Archiv der Pharmazie最新文献_第7页

Amorphous silica nanoparticles exhibit antitumor activity in triple-negative breast cancer cells 无定形二氧化硅纳米粒子对三阴性乳腺癌细胞具有抗肿瘤活性

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-09-10 DOI: 10.1002/ardp.202400316

Agustina Ibarra, María Julia Ferronato, Valentina Clemente, Anabel Barrientos, Eliana Noelia Alonso, María Eugenia Fermento, Georgina Pamela Coló, María Marta Facchinetti, Alejandro Carlos Curino, Mariela Agotegaray

{"title":"Amorphous silica nanoparticles exhibit antitumor activity in triple-negative breast cancer cells","authors":"Agustina Ibarra, María Julia Ferronato, Valentina Clemente, Anabel Barrientos, Eliana Noelia Alonso, María Eugenia Fermento, Georgina Pamela Coló, María Marta Facchinetti, Alejandro Carlos Curino, Mariela Agotegaray","doi":"10.1002/ardp.202400316","DOIUrl":"10.1002/ardp.202400316","url":null,"abstract":"Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is mainly treated with cytotoxic chemotherapy. However, this treatment is not always effective, and an important percentage of patients develop recurrence. Nanomaterials are emerging as alternative treatment options for various diseases, including cancer. This work reports the synthesis, characterization, antitumor activity evaluation, and sub-acute toxicity studies of two formulations based on amorphous silica nanoparticles (SiNPs). They are functionalized with 3-aminopropyltriethoxisilane (Si@NH2) and folic acid (FA; Si@FA). The results show that SiNPs reduce the viability and migration of TNBC MDA-MB-231 and 4T1 cell lines and Si@FA do not affect the growth of the mammary nonmalignant HC11 cells. In addition, Si@FA induces reactive oxygen species (ROS) generation and displays antiproliferative and subsequently proapoptotic effects in MDA-MB-231 cells. Moreover, none of the SiNPs cause signs of sub-acute toxicity in mice when administered at 30 mg/kg over a month. In conclusion, these nanosystems display intrinsic antitumor activity without causing toxic in vivo effects, being a promising therapeutic alternative for TNBC.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142218850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From dyes to drugs: The historical impact and future potential of dyes in drug discovery 从染料到药物：染料在药物发现中的历史影响和未来潜力。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-09-06 DOI: 10.1002/ardp.202400532

Mohammad Amin Manavi, Mohammadreza Salehi, Razieh Mohammad Jafari, Ahmad Reza Dehpour

引用次数: 0

Exploring the chemical space around chrysin to develop novel vascular CaV1.2 channel blockers, promising vasorelaxant agents 探索蛹虫草素周围的化学空间，开发新型血管 CaV1.2 通道阻断剂和有前景的血管舒张剂。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-09-06 DOI: 10.1002/ardp.202400536

Federica Falbo, Gabriele Carullo, Alice Panti, Ottavia Spiga, Beatrice Gianibbi, Amer Ahmed, Giuseppe Campiani, Anna Ramunno, Francesca Aiello, Fabio Fusi

{"title":"Exploring the chemical space around chrysin to develop novel vascular CaV1.2 channel blockers, promising vasorelaxant agents","authors":"Federica Falbo, Gabriele Carullo, Alice Panti, Ottavia Spiga, Beatrice Gianibbi, Amer Ahmed, Giuseppe Campiani, Anna Ramunno, Francesca Aiello, Fabio Fusi","doi":"10.1002/ardp.202400536","DOIUrl":"10.1002/ardp.202400536","url":null,"abstract":"The flavonoid chrysin is an effective vascular CaV1.2 channel blocker. The aim of this study was to explore the chemical space around chrysin to identify the structural features that can be modified to develop novel and more effective blockers. Four derivatives (Chrysin 1–4) were synthesised and a functional, electrophysiology and molecular docking approach was pursued to assess their binding mode to CaV1.2 channels and their activity in vascular preparations. Methylation of the 5- and 7-OH of the chrysin backbone caused a marked reduction of the Ca2+ antagonistic potency and efficacy. However, C-8 derivatives showed biophysical features similar to those of the parent compound and, like nicardipine, bound with high affinity to and stabilised the CaV1.2 channel in its inactivated state. The vasorelaxant effects of the four derivatives appeared vessel-specific, addressing the molecules' derivatization towards different targets. In conclusion, the scaffold of chrysin may be considered a valuable starting point for the development of innovative vascular CaV1.2 channel blockers.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking 芙蓉五味子通过恢复氧化还原平衡和抑制大鼠的炎症反应促进伤口愈合：代谢组分析和分子对接的启示。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-09-06 DOI: 10.1002/ardp.202400392

