Gastroenterologia y hepatologia最新文献

{"title":"Food-related quality of life in inflammatory bowel disease: Validity and reliability of the Brazilian version of the FR-QoL-29-Portuguese-Brazil.","authors":"Isadora Sayuri Macedo Tuma, Maria Paula Carlin Cambi, Sara Fernanda de Oliveira Dominski, Patrícia Ignácio, Daniéla Oliveira Magro, Kevin Whelan, Paulo Gustavo Kotze","doi":"10.1016/j.gastrohep.2026.502754","DOIUrl":"10.1016/j.gastrohep.2026.502754","url":null,"abstract":"<p><strong>Objective: </strong>Our aim was to (i) undertake a comprehensive translation of the FR-QoL-29 instrument to Brazilian-Portuguese; and (ii) evaluate its validity and reliability in patients with IBD in Brazil.</p><p><strong>Materials and methods: </strong>The FR-QoL-29 underwent forward and backward translation to Brazilian-Portuguese. A cross-sectional study was conducted in patients with IBD either in remission or with active disease at a tertiary referral center in Brazil. Clinical and demographic characteristics, Montreal classification and anthropometric measurements were collected. Data were compared with controls without any gastrointestinal disease.</p><p><strong>Results: </strong>A total of 203 consecutive patients were included, of whom 173 had IBD and 30 were controls. Cronbach's α was 0.93 for IBD patients without previous IBD-related surgery, 0.93 for IBD patients with previous intestinal surgery, and 0.80 for the control group. Using the Kaiser-Meyer-Olkin (KMO) test to assess sample adequacy, the result was 0.85 for IBD patients without previous surgery (p<0.001) and 0.73 for those with previous IBD-related operations (p<0.001).</p><p><strong>Conclusion: </strong>The FR-QoL-29-Portuguese-Brazil is a valid and reliable tool for use in this language and in this specific population to measure the important factor of food-related quality of life.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502754"},"PeriodicalIF":1.9,"publicationDate":"2026-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147616024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ischemic gastropathy: An uncommon manifestation of systemic atherosclerosis.","authors":"Marta Sánchez Tripiana, Marta Fernández Carrasco, Sara Sánchez Moreno, Carmelo Diéguez Castillo","doi":"10.1016/j.gastrohep.2026.502756","DOIUrl":"10.1016/j.gastrohep.2026.502756","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502756"},"PeriodicalIF":1.9,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147591758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AN ELEPHANT IN THE AUDITORIUM: EVIDENCE AND NORMATIVITY IN SECOND-LINE TREATMENT OF PRIMARY BILIAR CHOLANGITIS.","authors":"Mario Romero-Cristóbal","doi":"10.1016/j.gastrohep.2026.502720","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502720","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502720"},"PeriodicalIF":1.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional cure of chronic hepatitis B: the friendly face of allogenic hematopoietic stem cell transplantation.","authors":"Blanca Mesonero, Joud Zanabili, Elena Granda, Mercedes Rodríguez, Manuel Rodríguez","doi":"10.1016/j.gastrohep.2026.502721","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502721","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502721"},"PeriodicalIF":1.9,"publicationDate":"2026-03-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term effectiveness and safety of colonoscopy-guided Fecal Microbiota Transplantation in recurrent Clostridiodes difficile infection: a prospective case series.","authors":"A Celis, R Quera, P Núñez, C von Muhlenbrock, R Espinoza, A Concha, C Mendoza, F Marcet, D Araya, J Fuentes, F Riesco, P Correa","doi":"10.1016/j.gastrohep.2026.502719","DOIUrl":"https://doi.org/10.1016/j.gastrohep.2026.502719","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502719"},"PeriodicalIF":1.9,"publicationDate":"2026-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147511490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus document on the diagnosis, management, and treatment of chronic hepatitis B virus and hepatitis D virus infection in Spain.","authors":"Sabela Lens, Federico García, Juanjo Mascort, Marta Casado, Carolina Freyre, Alicia Lázaro, Gema Muñoz, Cristina Molera, Javier García-Samaniego, María Buti","doi":"10.1016/j.gastrohep.2026.502717","DOIUrl":"10.1016/j.gastrohep.2026.502717","url":null,"abstract":"<p><p>Chronic infection by hepatitis B virus (HBV) and hepatitis D virus (HDV) continues to pose a major public health challenge in Spain due to its high morbidity and mortality and the risk of progression to cirrhosis and hepatocellular carcinoma. Although effective tools exist for the control of hepatitis B and recent therapeutic advances have been made for hepatitis D, significant inequalities persist in early diagnosis, access to treatment, and appropriate patient follow-up. This consensus document has been jointly developed by the Spanish Association for the Study of the Liver (AEEH), the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC)-through its Viral Hepatitis Study Group (GEHEP)-the Spanish Society of Digestive Pathology (SEPD), the Spanish Society of Family and Community Medicine (semFYC), the Spanish Society of Hospital Pharmacy (SEFH), the Alliance for the Elimination of Viral Hepatitis in Spain (AEHVE), and the Spanish Society of Paediatric Gastroenterology, Hepatology and Nutrition (SEGHNP). The objective is to provide updated and consensus-based recommendations on the diagnosis, management, and treatment of chronic HBV and HDV infection, from a multidisciplinary perspective and adapted to real-world clinical practice. The document addresses screening and diagnostic strategies, criteria for assessing liver fibrosis, indications for antiviral treatment, specific management of hepatitis D, and the role of coordination between primary care and hospital care. Likewise, it emphasizes the need to implement strategies to advance toward the goals of viral hepatitis elimination.