Gut最新文献

{"title":"Blue-purple mucosa with luminal narrowing in ascending and transverse colon.","authors":"Guoxin Wang, Shufei Wei, Chao Yang, Mengmeng Zhang, Qifang Wu, Mingfu Tong","doi":"10.1136/gutjnl-2026-340360","DOIUrl":"https://doi.org/10.1136/gutjnl-2026-340360","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":""},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid muscle loss in cirrhosis: competing risks, scan timing and regression to the mean.","authors":"Vishavdeep Singh Rana, Jasvinder Nain, Naveen Bhagat, Arka De, Ajay Duseja","doi":"10.1136/gutjnl-2026-340341","DOIUrl":"https://doi.org/10.1136/gutjnl-2026-340341","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":""},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond average efficacy: how should patients be matched to gut-directed hypnotherapy for IBS?","authors":"Ao Wang, Yong Sun","doi":"10.1136/gutjnl-2026-340327","DOIUrl":"https://doi.org/10.1136/gutjnl-2026-340327","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":""},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SDC1⁺ CAFs secreting CTGF drive tumour metastasis via FGFR3 signalling in cancers.","authors":"Guan-Feng Gao, Zhao-Hui Ruan, Shi-Bo Zhang, Shuai He, Yi-Qi Li, Jin-Li Lyu, Yang Liu, Xing-Liang Tan, Yan-Jun Wang, Zhuo-Wei Liu, Guang-Zhao Lv, Gong Chen, Jie-Hai Yu, Pan-Pan Wei, Jian-Fu Zhao, Zhi-Ting Sun, Zheng Zhao, Yu Shi, Wei Liao, Shu-Wei Chen, Nu Zhang, Dong-Ming Kuang, Xin-Yuan Guan, Rou-Jun Peng, Mu-Yan Cai, Kai Yao, Xiu-Wu Bian, Pei-Rong Ding, Chun-Ling Luo, Jin-Xin Bei","doi":"10.1136/gutjnl-2025-337606","DOIUrl":"10.1136/gutjnl-2025-337606","url":null,"abstract":"<p><strong>Background: </strong>Cancer-associated fibroblasts (CAFs) are key stromal components of the tumour microenvironment (TME) that profoundly influence tumour progression. However, CAFs exhibit pronounced phenotypic and functional heterogeneity, and whether conserved CAF subtypes with shared functional hallmarks exist across different cancer types remains unclear.</p><p><strong>Objective: </strong>We sought to uncover universal CAF subtypes that transcend tumour origins, defining their core molecular signatures and pro-tumorigenic functions within the TME.</p><p><strong>Design: </strong>We constructed a pan-cancer CAF atlas through single-cell transcriptomic analysis of 554 specimens across 14 cancer types. To validate the findings, we performed further functional analyses, including in vitro migration and invasion assays, in vivo lymphatic metastasis models and mechanistic studies focusing on candidate signalling pathways.</p><p><strong>Results: </strong>We identified a conserved syndecan 1 (SDC1) ⁺ CAF subset associated with advanced tumour stage and poor outcomes. These CAFs enhanced tumour cell migration and invasion in vitro and promoted lymphatic metastasis in vivo. This effect is mediated through connective tissue growth factor (CTGF) secretion, which activates fibroblast growth factor receptor 3 (FGFR3) signalling in tumour cells to induce epithelial-mesenchymal transition (EMT). Blocking CTGF or FGFR3 signalling abrogated these effects. We also found that kruppel like factor 6 (KLF6) directly regulates CTGF in SDC1⁺ CAFs, establishing a complete KLF6-CTGF-FGFR3 metastatic axis.</p><p><strong>Conclusions: </strong>Our study establishes SDC1⁺ CAFs as a universal, metastasis-promoting CAF subset across multiple cancer types and uncovers a novel KLF6-CTGF-FGFR3 axis that drives EMT and tumour dissemination. These findings provide mechanistic insight into CAF-tumour cell crosstalk and highlight actionable stromal targets for anti-metastatic therapies across diverse malignancies.</p>","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1950-1962"},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146156762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multinational prevalence and burden of paediatric disorders of gut-brain interaction: results of the Rome Foundation paediatric global study.","authors":"Samuel Nurko, Tiffany Taft, Olafur S Palsson, Marc Benninga, Carlo DiLorenzo, Rachel Rosen, Miguel Saps, Johann P Hreinsson, Xiucai Fang, Mizu Jiang, Caterina Strisciuglio, Erick Toro-Monjaraz, Ami D Sperber","doi":"10.1136/gutjnl-2026-339667","DOIUrl":"10.1136/gutjnl-2026-339667","url":null,"abstract":"<p><strong>Background: </strong>Global prevalence estimates of paediatric disorders of gut-brain interaction (DGBI) are largely unknown and published studies are hindered by heterogeneous methodology.