Gynecologic Oncology Reports最新文献

{"title":"Granulosa cell tumor patients presenting with acute abdomen: a case series","authors":"Geertruid J. Brink ,&nbsp;Jolijn W. Groeneweg ,&nbsp;Ariane A. Sickinghe ,&nbsp;Christianne A.R. Lok ,&nbsp;Hans W. Nijman ,&nbsp;Jurgen M.J. Piek ,&nbsp;Ward Hofhuis ,&nbsp;Eva Maria Roes ,&nbsp;Luc R.C.W. van Lonkhuijzen ,&nbsp;Cor D. de Kroon ,&nbsp;Eelke H. Gort ,&nbsp;Petronella O. Witteveen ,&nbsp;Ronald P. Zweemer","doi":"10.1016/j.gore.2025.101781","DOIUrl":"10.1016/j.gore.2025.101781","url":null,"abstract":"<div><h3>Objective</h3><div>To highlight the unique clinical presentation of acute abdomen in granulosa cell tumor patients.</div></div><div><h3>Methods</h3><div>In a multicenter cohort study of adult-type granulosa cell tumors, women presenting with an acute abdomen at diagnosis were identified (<span><span>Brink, 2025</span></span>). After informed consent, clinical data were retrieved from patient records and collected in a Castor EDC database. Statistical analyses were performed to compare the subgroup of women with acute abdomen with the remainder of the adult type granulosa cell tumor cohort.</div></div><div><h3>Results</h3><div>Twenty-six out of 208 (12.5%) patients had an acute abdomen as presenting symptom of an adult-type granulosa cell tumor. All patients underwent emergency abdominal surgery. In 16 (62%) patients, the tumor mass was found to be ruptured pre-operatively, and 7 (27%) patients had an ovarian torsion. Seventeen patients (65%) of this group developed recurrent disease. When compared with the rest of the adult-type granulosa cell tumor cohort, patients with an acute abdomen at diagnosis were younger, had significantly more perioperative blood loss, and more often developed a recurrence.</div></div><div><h3>Conclusions</h3><div>Adult-type granulosa cell tumors present with an acute abdomen in over 10% of the cases. In case of an ovarian mass or hemoperitoneum in women with an acute abdomen, a granulosa cell tumor should be considered in the differential diagnosis. Surgery can then be performed with a more oncological approach, striving to avoid spill and thus decrease the risk of recurrence.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":"Article 101781"},"PeriodicalIF":1.2,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144313645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial carcinosarcoma presenting with a solitary breast metastasis − A rare case report","authors":"Inês Taborda Leal ,&nbsp;Maria Inês Barradas ,&nbsp;Gonçalo Freitas ,&nbsp;Filipa Castro Coelho ,&nbsp;Filipa Santos ,&nbsp;Mónica Cardoso ,&nbsp;Maria Ana Serrado ,&nbsp;Hugo Gaspar","doi":"10.1016/j.gore.2025.101780","DOIUrl":"10.1016/j.gore.2025.101780","url":null,"abstract":"<div><h3>Background</h3><div>Endometrial carcinosarcoma (ECS) is a rare and highly aggressive malignancy, accounting for approximately 5% of all uterine cancers. While peritoneal seeding and pulmonary metastases are relatively common, breast involvement is exceedingly rare, with only a few cases reported in the literature, primarily involving the serous or clear cell subtypes and typically associated with widespread metastatic disease. To the best of our knowledge, this is the second documented case of a primary ECS metastasizing to the breast, and the first presenting as a solitary breast mass.</div></div><div><h3>Case Report</h3><div>A 68-year-old woman presented to the emergency department with one week history of postmenopausal abnormal uterine bleeding. Endometrial biopsy confirmed the diagnosis of ECS. Staging thoracoabdominal computed tomography (CT) revealed a solitary 11 mm mass in the lower outer quadrant of the left breast, accompanied by two ipsilateral axillary lymph nodes, but otherwise no signs of distant metastases, additional lymphadenopathies, or peritoneal implants were described. Findings on abdominal and pelvic magnetic resonance imaging (MRI) were concordant with CT, demonstrating no suspicious lymphadenopathies or signs of distant metastatic disease. Breast biopsy revealed a papillary carcinoma with <em>CERB2</em> positivity. The patient underwent total hysterectomy, bilateral salpingo-oophorectomy, omentectomy, pelvic and lombo-aortic lymphadenectomy, as well as left breast lumpectomy and axillary lymphadenectomy. Complete cytoreductive surgery was performed with no macroscopic residual disease. Final pathology confirmed the breast lesioń metastatic origin.</div></div><div><h3>Conclusion</h3><div>This case holds clinical significance as it underscores the necessity of considering a broad differential diagnosis when encountering uncommon or atypical presentations, particularly in high-grade malignancies such as ECS.