Mariam I. Gamal El-Din, Eman M. Mantawy, Riham S. Said, Nouran M. Fahmy, Shaimaa Fayez, Mai I. Shahin, Maha Nasr, Ahmed M. Elissawy, Abdel Nasser B. Singab

{"title":"Hibiscus schizopetalus boosts wound healing via restoring redox balance and hindering inflammatory responses in rats: Insights on metabolome profiling and molecular docking","authors":"Mariam I. Gamal El-Din, Eman M. Mantawy, Riham S. Said, Nouran M. Fahmy, Shaimaa Fayez, Mai I. Shahin, Maha Nasr, Ahmed M. Elissawy, Abdel Nasser B. Singab","doi":"10.1002/ardp.202400392","DOIUrl":"10.1002/ardp.202400392","url":null,"abstract":"Hibiscus species (Malvaceae) possess a plethora of appealing pharmacological activities with an extended history of customary use in diverse medical conditions. The present study aimed at comparing the metabolomic analyses of three Hibiscus species native to Egypt, namely H. tiliaceus, H. schizopetalus extract (HSE), and H. rosa-sinensis, alongside identifying a promising natural wound healing candidate. Chemical profiling of the leaf extracts was achieved via UPLC-ESI/MS/MS-guided analysis that resulted in the tentative identification of a total of 48 secondary metabolites pertaining to phenolic acids, flavonoids, anthocyanins, fatty acids, and fatty amides. Remarkably, in vitro studies revealed that HSE exhibited the topmost wound healing activity. Subsequently, HSE was formulated into hydro- and nanogel (1% w/v) formulations for further assessing its efficacy in the wound excision model. HSE-nanogel demonstrated a significant in vivo wound contraction activity alongside improving histopathological abnormalities. Mechanistically, HSE-nanogel upregulated the wound antioxidant status through increasing the levels of reduced glutathione (GSH) and catalase activity. Moreover, HSE-nanogel suppressed the wound inflammatory responses by diminishing the expressions of NF-ĸB, TNF-α, and IL-6. Molecular docking studies were performed on HSE's major constituents using CDOCKER, which further supported the in vivo findings. Collectively, HSE nanogel exhibits notable aptitude as a wound-healing agent, warranting further clinical appraisal.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chalcone-based benzenesulfonamides as potent and selective inhibitors for human carbonic anhydrase II: Design, synthesis, in vitro, and in silico studies 基于查耳酮的苯磺酰胺类化合物作为人类碳酸酐酶 II 的强效选择性抑制剂：设计、合成、体外和硅学研究。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-09-06 DOI: 10.1002/ardp.202400069

Hwa Young Lee, Ahmed Elkamhawy, Ahmed A. Al-Karmalawy, Hossam Nada, Simone Giovannuzzi, Claudiu T. Supuran, Kyeong Lee

