Gut and Liver最新文献_第3页

Sex Differences in the Effect of Changes in Body Mass Index on the Risk of Developing Gastric Cancer: Findings from a Nationwide Retrospective Cohort Study. 体重指数变化对胃癌发生风险影响的性别差异：一项全国性回顾性队列研究的结果

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-25 DOI: 10.5009/gnl240555

Jieun Jang, Yonghoon Choi, Nayoung Kim

{"title":"Sex Differences in the Effect of Changes in Body Mass Index on the Risk of Developing Gastric Cancer: Findings from a Nationwide Retrospective Cohort Study.","authors":"Jieun Jang, Yonghoon Choi, Nayoung Kim","doi":"10.5009/gnl240555","DOIUrl":"https://doi.org/10.5009/gnl240555","url":null,"abstract":"Background/aims: This study examined sex differences in the effect of changes in body mass index (BMI) on the development of gastric cancer (GC) in South Korea.Methods: Using data from the National Health Insurance Service-Health Screening Cohort, a retrospective cohort study involving 333,169 Koreans with a median follow-up of 12 years was conducted. BMI was categorized into five groups (<18.5, 18.5-22.9, 23.0-24.9 [reference], 25.0-29.9, and ≥30.0 kg/m2) and the risk of developing GC was evaluated according to changes in BMI by calculating the hazard ratio (HR) using Cox proportional hazard regression.Results: Among males, BMI ≥30.0 kg/m2 was associated with a 1.27-fold higher overall risk of developing GC (95% confidence interval [CI], 1.02 to 1.57), but not in females. For non-cardia GC, a U-shaped association between BMI and risk of developing GC was observed in males, although statistical significance was observed only for BMI 18.5-22.9 kg/m2. Additionally, an increase in BMI to 23.0-24.9 kg/m2 was associated with a decreased non-cardia GC risk among males. In females, the largest waist circumference category was significantly associated with an increased risk of developing overall GC (HR, 1.37; 95% CI, 1.07 to 1.74).Conclusions: This study demonstrated that maintaining a BMI in the range of 23.0-24.9 kg/m2 is optimal for minimizing the risk of non-cardia GC, particularly in males. In females, visceral obesity, represented by a large waist circumference as a proxy, was associated with an increased risk of developing GC.","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143990050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comments on Risk Factors for Perforation in Endoscopic Treatment for Early Colorectal Cancer: A Nationwide ENTER-K Study: Reply. 内镜治疗早期结直肠癌穿孔的危险因素：一项全国性的enterk研究：回复。

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-21 DOI: 10.5009/gnl250114

Ik Hyun Jo, Hyun Gun Kim

引用次数: 0

Novel Risk Score for 30-Day Adverse Events Following Colonoscopy in Older Adults. 老年人结肠镜检查后30天不良事件的新风险评分。

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-21 DOI: 10.5009/gnl250010

Min-Jae Kim, Seoyoon Choi, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Tae Il Kim, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jaeyoung Chun

