Gynecologic Oncology Reports最新文献

{"title":"Laparoscopic radical trachelectomy and pelvic lymphadenectomy without uterine manipulator","authors":"Shaodan Lin ,&nbsp;Chuying Huo ,&nbsp;Zhongqiu Lin ,&nbsp;Huaiwu Lu","doi":"10.1016/j.gore.2026.102034","DOIUrl":"10.1016/j.gore.2026.102034","url":null,"abstract":"<div><h3>Introduction</h3><div>With the postponement of marriage and childbearing in modern society, an increasing proportion of patients diagnosed with cervical cancer are young and have not yet completed their reproductive plans. Fertility-preserving surgery, such as radical trachelectomy, plays an important role in selected patients with early-stage disease. However, the use of a uterine manipulator during minimally invasive surgery remains controversial.</div></div><div><h3>Case/surgical technique</h3><div>We present a surgical film demonstrating laparoscopic radical trachelectomy and pelvic lymphadenectomy without the use of a uterine manipulator in a young woman with early-stage cervical cancer. The patient was a 29-year-old nulliparous woman diagnosed with stage IB1 cervical squamous cell carcinoma following cervical conization, with a strong desire for fertility preservation.</div><div>Instead of a uterine manipulator, uterine suspension was adopted using absorbable sutures to coil the bilateral round ligaments with the anterior uterine wall, allowing controlled uterine traction. Bilateral pelvic lymphadenectomy was performed first, and frozen section analysis confirmed the absence of lymph node metastasis. Radical trachelectomy was subsequently carried out, with careful management of the vesicouterine ligament, preservation of the uterine artery branch, and protection against tumor exposure during colpotomy. Reconstruction of the residual cervix and vagina was performed using the cuff-sleeve suture technique, followed by placement of a cervical stent.</div></div><div><h3>Conclusion</h3><div>This surgical film demonstrates a uterine manipulator–free laparoscopic radical trachelectomy with pelvic lymphadenectomy for early-stage cervical cancer. The described uterine suspension technique provides adequate exposure while maintaining uterine integrity. This approach may facilitate fertility preservation without compromising oncologic principles in carefully selected patients.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102034"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147713919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulated papillary carcinoma arising in ectopic breast tissue in the vulva: A case report and review of literature","authors":"Lisa Su ,&nbsp;Devin R. Allison ,&nbsp;Erica V. Carballo ,&nbsp;Marta A. Crispens ,&nbsp;Mohan Narasimhamurthy","doi":"10.1016/j.gore.2026.102063","DOIUrl":"10.1016/j.gore.2026.102063","url":null,"abstract":"<div><h3>Background</h3><div>Encapsulated papillary carcinoma (EPC) is a rare breast neoplasm, typically seen in postmenopausal women, and is exceedingly uncommon in ectopic breast tissue. We report one such case of EPC arising in ectopic breast tissue of the vulva, highlighting diagnostic and management challenges.</div></div><div><h3>Case presentation</h3><div>A 51-year-old female patient presented with a slowly enlarging, painful cystic vulvar mass. Clinical examination revealed a firm, mobile nodule on the right labia majora. Imaging studies were inconclusive, and differential diagnoses included Bartholin gland cyst, epidermal inclusion cyst, and vulvar carcinoma. Histopathological evaluation following excisional biopsy revealed features consistent with encapsulated papillary carcinoma arising in an ectopic breast tissue with close margins. Multidisciplinary evaluation prompted re-excision, which showed no residual carcinoma. Sentinel node sampling was not performed.</div></div><div><h3>Conclusion</h3><div>EPC in vulvar ectopic breast tissue is a diagnostic rarity, often not considered in the differential diagnosis of vulvar masses. The absence of myoepithelial cells and the presence of a fibrous capsule are key histological features distinguishing EPC from other papillary neoplasms. Management mirrors that of native breast EPC, emphasizing complete surgical excision and hormone receptor profiling to guide adjuvant therapy. Given the indolent nature of non-invasive EPC, prognosis is generally favorable. This case underscores the importance of considering ectopic breast tissue in the differential diagnosis of vulvar masses and maintaining a low threshold for using breast-specific and hormonal immunohistochemistry for timely and accurate diagnosis.