Gynecological Endocrinology最新文献_第5页

Nonalcoholic fatty liver disease risk in polycystic ovary syndrome patients. 多囊卵巢综合征患者患非酒精性脂肪肝的风险。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-05-30 DOI: 10.1080/09513590.2024.2359031

Ana M Fernández-Alonso, Peter Chedraui, Faustino R Pérez-López

引用次数: 0

A prospective, multicenter, randomized, double-blind placebo-controlled trial on purified and specific Cytoplasmic pollen extract for hot flashes in breast cancer survivors. 一项前瞻性、多中心、随机、双盲安慰剂对照试验，研究纯化的特异性细胞质花粉提取物对乳腺癌幸存者潮热的治疗效果。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-05-17 DOI: 10.1080/09513590.2024.2334796

Valentina Elisabetta Bounous, Isabella Cipullo, Marta D'Alonzo, Silvia Martella, Dorella Franchi, Paola Villa, Nicoletta Biglia, Annamaria Ferrero

{"title":"A prospective, multicenter, randomized, double-blind placebo-controlled trial on purified and specific Cytoplasmic pollen extract for hot flashes in breast cancer survivors.","authors":"Valentina Elisabetta Bounous, Isabella Cipullo, Marta D'Alonzo, Silvia Martella, Dorella Franchi, Paola Villa, Nicoletta Biglia, Annamaria Ferrero","doi":"10.1080/09513590.2024.2334796","DOIUrl":"10.1080/09513590.2024.2334796","url":null,"abstract":"Objective: evaluate the efficacy and tolerability of PureCyTonin against hot flashes (HF) in breast cancer survivors (BCS).Methods: a prospective, multicenter, randomized, double-blind placebo-controlled trial was conducted in Italy.Interventions: administration of PureCyTonin or placebo, for 3 months. Effectiveness was investigated through the compilation of a daily diary for HF and of validated questionnaires (Menopause Rating Scale (MRS), Pittsburgh Sleep Quality Index (PSQI), Visual Analogical Scales (VAS) for HF, sweating, irritability, fatigue, sleep, quality of life), carried out before starting the treatment (T0), after 1 month (T1) and after 3 months (T2). Any side effects and HF diary were recorded at each visit.Results: 19 women were randomized to receive PureCyTonin and 20 to placebo. At T2 compared to T0, in the PureCyTonin group, we found a reduction in the number of HF (p = 0.02) measured by daily diary. An improvement in the subjective perception of women regarding HF intensity (p = 0.04), sweat nuisance (p = 0.02), irritability (p = 0.03) and fatigue (p = 0.04) was observed through VAS scale measurement at T2 compared to T0.The total MRS score was significantly better in the PureCyTonin group at T1 (p = 0.03) compared to T0.Conclusions: PureCyTonin significantly reduces HF number after 3 months of therapy in BCS and it is well-tolerated.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2334796"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140956813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis. 多囊卵巢综合征妇女血清血红素水平低：来自荟萃分析的证据。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-07-08 DOI: 10.1080/09513590.2024.2375568

