Gynecologic Oncology Reports最新文献

{"title":"Reexamining p16 IHC as a surrogate marker of HPV status in vulvar cancer","authors":"Simrit Warring, Jamie Bakkum-Gamez, Evdokiya Knyazhanskaya, Michaela McGree, Amanda L. Tapia, Mark Hopkins","doi":"10.1016/j.gore.2025.101880","DOIUrl":"10.1016/j.gore.2025.101880","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case report and review of the literature regarding management of primary uterine primitive neuroectodermal tumors (PNET)","authors":"Sarah Weinstein ,&nbsp;Allison R. Walker ,&nbsp;Kimberly Barr ,&nbsp;Andres Zorrilla-Vaca ,&nbsp;Deline Da Costa ,&nbsp;Israel Zighelboim ,&nbsp;Sarah P. Huepenbecker ,&nbsp;Ashley Graul ,&nbsp;Nicholas Taylor","doi":"10.1016/j.gore.2025.101775","DOIUrl":"10.1016/j.gore.2025.101775","url":null,"abstract":"<div><div>Primitive neuroectodermal tumors (PNET) arise primarily from the uterus, are rare, and lack consensus management recommendations. We present a case report of a patient with stage IVB uterine PNET and a comprehensive literature review on the topic.</div><div>Fifty-three papers including 90 cases of PNET were identified with an additional case report from our institution included. Data was collected on patient presentation, demographics, oncologic information, and survival. Median age of diagnosis was 51 years old, with most patients presenting with stage III disease. Most treatment regimens included hysterectomy with chemotherapy. Chemotherapy regimens in 77 % of cases were sarcoma-based, 57 % included a platinum agent, 49 % included an anthracycline agent, &lt;1 % involved Bevacizumab, and &lt;1 % utilized immunotherapy. Regarding survival status, 50 % of patients had no evidence of disease ranging from 1 month to 12 years, 10 % of patients were alive with disease from 1-24 months follow-up, and 27 % patients died from disease 2–36 months after diagnosis. One- and two-year overall survival was stratified by clinical and treatment characteristics. Kaplan-Meier curve analysis was also performed for overall survival.</div><div>Primary uterine PNETs are rare, and the literature is limited to case reports. Our patient had a positive response with carboplatin, etoposide, and atezolizumab. Our literature review found that most patients diagnosed with uterine PNET were postmenopausal women in their 50 s and 60 s who presented with vaginal bleeding at advanced stage disease. Treatment most commonly included a simple hysterectomy with chemotherapy, most commonly utilizing a regimen used to treat sarcomas. Stage I disease, younger age, and sarcoma-based chemotherapy regimen all demonstrated higher overall survival rates.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"59 ","pages":"Article 101775"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144243313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and fertility outcomes in lynch syndrome patients with endometrial carcinoma or endometrial Intraepthelial neoplasia treated with fertility sparing management","authors":"Hadley W. Reid ,&nbsp;Alexandria N. Young ,&nbsp;Sophia H. Yin ,&nbsp;Isabela Covelli Velez ,&nbsp;Mary Kathryn Abel ,&nbsp;David L. Kolin ,&nbsp;Elizabeth S. Ginsburg ,&nbsp;Matthew B. Yurgelun ,&nbsp;Colleen Feltmate ,&nbsp;Jessica D. St Laurent","doi":"10.1016/j.gore.2025.101768","DOIUrl":"10.1016/j.gore.2025.101768","url":null,"abstract":"<div><h3>Objectives</h3><div>Provide evidence on fertility-sparing treatment for patients with Lynch Syndrome (LS) and early-stage low grade endometrioid endometrial cancer (EC) or endometrial intraepithelial neoplasia (EIN).</div></div><div><h3>Methods</h3><div>We conducted a retrospective chart review of patients with EC or EIN, LS pathogenic germline variant, and treatment with progestin therapy without upfront hysterectomy due to desire to preserve fertility. Demographic, clinical, and reproductive variables were collected.