Haemostasis最新文献_第9页

High-dose dexamethasone for splenectomy in patients with idiopathic thrombocytopenic purpura. 大剂量地塞米松用于特发性血小板减少性紫癜患者脾切除术。

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022440

S Bulvik, A Winder, O Ben-Tal, A Szold, A Eldor

引用次数: 7

Adenosine 5'-diphosphate-induced platelet aggregation in uremia shows resistance to inhibition by the novel nitric oxide donor GEA 3175 but not by S-nitroso-N-acetylpenicillamine. 腺苷5′-二磷酸诱导的尿毒症血小板聚集对新型一氧化氮供体GEA 3175的抑制有抵抗力，但对s -亚硝基-n -乙酰青霉胺的抑制没有抵抗力。

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022441

P A Whiss, R Larsson

{"title":"Adenosine 5'-diphosphate-induced platelet aggregation in uremia shows resistance to inhibition by the novel nitric oxide donor GEA 3175 but not by S-nitroso-N-acetylpenicillamine.","authors":"P A Whiss, R Larsson","doi":"10.1159/000022441","DOIUrl":"https://doi.org/10.1159/000022441","url":null,"abstract":"Both bleeding and thrombosis are complications of uremia in patients on regular hemodialysis. An excessive endogenous formation of the vasodilator and platelet inhibitor nitric oxide (NO) has been proposed to contribute to the bleeding defect. Since exposure to pharmacological donors of NO, nitrovasodilators, can cause tolerance to NO, we investigated whether platelets from uremic patients on regular hemodialysis are influenced differently by NO donors than platelets from healthy subjects. A frequently used S-nitrosothiol, S-nitroso-N-acetylpenicillamine (SNAP), was compared to a recently synthezised mesoionic oxatriazole derivate, GEA 3175, regarding its capacity to inhibit adenosine 5'-diphosphate (ADP)-induced platelet aggregation in vitro. The final products of NO production, nitrite + nitrate, were found to be significantly increased in uremic patients. The capacity to inhibit platelet aggregation by SNAP was only slightly different between the groups. However, GEA 3175 showed a significantly marked and reduced capacity to inhibit aggregation of uremic platelets compared to controls. Interactions of erythropoietin (EPO) with NO have earlier been reported. Addition of EPO to platelets from healthy donors in vitro did not significantly influence the NO donor capacity to inhibit platelet aggregation, but showed a tendency to enhance the effect of SNAP while the effect of GEA 3175 was inhibited. These results suggest compound-specific resistance to NO donors in uremic platelet activation.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21286342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Massive intracranial bleeding requiring emergency splenectomy in a patient with CMV-associated thrombocytopenia. 巨细胞病毒相关血小板减少症患者大量颅内出血需要紧急脾切除术。

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022439

A Gural, S Gillis, A Gafanovich, Z Israel, D Wolf, S Pomeranz, D Ben-Yehuda

引用次数: 20

Relation between carotid intima-media thickness, platelet surface activation and endothelial cell markers. 颈动脉内膜-中膜厚度、血小板表面活化与内皮细胞标志物的关系。

Haemostasis Pub Date : 1998-09-01 DOI: 10.1159/000022442

N Ramsis, A A El-Hawary, E Ismail

{"title":"Relation between carotid intima-media thickness, platelet surface activation and endothelial cell markers.","authors":"N Ramsis, A A El-Hawary, E Ismail","doi":"10.1159/000022442","DOIUrl":"https://doi.org/10.1159/000022442","url":null,"abstract":"Background: The role of platelet activation and endothelial cell damage in the pathogenesis of atherosclerosis was investigated.Methods: Flow-cytometric detection of platelet activity was accomplished by measuring the surface expression of activated platelet glycoprotein IIb/IIIa (activated CD41) and the lysosomal integral membrane protein (CD63). Levels of thrombomodulin (TM) and von Willebrand factor (vWF) were estimated by the ELISA technique as markers of endothelial cell damage. These procedures were performed in healthy male subjects without obvious signs of atherosclerosis. Also, the intima-media thickness of the carotid artery was measured with high-resolution B- mode ultrasound to quantitate the presence and/or the extent of carotid atherosclerosis.Results: According to ultrasound findings patients were divided into those with apparent evidence of atherosclerosis (AS+) with intima-media thickness >1.1 mm (n = 19) and those without such evidence (AS-) with intima-media thickness <1.1 mm (n = 17). The percentages of activated CD41 and CD63 surface antigen expression were significantly increased in the AS+ compared to AS- subjects. TM levels were elevated in the former group compared to the latter, while vWF levels were not different in the two groups. Multivariate analysis indicated the independent association of carotid atherosclerosis with each of the expression of activated CD41, CD63 as well as TM levels after adjustment of other risk factors.Conclusion: This study demonstrates that platelets circulate in an enhanced activation state in asymptomatic atherosclerosis, which is closely related to the degree of endothelial cell damage as expressed by increased plasma levels of TM. The detection of platelet activation can be used as a potential marker for oncoming atherosclerosis.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1998-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022442","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21285845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Epidemiology of post-stroke dementia. 脑卒中后痴呆的流行病学。

Haemostasis Pub Date : 1998-05-01 DOI: 10.1159/000022424

F van Kooten, P J Koudstaal

引用次数: 24

Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study. 痴呆患者和非痴呆患者对活化蛋白C的反应。荷兰痴呆研究中的血管因素。

Haemostasis Pub Date : 1998-05-01 DOI: 10.1159/000022432

M L Bots, F van Kooten, M M Breteler, P E Slagboom, A Hofman, F Haverkate, P Meijer, P J Koudstaal, D E Grobbee, C Kluft

引用次数: 19

Role of platelet activation in dementia. 血小板活化在痴呆中的作用。

Haemostasis Pub Date : 1998-05-01 DOI: 10.1159/000022431

F van Kooten, G Ciabattoni, C Patrono, P J Koudstaal