Gynecologic Oncology Reports最新文献

{"title":"Improving clinical trial enrollment in minority racial and ethnic patients with gynecologic malignancy","authors":"Olivia D. Lara ,&nbsp;Kathryn Allen ,&nbsp;Amin Yakubov ,&nbsp;Bhavana Pothuri","doi":"10.1016/j.gore.2024.101495","DOIUrl":"10.1016/j.gore.2024.101495","url":null,"abstract":"<div><h3>Purpose</h3><p>Racial and ethnic minorities remain underrepresented in clinical trials . Underrepresentation of racial groups leads to the selection of therapeutic interventions that may not be representative of the population expected to use the medicine. This study evaluates the effectiveness of a set of implementation strategies to increase underrepresented patients in gynecologic cancer clinical trials.</p></div><div><h3>Methods</h3><p>An interrupted time series analysis evaluating implementation strategies (pre-screening and fast-track referral) was conducted from January 2021 to May 2022. Descriptive analysis of gynecologic oncology patient screening and accrual was compared before and after intervention implementation.</p></div><div><h3>Results</h3><p>During the study period (pre- and post-intervention), 26 patients were screened, and 9 patients enrolled in therapeutic gynecologic cancer clinical trials. Prior to the intervention, 7 patients were screened and 2 patients enrolled onto a clinical trial. Following the intervention, 19 patients were screened and 7 patients enrolled in a cancer clinical trial. Black patients comprised 13 of 19 (68.4%) of patients post-intervention compared to 1 of 7 (14.3 %) of patients screened pre-intervention (p &lt; 0.05). All 7 patients enrolled post intervention were racial and ethnic minorities (non-Hispanic Black [4 of 7] and Hispanic White [3 of 7]) compared to no minority patients enrolled pre-intervention (p &lt; 0.05). Screening increased 2.5-fold for all patients, and 5- fold for minority patients. Clinical trial enrollment increased 3.5-fold following intervention.</p></div><div><h3>Conclusions</h3><p>A combination of pre-screening and fast-track referral intervention in a racial and ethnically diverse urban academic hospital was associated with a significant increase in minority screening and enrollment. Structured strategies to overcome barriers to underrepresented racial and ethnic patient accrual in academic hospitals are urgently warranted.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001747/pdfft?md5=5c53edf50b8122566675cc162f0003d1&pid=1-s2.0-S2352578924001747-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Series: Rare cystic variant of adenomatoid tumor of the uterus","authors":"Prasanna D Tati ,&nbsp;Muhammad Omar Afridi ,&nbsp;Angelica Patel ,&nbsp;Monika Mansmann ,&nbsp;Victoria Petty ,&nbsp;Joyce Varughese","doi":"10.1016/j.gore.2024.101493","DOIUrl":"10.1016/j.gore.2024.101493","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001723/pdfft?md5=53a71d69c197188583beffadd32e3761&pid=1-s2.0-S2352578924001723-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142164400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ureteral stenting in patients with locally advanced cervical cancer: Predictors of low success rate","authors":"Kaleab Habtemichael Gebreselassie ,&nbsp;Tadele Aweke Adamu ,&nbsp;Andualem Deneke Beyene","doi":"10.1016/j.gore.2024.101491","DOIUrl":"10.1016/j.gore.2024.101491","url":null,"abstract":"<div><h3>Objective</h3><p>Cervical cancer is the leading gynecologic malignancy in Ethiopia. The diagnosis is often delayed and many patients present with locally advanced disease. Involvement of the ureters with or without the development of hydroureteronephrosis is a common finding. Ureteral stent placement is a modality utilized to relieve an established obstruction (therapeutic) or to prevent its early occurrence (prophylactic). However, the procedure may not be successful in all patients. The objective of this study is to assess the factors associated with low success rate of ureteral stenting in these patients with locally advanced disease.</p></div><div><h3>Methods</h3><p>This is a hospital based cross-sectional study of patients diagnosed with locally advanced cervical cancer for whom a retrograde ureteral stent placement is attempted from January 2019 to March 2020. Data of 175 patients were retrieved by a retrospective chart review and analyzed for factors associated with low procedural success.</p></div><div><h3>Results</h3><p>Socio-demographic data were similar between patients regardless of procedural success. The overall success rate of stenting was 54.2 %. In the prophylactic group (with no hydronephrosis and normal creatinine) success rate was 94 % and in the therapeutic group 42.6 %. Logistic regression analysis showed that bilateral hydronephrosis and increased serum creatinine were indicators of significant ureteral obstruction and were predictors of stent placement failure.</p></div><div><h3>Conclusion</h3><p>Increased serum creatinine and presence of hydronephrosis are risk factors for failed ureteral stenting. For these patients, other options of urinary diversion such as percutaneous nephrostomy should be considered from the outset.