</div></div><div><h3>Results</h3><div>Of the 273 patients who met criteria for LS with EIN (38) or EC (235) there were seven patients, three with an initial diagnosis of EIN and four with an initial diagnosis of EC who underwent fertility sparing treatment. The median age was 36 (range 31–44) at diagnosis with the following mutations <em>MLH1</em> (2), <em>PMS2</em> (1), <em>MSH2</em> (1) and <em>MSH6</em> (3). Four out of 7 (53%) patients responded to progestin therapy with a 33% (1/3) and 75% (3/4) regression rate for EIN and EC respectively. Two out of 4 patients (50%) subsequently recurred. There were three pregnancies and two live births. Five patients ultimately underwent hysterectomy. Two patients, both with mutant p53 expression on immunohistochemistry, had higher grade or stage pathology, one with stage 1A grade 2 EC and one with stage 1B grade 3 EC.</div></div><div><h3>Conclusion</h3><div>Fertility sparing management for LS patients with an EIN or EC diagnosis is uncommon. Progesterone response rates appear to be lower than those in sporadic cases, though similar clinical and histologic factors (age, BMI, and p53 expression pattern) may predict disease regression and fertility outcomes. A larger sample and standardized treatment paradigm are needed to provide more evidence on fertility sparing management for LS patients.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"59 ","pages":"Article 101768"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding Mirvetuximab sensitivity in platinum sensitive versus platinum resistant cell lines","authors":"Sadhvi Batra,&nbsp;Jessica Teitel,&nbsp;Analisa DiFeo","doi":"10.1016/j.gore.2025.101869","DOIUrl":"10.1016/j.gore.2025.101869","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of patient derived ovarian cancer organoids with native immune cells","authors":"Leah N. Wormack,&nbsp;Jose L. Cedano,&nbsp;Jaidev Bapat,&nbsp;Kailea Wiese,&nbsp;Sofia Ruau,&nbsp;Wanda Gan,&nbsp;Jocelyn Chapman,&nbsp;Lee-may Chen,&nbsp;Stephanie Cham,&nbsp;Katherine Fuh","doi":"10.1016/j.gore.2025.101871","DOIUrl":"10.1016/j.gore.2025.101871","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetes mellitus mortality amongst endometrial cancer patients: analysis of the SEER database","authors":"Kyra Hunsberger,&nbsp;Lily Zello,&nbsp;Devin Vitug,&nbsp;Dana M. Chase","doi":"10.1016/j.gore.2025.101850","DOIUrl":"10.1016/j.gore.2025.101850","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the association between family cancer history and variants of uncertain significance","authors":"Rebecca Shin,&nbsp;Natalie Ayoub,&nbsp;Haibo Lu,&nbsp;Bowen Li,&nbsp;Brittany C. Thomas,&nbsp;Joseph DeNagy","doi":"10.1016/j.gore.2025.101857","DOIUrl":"10.1016/j.gore.2025.101857","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delays in surgical treatment for endometrial cancer: long lasting impacts of COVID-19","authors":"Vaidehi Mujumdar,&nbsp;Robert Wendel Naumann","doi":"10.1016/j.gore.2025.101874","DOIUrl":"10.1016/j.gore.2025.101874","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"What matters to you?: A medical and art student collaboration to create immersive legacy memorials with gynecologic cancer patients anticipating end-of-life","authors":"Catherine L. Dugan,&nbsp;Jennifer Ferrin,&nbsp;Karen Gonzalez,&nbsp;Autumn Kleinman,&nbsp;Yu-Han Wang,&nbsp;Malini Adkins,&nbsp;Marientina Gotsis,&nbsp;X. Mona Guo","doi":"10.1016/j.gore.2025.101876","DOIUrl":"10.1016/j.gore.2025.101876","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human Papillomavirus (HPV) vaccination rates within a large national network of community health organizations: a cross-sectional study","authors":"Amanda S. Bruegl,&nbsp;Keely Ulmer,&nbsp;Kelly Ulmer,&nbsp;Ngoc Wasson,&nbsp;Taona Haderlein,&nbsp;Kristin Scott","doi":"10.1016/j.gore.2025.101822","DOIUrl":"10.1016/j.gore.2025.101822","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}