Jieou Nong, Hua Li, Yunfei Yang, Qiujie Lu, Yifan Sun, Qi Yin, Hongying He

{"title":"Low serum hepcidin levels in women with polycystic ovary syndrome: evidence from meta-analysis.","authors":"Jieou Nong, Hua Li, Yunfei Yang, Qiujie Lu, Yifan Sun, Qi Yin, Hongying He","doi":"10.1080/09513590.2024.2375568","DOIUrl":"10.1080/09513590.2024.2375568","url":null,"abstract":"Background: Iron metabolism plays a significant role in the development of metabolic disorders in women with polycystic ovary syndrome (PCOS). Despite the importance of hepcidin, a key iron regulator, current research on serum hepcidin levels in PCOS patients shows conflicting results.Methods: PubMed, Embase, Web of Science, Cochrane Library and the China National Knowledge Infrastructure (CNKI) database were systematically searched from their inception to 9 September 2023. The search aimed to identify studies in English and Chinese that examined hepcidin levels in women with PCOS compared to healthy control subjects. Standardized mean differences (SMDs) with corresponding 95% confidence intervals (95% CIs) were calculated to evaluate the difference in serum hepcidin levels between women with and without PCOS.Results: The meta-analysis included a total of 10 eligible studies, which encompassed 499 PCOS patients and 391 control subjects. The pooled analysis revealed a significant reduction in serum hepcidin levels among the PCOS patients compared to the healthy controls (SMD = -3.49, 95% CI: -4.68 to -2.30, p < .05). There was no statistically significant difference in serum hepcidin levels between PCOS patients with a body mass index (BMI) < 25 and those with a BMI ≥ 25 (p > .05).Conclusion: The serum hepcidin levels of women with PCOS were significantly lower than those of healthy controls, which suggests that serum hepcidin could be a potential biomarker for PCOS.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2375568"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of visnadine in the treatment of symptoms of sexual dysfunction in heterosexual women: a systematic review of randomized clinical trials. 维那丁治疗异性恋女性性功能障碍症状的有效性和安全性：随机临床试验的系统回顾。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-03-25 DOI: 10.1080/09513590.2024.2328619

Brenda Caira-Chuquineyra, Daniel Fernandez-Guzmán, Humberto Garayar-Peceros, Vicente A Benites-Zapata, Faustino R Pérez-López, Juan E Blümel, Edward Mezones-Holguín

{"title":"Efficacy and safety of visnadine in the treatment of symptoms of sexual dysfunction in heterosexual women: a systematic review of randomized clinical trials.","authors":"Brenda Caira-Chuquineyra, Daniel Fernandez-Guzmán, Humberto Garayar-Peceros, Vicente A Benites-Zapata, Faustino R Pérez-López, Juan E Blümel, Edward Mezones-Holguín","doi":"10.1080/09513590.2024.2328619","DOIUrl":"10.1080/09513590.2024.2328619","url":null,"abstract":"Objective: To synthesize the primary evidence on the efficacy and safety of visnadine on symptoms of sexual dysfunction (SD) in heterosexual women.Methods: We conducted a systematic review of randomized clinical trials (RCTs) with a primary search without language restriction in PubMed/Medline, Scopus, Embase, Web of Science, Cochrane Library, and international clinical trial registries. Trials reporting the use of visnadine by any route in women with SD were eligible. We performed screening, data extraction, and risk of bias assessment in a double-blind approach. The primary outcomes were the Female Sexual Function Index (FSFI) and its domains. Secondary outcomes were safety, arousal, lubrication, pleasure, orgasm, negative sensations, duration, and overall satisfaction.Results: Initially, 242 records were retrieved. We selected nine papers for full-text reading and finally included two RCTs: one with a parallel design and one with a crossover design with a total of 96 patients. One study compared visnadine aerosol with a placebo, while the other compared different frequencies of visnadine aerosol use. Visnadine use showed a statistically significant improvement (p < 0.05) in overall FSFI scores, regardless of the frequency of use. A meta-analysis was not possible due to the high clinical and methodological heterogeneity between available studies.Conclusion: RCTs regarding the use of visnadine for the Female SD are scarce and methodologically limited. This preliminary evidence shows visnadine as a potentially effective and safe option to alleviate some of the clinical symptoms of SD in heterosexual women. However, future better-designed randomized studies with larger sample numbers are required.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2328619"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140287375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Psychological stressors involved in the pathogenesis of premature ovarian insufficiency and potential intervention measures. 卵巢早衰发病机制中的心理压力因素及潜在干预措施。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-05-30 DOI: 10.1080/09513590.2024.2360085

Ying-Pei Xu, Ji-Chun Fu, Zhi-Lin Hong, De-Fei Zeng, Chao-Qin Guo, Ping Li, Jin-Xiang Wu