{"title":"Novel Risk Score for 30-Day Adverse Events Following Colonoscopy in Older Adults.","authors":"Min-Jae Kim, Seoyoon Choi, Jihye Park, Soo Jung Park, Jae Jun Park, Jae Hee Cheon, Tae Il Kim, Yuna Kim, Jie-Hyun Kim, Young Hoon Youn, Hyojin Park, Jaeyoung Chun","doi":"10.5009/gnl250010","DOIUrl":"https://doi.org/10.5009/gnl250010","url":null,"abstract":"Background/aims: Physicians are challenged with balancing benefits and risks of performing colonoscopies in older adults. We identified adverse event risk factors in this population and developed a predictive risk score for colonoscopy-related adverse events.Methods: From August 2017 to August 2022, 8,154 patients aged ≥60 years who underwent screening or diagnostic colonoscopies were enrolled at Gangnam Severance Hospital. The primary outcome was 30-day adverse events, defined as emergency room visits or unplanned hospitalizations post-colonoscopy. The frailty index calculated via laboratory findings (FI-LAB) was derived from blood test results and vital signs. A risk score was developed and categorized to predict colonoscopy-related adverse events. Data from 9,154 colonoscopies from September 2022 to December 2023 at two tertiary referral hospitals were used for internal and external validation.Results: The mean age was 67.9 years (range, 60 to 94 years). The 30-day adverse event rate was 1.4%. Adverse events were independently associated with the use of aspirin (adjusted odds ratio [aOR], 2.24), P2Y12 inhibitors (aOR, 1.79), and anticoagulants (aOR, 2.47) and with moderate (aOR, 4.54) and high (aOR, 11.40) FI-LABs. The incidence of adverse events in the low-, moderate-, and high-risk groups were 0.3%, 2.2%, and 10.7%, respectively (p<0.001). The area under the receiver operating characteristic curve for the risk scores were 0.821, 0.856, and 0.757 for the derivation, internal, and external cohorts, respectively.Conclusions: Colonoscopy-related adverse events in older adults were linked to frailty and medication use and were not dependent on age. This novel risk score supports personalized decision-making when performing colonoscopies in older adults.","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Associations of Tobacco, Alcohol, and Coffee Consumption with Upper and Lower Gastrointestinal Disease Risk: A Mendelian Randomization Study. 烟草、酒精和咖啡消费与上、下消化道疾病风险的关系：一项孟德尔随机研究

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-11 DOI: 10.5009/gnl240440

Fei Xue, Jiajing Xue, Bingbing Zhao, Shuai Zhu

{"title":"The Associations of Tobacco, Alcohol, and Coffee Consumption with Upper and Lower Gastrointestinal Disease Risk: A Mendelian Randomization Study.","authors":"Fei Xue, Jiajing Xue, Bingbing Zhao, Shuai Zhu","doi":"10.5009/gnl240440","DOIUrl":"https://doi.org/10.5009/gnl240440","url":null,"abstract":"Background/aims: Gastrointestinal diseases present a significant global health challenge and greatly impact healthcare expenditures. Despite alcohol, tobacco, and coffee being universally recognized risk factors for various gastrointestinal disorders, the exact causal linkages have not been clarified because of the predominance of observational studies on this topic. Mendelian randomization (MR) was used to explore to what extent alcohol, tobacco, and coffee increase the risk of developing 13 upper and lower gastrointestinal diseases.Methods: Genetic data from large genome-wide association studies including GSCAN, FinnGen, UK Biobank, IIBDGC, GERA, and other consortia were used for both univariable and multivariable MR analyses. Single-nucleotide polymorphisms were used as instrumental variables and sensitivity analyses were conducted to identify potential pleiotropic effects.Results: Genetically predicted smoking was positively associated with esophageal cancer, Crohn's disease, gastric ulcer, irritable bowel syndrome, and gastroesophageal reflux risk, but was negatively associated with celiac disease risk. Alcohol intake was positively correlated with both esophageal cancer and chronic gastritis risk. These findings were confirmed by multivariable MR analyses, albeit with some variations. Coffee consumption was linked to esophageal cancer, but the association became nonsignificant after adjusting for hot beverage consumption.Conclusions: This comprehensive MR study suggests that alcohol and tobacco consumption are associated with the occurrence of several gastrointestinal diseases. These results support the need for public health initiatives to reduce smoking and alcohol abuse, with the aim of preventing both upper and lower gastrointestinal diseases.","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144013499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Prospective Study on the Detection of Gastric Neoplasms Using Pepsinogen and Gastrin-17 Levels. 胃蛋白酶原和胃泌素-17水平检测胃肿瘤的前瞻性研究。

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-11 DOI: 10.5009/gnl240544

Sun-Young Lee, Hee-Won Moon, Yeon-Sun Ahn, Joo Hye Song, Jeong Hwan Kim, In-Kyung Sung

