IF 1.6 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-01-20 DOI: 10.1007/s00059-025-05359-1

Nadine Abanador-Kamper, Torben Lange, Alexander Schulz, Theresa Reiter, Grigorios Korosoglou, Andreas Schuster, Jan Gröschel, Jeanette Schulz-Menger

{"title":"[Potential of imaging in the clinical routine : Focus on cardiovascular MRI].","authors":"Nadine Abanador-Kamper, Torben Lange, Alexander Schulz, Theresa Reiter, Grigorios Korosoglou, Andreas Schuster, Jan Gröschel, Jeanette Schulz-Menger","doi":"10.1007/s00059-025-05359-1","DOIUrl":"10.1007/s00059-025-05359-1","url":null,"abstract":"Cardiac magnetic resonance imaging (CMR) provides decisive advantages, particularly in coronary heart disease, myocarditis and cardiomyopathy. It accurately detects ischemia, scarring, edema and microvascular disorders, enables reliable risk stratification and supports treatment decisions such as revascularization or medication adjustments. Modern quantitative perfusion methods and artificial intelligence (AI)-based analyses further increase the diagnostic accuracy. In inflammatory myocardial and pericardial diseases, CMR using mapping techniques and late gadolinium enhancement (LGE) forms the basis for differentiated diagnostics and estimation of the prognosis. It also enables a precise etiological classification and provides prognostically relevant parameters in cases of hypertrophic, dilated, arrhythmogenic and restrictive cardiomyopathies. In the diagnostics of valvular diseases and the planning of interventional procedures and cardiac tumors, CMR provides essential additional information and demonstrates a high sensitivity and specificity. New techniques such as quantitative 4‑dimensional (4D) flow measurements, high-resolution 3D imaging and electrocardiograph (ECG)-independent scans will further increase its value. Due to the increasing number of CMR examinations, standardized procedures, qualified personnel and structured training programs are essential to ensure a high quality of care in the long term.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"116-125"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146009913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Update ERC guidelines 2025 on cardiopulmonary resuscitation]. [更新ERC心肺复苏指南2025]。

IF 1.6 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-01-26 DOI: 10.1007/s00059-026-05365-x

Guido Michels, Bernd W Böttiger, Hans-Jörg Busch, Camilla Metelmann, Tobias Wengenmayer, Dawid L Staudacher

引用次数: 0

[Cardiac arrhythmias-Cellular mechanisms, consequences and challenges in the diagnostics using human models]. [心律失常-使用人体模型诊断的细胞机制，后果和挑战]。

IF 1.6 4区医学

Herz Pub Date : 2026-03-01 Epub Date: 2026-02-13 DOI: 10.1007/s00059-026-05369-7

Katrin Streckfuß-Bömeke, Christoph Maack, Samuel Sossalla

{"title":"[Cardiac arrhythmias-Cellular mechanisms, consequences and challenges in the diagnostics using human models].","authors":"Katrin Streckfuß-Bömeke, Christoph Maack, Samuel Sossalla","doi":"10.1007/s00059-026-05369-7","DOIUrl":"10.1007/s00059-026-05369-7","url":null,"abstract":"Cardiac arrhythmias significantly contribute to morbidity and mortality in cardiovascular diseases. Hereditary ion channel disorders, including Brugada syndrome, long/short QT syndrome and catecholaminergic polymorphic ventricular tachycardia (CPVT), represent critical entities with elevated risk of malignant ventricular arrhythmias. Although beta-blockers, ion channel modulators and implantable cardioverter defibrillators (ICD) are available and the indications for them are increasingly based on genetic analyses, variants of uncertain significance (VUS) substantially impair the risk stratification. Atrial tachyarrhythmias, particular atrial fibrillation, can cause an often-reversible arrhythmia-induced cardiomyopathy (AIC). Pathophysiologically, the Ca2+/calmodulin-dependent protein kinase II (CaMKII) plays an important role in atrial and ventricular arrhythmias. It can be activated by various pathological triggers, such as high heart rate, neuroendocrine activation and oxidative stress, the latter often resulting from mechano-energetic uncoupling. The development of effective treatment options for arrhythmia-associated cardiovascular diseases requires the use of human model systems in addition to animal experimental approaches, due to the genetic heterogeneity and systemic comorbidities. Patient-specific cardiac stem cell-models enable the classification of VUS and personalised drug testing. The integration of new methodological approaches into existing animal experimental approaches thus paves the way for functionally validated precision medicine and could fundamentally transform the treatment of both disease patterns.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"81-91"},"PeriodicalIF":1.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146179181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Cardiovascular imaging using cardiac computed tomography and cardiac magnetic resonance imaging]. [使用心脏计算机断层扫描和心脏磁共振成像的心血管成像]。