引用次数: 0

Changes in polyunsaturated fatty acids are linked to metabolic syndrome in climacteric syndrome patients. 多不饱和脂肪酸的变化与更年期综合征患者的代谢综合征有关。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-12-23 DOI: 10.1080/09513590.2024.2433133

Hua Ye, Linju Zhou, Qing Liu, Wanghua Xiao

{"title":"Changes in polyunsaturated fatty acids are linked to metabolic syndrome in climacteric syndrome patients.","authors":"Hua Ye, Linju Zhou, Qing Liu, Wanghua Xiao","doi":"10.1080/09513590.2024.2433133","DOIUrl":"https://doi.org/10.1080/09513590.2024.2433133","url":null,"abstract":"Objective: This study explored the association between ω-6 to ω-3 polyunsaturated fatty acids (PUFAs) and metabolic syndrome in women experiencing climacteric syndrome.Methods: The study involved 186 female participants and utilized surveys, anthropometric measurements (waist circumference, height, BMI, waist-to-height ratio), blood pressure assessments, and blood samples for lipid profile, glucose, insulin, HbA1c analysis. Serum PUFAs levels were analyzed using gas chromatography-mass spectrometry.Results: The study found significantly higher measurements of waist circumference, waist-to-height ratio, systolic and diastolic blood pressure in postmenopausal women with metabolic syndrome compared to the control group. In addition, the metabolic syndrome group showed significantly higher levels of fasting blood glucose, triglycerides, low-density lipoprotein cholesterol, HbA1c, insulin, triglyceride to high-density lipoprotein ratio, and total cholesterol to high-density lipoprotein ratio. Furthermore, the study also identified significant differences among premenopausal women, postmenopausal women with metabolic syndrome, and postmenopausal women without metabolic syndrome in terms of omega-3 alpha-linolenic acid, omega-3 docosahexaenoic acid, omega-6 arachidonic acid, and omega-6 to omega-3 ratio.Conclusions: We observed that high ω-6 arachidonic acid and ω-6/ω-3 ratio and low ω-3 ALA and ω-3 DHA were associated with high TG and WHtR. High TG and WHtR levels in postmenopausal women are associated with increased risk of Mets.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2433133"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lower serum LH level was related to poor embryo quality and adverse pregnancy outcomes in fixed GnRH antagonist protocol with estradiol pretreatment. 在雌二醇预处理的固定 GnRH 拮抗剂方案中，血清 LH 水平较低与胚胎质量差和不良妊娠结局有关。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-10-03 DOI: 10.1080/09513590.2024.2409147

Ying Chen, Yizhe Li, Xu Li, Linhong Liu, Zhen Liu, Wenwu Gui, Xiru Liu, Ying Chen

{"title":"Lower serum LH level was related to poor embryo quality and adverse pregnancy outcomes in fixed GnRH antagonist protocol with estradiol pretreatment.","authors":"Ying Chen, Yizhe Li, Xu Li, Linhong Liu, Zhen Liu, Wenwu Gui, Xiru Liu, Ying Chen","doi":"10.1080/09513590.2024.2409147","DOIUrl":"https://doi.org/10.1080/09513590.2024.2409147","url":null,"abstract":"Objective: To disclose the relationships between serum LH and reproductive outcomes in Gonadotropin-releasing hormone (GnRH) antagonist protocol pretreated with luteal estradiol.Methods: 371 patients, pretreated with estradiol, followed the GnRH antagonist protocol. They were divided into four groups based on the quartiles of serum LH levels on the day of gonadotropin (Gn) initiation(LHGI) and trigger (LHtrigger). Data on various pregnancy outcomes were collected.Results: As serum LHGI increased, anti-Müllerian hormone (AMH) level, antral follicle count (AFC), LHtrigger, estradiol (E2) and P on the trigger day, E2/oocytes, and oocyte numbers increased and peaked in Q4, while Gn dose decreased. Good-quality embryo and blast formation rates increased and peaked in Q3. LHGI <3.93 mIU/ml impaired ongoing pregnancy rate and LBR. After adjusting for AMH and AFC, the impacts were not significant. As LHtrigger increased, E2/oocytes and good-quality embryo rate increased and peaked in T4 and implantation rate increased and peaked in T3. LHtrigger <1.49 mIU/ml independently influenced clinical pregnancy rate (CPR) after adjusting for AMH and AFC. LHGI was positively related to AMH, AFC, LHtrigger, blast formation rate and negatively related to BMI, age and Gn dose. LHtrigger was positively related to E2/oocytes and good quality embryo rate.Conclusions: Lower serum LH represents as a potential indicator for embryo quality and reproductive outcomes in GnRH antagonist fixed protocol pretreated with estradiol. Early identification of excessive suppression of LH levels will benefit individuals with normal ovarian reserve more.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2409147"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The role of inositols during pregnancies complicated by gestational diabetes mellitus: a narrative review. 肌醇在妊娠并发妊娠糖尿病期间的作用：叙述性综述。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-10-04 DOI: 10.1080/09513590.2024.2411727