</p><p><strong>Objective: </strong>To determine the multinational prevalence and burden of paediatric DGBI as defined by Rome V.</p><p><strong>Design: </strong>Caregivers of 8000 children aged 0-17 years from China, Italy, Mexico and the USA completed an online Rome V survey assessing gastrointestinal symptoms, illness burden and comorbid health conditions. Prevalence was calculated by DGBI category, country, sex and age.</p><p><strong>Results: </strong>Paediatric DGBI were highly prevalent, affecting 28.0% (95% CI 27.0% to 29.0%) of children. Upper DGBI were present in 8.7% (95% CI 8.2% to 9.5%) and lower DGBI in 23.7% (95% CI 22.8% to 24.7%). The most common lower DGBI were defecation and anorectal disorders (20.2%) followed by abdominal pain disorders (4.4%) and discomfort disorders (1.8%). The most common upper DGBI were gastroduodenal disorders (6.6%), followed by functional feeding disorders (3.4%) and oesophageal disorders (0.6%). Significant geographic differences were observed with the highest prevalence in Mexico and the lowest in China. There was a female predominance in gastroduodenal and discomfort disorders. Overall prevalence declined with age, from approximately 41% in children aged 0-3 years to 22% in adolescents. DGBI were associated with significant anxiety, depression, functional disability and healthcare utilisation, as well as parental time spent in care and coordination particularly when upper and lower DGBI overlapped.</p><p><strong>Conclusions: </strong>This global Rome V study demonstrates the high multi-national prevalence, burden and heterogeneity of paediatric DGBI, supporting improved recognition, classification, research and clinical care.</p>","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1898-1909"},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148792152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kynurenic acid mitigates poststroke brain damage through the gut-brain neural circuit.","authors":"Wen Zhang, Shengnan Chen, Xiaoqi Huang, Jie Li, Siqi Yang, Yisi Liu, Peibo Yuan, Jiaxuan Wang, Yonghui Guo, Zhuang Li, Jia Yin, Hongwei Zhou, Kaiyu Xu","doi":"10.1136/gutjnl-2025-337690","DOIUrl":"10.1136/gutjnl-2025-337690","url":null,"abstract":"<p><strong>Background: </strong>Stroke induces complex pathophysiological responses that extend beyond the brain, yet the mechanisms through which peripheral signals influence stroke recovery remain largely unclear.</p><p><strong>Objective: </strong>Here, we identify a novel gut-brain neural circuit that promotes stroke recovery via kynurenic acid (KYNA) signalling.</p><p><strong>Design: </strong>In a training cohort (30 patients with acute ischaemic stroke (AIS) and 30 controls), untargeted metabolomics profiled intestinal metabolites and the key metabolite KYNA was validated in an independent cohort (100 patients with AIS and 100 controls) using targeted metabolomics and assessed for its 3-month prognostic value. In stroke mouse models, KYNA was administered to evaluate therapeutic effects. Mechanistic studies combined neuronal calcium imaging, enteric neuron receptor manipulation, vagotomy, neuronal tracing, electrophysiology and immunofluorescence to delineate the KYNA-mediated gut-brain neural circuit regulating stroke recovery.</p><p><strong>Results: </strong>Our study demonstrates a significant reduction of intestinal KYNA in patients with AIS and validates its prognostic value for neurological recovery at 3 months poststroke in both the training and validation cohorts. Oral KYNA supplementation markedly improves poststroke cerebral injury by activating G protein-coupled receptor 35 (GPR35) on enteric neurons, initiating vagal nerve signalling. Mechanistically, KYNA-GPR35 interaction activates vagal afferents, transmitting signals through the nucleus tractus solitarius to hippocampal and hypothalamic regions. This GPR35-vagus nerve signalling pathway, further validated with the selective GPR35 agonist Zaprinast, confers neuroprotection by shifting microglial polarisation towards the anti-inflammatory M2 phenotype and enhancing neuronal α7 nicotinic acetylcholine receptor activity.