IF 1.6 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2025-12-03 DOI: 10.1007/s00059-025-05350-w

Nadine Abanador-Kamper, Andreas A Giannopoulos, Miltiadis Georgiadis, Grigorios Korosoglou

{"title":"[Cardiovascular imaging using cardiac computed tomography and cardiac magnetic resonance imaging].","authors":"Nadine Abanador-Kamper, Andreas A Giannopoulos, Miltiadis Georgiadis, Grigorios Korosoglou","doi":"10.1007/s00059-025-05350-w","DOIUrl":"10.1007/s00059-025-05350-w","url":null,"abstract":"Noninvasive cardiac imaging using cardiac computed tomography (CCT) and cardiac magnetic resonance imaging (CMRI) has become established as an indispensable diagnostic instrument in modern cardiology for the assessment of cardiovascular diseases. Both techniques are complementary in their diagnostic potential and enable an individualized clinical care, including diagnostic confirmation, prognosis estimation and treatment planning. The use of CCT enables a precise visualization of the coronary vessels, including the detection and quantification of luminal stenosis and additional plaque characterization. It is particularly suitable for the noninvasive clarification of coronary artery disease (CAD) in patients with a low to moderate pretest probability and for procedural planning in cardiology. The high negative predictive value of CCT enables its use as a gatekeeper for unnecessary invasive diagnostics of CAD. The use of CMRI provides a combination of functional morphological diagnostics with a precise myocardial tissue characterization, which are helpful for the assessment of CAD, inflammatory heart diseases and cardiomyopathies. Due to the possibility to quantify myocardial damage, CMRI has a high prognostic value. The combination of both non-invasive techniques in the present-day modern cardiac diagnostics is essential for guideline-compliant and patient-centered care by the coverage of the broad spectrum of cardiac diseases and the supplementary methods.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"66-78"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Palliative care and change in treatment goals for heart failure in the outpatient sector : A survey among office-based physicians in Germany on the current state of healthcare provision]. [姑息治疗和门诊心力衰竭治疗目标的变化：一项针对德国诊所医生的医疗保健现状的调查]。

IF 0.9 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2025-06-26 DOI: 10.1007/s00059-025-05325-x

Moritz Blum, Mark Weber-Krüger, Hashim Abdul-Khaliq, Bernd Alt-Epping, Marc Dittrich, Tanja Henking, Gerald Neitzke, Harald Rittger, Henrikje Stanze, Dorit Knappe, Klaus K Witte, Jochen Dutzmann, Franz Goss

{"title":"[Palliative care and change in treatment goals for heart failure in the outpatient sector : A survey among office-based physicians in Germany on the current state of healthcare provision].","authors":"Moritz Blum, Mark Weber-Krüger, Hashim Abdul-Khaliq, Bernd Alt-Epping, Marc Dittrich, Tanja Henking, Gerald Neitzke, Harald Rittger, Henrikje Stanze, Dorit Knappe, Klaus K Witte, Jochen Dutzmann, Franz Goss","doi":"10.1007/s00059-025-05325-x","DOIUrl":"10.1007/s00059-025-05325-x","url":null,"abstract":"Background: Palliative care is a crucial part of the holistic management of advanced heart failure; however, it remains unclear how palliative care is currently provided in the outpatient sector in Germany.Methods: We conducted a survey among office-based cardiologists and general practitioners (GPs) in Germany on the current provision of palliative care for people with advanced heart failure. The survey was developed by a multiprofessional project group of the German Cardiac Society (DGK e. V.) and administered online by the National Association of Office-Based Cardiologists (BNK e.V.).Results: A total of 235 individuals participated in the study. The majority of respondents reported frequently or always discussing goals of care with patients with advanced heart failure. The GPs reported significantly more often than cardiologists that they always or frequently address primary palliative care needs. None of the surveyed office-based cardiologists but 35.1% of GPs stated that they frequently or always prescribe specialized outpatient palliative care (SAPV) for patients with advanced heart failure. Over 90% of the cardiologists reported that they rarely or never continue to care for patients when they cannot come to the practice themselves.Conclusion: Only few office-based physicians in Germany regularly refer patients with advanced heart failure to specialized palliative care services. Primary palliative care and the involvement of SAPV are significantly more often managed by GPs than by office-based cardiologists.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"45-55"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12855335/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144505548","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognosticating short-term outcomes in patients with STEMI-ACS and intra-procedural slow-flow/no-reflow phenomenon. STEMI-ACS患者术中慢流/无血流现象的短期预后