Ilaria Mazzera, Annalisa Graziano, Giuseppe Vizzielli, Lorenza Driul

引用次数: 0

HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation. 树突状细胞和基质细胞中 HSD11B1 的过度表达会抑制树突状细胞的增殖和成熟，从而与子宫内膜异位症有关。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-10-10 DOI: 10.1080/09513590.2024.2411607

Xu Yang, Lu Jiang, Yao Xu

{"title":"HSD11B1 overexpression in dendritic cells and stromal cells relates to endometriosis by inhibiting dendritic cell proliferation and maturation.","authors":"Xu Yang, Lu Jiang, Yao Xu","doi":"10.1080/09513590.2024.2411607","DOIUrl":"https://doi.org/10.1080/09513590.2024.2411607","url":null,"abstract":"Aims: This study aims to explore the alterations of dendritic cells (DCs) subpopulations in ectopic endometrial lesions and unveil the underlying mechanisms.Materials and methods: Patients with endometriosis (n = 81) and women without endometriosis (n = 19) were recruited in this study. Dendritic cells (DCs) in the endometrial samples were counted after immunohistochemistry staining. The proportion of myeloid DCs and plasmacytoid DCs was calculated by flow cytometry. Primary DCs were isolated from tissues, and the cell viability and apoptosis were examined by MTT assay and flow cytometry. Cytokines were detected by the enzyme-linked immunosorbent assay. Differentially expressed genes were filtered by analyzing two datasets that were downloaded from GEO database and detected by RT-qPCR in tissues and isolated DCs. The function of HSD11B1 was examined in an endometrial stromal cell-DCs co-culture system and in vitro cultured DCs.Results: Reduced myeloid DCs and increased CD11c-CD304-DCs were found in ectopic endometrium compared to control endometrium and eutopic endometrium from endometriosis patients. Myeloid DCs isolated from ectopic endometrium expressed less CD80, CD83, CD86 and had reduced proliferation, increased apoptosis, and reduced cytokine production. The expression of HSD11B1 was significantly increased in both ectopic endometrium and isolated myeloid DCs. Overexpression of HSD11B1 in immature DCs could repress DCs maturation and cytokine production. Endometrial stromal cells overexpressing HSD11B1 secreted increased cortisol, which repressed DCs maturation.Conclusions: HSD11B1 is upregulated in ectopic endometrial lesions, which may contribute to endometriosis through repressing myeloid DCs maturation.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"40 1","pages":"2411607"},"PeriodicalIF":2.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expression of Concern: Laparoscopic ovarian drilling versus GnRH antagonist combined with cabergoline as a prophylaxis against the re-development of ovarian hyperstimulation syndrome. 表达关切：腹腔镜卵巢钻孔术与 GnRH 拮抗剂联合卡麦角林作为预防卵巢过度刺激综合征再次发生的方法。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2024-12-01 Epub Date: 2024-03-11 DOI: 10.1080/09513590.2024.2307189

引用次数: 0