{"title":"A Prospective Study on the Detection of Gastric Neoplasms Using Pepsinogen and Gastrin-17 Levels.","authors":"Sun-Young Lee, Hee-Won Moon, Yeon-Sun Ahn, Joo Hye Song, Jeong Hwan Kim, In-Kyung Sung","doi":"10.5009/gnl240544","DOIUrl":"https://doi.org/10.5009/gnl240544","url":null,"abstract":"Background/aims: GastroPanel tests include gastrin-17 (G-17) levels in addition to pepsinogen (PG) and Helicobacter pylori serology tests. The aim of this study was to identify significant test findings in patients with gastric neoplasms by comparing the findings of GastroPanel tests and conventional serum PG assays.Methods: Consecutive individuals who underwent serological testing were included from May 2023 to August 2024. Foreigners and those with gastrectomy, renal insufficiency, previous H. pylori eradication, and recent acid suppressant use were excluded.Results: Among the 1,101 participants, 122 were diagnosed with gastric neoplasms. High G-17 levels (odds ratio [OR], 1.030; 95% confidence interval [CI], 1.008 to 1.052), low I/II ratios determined by GastroPanel tests (OR, 0.834; 95% CI, 0.779 to 0.894), and low I/II ratios determined by HBI PG assays (OR, 0.584; 95% CI, 0.511 to 0.668) were significant variables for detecting gastric neoplasms. The cutoff values for low I/II ratios were <6.15 (GastroPanel test) and <3.005 (HBI assay), with no differences in diagnostic performance between the two tests (p=0.085). Although the I/II ratio alone was a significant independent variable for detecting early gastric cancers, advanced gastric cancers, adenomas, and neuroendocrine tumors, the G-17 level alone was significant only for adenomas and neuroendocrine tumors. The findings of the patients with gastrointestinal stromal tumors did not differ from those of the controls.Conclusions: Blood test findings are useful for detecting gastric neoplasms, except for gastrointestinal stromal tumors. The addition of G-17 levels to PG tests is only beneficial for diagnosing gastric neoplasms associated with corpus atrophy, such as adenoma and neuroendocrine tumors (ClinicalTrials.gov identifier NCT05883345).","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143988522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Endoscopic Features of Gastrointestinal Amyloidosis: A Proposed Endoscopic Classification. 胃肠道淀粉样变的内镜特征：一种建议的内镜分类。

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-01 DOI: 10.5009/gnl240383

Joo Hye Song, Hye Mi Jung, Ji Won Kim, Eun Ran Kim, Ga Yeon Lee, Sang Eun Yoon, Seok Jin Kim, Jung-Sun Kim, Dong Kyung Chang, Young-Ho Kim, Eun-Seok Jeon, Kihyun Kim, Sung Noh Hong

