Gynecological Endocrinology最新文献_第5页

Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol. 超重/肥胖多囊卵巢综合征患者接受肉毒碱、l -精氨酸、l -半胱氨酸和肌醇综合治疗后胰岛素敏感性和生殖特征的改善

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-01-28 DOI: 10.1080/09513590.2025.2458710

Alessandro D Genazzani, Christian Battipaglia, Martina Foschi, Elisa Semprini, Claudia Aio, Eleonora Spelta, Anna Kostrzak, Maria Laura Rusce, Anna Szeliga, Blazej Meczekalski

{"title":"Improved insulin sensitivity and reproductive profile in overweight/obese PCOS patients undergoing integrative treatment with carnitines, L-arginine, L-cysteine and myo-inositol.","authors":"Alessandro D Genazzani, Christian Battipaglia, Martina Foschi, Elisa Semprini, Claudia Aio, Eleonora Spelta, Anna Kostrzak, Maria Laura Rusce, Anna Szeliga, Blazej Meczekalski","doi":"10.1080/09513590.2025.2458710","DOIUrl":"10.1080/09513590.2025.2458710","url":null,"abstract":"Objective: To evaluate the effects of a combination of carnitines, L-arginine, L-cysteine and myo-inositol on metabolic and reproductive parameters in PCOS overweight/obese patients.Methods: This was a retrospective study analyzing information of a group of PCOS (n = 25) overweight/obesity patients, not requiring hormonal treatment, selected from the database of the ambulatory clinic of the Gynecological Endocrinology Center at the University of Modena and Reggio Emilia, Modena, Italy. The hormonal profile, routine exams and insulin and C-peptide response to oral glucose tolerance test (OGTT) were evaluated before and after 12 weeks of a daily oral complementary treatment with L-carnitine (500 mg), acetyl-L-carnitine (250 mg), L-arginine (500 mg), L-cysteine (100 mg) and myo-inositol (1 gr). The hepatic insulin extraction index was also calculated.Results: The mix of complementary substances significantly improved metabolic parameters, homeostatic model assessment for insulin resistance index values and gonadotropin plasma levels. Glucose, C-peptide and insulin response to OGTT was significantly reduced as well as the hepatic insulin extraction index.Conclusion: The administration of a combination of carnitines, L-arginine, L-cysteine and myoinositol improved gonadotropin plasma levels and insulin sensitivity in overweight/obese PCOS patients and restored hepatic clearance of insulin as demonstrated by the decreased hepatic insulin extraction index.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2458710"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Studys on the effect of decidual stromal cells and trophoblast cells on cytokine secretion by decidual NK cells. 间质细胞和滋养细胞对蜕膜NK细胞分泌细胞因子影响的研究。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-04-28 DOI: 10.1080/09513590.2025.2497857

Jia Liu, Peng Dong, Xi Wen, Jian Li, Shijun Wang, Qinghua Zhang

{"title":"Studys on the effect of decidual stromal cells and trophoblast cells on cytokine secretion by decidual NK cells.","authors":"Jia Liu, Peng Dong, Xi Wen, Jian Li, Shijun Wang, Qinghua Zhang","doi":"10.1080/09513590.2025.2497857","DOIUrl":"https://doi.org/10.1080/09513590.2025.2497857","url":null,"abstract":"Unexplained recurrent pregnant loss (URPL) is associated with immune imbalance at the maternal-fetal interface. Decidual immune cells regulate the response of the maternal immune system to the fetus. However, the effect of decidual stromal cells (DSCs) and trophoblast cells on cytokine secretion by decidual NK cells remains unclear. In this study, we investigated the influence of JEG-3 cells and DSCs on the secretion of cytokines in dNK cells. Furthermore, we investigated whether or not cytokine secretion was regulated by the mitogen-activated protein kinase (MAPK) signaling pathway at the maternal-fetal interface. Our study showed that the secretions of both IFN-γ and TNF-α in dNK cells in URPL were significantly higher than those in normal pregnancy. In the coculture of JEG-3, DSCs, and dNK cells, IL-10 and IL-4 production increased in dNK cells during normal pregnancy; whereas IFN-γ and TNF-α production increased but IL-10 and IL-4 levels decreased during URPL. Furthermore, pretreatment with P38/MAPK inhibition significantly inhibited the secretion of NK1- and NK2-type cytokines in the coculture of the three types of cells. Our study elucidated the influence of trophoblasts and DSCs on the expression of cytokines in dNK cells in patients with URPL and uncovered a complicated crosstalk through the MAPK signal at the maternal-fetal interface.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2497857"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143976332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormone therapy with different administration routes for patients with perimenopausal syndrome: a systematic review and network meta-analysis. 围绝经期综合征患者不同给药途径的激素治疗：系统综述和网络荟萃分析。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-02-13 DOI: 10.1080/09513590.2025.2462067

