Haemostasis最新文献_第8页

Risk Factors and Coagulation Disorders - LMWH Pharmacokinetics and Pharmacodynamics. 危险因素和凝血障碍-低分子肝素药代动力学和药效学。

Haemostasis Pub Date : 1998-11-01

引用次数: 0

Thromboprophylaxis in Pregnancy, Orthopaedic Surgery Patients and in Long-Term Strategies. 妊娠、骨科手术患者的血栓预防及其长期策略。

Haemostasis Pub Date : 1998-11-01

引用次数: 0

Glycemic control and coagulation inhibitors in diabetic patients. 糖尿病患者的血糖控制和凝血抑制剂。

Haemostasis Pub Date : 1998-11-01 DOI: 10.1159/000022447

H Altunbaş, U Karayalçin, L Undar

{"title":"Glycemic control and coagulation inhibitors in diabetic patients.","authors":"H Altunbaş, U Karayalçin, L Undar","doi":"10.1159/000022447","DOIUrl":"https://doi.org/10.1159/000022447","url":null,"abstract":"Objective: To investigate the plasma antigenic levels and functional activities of coagulation inhibitors in poorly controlled diabetic patients and the possible effect of good glycemic control on these parameters.Research design and methods: Both functional activities and plasma antigenic levels of coagulation inhibitors (antithrombin III, heparin cofactor II, protein C, and protein S) and plasma levels of C4b-binding protein were measured in 28 diabetic patients (13 males, 15 females; 2 IDDM, 26 NIDDM; median age 56.5 years; median duration of diabetes 5.5 years) with poor glycemic control (median HbA(1c) 11.8%). Twenty-three healthy subjects were enrolled as controls. Following a 3-month intensification of antihyperglycemic therapy, good glycemic control (HbA(1c) <8%) was achieved in 17 patients, and the plasma levels of the same parameters during this period were compared with baseline values.Results: Functional activities and plasma antigenic levels of coagulation inhibitors were comparable in poorly controlled diabetic patients and healthy subjects. In patients achieving good control after 3 months, there was a significant reduction in plasma antigenic levels of protein S (p = 0.005) and C4b-binding protein (p = 0.03); however, no difference could be observed in other parameters. HbA(1c) did not show any correlation with plasma antigenic levels or functional activities of coagulation inhibitors either at baseline or at 3 months of good glycemic control.Conclusions: Our findings suggest that in poorly controlled diabetic patients, coagulation inhibitors are not different from healthy controls. Short-term good glycemic control may not exert a profound effect on coagulation inhibitors except protein S and its binding protein, C4b-binding protein.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"28 6","pages":"307-12"},"PeriodicalIF":0.0,"publicationDate":"1998-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022447","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21325122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

The procoagulant effect of thrombin on fibrin(ogen)-bound platelets. 凝血酶对纤维蛋白(原)结合血小板的促凝作用。

Haemostasis Pub Date : 1998-11-01 DOI: 10.1159/000022445

M W Sanders, C M Nieuwenhuys, M A Feijge, M Rook, S Béguin, J W Heemskerk

{"title":"The procoagulant effect of thrombin on fibrin(ogen)-bound platelets.","authors":"M W Sanders, C M Nieuwenhuys, M A Feijge, M Rook, S Béguin, J W Heemskerk","doi":"10.1159/000022445","DOIUrl":"https://doi.org/10.1159/000022445","url":null,"abstract":"In a final stage of activation, platelets become procoagulant because of the appearance of phosphatidylserine (PS) at the membrane outer surface. This PS exposure requires a rise in cytosolic [Ca(2+)](i), is accompanied by formation of membrane blebs, and stimulates the formation of thrombin from its precursor prothrombin. Here, we investigated whether thrombin, as a potent platelet agonist, can induce this procoagulant response in plasma-free platelets interacting with fibrin or fibrinogen through their integrin alpha(IIb)beta(3) receptors. First, in platelets that were stimulated to spread over fibrin or fibrinogen surfaces with adrenaline, addition of thrombin and CaCl(2) caused a potent Ca(2+) signal that in about 30% of the cells was accompanied by exposure of PS. At low doses, integrin alpha(IIb)beta(3) receptor antagonist (RGD peptide) inhibited platelet spreading as well as thrombin-evoked PS exposure. Second, in platelet-fibrinogen microaggregates that were preformed in the presence of adrenaline, thrombin/CaCl(2) induced PS exposure and bleb formation of about 35% of the cells. Third, a potent, thrombin-dependent stimulation of prothrombinase activity was measured in platelet suspensions that were incubated with a fibrin clot. These results indicate that, in the absence of coagulating plasma, thrombin is a moderate inducer of the procoagulant response of platelets, once integrin alpha(IIb)beta(3)-mediated interactions are stimulated (by adrenaline) and CaCl(2) is present.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"28 6","pages":"289-300"},"PeriodicalIF":0.0,"publicationDate":"1998-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022445","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21325782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