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235257892400170X/pdfft?md5=cc5f0fb2e89a9cf6e8f65b00232a8c31&pid=1-s2.0-S235257892400170X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent high grade serous endometrial cancer with brain metastases: Immunotherapy confers improved quality of life and survival","authors":"Kierany B. Shelvin ,&nbsp;Jill Vincent ,&nbsp;Shawna Morron ,&nbsp;Michael Morin ,&nbsp;Aaron Mammoser ,&nbsp;Navya Nair","doi":"10.1016/j.gore.2024.101494","DOIUrl":"10.1016/j.gore.2024.101494","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001735/pdfft?md5=84f8fceb6282b116821a71d399c43726&pid=1-s2.0-S2352578924001735-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of high-grade ovarian adenocarcinoma in an intraperitoneal pelvic renal transplant recipient","authors":"Esra Demirel ,&nbsp;Seth Cohen ,&nbsp;Ronald D. Ennis ,&nbsp;Farr R. Nezhat","doi":"10.1016/j.gore.2024.101489","DOIUrl":"10.1016/j.gore.2024.101489","url":null,"abstract":"<div><h3>Background</h3><p>Number of organ transplant recipients continues to rise worldwide with increasing accessibility and growing advancements in transplant medicine. Transplant patients have at least a two-to-four fold higher risk of developing cancer compared to the general population. As the prevalence of transplant patients increases, a growing number of these patients are expected to present with concurrent conditions such as cancer, requiring more complex and interdisciplinary care.</p></div><div><h3>Case</h3><p>A 44-year-old patient with an intraperitoneal pelvic renal transplant, found to have high-grade ovarian adenocarcinoma most likely arising from endometriosis, successfully underwent surgical staging, adjuvant chemotherapy, and subsequent pelvic radiation for recurrence. Her kidney function and graft viability were preserved throughout her treatment with careful monitoring.</p></div><div><h3>Conclusion</h3><p>Management of reproductive tract cancers in kidney transplant recipients is complex. Current practices largely rely on evidence from observational studies and case reports for these cancers and more research is needed in this area.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001681/pdfft?md5=5ff6dc51a65022421dfd3bf07e208ef4&pid=1-s2.0-S2352578924001681-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Near fatal case of mirvetuximab soravtansine-gynx induced interstitial lung disease and a review of the primary literature","authors":"Joshua Clark ,&nbsp;Andrew Blake ,&nbsp;Scott Vasher ,&nbsp;Richard C. Boucher ,&nbsp;Alexis R. Jones ,&nbsp;Hee Jae Choi ,&nbsp;Benjamin B. Albright","doi":"10.1016/j.gore.2024.101486","DOIUrl":"10.1016/j.gore.2024.101486","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001656/pdfft?md5=a238b2fc3d18a2e09aed66a2f936fa3c&pid=1-s2.0-S2352578924001656-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142083625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time series and risk factors associated with mortality in women with cervical cancer from 2000 to 2021","authors":"Talita de Oliveira Lima,&nbsp;José Erialdo da Silva Junior,&nbsp;Giulianna Aparecida Vieira Barreto,&nbsp;Max Wellington Sátiro Justino,&nbsp;Maria Lia Coutinho Carvalho,&nbsp;Marcelo Gurgel Carlos da Silva,&nbsp;Daniele Alves Ferreira,&nbsp;Lúcio Flávio Gonzaga Silva,&nbsp;Paulo Goberlânio de Barros Silva","doi":"10.1016/j.gore.2024.101490","DOIUrl":"10.1016/j.gore.2024.101490","url":null,"abstract":"<div><h3>Introduction</h3><p>Cervical cancer is a significant public health problem worldwide. The development of cervical neoplasms is associated with persistent infection by oncogenic subtypes of the HPV virus, which are responsible for around 70% of cervical cancers.A study carried out in Brazil between 2002 and 2021 recorded 133,429 deaths from cervical cancer..</p></div><div><h3>Methodology</h3><p>An observational, retrospective, cross-sectional, quantitative study was carried out using data collected by the Cancer Registry Service of the Haroldo Juaçaba Hospital/Ceará Cancer Institute (HHJ/ICC) over 22 years.</p></div><div><h3>Results</h3><p>The sample consisted of 9096 women. The mean age was 51.4 ± 15.5, ranging from 15 to 100, with a median age of 60 years. Median overall survival was 59.77. The most frequent histological type was squamous cell carcinoma, with 8023 (88.2 %) cases. Around 25 % of patients (n = 2270) entered the service with stage 4A. The most common treatment was radiotherapy combined with chemotherapy (n = 3270, 35.9 %), followed by surgical removal (n = 1909, 21.0 %).In multivariate analysis, age (p = 0.019), race (p = 0.016), low level of education (p &lt; 0.001), tumor location, staging (p &lt; 0.001), and treatment (p = 0.011) were risk factors independently associated with a higher chance of death in the sample studied.</p></div><div><h3>Conclusion</h3><p>The sociodemographic characteristics of mortality from cervical cancer in patients followed up at the Haroldo Juaçaba Hospital (HHJ/ICC) highlight the higher frequency of deaths in women aged over 60, indigenous and black, with low levels of education, as well as clinical variables related to tumor location, staging and type of treatment.