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102063"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complete and durable response to trastuzumab deruxtecan in HER2-amplified invasive vulvar adenocarcinoma: A case report","authors":"Alice P. Barr,&nbsp;Ngoctran Nakamura,&nbsp;Nancy T. Nguyen","doi":"10.1016/j.gore.2026.102070","DOIUrl":"10.1016/j.gore.2026.102070","url":null,"abstract":"<div><h3>Background</h3><div>Vulvar adenocarcinoma represents a rare subset of gynecologic malignancies, with limited therapeutic options in the advanced or recurrent setting. HER2 testing is not routinely performed on vulvar carcinoma.</div></div><div><h3>Case presentation</h3><div>We report the case of a 69-year-old woman diagnosed with human epidermal growth factor 2 (HER2)-amplified recurrent metastatic vulvar adenocarcinoma arising in the context of extramammary Paget’s disease. Despite multiple standard systemic therapies, she experienced marked disease with diffuse metastases. With subsequent trastuzumab deruxtecan (T-Dxd) treatment, she achieved a complete and durable response and remains with no evidence of disease after one year of follow-up.</div></div><div><h3>Conclusion</h3><div>This report underscores the potential utility of HER2-directed therapy in select cases of vulvar carcinoma and emphasizes the importance of molecular profiling in rare gynecologic neoplasms.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102070"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consideration for HPV vaccination recommendations in patients with vulvar dysplasia and malignancy following resection: A retrospective study investigating rural-urban vaccination practices in patients served by an academic medical center in the heartland","authors":"Zoe Keese ,&nbsp;Kaeli Samson ,&nbsp;Santiago Ortiz Barragan ,&nbsp;Lindsey A. McAlarnen","doi":"10.1016/j.gore.2026.102067","DOIUrl":"10.1016/j.gore.2026.102067","url":null,"abstract":"<div><h3>Objectives</h3><div>The American College of Obstetricians and Gynecologists (ACOG) recommends the HPV vaccine for unvaccinated or incompletely vaccinated individuals as an adjuvant treatment for cervical intraepithelial neoplasia (CIN) 2 + . Due to no such recommendation for adjuvant HPV vaccination for patients with vulvar intraepithelial neoplasia (VIN) 2 + after resection, and due to the large catchment area of our institution comprising rural and urban patient populations, which are disproportionately affected by HPV-associated cancers, we examined HPV vaccination uptake in patients with VIN2 + and vulvar malignancy and assessed relationships between social vulnerability and rurality.</div></div><div><h3>Methods</h3><div>We performed a retrospective analysis of patients treated between 2018 and 2023 at a single Midwestern academic medical center. The study analyzed clinical and demographic data along with the associated social vulnerability index (SVI) and Rural-Urban Commuting Area (RUCA) codes.</div></div><div><h3>Results</h3><div>Two hundred three unique patients met inclusion criteria. Of these, 36.5% (n = 74) lived in non-urban areas and 63.5% (n = 129) lived in urban areas. In the population of patients younger than 45 years of age who were not vaccinated for HPV prior to their VIN2 + diagnosis and treatment (n = 31), only 19.4% (n = 6) received at least one dose of the HPV vaccine in the adjuvant setting. Social vulnerability in housing and transportation was greatest in those living in rural areas.</div></div><div><h3>Conclusions</h3><div>Extending the ACOG 2023 practice advisory recommendation for adjuvant HPV vaccination after excisional procedures for CIN2 + to encompass patients treated for VIN2 + may help reduce the burden of HPV-associated cancers.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102067"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lymphoplasmacytic lymphoma/Waldenström macroglobulinaemia initially presenting as postmenopausal pelvic pain and bleeding: a rare case report with literature review","authors":"Mackenzie Dent ,&nbsp;Mustafa Al-Kawaaz ,&nbsp;Kadam Maruthi ,&nbsp;Jenci Hawthorne ,&nbsp;Whitney Goldsberry ,&nbsp;Catherine Spencer ,&nbsp;Samer Z. Al-Quran","doi":"10.1016/j.gore.2026.102075","DOIUrl":"10.1016/j.gore.2026.102075","url":null,"abstract":"<div><h3>Background</h3><div>Lymphoplasmacytic lymphoma / Waldenström macroglobulinemia (LPL/WM) is a rare and indolent low-grade B-cell lymphoproliferative neoplasm that often presents with vague symptoms or asymptomatically. While it most commonly involves the bone marrow, LPL/WM can sometimes involve the lymph nodes and spleen, and rarely the central nervous system, skin, and pleural cavities. We report a rare case of lymphoplasmacytic lymphoma/ Waldenström macroglobulinaemia presenting with predominant myometrial and cervical involvement.