Heart rhythmPub Date : 2025-01-01Epub Date: 2024-07-04DOI: 10.1016/j.hrthm.2024.07.003
William T C Procter, Jonathan Bennett, James Elliott, Rok Mravljak, George D Thornton, Nikoo Aziminia, Francisco Gama, Christian Nitsche, Zoe Carter, Jincymol Binoy, Christopher Monkhouse, Mark Earley, Ross J Hunter, Thomas A Treibel
{"title":"Safety of ward-based, non-physician-led, cardiac monitor implantation.","authors":"William T C Procter, Jonathan Bennett, James Elliott, Rok Mravljak, George D Thornton, Nikoo Aziminia, Francisco Gama, Christian Nitsche, Zoe Carter, Jincymol Binoy, Christopher Monkhouse, Mark Earley, Ross J Hunter, Thomas A Treibel","doi":"10.1016/j.hrthm.2024.07.003","DOIUrl":"10.1016/j.hrthm.2024.07.003","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":"271-272"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141544767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01DOI: 10.1016/j.hrthm.2024.09.051
George J Klein, Raymond Yee
{"title":"Operative therapy for cardiac arrhythmias: Setting the stage for catheter ablation.","authors":"George J Klein, Raymond Yee","doi":"10.1016/j.hrthm.2024.09.051","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.09.051","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"22 1","pages":"4-5"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01Epub Date: 2024-06-28DOI: 10.1016/j.hrthm.2024.06.047
Nicholas Weinand, Tiffany Hu, Kanae Hasegawa, Arvind Kanagasundram, Harikrishna Tandri, William Stevenson, Travis Richardson
{"title":"Distribution of myocardial fibrosis in patients with nonischemic cardiomyopathy and ventricular tachycardia based on genetic variant.","authors":"Nicholas Weinand, Tiffany Hu, Kanae Hasegawa, Arvind Kanagasundram, Harikrishna Tandri, William Stevenson, Travis Richardson","doi":"10.1016/j.hrthm.2024.06.047","DOIUrl":"10.1016/j.hrthm.2024.06.047","url":null,"abstract":"<p><strong>Background: </strong>Many genetic nonischemic dilated cardiomyopathies (NICMs) cause ventricular tachycardias (VTs) originating from scar substrate identified as areas of low electrogram voltage. Substrate locations vary, and the causes of scar are not well defined.</p><p><strong>Objective: </strong>This study evaluated VT substrate locations in genetic NICM patients undergoing VT ablation to evaluate spatial relationships between specific variants and substrate locations.</p><p><strong>Methods: </strong>In this retrospective case series analysis, 32 patients (aged 55 ± 16 years; 94% male; left ventricular ejection fraction, 34% ± 13%) with genetic NICM referred for VT ablation between October 2018 and November 2022 at a single medical center were evaluated. Scar locations were defined as areas of low unipolar or bipolar voltage.</p><p><strong>Results: </strong>Of the 32 patients evaluated, mutations in TTN (n = 11), LMNA (n = 6), PKP2 (n = 5), MYBPC3 (n = 3), DSP (n = 2), TTR (n = 1), FLNC (n = 1), AGL (n = 1), DES (n = 1), and DSG2 (n = 1) were observed. Substrates associated with mutations in TTN were observed only in basal subregions, predominantly anterior (100%) and septal (50%) regions. LMNA mutations were associated with fibrosis in mid inferolateral (60%) and apical inferolateral (60%) regions. Substrate location for individuals with PKP2 mutations was solely observed in the right ventricle, predominantly basal inferolateral regions.</p><p><strong>Conclusion: </strong>Understanding spatial relationships between genetic variants causing NICM and VT substrate locations can help lead to generalizable regions in patients with genetically related NICM presenting in VT, which can be investigated during ablation procedures.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":"100-105"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01Epub Date: 2024-07-02DOI: 10.1016/j.hrthm.2024.06.058
Patrick Badertscher, Sven Knecht, Raphael Rosso, Philipp Krisai, David Spreen, Josip Katic, Jeanne Du Fay de Lavallaz, Christian Sticherling, Michael Kühne
{"title":"How to perform pulmonary vein isolation using a pentaspline pulsed field ablation system for treatment of atrial fibrillation.","authors":"Patrick Badertscher, Sven Knecht, Raphael Rosso, Philipp Krisai, David Spreen, Josip Katic, Jeanne Du Fay de Lavallaz, Christian Sticherling, Michael Kühne","doi":"10.1016/j.hrthm.2024.06.058","DOIUrl":"10.1016/j.hrthm.2024.06.058","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":"69-79"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01Epub Date: 2024-06-20DOI: 10.1016/j.hrthm.2024.06.028
Leonard A Dijkshoorn, Lonneke Smeding, Shari Pepplinkhuizen, Jolien A de Veld, Reinoud E Knops, Louise R A Olde Nordkamp