The beneficial effect of a beta-D-xyloside, Iliparcil, in the prevention of postthrombolytic rethrombosis in the rat. 一种β - d -木糖苷，伊立帕尔，在预防大鼠溶栓后再血栓形成中的有益作用。

Haemostasis Pub Date : 1998-11-01 DOI: 10.1159/000022448

P Chicaud, J R Rademakers, J Millet

{"title":"The beneficial effect of a beta-D-xyloside, Iliparcil, in the prevention of postthrombolytic rethrombosis in the rat.","authors":"P Chicaud, J R Rademakers, J Millet","doi":"10.1159/000022448","DOIUrl":"https://doi.org/10.1159/000022448","url":null,"abstract":"The effect of Iliparcil, a new orally active beta-D-xyloside venous antithrombotic, was studied on the rethrombosis following thrombolytic therapy in rats, using a modified Umetsu model. The drug was administered by oral route prior to thrombolytic therapy, which consisted of administering a combination of heparin and urokinase (H/U) at 37.5 and 70,000 IU/kg, respectively. Time to reocclusion increased from 3.9 min with saline to 10.5 min following H/U injection. When Iliparcil (30 mg/kg, oral route) was administered 4 h before H/U injection, the time to reocclusion was increased by 250% compared with H/U alone (p < 0.001). Similarly, dermatan sulfate (DS), administered intravenously (3 mg/kg) 5 min before thrombus induction, also increased the time to reocclusion (300% compared with H/U alone; p < 0.001). It was also shown that times to reocclusion following Iliparcil or DS treatments were still increased even when heparin dosage was decreased. These results suggest that an antithrombotic product derived from the beta-D-xyloside family could be advantageously used in combination with thrombolytic treatment instead of heparin, which causes complications and side effects.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"28 6","pages":"313-20"},"PeriodicalIF":0.0,"publicationDate":"1998-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022448","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21325119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Home Treatment of Venous Thromboembolism with Low-Molecular-Weight Heparins. chairman's summary. 低分子肝素在家治疗静脉血栓栓塞。主席的总结。

Haemostasis Pub Date : 1998-11-01 DOI: 10.1159/000022409

Prandoni

引用次数: 0

Prevalence of Arg306 mutation of the factor V gene in Korean patients with thrombosis. 韩国血栓患者中V因子基因Arg306突变的发生率

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022443

K S Song, Y S Park, H K Kim, J R Choi, Q Park

{"title":"Prevalence of Arg306 mutation of the factor V gene in Korean patients with thrombosis.","authors":"K S Song, Y S Park, H K Kim, J R Choi, Q Park","doi":"10.1159/000022443","DOIUrl":"https://doi.org/10.1159/000022443","url":null,"abstract":"Accessible online at: http://BioMedNet.com/karger Dear Sir, Factor V Leiden is the most common inherited risk factor that has yet been identified for thromboembolism [1, 2]. However, this mutation has been reported to be rare in several ethnic populations including Koreans [3–5]. Recently, Chan et al. [6] analyzed 83 unrelated Hong Kong Chinese for the presence of genetic variants of factor V gene (exon 7, 10 and 13, where the codons for Arg306, Arg506, and Arg 679 are located, respectively) and the mutation in exon 10 or exon 13 was not detectable in any of the 83 subjects. However, they have identified a novel mutation (A1090G) in exon 7 that resulted in Arg306→Gly substitution in 2 thrombotic patients and 1 nonthrombotic subject. In addition, Williamson et al. [7] found Arg306→Thr mutation in 1 patient from a carefully selected group of 17 patients with venous thrombosis and confirmed activated protein C resistance in the absence of the common Gln506 mutation. Therefore, we investigated the prevalence of Arg306 mutation of factor V in Korean patients with thrombosis. The study group (49 males and 62 females) included 111 unrelated individuals (median age 57 years, range 20–86 years) who had been referred due to venous or arterial thrombotic events (21 deep vein thrombosis, 7 pulmonary embolism, 4 isolated mesenteric or portal veins, 60 stroke, 8 myocardial infarct, 11 peripheral artery obstructive diseases). Sequence variations were detected by polymerase chain reaction and restriction enzyme analysis according to Williamson et al. [7]. As a result, a normal digest pattern was detected in all 111 patients. This finding demonstrates a very low prevalence of Arg306 mutation of the factor V gene in the Korean population and this mutation may not play a major role in the pathogenesis of venous or arterial thrombosis.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"28 5","pages":"276"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022443","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21285799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Secondary prevention of venous thromboembolism: A role for low-molecular-weight heparin. 静脉血栓栓塞的二级预防:低分子肝素的作用。