IF 1.6 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2025-08-14 DOI: 10.1007/s00059-025-05326-w

Rajesh Kumar, Abdul Hakeem Shaikh, Ayaz Mir, Uroosa Safdar, Ishrat Fatima, Mahesh Kumar Batra, Musa Karim

{"title":"Prognosticating short-term outcomes in patients with STEMI-ACS and intra-procedural slow-flow/no-reflow phenomenon.","authors":"Rajesh Kumar, Abdul Hakeem Shaikh, Ayaz Mir, Uroosa Safdar, Ishrat Fatima, Mahesh Kumar Batra, Musa Karim","doi":"10.1007/s00059-025-05326-w","DOIUrl":"10.1007/s00059-025-05326-w","url":null,"abstract":"Background: In this study, we compared the incidence of short-term outcomes between two groups of patients based on the occurrence of intra-procedural slow-flow/no-reflow phenomenon (SF/NR) and identified predictors of short-term outcomes. This study enrolled a consecutive series of patients diagnosed with ST-elevation myocardial infarction (STEMI) who underwent primary percutaneous coronary intervention (PCI).Methods: The patients were divided into two groups based on the presence or absence of SF/NR, and the incidence of short-term major adverse cardiovascular events (MACE) was compared between the two groups. Furthermore, the study aimed to identify predictors of short-term mortality in these patients. A total of 2582 patients were included, of whom 79.1% (n=2042) were male.Results: The average age of the patients was 55.7 ± 11.2 years. Intra-procedural SF/NR was observed in 21.7% (560) of the patients. During median short-term follow-up of 180 days (144-205), patients with SF/NR exhibited a higher incidence of all-cause mortality (23.6% vs. 12.3%; p < 0.001) and MACE (30.4% vs. 16.9%; p < 0.001), with a hazard ratio of 1.82 (1.46-2.27; p < 0.001) and 1.69 (1.39-2.05; p < 0.001), respectively. Among patients with SF/NR, the following were found to be independent predictors of short-term mortality (adjusted odds ratios): total ischemic time, 1.04 (1.00-1.07; p = 0.041); random blood sugar levels, 1.01 (1.00-1.01; p < 0.001); intubation status, 2.79 (1.26-6.18; p = 0.011); post-procedural sub-optimal flow, 1.76 (1.04-2.98; p = 0.034); and intra-procedural arrhythmias, 5.48 (2.03-14.79; p < 0.001).Conclusion: The presence of intra-procedural SF/NR has significant prognostic implications. Patients with intra-procedural SF/NR face a significantly higher risk of short-term adverse outcomes.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"56-63"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144855093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ESC/EACTS guidelines 2025 on the treatment of valvular heart disease : New standards in diagnostics and treatment]. [ESC/EACTS 2025年瓣膜性心脏病治疗指南：诊断和治疗新标准]。

IF 1.6 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2025-11-12 DOI: 10.1007/s00059-025-05349-3

Anna Juliane Buch, Mateo Marin-Cuartas, Michael A Borger, Holger Thiele, Janine Pöss

{"title":"[ESC/EACTS guidelines 2025 on the treatment of valvular heart disease : New standards in diagnostics and treatment].","authors":"Anna Juliane Buch, Mateo Marin-Cuartas, Michael A Borger, Holger Thiele, Janine Pöss","doi":"10.1007/s00059-025-05349-3","DOIUrl":"10.1007/s00059-025-05349-3","url":null,"abstract":"The treatment of valvular heart disease plays an important role in cardiovascular medicine. The 2025 European Society of Cardiology (ESC)/European Association for Cardio-Thoracic Surgery (EACTS) guidelines for the management of valvular heart disease set new standards for diagnostics and treatment based on scientific evidence with the aim to avoid both undertreatment and overtreatment. Recommendations for interventional treatment of valvular diseases are given greater importance compared to the 2021 guidelines. At the same time, surgical expertise remains indispensable, especially in younger patients and those with complex anatomy. Particular emphasis is placed on precise diagnostics using multimodal imaging, the recommendation for treatment of patients in high-volume centers (Heart Valve Centers) and an optimal patient selection by the multidisciplinary heart team. The ESC/EACTS guidelines advocate individualized, multidisciplinary treatment decisions based on the best available evidence. In practice, this can only be achieved by more intensive cooperation between the individual institutions of outpatient and inpatient care as well as specialized centers.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"26-36"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145495311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[ESC Guidelines on cardiovascular diseases and pregnancy-most important facts of the 2025 update]. [ESC心血管疾病和妊娠指南- 2025年更新的最重要事实]。