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":"Article 101780"},"PeriodicalIF":1.2,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extended neoadjuvant chemotherapy in advanced ovarian cancer treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy: decision drivers and surgical outcomes","authors":"Kseniia Uzhegova,&nbsp;Armando Sardi,&nbsp;Mary Caitlin King,&nbsp;Vladislav Kovalik,&nbsp;Sergei Iugai,&nbsp;Luis Felipe Falla-Zuniga,&nbsp;Abeerah Wasti,&nbsp;Carol Neiroda,&nbsp;Teresa Diaz-Montes,&nbsp;Vadim Gushchin","doi":"10.1016/j.gore.2025.101867","DOIUrl":"10.1016/j.gore.2025.101867","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183583","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coping with cancer: a trilingual graphic medicine approach to women’s oncology","authors":"Alexandra Bartholomew,&nbsp;Amelia Jernigan,&nbsp;Pui Cheng,&nbsp;Tara Castellano,&nbsp;Jason C Mussell","doi":"10.1016/j.gore.2025.101819","DOIUrl":"10.1016/j.gore.2025.101819","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ovarian Cancer in Patients over 70 years old with Pathogenic Variants: Real-World Genetic Testing Data Informing Screening and Risk Reduction in Older Age","authors":"Eliya Shachar,&nbsp;Breanna Roscow,&nbsp;Lorna Kwan,&nbsp;Maral Demirjian,&nbsp;Rachel Frankenthal,&nbsp;Beth Karlan,&nbsp;Dana M. Chase","doi":"10.1016/j.gore.2025.101840","DOIUrl":"10.1016/j.gore.2025.101840","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postoperative outcomes in gynecologic oncology: the role of social determinants of health","authors":"Jorge Cervantes,&nbsp;Lavanya H. Palavalli Parsons,&nbsp;Madison Schulz,&nbsp;Bailey Widstrom,&nbsp;Rosa Guerra,&nbsp;Abigail S. Zamorano,&nbsp;Elizabeth Nugent,&nbsp;Joseph A. Lucci III,&nbsp;Diego Aviles","doi":"10.1016/j.gore.2025.101845","DOIUrl":"10.1016/j.gore.2025.101845","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neighborhood-level housing and transportation vulnerability negatively impacts the timely treatment of cervical cancer","authors":"Julie Sammouri,&nbsp;Jorge Cervantes,&nbsp;Joe Haydamous,&nbsp;Jooeun Jeong,&nbsp;Samantha Antonioli,&nbsp;Joseph A. Lucci III,&nbsp;Elizabeth Nugent,&nbsp;Lavanya H. Palavalli Parsons,&nbsp;Rosa Guerra,&nbsp;Diego Aviles,&nbsp;Ioana Bondre,&nbsp;Katelyn F. Handley,&nbsp;Abigail S. Zamorano","doi":"10.1016/j.gore.2025.101856","DOIUrl":"10.1016/j.gore.2025.101856","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rising burden of benign consults in gynecologic oncology","authors":"Nora Badiner,&nbsp;Kelly Hood,&nbsp;Yevgeniya Ioffe,&nbsp;Vishwa Shah,&nbsp;Linda Hong","doi":"10.1016/j.gore.2025.101873","DOIUrl":"10.1016/j.gore.2025.101873","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cervical cancer patients’ knowledge and experiences with palliative care – A qualitative study","authors":"Jaclyn A. Wall ,&nbsp;Tamara Nix-Parker ,&nbsp;Katherine Klein ,&nbsp;Marie A. Bakitas","doi":"10.1016/j.gore.2025.101774","DOIUrl":"10.1016/j.gore.2025.101774","url":null,"abstract":"<div><h3>Objective</h3><div>There is limited research examining palliative care (PC) knowledge and experiences in patients with cervical cancer. As this may inform who may benefit from specialty PC services, we investigated PC awareness, perspectives, needs, and acceptability in this population.</div></div><div><h3>Methods</h3><div>We conducted a qualitative study of patients with newly diagnosed (&lt;12 months) cervical cancer. Eligible patients were &gt; 18 years old and English-speaking. Semi-structured interview topics included knowledge/perceptions of PC, knowledge/perceptions of hospice, and experiences with PC or hospice. Participants were then read a brief definition and overview of services provided by PC (education). We then explored perceptions of PC acceptability and timing. Interviews were deidentified, professionally transcribed, and coded. Codes were grouped into categories and themes.</div></div><div><h3>Results</h3><div>Seventeen patients participated. Median age was 52, 64 % were white, all had insurance. 35 % had stage I disease, 17.6 % stage II, and 47 % stage III. Most had minimal PC knowledge (12/17, 70.6 %) but were aware of hospice (16/17, 94.1 %) and understood it as end-of-life care (10/17, 58.8 %). Following our education, most felt PC would be beneficial (13/17, 76.5 %), and favored early introduction in their care (11/17, 64.7 %). We identified four main themes: two pre-education (PC knowledge is lacking, hospice is well-understood and favorably viewed) and two post-education (PC would provide an unmet benefit, early PC is preferable).</div></div><div><h3>Conclusions</h3><div>PC knowledge was limited. However, following brief education, most patients found it desirable and favored early integration. This highlights the need for further research on developing early PC initiatives for patients with cervical cancer.</div></div>","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"59 ","pages":"Article 101774"},"PeriodicalIF":1.2,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144205499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is AI your next genetic counselor for patients with gynecologic malignancy?","authors":"Riley Shin,&nbsp;Ashley K. Shin,&nbsp;Mia Ramirez,&nbsp;Ioana Bondre,&nbsp;Brittanie Shelton,&nbsp;Leslie Dunnington,&nbsp;Elizabeth Nugent","doi":"10.1016/j.gore.2025.101836","DOIUrl":"10.1016/j.gore.2025.101836","url":null,"abstract":"","PeriodicalId":12873,"journal":{"name":"Gynecologic Oncology Reports","volume":"60 ","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145183602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}