Liping Wang, Xinrui Luo, Mulan Ren, Yan Wang

{"title":"Hormone therapy with different administration routes for patients with perimenopausal syndrome: a systematic review and network meta-analysis.","authors":"Liping Wang, Xinrui Luo, Mulan Ren, Yan Wang","doi":"10.1080/09513590.2025.2462067","DOIUrl":"10.1080/09513590.2025.2462067","url":null,"abstract":"Purpose: To comprehensively compare and rank hormone therapy for patients with perimenopausal syndrome.Methods: A comprehensive search was conducted on PubMed, Embase, Cochrane Library, Web of Science, CNKI, VIP, and Wanfang databases from inception to August 20, 2024. The quality of the included randomized controlled trials (RCTs) were measured by the Cochrane risk of bias tool. The Grading of Recommendations Assessment, Development and Evaluation (GRADE) method was applied to grade the quality of evidence in this network meta-analysis. Network plots were depicted to show direct and indirect comparisons of hormone therapy for each outcome. The influences of different hormone therapy on the outcomes were illustrated via forest plots and league tables. Rank probabilities showed the ranking of different administration routes.Results: Seven studies involving 704 perimenopausal syndrome patients were included. The rank probabilities suggested that oral estradiol (E2) combined with medroxyprogesterone and general health guidance had the highest likelihood to be the optimal therapy for the severity of menopausal syndrome. General health guidance combined with oral E2 was less likely to have a nausea and vomiting, and breast pain.Conclusion: Oral E2 and medroxyprogesterone or general health guidance combined with oral E2 may be the effective and safe option for the management of perimenopausal syndrome.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2462067"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143407117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and predictive factors for vitamin D deficiency in pregnant Lebanese women: a retrospective cohort study. 黎巴嫩孕妇维生素D缺乏的患病率和预测因素：一项回顾性队列研究。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-06-24 DOI: 10.1080/09513590.2025.2521531

Muhieddine Seoud, Iman Jaafar, Dalal Kojok, Sara Sleiman, Talal Seoud, Ghina Ghaziri, Fadi Mirza

{"title":"Prevalence and predictive factors for vitamin D deficiency in pregnant Lebanese women: a retrospective cohort study.","authors":"Muhieddine Seoud, Iman Jaafar, Dalal Kojok, Sara Sleiman, Talal Seoud, Ghina Ghaziri, Fadi Mirza","doi":"10.1080/09513590.2025.2521531","DOIUrl":"https://doi.org/10.1080/09513590.2025.2521531","url":null,"abstract":"Objective: This study aimed to determine the prevalence of vitamin D deficiency and its associated factors among women attending women's health clinics at a university medical center in Lebanon.Methods: We retrospectively reviewed clinical and obstetric data, including 25-hydroxyvitamin D [25OHD] serum levels and vitamin D3 supplementation, from 873 healthy singleton pregnancies delivered between 2006 and 2017. Women with preexisting comorbidities or prior gestational complications were excluded. VDD was defined as a 25OHD serum level <20 ng/ml.Results: At baseline, 63% of participants were vitamin D deficient. Poisson regression was used to identify independent predictors of deficiency. In early gestation, 25OHD levels varied significantly by age, pre-pregnancy BMI, parity, smoking status, and season of presentation (all p < 0.05). At late gestation, vitamin D levels were associated with pre-pregnancy BMI, hemoglobin status at delivery, and vitamin D status at early gestation. Women with 25OHD <20 ng/ml at late gestation were more likely to be anemic compared to those with levels ≥20 ng/ml (adjusted odds ratio 1.6; 95% CI: 1.1-2.5).Conclusion: Vitamin D deficiency is highly prevalent among pregnant Lebanese women. Identified risk factors including higher BMI, younger age, multiparity, and anemia should prompt consideration of more aggressive vitamin D supplementation strategies for women planning pregnancy.Synopsis: Vitamin D deficiency is quite prevalent among pregnant women in the Middle East. We aim to report the prevalence of Vitamin D deficiency and its associated predictors during pregnancy.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2521531"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144484081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Beyond body mass index: redefining the diagnosis of obesity. 超越身体质量指数：重新定义肥胖的诊断。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-03-20 DOI: 10.1080/09513590.2025.2480332