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001693/pdfft?md5=4774ca881b1b28b1573361d5980e19a5&pid=1-s2.0-S2352578924001693-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142058445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial cancer of both uterine horns in a premenopausal patient with uterine didelphys: Surgical approach and considerations for adjuvant treatment","authors":"Meyha Swaroop ,&nbsp;Anna Nevels ,&nbsp;Meg Hubregsen ,&nbsp;Janelle P. Darby","doi":"10.1016/j.gore.2024.101492","DOIUrl":"10.1016/j.gore.2024.101492","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001711/pdfft?md5=2d6406cb6faa57ebe2baf08645e53c1b&pid=1-s2.0-S2352578924001711-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudomyxoma peritonei arising from mature ovarian teratoma, a rare entity: Report of six cases and review of current literature","authors":"Minah Ha ,&nbsp;Amy Jamieson ,&nbsp;Justine Pickett ,&nbsp;Justin M. McGinnis ,&nbsp;Tom De Greve","doi":"10.1016/j.gore.2024.101488","DOIUrl":"10.1016/j.gore.2024.101488","url":null,"abstract":"<div><h3>Background</h3><p>Pseudomyxoma peritonei (PMP) is a clinical syndrome characterised by intraperitoneal accumulation of mucus due to mucinous neoplasia. It is a rare condition affecting 1–2 per million individuals per year. The majority of PMP arises from a ruptured mucinous appendiceal tumour, with infrequent occurrences from other primary gastrointestinal tumours and mucinous ovarian tumours. PMP arising from a mature ovarian teratoma is a rare entity, with limited case reports in the literature. Given the infrequent and sporadic occurrences of these tumours, little is known about the tumour behaviour and prognosis.</p></div><div><h3>Case series and literature review</h3><p>Herein, we report six cases of PMP arising from a mature ovarian teratoma who were treated with primary cytoreductive surgery (CRS), with one case of recurrence. Literature review identified 21 cases from 12 manuscripts. Nineteen patients were treated with CRS alone, with two patients receiving adjuvant hyperthermic intraperitoneal chemotherapy (HIPEC). Follow up data were variably reported, with no recurrence in 20 patients during their follow up of 5–54 months. One patient reported to have died of disease at 49 months.</p></div><div><h3>Conclusion</h3><p>Despite the lack of high-quality evidence and limitations of small case series, our review indicates that close surveillance after CRS could be considered as the preferred treatment over more morbid CRS and HIPEC, with HIPEC reserved for patients who recur or progress after CRS.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S235257892400167X/pdfft?md5=4464113ec05d4dd1440c5d226da0e7d1&pid=1-s2.0-S235257892400167X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors related to cervical cancer and human papilloma virus awareness among rural women of southern Bangladesh: A cross-sectional study","authors":"Sattyajit Datta ,&nbsp;Syed Baqui Billah ,&nbsp;Anik Halder ,&nbsp;Tarequr Rahman","doi":"10.1016/j.gore.2024.101481","DOIUrl":"10.1016/j.gore.2024.101481","url":null,"abstract":"<div><h3>Introduction</h3><p>Cervical cancer is an important public health issue in Bangladesh. Despite government efforts, the awareness and healthcare utilization in rural areas are inadequate.</p></div><div><h3>Methodology</h3><p>This cross-sectional study was conducted in six districts of Barishal division over 997 respondents aged 15–64 years. The demographic variables, accessibility to healthcare, vaccination status, awareness of HPV causing cervical cancer, and knowledge of the HPV vaccine were recorded through a structured questionnaire. T-test for univariate and chi-square test for bi-variate analysis were used. Logistic regression was used to determine factors associated with awareness.</p></div><div><h3>Results</h3><p>Most of the participants were SSC passed (45.3%), unemployed (54.4%), and married (74.4%). While 83.5% were aware of cervical cancer, only 3.3% knew about HPV’s role. The majority (96.2%) had never been tested for HPV, albeit 79.5% knew about the vaccine, and only 2.45% were vaccinated. Knowledge levels were low, with only 1.4% demonstrating sound knowledge, mostly associating with higher income, residing closer to healthcare facilities, and being married. Bhola district participants had highest level of awareness, and the lowest was in Pirojpur. Education level was positively correlated with knowledge, with graduates being most aware. Logistic regression showed education, marital status, willingness to vaccinate daughters, and district were significantly related with better awareness, while income, distance, and age did not.</p></div><div><h3>Conclusion</h3><p>Mass education and awareness campaigns may improve the awareness level in rural community.</p></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":null,"pages":null},"PeriodicalIF":1.2,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2352578924001607/pdfft?md5=2b3ec36872e055f6923b591a8e58f141&pid=1-s2.0-S2352578924001607-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141998154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}