{"title":"Chalcone-based benzenesulfonamides as potent and selective inhibitors for human carbonic anhydrase II: Design, synthesis, in vitro, and in silico studies","authors":"Hwa Young Lee, Ahmed Elkamhawy, Ahmed A. Al-Karmalawy, Hossam Nada, Simone Giovannuzzi, Claudiu T. Supuran, Kyeong Lee","doi":"10.1002/ardp.202400069","DOIUrl":"10.1002/ardp.202400069","url":null,"abstract":"Sulfonamides are promising classical carbonic anhydrase (CA; EC 4.2.1.1) inhibitors, being used for several medical purposes such as diuretics, anticonvulsants, topically acting antiglaucoma agents, for antiobesity and anticancer therapies. Herein, a series of chalcone-based benzenesulfonamides (3a‒m) was synthesized and assessed for its inhibitory activity against a panel of four human carbonic anhydrases (hCA isoforms I, II, IX, and XII). Most compounds displayed single- to double-digit nanomolar inhibition constants (Kis), with some derivatives being more potent and/or selective than the standard drug acetazolamide (AAZ). Among the synthesized compounds, 3g compound demonstrated the highest inhibitory activity against the hCA II isoform (Ki = 2.5 nM) with 30-, 9-, and 11-fold selectivity for hCA II over the I, IX, and XII isoforms, respectively. Structure–activity relationships for different substitution patterns were analyzed. Additionally, a molecular docking study showed that compound 3g bound to hCA II by coordinating with the zinc ion through the deprotonated benzenesulfonamide moiety, in addition to a hydrogen bond formed between an oxygen of the sulfonamide moiety and Thr199. Moreover, the chalcone core participated in van der Waals interactions with some active site residues, such as Ile91, Val121, and Leu198. Consequently, this report introduces a successful approach toward identifying compound 3g as a highly potent and selective chalcone-based benzenesulfonamide inhibitor of hCA II worthy of further investigation.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ardp.202400069","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142138746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Insights into medicinal attributes of imidazo[1,2-a]pyridine derivatives as anticancer agents 深入了解咪唑并[1,2-a]吡啶衍生物作为抗癌剂的药用特性。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-09-02 DOI: 10.1002/ardp.202400402

Ankush Kumar, Vishakha Sharma, Tapan Behl, Subbulakshmi Ganesan, Deepak Nathiya, Monica Gulati, Mohammad Khalid, Gehan M. Elossaily, Sridevi Chigurupati, Monika Sachdeva

{"title":"Insights into medicinal attributes of imidazo[1,2-a]pyridine derivatives as anticancer agents","authors":"Ankush Kumar, Vishakha Sharma, Tapan Behl, Subbulakshmi Ganesan, Deepak Nathiya, Monica Gulati, Mohammad Khalid, Gehan M. Elossaily, Sridevi Chigurupati, Monika Sachdeva","doi":"10.1002/ardp.202400402","DOIUrl":"10.1002/ardp.202400402","url":null,"abstract":"Cancer ranks among the most life-threatening diseases worldwide and is continuously affecting all age groups. Consequently, many research studies are being carried out to develop new cancer treatments, but many of them experience resistance and cause severe toxicity to the patients. Therefore, there is a continuous need to design novel anticancer agents that are target-based, have a higher potency, and have minimal toxicity. The imidazo[1,2-a]pyridine (IP) pharmacophore has been found to be a prominent moiety in the field of medicinal chemistry due to its vast biological properties. Also, it holds immense potential for combating cancer with minimal side effects, depending on the substitution patterns of the core structure. IPs exhibit significant capability in regulating various cellular pathways, offering possibilities for targeted anticancer effects. The present review summarizes the anticancer profile of numerous IP derivatives synthesized and developed by various researchers from 2016 till now, as inhibitors of phosphoinositide-3-kinase/mammalian target of rapamycin (PI3K/mTOR), protein kinase B/mammalian target of rapamycin (Akt/mTOR), aldehyde dehydrogenase (ALDH), and tubulin polymerization. This review provides a comprehensive analysis of the anticancer activity afforded by the discussed IP compounds, emphasizing the structure–activity-relationships (SARs). The aim is also to underscore the potential therapeutic future of the IP moiety as a potent partial structure for upcoming cancer drug development and to aid researchers in the field of rational drug design.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Issue Information: Arch Pharm (9/2024) 发行信息：Arch Pharm（9/2024）