</div></div><div><h3>Case presentation</h3><div>A 57-year-old G2P2 postmenopausal female with a history of HPV + HSIL presented following a single episode of abnormal uterine bleeding with associated urinary urgency and pelvic pressure. Transvaginal ultrasound examination was unremarkable and endometrial biopsy via hysteroscopy was unsuccessful due to stenotic cervical os. The patient subsequently underwent a total robotic hysterectomy with bilateral salpingo-oophorectomy. Examination of histologic sections showed atypical perivascular lymphoid aggregates consistent with involvement by a low-grade B-cell lymphoma with predominant myometrial and cervical involvement. Differential diagnosis at the time included marginal zone lymphoma (MZL) and lymphoplasmacytic lymphoma (LPL). Additional testing identified an IgM kappa paraproteinemia with MYD88<!--> <!-->p.L265P mutation. Bone marrow biopsy and aspirate confirmed the diagnosis of lymphoplasmacytic lymphoma / Waldenström macroglobulinaemia (LPL/WM).</div></div><div><h3>Conclusion</h3><div>To our knowledge, there have been only two cases previously described in the literature of LPL/WM involvement in the female genital tract; both of which had prominent involvement of the ovaries. Although exceedingly rare, LPL/WM involvement of the female genital tract should be considered on the differential diagnosis if atypical lymphoid cells or dense lymphoid aggregates are observed.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102075"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modified posterior pelvic exenteration for ovarian cancer in 8 steps","authors":"Shaodan Lin ,&nbsp;Chuying Huo ,&nbsp;Yunyun Liu ,&nbsp;Kailai Ma ,&nbsp;Huaiwu Lu","doi":"10.1016/j.gore.2026.102033","DOIUrl":"10.1016/j.gore.2026.102033","url":null,"abstract":"<div><h3>Introduction</h3><div>Posterior pelvic exenteration is frequently required during cytoreductive surgery for advanced ovarian cancer with extensive pelvic involvement. Despite its oncologic importance, the procedure remains technically demanding, with substantial variability in surgical planes, sequence, and complexity. A standardized and streamlined approach is lacking.</div></div><div><h3>Case/surgical technique</h3><div>We present a surgical film demonstrating a modified posterior pelvic exenteration performed for advanced ovarian cancer with rectal involvement. Following comprehensive preoperative evaluation, tumor debulking surgery was undertaken. Intraoperative findings revealed complete obliteration of the pouch of Douglas, necessitating posterior pelvic exenteration. The procedure is organized into eight standardized steps (1) retroperitoneal access and vascular control, (2) bladder peritoneum incision and vesicovaginal space development, (3) pararectal and paravesical space dissection, (4) vaginal and ligamentous dissection, (5) sigmoid and rectal mobilization, (6) distal rectal transection, (7) proximal rectal transection, and (8) colorectal anastomosis. Unlike traditional techniques, this modification avoids routine dissection of the lateral paravesical and Latzk’s spaces and limits excessive ureteric manipulation.</div></div><div><h3>Conclusion</h3><div>This modified posterior pelvic exenteration technique simplifies surgical workflow while preserving oncologic radicality. By reducing unnecessary dissections, the approach may decrease operative complexity, minimize the risk of bleeding and ureteric ischemia, and shorten operative time. The standardized eight-step framework also facilitates anatomical understanding and may reduce the learning curve for surgeons performing complex pelvic cytoreductive procedures.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102033"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147713920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of perioperative and intraoperative management of a rare vaginal paraganglioma","authors":"Sara Wetzler ,&nbsp;Ann Marie Mercier ,&nbsp;Rohan Maini ,&nbsp;Rachel Sheskier ,&nbsp;Eric Craig ,&nbsp;Yuxin Liu ,&nbsp;Konstantin Zakashansky","doi":"10.1016/j.gore.2026.102044","DOIUrl":"10.1016/j.gore.2026.102044","url":null,"abstract":"<div><h3>Background</h3><div>We present the case of a 24-year-old woman with a vaginal paraganglioma and review management considerations, noting that only eleven cases have been previously reported in the literature.