognosis, state the effectiveness of complex therapy and adjust the dispensary observation plan.","PeriodicalId":129151,"journal":{"name":"Sechenov Medical Journal","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117243557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}