Santiago Palacios, Rodrigo Orozco, Jose M Garcia-Almeida

引用次数: 0

The influence of male smoking on success rates after IVF/ICSI. 男性吸烟对试管婴儿/卵胞浆内单精子显微注射成功率的影响。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-02-25 DOI: 10.1080/09513590.2025.2465594

S De Brucker, E Dhooge, P Drakopoulos, V Uvin, S Mackens, L Boudry, M De Vos, V Vloeberghs, H Tournaye, M De Brucker

{"title":"The influence of male smoking on success rates after IVF/ICSI.","authors":"S De Brucker, E Dhooge, P Drakopoulos, V Uvin, S Mackens, L Boudry, M De Vos, V Vloeberghs, H Tournaye, M De Brucker","doi":"10.1080/09513590.2025.2465594","DOIUrl":"10.1080/09513590.2025.2465594","url":null,"abstract":"Objective: It has been established that male cigarette smoking has a negative effect on the semen quality and that it can induce DNA damage leading to worsening of reproductive outcomes. The aim of our large retrospective study is to determine the influence of male cigarette smoking on assisted reproduction, more specifically in IVF and ICSI outcomes.Materials and methods: Our study included all consecutive infertile couples (with a nonsmoking female partner) having their first IVF/ICSI cycle. All patients had smoking assessment. Smokers were further classified into mild (1-10 cigarettes/day), moderate (11-20 cigarettes/day) or heavy smokers (>20 cigarettes/day). The primary outcome was live birth rates (LBR).Results: The overall number of patients analyzed was 4004 and among them 433 (10.8%) were smokers. Baseline characteristics, such as female age and BMI differed significantly between nonsmokers and smokers. The crude analysis showed higher positive hCG and LBR in smokers (positive hCG 28.34% in nonsmokers vs 33.95% in smokers, p = 0.015; LBR 23.55% in nonsmokers vs 28.64% in smokers, p = 0.019) However after adjustment for relevant confounders (female age, BMI, cause of infertility, number of oocytes retrieved, insemination procedure, number of embryos transferred and day of embryo transfer) the smoking status was not significantly associated with fresh LBR (OR = 1.16, CI = 0.92-1.48; p = 0.2). The results were replicated after classification of smoking into mild/moderate/heavy [OR for nonsmokers (reference category) vs. mild vs. moderate vs. heavy= 1, 1.17, 1, 2.99; p = 0.18)].Conclusion: Male smoking does not seem to impair live birth rates in patients undergoing IVF/ICSI treatment.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2465594"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive hormone characteristics of obese Chinese patients with polycystic ovarian syndrome: a meta-analysis. 中国肥胖多囊卵巢综合征患者的生殖激素特征：荟萃分析。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-04-27 DOI: 10.1080/09513590.2025.2497854