</p><p><strong>Conclusion: </strong>KYNA acts through an intestinal GPR35-vagus neural pathway to influence stroke recovery, highlighting this gut-brain signalling axis as a promising therapeutic avenue.</p>","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1910-1921"},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146113128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential of GDF15 goes beyond its role as a non-invasive biomarker for MASLD.","authors":"Mijra Koning, Isabelle van Thiel, Wouter J de Jonge, Joanne Verheij, Sjoerd Bruin, Max Nieuwdorp, Abraham Meijnikman","doi":"10.1136/gutjnl-2025-337507","DOIUrl":"10.1136/gutjnl-2025-337507","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"2073-2075"},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145654254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual case of diarrhoea.","authors":"Lin Han, Lu Hong, Lisha Yi, Yadong Lai, Qunzhang Zeng","doi":"10.1136/gutjnl-2026-339123","DOIUrl":"10.1136/gutjnl-2026-339123","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"1886-2043"},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147769840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-transplant CKLM: extending integrated clinical trial design to solid organ transplant recipients.","authors":"Alessandro Mattina, Ilaria Tarantino, Massimo Pinzani","doi":"10.1136/gutjnl-2026-340432","DOIUrl":"https://doi.org/10.1136/gutjnl-2026-340432","url":null,"abstract":"","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":""},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148906035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterisation of plasmablast-derived HBsAg-specific antibody and its structural basis for binding to native HBsAg dimer.","authors":"Bin Ju, Zhouqing Liu, Hu Yan, Yong Liu, Lu Zhang, Xiangyang Ge, Xin Wang, Zhu Si, Bing Zhou, Qing Fan, Miao Wang, Yuxiao Li, Wenlong Lai, Jianhui Gan, Haiyan Wang, Juanjuan Zhao, Yuchen Xia, Maofu Liao, Zheng Zhang","doi":"10.1136/gutjnl-2025-336641","DOIUrl":"10.1136/gutjnl-2025-336641","url":null,"abstract":"<p><strong>Background: </strong>Plasmablast-derived HBV surface antigen (HBsAg)-specific monoclonal antibody (mAb) and structural basis for binding to native HBsAg are poorly known.</p><p><strong>Objective: </strong>We aimed to identify plasmablast-derived HBsAg-specific mAbs, evaluate their antiviral activities and resolve their structure for binding to native HBsAg.</p><p><strong>Design: </strong>A previously vaccinated volunteer was enrolled in this study, who was boosted with a dose of recombinant hepatitis B vaccine and donated the blood sample. Activated plasmablasts were sorted from fresh peripheral blood mononuclear cells and mAbs were expressed. Their gene features, cross-genotypic binding activities and antiviral functions in vitro and in vivo were comprehensively analysed. The cryo-electron microscopy (cryo-EM) was used to determine the structure of representative mAb bound to the native HBsAg.</p><p><strong>Results: </strong>In this study, we cloned a series of HBsAg-specific mAbs directly from clonally expanded plasmablasts from a vaccinated individual. Most of the mAbs displayed cross-reactivities of binding to different genotype HBsAg proteins and antiviral functions such as neutralisation and antibody-dependent cellular phagocytosis. These human anti-HBsAg mAbs, especially SY-4-class and SY-23-class, could be good candidates for antibody drugs. The cryo-EM structure of SY-23 bound to the dimeric HBsAg was determined, revealing its binding mechanism and unprecedented structural detail of the major antigenic loop (AGL) of HBsAg.</p><p><strong>Conclusion: </strong>Overall, our work has uncovered the diverse gene features and varied anti-HBV activities of plasmablast-derived mAbs, providing a series of antibody drug candidates and the long-sought-after atomic model of AGL has paved the way for a wholistic characterisation of the AGL's dynamic conformation during HBV infection and immune response.</p>","PeriodicalId":12825,"journal":{"name":"Gut","volume":" ","pages":"2028-2043"},"PeriodicalIF":24.6,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13638324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146149560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}