</div></div><div><h3>Case presentation</h3><div>Our patient was initially evaluated during a pregnancy complicated by severe pre-eclampsia and later presented with persistent catecholamine-related symptoms, including headaches, diaphoresis, and tachycardia. Laboratory testing demonstrated markedly elevated normetanephrines, and imaging subsequently revealed a paravaginal mass. Given the clinical presentation, a paraganglioma was suspected. Notably, the mass was not avid on the^68 Ga-DOTATATE scan. To obtain a definitive diagnosis, an excisional procedure was planned. Because of the hypervascular nature of these tumors, preoperative embolization was performed to reduce intraoperative blood loss. The patient experienced a hypertensive crisis episode at the time of embolization that was successfully managed with antihypertensive medications in the ICU setting. Final pathology confirmed a 3.6-cm paraganglioma with extensive necrosis and negative surgical margins.</div></div><div><h3>Conclusion</h3><div>This case is the first reported case of arterial embolization with delayed surgical resection of a vaginal paraganglioma. While arterial embolization has been reported previously, in our case, resection was delayed due to a hypertensive crisis. Multidisciplinary management strategies are discussed.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102044"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146192916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-volume nodal disease in early-stage cervical cancer: a case report of favorable outcome without adjuvant therapy","authors":"Francesco Pio Toscano ,&nbsp;Lucio M.A. Cipullo ,&nbsp;Anna I. Rispoli ,&nbsp;Bruno Curcio ,&nbsp;Maria D’Angelo ,&nbsp;Raffaella Del Papato ,&nbsp;Roberta Gallo ,&nbsp;Sara Mari ,&nbsp;Giuseppe Laurelli","doi":"10.1016/j.gore.2026.102077","DOIUrl":"10.1016/j.gore.2026.102077","url":null,"abstract":"<div><h3>Background</h3><div>Low-volume nodal disease is increasingly detected in early-stage cervical cancer due to sentinel lymph node biopsy and ultrastaging. Although any nodal metastasis is classified as FIGO 2018 stage IIIC and generally warrants adjuvant chemoradiotherapy after radical surgery, the prognostic and therapeutic relevance of isolated micrometastases remains uncertain.</div></div><div><h3>Case presentation</h3><div>A 58-year-old woman with FIGO 2018 stage IB2 HPV-related squamous cervical carcinoma underwent radical hysterectomy with bilateral adnexectomy and extended pelvic lymphadenectomy. Histopathological ultrastaging identified a single intracapsular micrometastasis in one of 41 pelvic lymph nodes examined (pT1b1 G2 pN1, FIGO IIIC1). Surgical margins and parametria were negative. Adjuvant concurrent chemoradiotherapy was formally indicated; however, severe postoperative wound infection with prolonged delayed healing prevented timely treatment. Given the extended recovery, absence of macrometastatic disease, and isolated micrometastasis without additional high-risk features beyond lymphovascular space invasion, close surveillance was adopted. At nearly 24 months of follow-up, the patient remains clinically, radiologically, and metabolically disease-free.</div></div><div><h3>Conclusion</h3><div>This case underscores the need for continued investigation into the biological and clinical significance of minimal nodal tumor burden in early-stage cervical cancer. Further prospective data may help refine risk stratification and optimize treatment allocation within established guideline frameworks.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102077"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liver resection at the time of secondary cytoreduction in ovarian cancer","authors":"Christina Harlev ,&nbsp;Lindsey Finch ,&nbsp;Dennis S. Chi ,&nbsp;William R. Jarnagin ,&nbsp;Kevin Soares","doi":"10.1016/j.gore.2026.102022","DOIUrl":"10.1016/j.gore.2026.102022","url":null,"abstract":"<div><h3>Background</h3><div>Hepatic involvement in recurrent ovarian cancer has historically been considered a relative contraindication to cytoreductive surgery. Advances in hepatobiliary surgery and multidisciplinary collaboration have expanded the role of liver resection (<span><span>Farges et al., 2012</span></span>, <span><span>Fong et al., 2005</span></span>, <span><span>Hiatt et al., 1994</span></span>, <span><span>Curley and Glazer, 2025</span></span>. This video demonstrates the technical considerations and feasibility of hepatic resection during secondary cytoreductive surgery for ovarian cancer.