{"title":"Endoscopic Features of Gastrointestinal Amyloidosis: A Proposed Endoscopic Classification.","authors":"Joo Hye Song, Hye Mi Jung, Ji Won Kim, Eun Ran Kim, Ga Yeon Lee, Sang Eun Yoon, Seok Jin Kim, Jung-Sun Kim, Dong Kyung Chang, Young-Ho Kim, Eun-Seok Jeon, Kihyun Kim, Sung Noh Hong","doi":"10.5009/gnl240383","DOIUrl":"https://doi.org/10.5009/gnl240383","url":null,"abstract":"Background/aims: Gastrointestinal amyloidosis (GIA) is a common condition that presents with a variety of endoscopic features. However, the classification of these endoscopic features of GIA and its clinical implications have not been investigated.Methods: The endoscopic findings of 127 patients with GIA were reviewed and classified by three experienced endoscopists. The relationships of the endoscopic classification of GIA with clinical amyloidosis entities, symptoms, and patient outcomes were evaluated.Results: Five distinct types of endoscopic lesion features were identified in GIA patients: protruding, granular, hemorrhagic, ulcerative, and nonspecific. The hemorrhagic type was most common (n=32, 25.2%), followed the by protruding (n=30, 23.6%), ulcerative (n=28, 22.0%), granular (n=20, 15.7%), and nonspecific types (n=17, 13.4%). The protruding type was significantly prevalent in patients with localized amyloidosis (23/49, 71.4%), whereas the hemorrhagic type was the most common in patients with immunoglobulin light chain amyloidosis (20/47, 42.6%), and the ulcerative type was the most common in patients with amyloid A amyloidosis (8/17, 47.1%) (p<0.001). The granular type was related to dysmotility symptoms (p=0.018). Among 30 GIA patients with the protruding type, two died, whereas 36.1% of patients with the other endoscopic types (35/97) died during a median follow-up of 95.5 months (interquartile range, 65.8 to 132.0 months) (p=0.007).Conclusions: Five types of GIA lesions were identified, and on this basis, an endoscopic classification system was proposed. This system may be of diagnostic and prognostic value.","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tumor Budding as an Additional Factor in Determining the Need for Surgery after Endoscopic Resection in Mucosal Invasive Gastric Cancer: A Retrospective Study from a Korean Tertiary Hospital. 肿瘤出芽是决定内镜下粘膜浸润性胃癌切除术后是否需要手术的一个额外因素：韩国一家三级医院的回顾性研究

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-01 DOI: 10.5009/gnl240352

Yeonjin Je, Yuna Kim, Su-Jin Shin, Jie-Hyun Kim, Goeun Park, Jaeyoung Chun, Young Hoon Youn, Hyojin Park, Sung Hoon Noh, In Gyu Kwon

{"title":"Tumor Budding as an Additional Factor in Determining the Need for Surgery after Endoscopic Resection in Mucosal Invasive Gastric Cancer: A Retrospective Study from a Korean Tertiary Hospital.","authors":"Yeonjin Je, Yuna Kim, Su-Jin Shin, Jie-Hyun Kim, Goeun Park, Jaeyoung Chun, Young Hoon Youn, Hyojin Park, Sung Hoon Noh, In Gyu Kwon","doi":"10.5009/gnl240352","DOIUrl":"https://doi.org/10.5009/gnl240352","url":null,"abstract":"Background/aims: The presence of individual cancer cells at the invasive tumor front is referred to as tumor budding (TB). The purpose of this study was to assess the clinicopathological significance of TB in patients with early gastric cancer (EGC).Methods: A total of 939 patients who received radical surgery for EGC were included in this retrospective study. We assessed clinicopathological features in relation to TB including the grade of histologic differentiation, the extent of invasion depth, the width of submucosal (SM) invasion, and the presence of lymphovascular invasion (LVI), lymph node metastasis (LNM) and perineural invasion (PNI).Results: TB was identified in 59.5% of the patients with EGC, 38.7% of the patients with mucosal invasive cancer, and 80.4% of the patients with SM invasive cancers. TB showed significant association with male sex, undifferentiated tumor types, SM invasion, LVI, PNI, and LNM. The presence of SM invasion (odds ratio [OR], 8.750; p<0.001), TB (OR, 5.586; p<0.001), and an undifferentiated-type histology (OR, 2.648; p=0.0005) were found to be significantly associated with LNM/LVI. TB was the sole significant risk factor for LNM/LVI (OR, 7.181; p=0.0016) among the mucosal invasive cancers. In SM invasive cancers, three independent risk factors for LNM/LVI were identified: a tumor located in the lower third of the stomach (OR, 3.425; p=0.0061), an undifferentiated-type histology (OR, 2.320; p=0.0177), and an SM invasion width greater than 4,000 μm (OR, 2.849; p=0.0041).Conclusions: TB may be an important factor associated with LNM, particularly in mucosal gastric cancer.","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Comparative Study of MiroCam MC2000 and PillCam SB3 in Detecting Small Bowel Bleeding: A Multicenter Prospective Randomized Crossover Study. microcam MC2000和PillCam SB3检测小肠出血的比较研究：一项多中心前瞻性随机交叉研究