{"title":"Fifteen years of subcutaneous implantable cardioverter-defibrillator therapy: Where do we stand, and what will the future hold?","authors":"Leonard A Dijkshoorn, Lonneke Smeding, Shari Pepplinkhuizen, Jolien A de Veld, Reinoud E Knops, Louise R A Olde Nordkamp","doi":"10.1016/j.hrthm.2024.06.028","DOIUrl":"10.1016/j.hrthm.2024.06.028","url":null,"abstract":"<p><p>The subcutaneous implantable cardioverter-defibrillator (S-ICD) has emerged as a feasible alternative to the transvenous ICD in the treatment of ventricular tachyarrhythmias in patients without indications for pacing or cardiac resynchronization therapy. Since its introduction, numerous innovations have been made and clinical experience has been gained, leading to its adoption in current practice and preference in certain populations. Moreover, emerging technologies like the extravascular ICD and the combination of the S-ICD with the leadless pacemaker offer new possibilities for the future. These advancements underscore the evolving role of the S-ICD in management of ventricular tachyarrhythmias. This review outlines implantation considerations, patient selection, and troubleshooting advancements in the last 15 years and provides insights into future perspectives.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":"150-158"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141440414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ruxolitinib as a CaMKII inhibitor for treatment of cardiac arrhythmias: Applications and prospects.","authors":"Qingbo Guo, Yiran Huo, Qiming Liu, Shenghua Zhou, Yichao Xiao","doi":"10.1016/j.hrthm.2024.07.118","DOIUrl":"10.1016/j.hrthm.2024.07.118","url":null,"abstract":"<p><p>Recent studies have highlighted the critical role of calcium/calmodulin-dependent protein kinase II (CaMKII) overactivation in the pathogenesis of various cardiac arrhythmias. Ruxolitinib, a Janus kinase inhibitor widely used for the treatment of myelofibrosis and acute graft-vs-host disease, has expanded its research horizons to include its potential as a CaMKII inhibitor in the treatment of cardiac arrhythmias. This article reviews the basic pharmacologic properties of ruxolitinib and delves into the role of CaMKII in cardiac arrhythmias, including its structural fundamentals, activation mechanisms, and association with arrhythmic conditions. Furthermore, the current state of CaMKII inhibitor research is discussed, with a special focus on the advances and clinical potential of ruxolitinib in this field. Studies indicate that ruxolitinib effectively inhibits CaMKII activity and has therapeutic potential against cardiac arrhythmias in animal models and at the cellular level. In addition, we address the critical issues that need to be resolved before the clinical application of ruxolitinib in arrhythmia treatment, including dosage concerns, long-term inhibitory effects, potential impacts on the nervous system, and efficacy across different types of arrhythmias. Future research directions involve further exploration of the clinical application potential of ruxolitinib, particularly in diseases such as heart failure, hypertrophic cardiomyopathy, dilated cardiomyopathy, and ischemic arrhythmias. In summary, the efficacy, low toxicity, and safety profile of ruxolitinib as a CaMKII inhibitor in the treatment of cardiac arrhythmias suggest a promising future for its development as a therapeutic drug in this domain.</p>","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":"231-239"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141901465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01DOI: 10.1016/j.hrthm.2024.08.043
David S Park, John Santucci, Samantha Hall
{"title":"Advances in transcriptional regulation of the heart rhythm.","authors":"David S Park, John Santucci, Samantha Hall","doi":"10.1016/j.hrthm.2024.08.043","DOIUrl":"10.1016/j.hrthm.2024.08.043","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"22 1","pages":"287-288"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11706356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01DOI: 10.1016/j.hrthm.2024.11.013
Bettina F Cuneo
{"title":"Fetal long QT syndrome.","authors":"Bettina F Cuneo","doi":"10.1016/j.hrthm.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.11.013","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"22 1","pages":"285-286"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01DOI: 10.1016/j.hrthm.2024.11.025
Sami Viskin
{"title":"HeartRhythm 2025: State of the Journal.","authors":"Sami Viskin","doi":"10.1016/j.hrthm.2024.11.025","DOIUrl":"https://doi.org/10.1016/j.hrthm.2024.11.025","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":"22 1","pages":"1-2"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Heart rhythmPub Date : 2025-01-01Epub Date: 2024-06-25DOI: 10.1016/j.hrthm.2024.06.044
Masaaki Yokoyama, Konstantinos Vlachos, Thomas Pambrun, Nicolas Derval, Pierre Jaïs, Josselin Duchateau
{"title":"Importance of extracardiac vagal stimulation during catheter ablation for vagal atrial fibrillation: What is the hidden trigger?","authors":"Masaaki Yokoyama, Konstantinos Vlachos, Thomas Pambrun, Nicolas Derval, Pierre Jaïs, Josselin Duchateau","doi":"10.1016/j.hrthm.2024.06.044","DOIUrl":"10.1016/j.hrthm.2024.06.044","url":null,"abstract":"","PeriodicalId":12886,"journal":{"name":"Heart rhythm","volume":" ","pages":"65-68"},"PeriodicalIF":5.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141467550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}