</div></div><div><h3>Case</h3><div>A 61-year-old woman with early-stage ovarian cancer and a long disease-free interval developed an isolated hepatic recurrence. Imaging revealed a centrally necrotic mass in the right hepatic lobe with contiguous involvement of the right adrenal gland. Biopsy confirmed metastatic high-grade Müllerian carcinoma. Following systemic chemotherapy with radiographic response, the patient was selected for secondary cytoreductive surgery.</div></div><div><h3>Surgical technique</h3><div>The procedure included partial hepatectomy of segments V and VI with en bloc right adrenalectomy and cholecystectomy. Small-volume pelvic disease was removed via low anterior rectal resection, achieving complete gross tumor resection. The video highlights hepatic mobilization, identification of key anatomic landmarks including the hepatoduodenal ligament, Glissonian pedicles, and hepatic venous structures, and parenchymal transection using the clamp-crush technique with vascular control via the Pringle maneuver. Intraoperative ultrasound confirmed vascular anatomy and perfusion of the remnant liver.</div><div>OutcomeEstimated blood loss was 450 mL with a Pringle time of 25 min. Pathology confirmed metastatic high-grade Müllerian adenocarcinoma with negative hepatic margins. The patient was discharged on postoperative day ten without major postoperative complications.</div></div><div><h3>Conclusion</h3><div>Hepatic resection during secondary cytoreductive surgery for ovarian cancer is safe and feasible in carefully selected patients when performed by experienced multidisciplinary teams with detailed knowledge of hepatic anatomy.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102022"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147714005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of multifocal vulvar carcinoma of mammary gland type (AMGT) with mucinous features: Differential diagnosis and literature review","authors":"Shandice B. Waugh ,&nbsp;Henrietta O. Maku ,&nbsp;Danielle D. Antosh ,&nbsp;Sarah K. Rozycki ,&nbsp;Aparna A. Kamat ,&nbsp;Ekene I. Okoye ,&nbsp;Donna M. Coffey ,&nbsp;Micheal T. Deavers ,&nbsp;Mary R. Schwartz ,&nbsp;Yimin Ge","doi":"10.1016/j.gore.2026.102068","DOIUrl":"10.1016/j.gore.2026.102068","url":null,"abstract":"<div><h3>Background</h3><div>Primary vulvar adenocarcinoma of mammary gland type (AMGT) is a rare gynecologic cancer with only 54 reported cases to date. The tumor may have variety of histologic patterns and can be confused with other more common entities of vulvar tumors. Here, we report a rare mucinous variant of AMGT coexisting with ductal carcinoma in situ (DCIS) and benign mammary-like glands in the vulva. We further review the clinicopathological features of previously reported cases in the literature and discuss the differential diagnosis and treatment updates of this rare entity.</div></div><div><h3>Case presentation</h3><div>A 78-year-old woman with a complex gynecological history who presented with gradually enlarging vulvar nodules and underwent wide local resection. Histological examination revealed mucinous adenocarcinoma and DCIS arising from benign mammary-like glands. The tumor shared histological and immunohistochemical features with invasive ductal carcinoma of the breast, including immunoreactivity to GATA binding protein 3 (GATA3), estrogen receptor (ER), progesterone receptor (PR), and gross cystic disease fluid protein 15 (GCDFP-15). Additional imaging did not reveal primary tumor in the breast, gastrointestinal tract, or other organs.</div></div><div><h3>Conclusion</h3><div>Accurate diagnosis of AMGT relies on awareness of this rare entity, recognition of its typical “milk line” location, and familiarity with its morphological and immunohistochemical similarities to breast carcinoma. The diagnostic importance of identifying tumor-associated benign mammary-like glands or DCIS cannot be overemphasized. Immunohistochemistry is critical in identifying the “mammary-like” phenotype of AMGT and excluding other primary and metastatic tumors of vulva. The unique biologic profile of AMGT dictates a treatment strategy distinct from other primary vulvar tumors.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"64 ","pages":"Article 102068"},"PeriodicalIF":1.3,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147656377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}