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-01 DOI: 10.5009/gnl240541

Ji Eun Kim, Eun Ran Kim, Jae Jun Park, Kyeong Ok Kim, Yehyun Park, Young Joo Yang, Hyun Joo Jang

{"title":"Comparative Study of MiroCam MC2000 and PillCam SB3 in Detecting Small Bowel Bleeding: A Multicenter Prospective Randomized Crossover Study.","authors":"Ji Eun Kim, Eun Ran Kim, Jae Jun Park, Kyeong Ok Kim, Yehyun Park, Young Joo Yang, Hyun Joo Jang","doi":"10.5009/gnl240541","DOIUrl":"https://doi.org/10.5009/gnl240541","url":null,"abstract":"Background/aims: The MiroCam MC2000 (MC2000) is a double-tip capsule with a camera on each side. It is designed to provide more extensive visualization of the small bowel mucosa, potentially reducing the chance of missing lesions. This study aimed to compare the detection rates for lesions in the ampulla of Vater (AoV) and the small bowel of the MC2000 and the PillCam SB3 (SB3) for patients with suspected small bowel bleeding.Methods: This prospective, multicenter, randomized crossover trial compared the lesion detection capabilities of the MC2000 and SB3 capsules, ingested one hour apart by patients with suspected small bowel bleeding. The primary outcome was the detection of lesions in the AoV, while the secondary outcome was the assessment of the detection of P1 and P2 lesions, known underlying causes of small bowel bleeding.Results: There was no significant difference in AoV lesion detection rates between the devices. However, MC2000 demonstrated significantly greater detection of red spots in patients with visible bleeding (p=0.018) and tended to detect a greater number of small bowel lesions, including P2 lesions. Minor complications included device stasis, with fewer incidents with the MC2000 than with the SB3, and one instance of small bowel retention due to ulcers.Conclusions: The MC2000's dual-camera system appears to enhance the detection of small bowel lesions over the SB3, especially for more important lesions. These findings suggest that the MC2000 may offer superior diagnostic capabilities for patients with suspected small bowel bleeding, potentially leading to better clinical outcomes (this trial registered KCT0005591).","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TEAD4 Transcriptionally Activates TRIB3 to Induce Ferroptosis Resistance through the MEK/ERK Signaling Pathway in Colorectal Cancer. TEAD4通过MEK/ERK信号通路转录激活TRIB3诱导结直肠癌铁下沉抗性