Xiaolin Chen, Zhuoni Xiao, Yuli Cai, Yizhuo Pan

{"title":"Reproductive hormone characteristics of obese Chinese patients with polycystic ovarian syndrome: a meta-analysis.","authors":"Xiaolin Chen, Zhuoni Xiao, Yuli Cai, Yizhuo Pan","doi":"10.1080/09513590.2025.2497854","DOIUrl":"https://doi.org/10.1080/09513590.2025.2497854","url":null,"abstract":"The aim of this analysis is to assess the effect of obesity on reproductive hormones in Chineses patients with polycystic ovarian syndrome (PCOS). Seven databases were searched. The Newcastle-Ottawa Scale (NOS) assessed the quality of included studies. A meta-analysis was performed using random-effects model. The means and standard deviations of the outcomes were synthesized as standardized mean differences (SMDs) with corresponding 95% confidence intervals (CIs). A total of 23 studies involving 4554 patients with PCOS were included. No significant differences in follicle-stimulating hormone (FSH) (p = 0.51), estradiol (E2) (p = 0.48), and prolactin (PRL) (p = 0.46) levels were found between obese and nonobese PCOS patients. However, obese PCOS patients had significantly lower levels of luteinizing hormone (LH) (p < 0.00001), LH/FSH (p = 0.001), progesterone (P) (p = 0.009), and anti-mullerian hormone (AMH) (p = 0.001). Conversely, they exhibited significantly higher testosterone (T) (p = 0.001) levels. Obese PCOS patients exhibited lower levels of LH, LH/FSH, P, and AMH, but higher T levels compared to nonobese PCOS patients, and no significant difference were observed in FSH, E2, and PRL levels in PCOS patients with and without obesity.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2497854"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143992824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systematic review and meta-analysis on the association of metabolic syndrome in women with overactive bladder. 膀胱过动症女性代谢综合征相关性的系统回顾和荟萃分析。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-01-02 DOI: 10.1080/09513590.2024.2445682

Ana M Fernández-Alonso, María T López-Baena, Pascual García-Alfaro, Faustino R Pérez-López

{"title":"Systematic review and meta-analysis on the association of metabolic syndrome in women with overactive bladder.","authors":"Ana M Fernández-Alonso, María T López-Baena, Pascual García-Alfaro, Faustino R Pérez-López","doi":"10.1080/09513590.2024.2445682","DOIUrl":"10.1080/09513590.2024.2445682","url":null,"abstract":"Aims: A systematic review and meta-analysis were performed to determine the association of metabolic syndrome (METS) in women with and without overactive bladder (OAB).Methods: PRISMA guidelines were followed and the protocol was registered at PROSPERO (CRD42024606398). We searched PubMed, Embase, Cochrane Library, and LILACS databases to obtain relevant articles for studies reporting METS outcomes related to OAB published through October 2024. A meta-analysis was performed of available studies using random effect models. Results are reported as mean difference (MD), standardized MD (SMD), or odds ratio (OR) and their 95% confidence interval (CI). Heterogeneity was described with the I2 statistic. The quality of studies was assessed using the Newcastle-Ottawa Scale.Results: Of the 108 non-duplicated retrieved citations, after successive selection, four case-control studies with low or moderate risk of bias reported information about the association of METS in women assessed with the 8-item OAB Symptom Bother Scale. OAB patients displayed higher body mass index (BMI, MD: 3.27, 95% CI: 2.12, 4.43), waist circumference (MD: 7.96, 95% CI: 4.41, 11.52), fasting blood glucose (SMD: 1.26, 95% CI: 0.18, 2.34), triglycerides (SMD: 0.24, 95% CI: 0.01, 0.47), and LDL-cholesterol (SMD: 0.30, 95%CI: 0.06, 0.54) levels. In addition to low HDL-cholesterol levels (SMD: -0.40, 95% CI: -0.74, -0.06) compared to the control group. There were no significant differences in circulating total cholesterol levels and rates of hypertension, hysterectomy, postmenopausal status, and constipation in women with and without OAB.Conclusion: Women with OAB display associations with age, BMI, waist circumference, and METS factors.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2445682"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study. 卵巢功能不全与心血管疾病的因果关系：一项孟德尔随机研究

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-04-04 DOI: 10.1080/09513590.2025.2487498

Xinyun Yang, Tongtong Lin, Lina Luo, Hao Chen, Yifei Dai, Dingheng Li, Linling Zhu