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022437

M Monreal, F J Roncales, J Ruiz, J Muchart, M Fraile, J Costa, J A Hernandez

{"title":"Secondary prevention of venous thromboembolism: A role for low-molecular-weight heparin.","authors":"M Monreal, F J Roncales, J Ruiz, J Muchart, M Fraile, J Costa, J A Hernandez","doi":"10.1159/000022437","DOIUrl":"https://doi.org/10.1159/000022437","url":null,"abstract":"Background: After a short initial course of heparin therapy, patients with venous thrombo-embolism (VTE) require continuing anticoagulant therapy for several months after hospital discharge. At present, two small-scale studies have compared the efficacy and safety of low-molecular-weight heparin (LMWH) with warfarin in the secondary prevention of VTE.Patients and methods: We studied 654 consecutive patients, 202 with pulmonary embolism (PE) and 452 patients with deep vein thrombosis (DVT) of the lower limbs. 220/654 patients (34%) were considered to have some contraindications to coumarin, and were discharged on LMWH (dalteparin, Fragmin((R)), 10, 000 IU s.c. once daily). The remaining 434/654 patients were asked to choose between either coumarin or LMWH: 190 patients preferred LMWH and 244 coumarin. Patients were followed up for a 3-month (DVT patients) or 6-month (PE patients) period.Results: 14/654 patients (2%) developed recurrent VTE while on anticoagulant therapy. One in every three recurrent episodes was PE (which was fatal in 2/5 patients), and half of the recurrent DVT were located in the contralateral leg. We failed to find any differences between patients receiving LMWH and those on coumarin therapy, but recurrences were more common in patients with cancer (hazard ratio: 17.15; 95% CI: 4.0-73.5; p < 0.001). 21 patients (3.3%) bled (major bleeding 5 patients; minor bleeding 16). Bleeding was more common in patients on coumarin therapy (hazard ratio: 3.14; 95% CI: 1.20-8.22; p = 0.02).Conclusions: Long-term LMWH therapy proved to be both effective and safe in the long-term treatment of VTE. Thus, we suggest long-term LMWH therapy should be considered for patients with contraindications to coumarin, or those with difficulties in coming to laboratory control.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"28 5","pages":"236-43"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022437","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21285844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

Efficacy of unfractionated heparin, low molecular weight heparin and both combined for releasing total and free tissue factor pathway inhibitor. 未分离肝素、低分子量肝素及两者联合释放总组织因子和游离组织因子途径抑制剂的疗效。

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022436

R Altman, A Scazziota, J Rouvier

{"title":"Efficacy of unfractionated heparin, low molecular weight heparin and both combined for releasing total and free tissue factor pathway inhibitor.","authors":"R Altman, A Scazziota, J Rouvier","doi":"10.1159/000022436","DOIUrl":"https://doi.org/10.1159/000022436","url":null,"abstract":"Unfractionated heparin (UFH) exerts its anticoagulant properties by increasing the inactivation of thrombin and activated factor X by antithrombin III. Apart from this main action release of tissue factor pathway inhibitor (TFPI) from endothelial cells could also be important for the antithrombotic activity of heparins. Four different heparin preparations were injected subcutaneously into 5 healthy volunteers 1 week apart: (1) UFH 2,500 IU fix dose (FixUFH), (2) 1 mg/kg body weight of low molecular weight heparin (LMWH), (3) the combined LMWH-adjusted dose plus UFH 2,500 IU fix dose (ComHep) and (4) UFH 2,500 IU/10 kg body weight (UFHvar). Plasma samples were drawn before and 1, 2, 4, 6, 12 and 24 h afterwards. FixUFH did not affect the concentration of total and free TFPI. Total TFPI increased in the 1st hour after LMWH injection from 74 to 124 ng/ml (p < 0.01), after ComHep from 82 to 144 ng/ml (p < 0.01), and after UFHvar from 91 to 113 ng/ml (p < 0.05). All observed elevations were significant at the peak value (+/- 2 h, p < 0.01 compared with baselines). The increase of free TFPI produced by UFHvar (74.5 and 70.5 ng/ml) was significantly higher than with LMWH (42.8 and 38.0 ng/ml) at 2 and 4 h (p < 0.001 and p < 0.01, respectively). UFHvar and ComHep but not LMWH produced a statistically significant increase of free TFPI compared with FixUFH at 2, 4 and 6 h (p < 0. 01). We concluded that at comparable therapeutic doses, subcutaneous UFHvar released more free TFPI than LMWH and ComHep. A synergism between LMWH and low dose of UFH was found in 4-, 6- and 12-hour blood samples.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"28 5","pages":"229-35"},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022436","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21285154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Antibodies against factor VIII in patients with solid tumors: successful treatment of cancer may suppress inhibitor formation. 实体瘤患者抗因子VIII抗体:成功治疗癌症可能抑制抑制剂的形成。

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022438

S Sallah, P Singh, L R Hanrahan

引用次数: 31