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-01 DOI: 10.5009/gnl240439

Jianguo Wang, Xiangbo Wu

{"title":"TEAD4 Transcriptionally Activates TRIB3 to Induce Ferroptosis Resistance through the MEK/ERK Signaling Pathway in Colorectal Cancer.","authors":"Jianguo Wang, Xiangbo Wu","doi":"10.5009/gnl240439","DOIUrl":"https://doi.org/10.5009/gnl240439","url":null,"abstract":"Background/aims: Colorectal cancer (CRC) is the third most prevalent malignancy and the second leading cause of cancer-associated death worldwide. Ferroptosis is a form of regulated cell death that has been linked to the treatment of CRC. Tribbles homolog 3 (TRIB3) and TEA domain transcription factor (TEAD4) are linked with the progression of various cancers, but their role in ferroptosis remains unclear.Methods: We analyzed TRIB3 and TEAD4 expression in CRC tissues using bioinformatics and examined the TRIB3-ferroptosis association. Immunohistochemistry was employed to determine the expression levels of TRIB3 and glutathione peroxidase 4 (GPX4). Real-time quantitative polymerase chain reaction was utilized to measure the mRNA levels of TRIB3 and TEAD4. Western blot was performed to assess the changes in the levels of proteins related to ferroptosis and MEK/ERK pathway. Dual luciferase assays and chromatin immunoprecipitation assays were employed to detect TEAD4TRIB3-TEAD4 targeting. We also employed colony formation assays to analyze cell proliferation, flow cytometry to measure reactive oxygen species levels, and detection kits to measure Fe2 +, glutathione and NADPH levels.Results: TRIB3 was upregulated in CRC cells and tissues and was implicated in the ferroptosis pathway, demonstrating a positive association with GPX4. TRIB3 positively modulated ferroptosis proteins and the MEK/ERK signaling pathway, increasing the ferroptosis resistance of CRC cells. Overexpression of TRIB3 in TEAD4-knockdown cells significantly increased the ferroptosis resistance of CRC cells.Conclusions: TEAD4 increases the expression level of TRIB3 through transcriptional activation, thereby controlling the MEK/ERK signaling pathway and inducing ferroptosis resistance in CRC cells.","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated Whole-Liver Fat Quantification with Magnetic Resonance Imaging-Derived Proton Density Fat Fraction Map: A Prospective Study in Taiwan. 磁共振成像衍生质子密度脂肪分数图自动全肝脂肪定量：台湾前瞻性研究。

IF 3.4 3区医学

Gut and Liver Pub Date : 2025-04-01 DOI: 10.5009/gnl240408

Chih-Horng Wu, Kuang-Chen Yen, Li-Ying Wang, Ping-Lun Hsieh, Wei-Kai Wu, Pei-Lin Lee, Chun-Jen Liu

{"title":"Automated Whole-Liver Fat Quantification with Magnetic Resonance Imaging-Derived Proton Density Fat Fraction Map: A Prospective Study in Taiwan.","authors":"Chih-Horng Wu, Kuang-Chen Yen, Li-Ying Wang, Ping-Lun Hsieh, Wei-Kai Wu, Pei-Lin Lee, Chun-Jen Liu","doi":"10.5009/gnl240408","DOIUrl":"https://doi.org/10.5009/gnl240408","url":null,"abstract":"Background/aims: Magnetic resonance imaging (MRI) with a proton density fat fraction (PDFF) sequence is the most accurate, noninvasive method for assessing hepatic steatosis. However, manual measurement on the PDFF map is time-consuming. This study aimed to validate automated whole-liver fat quantification for assessing hepatic steatosis with MRI-PDFF.Methods: In this prospective study, 80 patients were enrolled from August 2020 to January 2023. Baseline MRI-PDFF and magnetic resonance spectroscopy (MRS) data were collected. The analysis of MRI-PDFF included values from automated whole-liver segmentation (autoPDFF) and the average value from measurements taken from eight segments (avePDFF). Twenty patients with ≥10% autoPDFF values who received 24 weeks of exercise training were also collected for the chronologic evaluation. The correlation and concordance coefficients (r and ρ) among the values and differences were calculated.Results: There were strong correlations between autoPDFF versus avePDFF, autoPDFF versus MRS, and avePDFF versus MRS (r=0.963, r=0.955, and r=0.977, all p<0.001). The autoPDFF values were also highly concordant with the avePDFF and MRS values (ρ=0.941 and ρ=0.942). The autoPDFF, avePDFF, and MRS values consistently decreased after 24 weeks of exercise. The change in autoPDFF was also highly correlated with the changes in avePDFF and MRS (r=0.961 and r=0.870, all p<0.001).Conclusions: Automated whole-liver fat quantification might be feasible for clinical trials and practice, yielding values with high correlations and concordance with the time-consuming manual measurements from the PDFF map and the values from the highly complex processing of MRS (ClinicalTrials.gov identifier: NCT04463667).","PeriodicalId":12885,"journal":{"name":"Gut and Liver","volume":" ","pages":""},"PeriodicalIF":3.4,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0