{"title":"Causal associations between premature ovarian insufficiency and cardiovascular diseases: a Mendelian randomization study.","authors":"Xinyun Yang, Tongtong Lin, Lina Luo, Hao Chen, Yifei Dai, Dingheng Li, Linling Zhu","doi":"10.1080/09513590.2025.2487498","DOIUrl":"10.1080/09513590.2025.2487498","url":null,"abstract":"To date, there remains a paucity of prospective studies examining the association between premature ovarian insufficiency (POI) and cardiovascular diseases (CVD). The objective of this study was to investigate the potential association between POI and CVD utilizing the method of Mendelian randomization (MR). MR analyses utilized summary statistics from the most extensive genome-wide association studies (GWAS) on POI and CVD extracted from European ancestry cohorts and the FinnGen biobank. The inverse variance-weighted (IVW) method was the primary MR analysis technique. Supplementary analyses were performed using MR-Robust Adjusted Profile Score (MR-RAPS). Cochran's Q statistic, MR-Egger, and weighted median MR models were employed to further assess heterogeneity and horizontal pleiotropy. Causal effects of POI on coronary heart disease (odds ratio [OR] = 1.048, 95% confidence interval [CI]: 1.006-1.091; p = 0.023)] and ischemic stroke (OR = 1.010, 95% CI: 1.000-1.020; p = 0.0498) were found. However, we did not observe a significant correlation between POI and hypertension (OR = 0.999, 95% CI: 0.994-1.004, p = 0.691), heart failure (OR = 1.009, 95% CI: 0.999-1.020, p = 0.0725), atrial fibrillation (OR = 0.995, 95% CI: 0.986-1.004, p = 0.3035), and myocardial infarction (OR = 1.002, 95% CI: 0.991-1.013, p = 0.7061). POI was causally associated with coronary heart disease and ischemic stroke, with no apparent impact on hypertension, heart failure, atrial fibrillation, or myocardial infarction. The causal relationship between POI and CVD underscores the imperative for proactive cardiovascular risk management in individuals with POI.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2487498"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143784450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect over coagulation and fibrinolysis parameters of a prolonged release 24 + 4 daily use regime contraceptive formulation containing 2 mg dienogest/0.02 mg ethinylestradiol. 含2 mg双孕酮/0.02 mg炔雌醇的缓释24 + 4日用药方案对凝血和纤溶参数的影响。

IF 2 4区医学

Gynecological Endocrinology Pub Date : 2025-12-01 Epub Date: 2025-02-04 DOI: 10.1080/09513590.2025.2458708

Pedro-Antonio Regidor, Alicyoy Angulo, Enrico Colli

{"title":"Effect over coagulation and fibrinolysis parameters of a prolonged release 24 + 4 daily use regime contraceptive formulation containing 2 mg dienogest/0.02 mg ethinylestradiol.","authors":"Pedro-Antonio Regidor, Alicyoy Angulo, Enrico Colli","doi":"10.1080/09513590.2025.2458708","DOIUrl":"10.1080/09513590.2025.2458708","url":null,"abstract":"Background: A prolonged release combined oral contraceptive (COC) pill, containing 2 mg dienogest (DNG)/0.02 mg ethinylestradiol (EE) in a 24 + 4 daily dosing regimen has recently been approved in Europe.Objective: To determine if this COC impacts coagulation and fibrinolytic factors in comparison to an immediate release COC containing 3 mg drospirenone (DRSP)/0.02 mg EE.Method: Forty-four patients received the novel product, and forty-seven the comparator (immediate release formulation) during nine complete cycles. Coagulation and fibrinolytic parameters were evaluated: activated protein C resistance ratio, Antithrombin III (AT III), C-reactive protein, Factor VII, Factor VIII, and D-Dimer.Results: Compared to baseline, at the end of the study both groups displayed significantly higher mean values for AT III: 1.06 mg/mL (standard deviation [SD], 95% CI, 0.98-1.15) for the DNG/EE formulation and 1.04 mg/mL (SD 95% CI, 0.96-1.12) for the comparator (p = 0.0006 and p = 0.0009, respectively). D-dimer showed a non-significant slight reduction in the DNG/EE group, from 276.62 ng/mL (SD, 95% CI, 228.92-334.26) before treatment to 243.98 ng/mL (SD, 95% CI, 192.45-309.31) ng/mL after treatment. Contrarily, the comparator displayed a non-significant rise in D-dimer values from 246.46 ng/mL (SD, 95% CI, 205.44-295.66) ng/mL to 275.30 ng/mL (SD, 95% CI 219.21-345.75; p = 0.4520). All other parameters showed no significant differences before and after the treatment for both groups.Conclusion: The COC 2 mg DNG/0.02 mg EE was not associated with any meaningful changes in the analyzed coagulation and fibrinolytic parameters indicating that a prolonged release formulation does not impact on these factors.Clinical trial registry: EudraCT: 2019-0018-77-97.","PeriodicalId":12865,"journal":{"name":"Gynecological Endocrinology","volume":"41 1","pages":"2458708"},"PeriodicalIF":2.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143189063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0