IF 1.6 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2025-12-18 DOI: 10.1007/s00059-025-05358-2

Ute Seeland

{"title":"[ESC Guidelines on cardiovascular diseases and pregnancy-most important facts of the 2025 update].","authors":"Ute Seeland","doi":"10.1007/s00059-025-05358-2","DOIUrl":"10.1007/s00059-025-05358-2","url":null,"abstract":"The 2025 European Society of Cardiology (ESC) Guidelines on cardiovascular disease in pregnancy represents the second revision of the guideline versions published in 2011 and 2018. The new version aims to incorporate the most up-to-date evidence and update the resulting recommendations for clinical practice. The experts appointed by the ESC constitute a new task force compared with the first two versions. However, the thematic focus does not differ fundamentally from the 2018 guidelines. In view of the expanding evidence base, several chapters have become substantially more precise, for example those on risk stratification in women with pre-existing cardiovascular disease; the need for structured, obligatory postpartum follow-up in the event of complications during pregnancy; and the recommended measures for pre-pregnancy screening and counselling. The recommendations continue to be based predominantly on level C evidence, i.e., on expert opinion and consensus. Since the thalidomide scandal in 1962, there have been very few prospective randomized trials including pregnant women. Explicit presentation of level C evidence is therefore particularly important, as individual physicians are only rarely involved in the care of pregnant women. This task is demanding, because both the pregnant woman and the fetus require individual consideration. This should, however, not be discouraging but rather viewed as a positive challenge. This work is substantially supported by the establishment of the institution of a \"Pregnancy Heart Team.\" These teams, usually available 24/7 in larger centers, ensure interdisciplinary collaboration among multiple specialties and professions in order to arrive at the best possible decisions for both mother and child. The 2025 guidelines devote an expanded chapter to this topic.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"18-25"},"PeriodicalIF":1.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145774375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[2025 ESC Guidelines-new and revised recommendations]. [2025 ESC指南-新的和修订的建议]。

IF 1.6 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2026-01-29 DOI: 10.1007/s00059-025-05356-4

Rolf Dörr, Bernhard Maisch

引用次数: 0

[ESC guidelines on myocarditis and pericarditis : First combined European guidelines for myocarditis and pericarditis]. [ESC心肌炎和心包炎指南：首次合并欧洲心肌炎和心包炎指南]。

IF 0.9 4区医学

Herz Pub Date : 2026-02-01 Epub Date: 2026-01-09 DOI: 10.1007/s00059-025-05355-5

Bernhard Maisch, Jan Gröschel, Bettina Heidecker, Jeanette Schulz-Menger

{"title":"[ESC guidelines on myocarditis and pericarditis : First combined European guidelines for myocarditis and pericarditis].","authors":"Bernhard Maisch, Jan Gröschel, Bettina Heidecker, Jeanette Schulz-Menger","doi":"10.1007/s00059-025-05355-5","DOIUrl":"10.1007/s00059-025-05355-5","url":null,"abstract":"The new guidelines for myocarditis and pericarditis from the European Society of Cardiology (ESC) are the first guidelines for myocarditis and for the first time they also combine the two entities. A key aspect is the introduction of the term inflammatory myopericardial syndrome (IMPS), an umbrella term that covers the spectrum of both diseases and enables uniform diagnostics and treatment but in particular draws attention to the fact that there are overlapping causes, diagnostic approaches and treatment options. Other major aspects relate to noninvasive diagnostics using multimodal imaging. There is a paradigm shift that enables the definitive diagnosis of myocarditis also using cardiovascular magnetic resonance imaging. An etiologically oriented treatment mostly requires an endomyocardial biopsy in pericardial effusion cytological work-up is instrumental. Furthermore, an intuitive risk stratification is introduced, which influences both the treatment and follow-up examinations and involves abandoning fixed waiting periods with respect to resuming sports and work. Diagnostic algorithms are based on the initial symptoms, such as chest pain, heart failure and arrhythmia and integrate the risk stratification into the treatment process. For pericarditis, innovative treatment approaches using interleukin‑1 antagonists are coming to the fore. Another focus is the consideration of genetic factors, which are particularly relevant in recurrent forms.","PeriodicalId":12863,"journal":{"name":"Herz","volume":" ","pages":"12-17"},"PeriodicalIF":0.9,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12855212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145933039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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