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-09-01 DOI: 10.1002/ardp.202470036

引用次数: 0

Cyclization of acyl thiosemicarbazides led to new Helicobacter pylori α-carbonic anhydrase inhibitors 酰基硫代氨基甲酰肼的环化导致了新的幽门螺旋杆菌α-碳酸酐酶抑制剂的产生。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-08-29 DOI: 10.1002/ardp.202400548

Arzu Gumus, Ilaria D'Agostino, Valentina Puca, Valentina Crocetta, Simone Carradori, Luigi Cutarella, Mattia Mori, Fabrizio Carta, Andrea Angeli, Clemente Capasso, Claudiu T. Supuran

{"title":"Cyclization of acyl thiosemicarbazides led to new Helicobacter pylori α-carbonic anhydrase inhibitors","authors":"Arzu Gumus, Ilaria D'Agostino, Valentina Puca, Valentina Crocetta, Simone Carradori, Luigi Cutarella, Mattia Mori, Fabrizio Carta, Andrea Angeli, Clemente Capasso, Claudiu T. Supuran","doi":"10.1002/ardp.202400548","DOIUrl":"10.1002/ardp.202400548","url":null,"abstract":"The eradication of Helicobacter pylori, the etiologic agent of gastric ulcer and adenocarcinoma, is a big concern in clinics due to the increasing drug resistance phenomena and the limited number of efficacious treatment options. The exploitation of the H. pylori carbonic anhydrases (HpCAs) as promising pharmacological targets has been validated by the antibacterial activity of previously reported CA inhibitors due to the role of these enzymes in the bacterium survival in the gastric mucosa. The development of new HpCA inhibitors seems to be on the way to filling the existing antibiotics gap. Due to the recent evidence on the ability of the coumarin scaffold to inhibit microbial α-CAs, a large library of derivatives has been developed by means of a pH-regulated cyclization reaction of coumarin-bearing acyl thiosemicarbazide intermediates. The obtained 1,3,4-thiadiazoles (10–18a,b) and 1,2,4-triazole-3-thiones (19–26a,b) were found to strongly and selectively inhibit HpαCA and computational studies were fundamental to gaining an understanding of the interaction networks governing the enzyme–inhibitor complex. Antibacterial evaluations on H. pylori ATCC 43504 highlighted some compounds that maintained potency on a resistant clinical isolate. Also, their combinations with metronidazole decreased both the minimal inhibitory concentration and minimal bactericidal concentration values of the antibiotic, with no synergistic effect.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ardp.202400548","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142102526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

DNA interaction of selected tetrahydropyrimidine and its effects against CCl4-induced hepatotoxicity in vivo: Part II 精选四氢嘧啶的 DNA 相互作用及其对四氯化碳诱导的体内肝毒性的影响：第二部分。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-08-27 DOI: 10.1002/ardp.202400409

Emilija Milović, Sanja Lj. Matić, Jelena S. Katanić Stanković, Nikola Srećković, Ignjat Filipović, Jovana Bradić, Anica Petrović, Vladimir Jakovljević, Natalia Busto Vazquez, Nenad Janković

{"title":"DNA interaction of selected tetrahydropyrimidine and its effects against CCl4-induced hepatotoxicity in vivo: Part II","authors":"Emilija Milović, Sanja Lj. Matić, Jelena S. Katanić Stanković, Nikola Srećković, Ignjat Filipović, Jovana Bradić, Anica Petrović, Vladimir Jakovljević, Natalia Busto Vazquez, Nenad Janković","doi":"10.1002/ardp.202400409","DOIUrl":"10.1002/ardp.202400409","url":null,"abstract":"Tetrahydropyrimidine (compound A = methyl 4-[4′-(heptyloxy)-3′-methoxyphenyl]-1,6-dimethyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate) was chosen for in vivo studies after exhibiting noteworthy in vitro activity against the K562 and MDA-MB-231 cell lines, with IC50 values of 9.20 ± 0.14 µM and 12.76 ± 1.93 µM, respectively. According to experimental (fluorescence titration, viscosity, and differential scanning calorimetry) results, A interacts with DNA via the minor groove. In vivo, acute oral toxicity studies in Wistar albino rats proved no noticeable symptoms of either toxicity or death during the follow-up period. Genotoxic and antigenotoxic studies at three different concentrations of A (5, 10, and 20 mg/kg of body weight) in Wistar albino rats showed that the dose of 5 mg/kg body weight did not cause DNA damage and had a remarkable DNA protective activity against CCl4-induced DNA damage, with a percentage reduction of 78.7%. It is also important to note that, under the investigated concentrations of A, liver damage is not observed. Considering all experimental outcomes realized under various in vivo investigations (acute oral toxicity, genotoxicity, antigenotoxicity, and biochemical tests), compound A could be a promising candidate for further clinical testing.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142071517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Green preparation and evaluation of the anti-psoriatic activity of vesicular elastic nanocarriers of kojic acid from Aspergillus oryzae N12: Repurposing of a dermo-cosmetic lead 来自黑曲霉 N12 的曲酸囊泡弹性纳米载体的绿色制备和抗银屑病活性评估：一种皮肤化妆品先导物的再利用。

IF 4.3 3区医学

Archiv der Pharmazie Pub Date : 2024-08-23 DOI: 10.1002/ardp.202400410

Ashaimaa Y. Moussa, Haidy Abbas, Mariam Zewail, Passent M. E. Gaafar, Nehal Ibrahim

{"title":"Green preparation and evaluation of the anti-psoriatic activity of vesicular elastic nanocarriers of kojic acid from Aspergillus oryzae N12: Repurposing of a dermo-cosmetic lead","authors":"Ashaimaa Y. Moussa, Haidy Abbas, Mariam Zewail, Passent M. E. Gaafar, Nehal Ibrahim","doi":"10.1002/ardp.202400410","DOIUrl":"10.1002/ardp.202400410","url":null,"abstract":"Psoriasis is a skin disorder characterized by impaired epidermal differentiation that is regularly treated by systemic drugs with undesirable side effects. Based on its anti-inflammatory, antiproliferative and anti-melanoma attributes, the fungal metabolite kojic acid represents an attractive candidate for anti-psoriatic research. The present work aims to investigate an efficient topical bio-friendly vesicular system loaded with kojic acid isolated from Aspergillus oryzae as an alternative way for the management of psoriasis to avoid systemic toxicity. Kojic acid-loaded spanlastics were prepared by ethanol injection technique, employing span 60 along with brij 35 and cremophor rh40 as edge activators, with the complete in vitro characterization of the developed nanoplatform. The selected formulation displayed a spherical morphology, an optimum particle size of 234.2 ± 1.65 nm, high entrapment efficiency (87.4% ± 0.84%) and significant sustained drug release compared with the drug solution. In vivo studies highlighted the superior relief of psoriasis symptoms and the ability to maintain healthy skin with the least changes in mRNA expression of inflammatory cytokines, achieved by the developed nanoplatform compared to kojic acid solution. Moreover, the in vivo histopathological studies confirmed the safety of the topically applied spanlastics. In addition, the molecular mechanism was approached through in vitro assessment of cathepsin S and PDE-4 inhibitory activities and in silico investigation of kojic acid docking in several anti-psoriatic drug targets. Our results suggest that a topically applied vesicular system loaded with kojic acid could lead to an expansion in the dermo-cosmetic use of kojic acid as a natural bio-friendly alternative for systemic anti-psoriatic drugs.","PeriodicalId":128,"journal":{"name":"Archiv der Pharmazie","volume":"357 11","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142046018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0