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502717"},"PeriodicalIF":1.9,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fournier's gangrene in a patient with hepatocellular carcinoma receiving systemic therapy with atezolizumab plus bevacizumab.","authors":"Elena Granda Villanueva, Blanca Mesonero de la Cruz, Jaime Álvarez Grau, Andrés Curiel Elizondo, Lorena Carballo Folgoso, Andrés Castaño García","doi":"10.1016/j.gastrohep.2026.502718","DOIUrl":"10.1016/j.gastrohep.2026.502718","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502718"},"PeriodicalIF":1.9,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improving quality in IBD - Evaluation of corticosteroid excess prescription trends and its predictive role in disease-related outcomes.","authors":"José Damasceno, Tânia Carvalho, Bruno Arroja, João Soares, Sofia Mendes, Bruno Gonçalves, Ana Rebelo, Raquel Gonçalves, Tiago Leal","doi":"10.1016/j.gastrohep.2026.502716","DOIUrl":"10.1016/j.gastrohep.2026.502716","url":null,"abstract":"<p><strong>Objective: </strong>Corticosteroids (CS) are effective in the induction of remission in inflammatory bowel disease (IBD), but have an unfavorable side effect profile. A CS sparing strategy is frequently recommended, but its consequences in IBD outcomes have been scarcely studied. Our primary aim was to evaluate current CS use and excess in IBD patients, comparing them with a historic cohort. Our secondary aims were to identify predictors of CS excess and compare outcomes (surgery, hospitalization, new CS cycle, structural damage and a composite outcome) at 12 months between three prescription groups (no CS use, standard CS use, and excess CS use).</p><p><strong>Patients and methods: </strong>A retrospective study, including adult IBD outpatients from two trimesters (one in 2014 and one in 2023). CS prescription trends were compared between groups. The latter was used to identify predictors of CS excess and compare outcomes between prescription groups.</p><p><strong>Results: </strong>A total of 1131 outpatients with IBD were included, 374 in 2014 and 757 in 2023. CS use was 3.2 times lower in 2023 (6.5% vs. 20.6%, p<0.001), and CS excess was 5.5 times lower (12.0% vs. 2.2%, p<0.001). Crohn's disease, extraintestinal manifestations, absence of medication, clinical activity and hospitalization in the previous 12 months were independent predictors of CS excess. CS excess prescription was an independent predictor of hospitalization (HR 15.225, 95% CI 2.189-105.913, p=0.006), new CS cycle (HR 38.392, 95% CI 13.866-106.299, p<0.001) and the composite outcome (HR 32.253, 95% CI 13.260-78.452, p<0.001) at 12 months.</p><p><strong>Conclusions: </strong>CS prescription rate has significantly decreased in our center. CS excess was associated with negative outcomes, namely hospitalization and new CS cycles. Improving quality-of-care in IBD should focus on avoiding excess CS prescription.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502716"},"PeriodicalIF":1.9,"publicationDate":"2026-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147456670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive vs. moderate fluid resuscitation in acute pancreatitis: A systematic review and meta-analysis.","authors":"Naomi Salcedo-Campos, Jose Caballero-Alvarado, Victor Lau-Torres, Carlos Zavaleta-Corvera","doi":"10.1016/j.gastrohep.2026.502715","DOIUrl":"10.1016/j.gastrohep.2026.502715","url":null,"abstract":"<p><strong>Objective: </strong>Intravenous fluid resuscitation is central to the early management of acute pancreatitis (AP), but the optimal intensity remains uncertain. This systematic review and meta-analysis compared intensive or aggressive vs. moderate fluid resuscitation in adults with AP.</p><p><strong>Patients and methods: </strong>This systematic review and meta-analysis followed PRISMA 2020 and was registered in PROSPERO (CRD42024626152). PubMed, Scopus, Web of Science, and Embase were searched from inception to February 15, 2024 for Randomized Controlled Trials (RCT) enrolling adults with acute pancreatitis and comparing intensive/aggressive vs. moderate fluid resuscitation. The primary outcome was in-hospital mortality; secondary outcomes were length of hospital stay, persistence of systemic inflammatory response syndrome (SIRS), fluid-overload complications, and early clinical improvement (≤36h). Risk of bias was assessed with RoB 2.0. Pooled relative risks (RR) and mean differences (MD) with 95% confidence intervals (CI) were calculated using fixed- or random-effects models according to heterogeneity (I²). Analyses were performed in RevMan 5.4.1.</p><p><strong>Results: </strong>Seven RCTs were included. IFR was associated with higher mortality than MFR (RR 2.60; 95% CI 1.48-4.57; I²=0%). IFR did not reduce LOS (MD 1.21 days; 95% CI 0.72-1.69; I²=65%) or SIRS persistence (RR 0.87; 95% CI 0.50-1.52; I²=26%). Fluid-overload complications were more frequent with IFR (RR 3.34; 95% CI 1.60-6.98; I²=0%). Early clinical improvement did not differ (RR 1.20; 95% CI 0.63-2.29; I²=72%). Risk of bias was generally low.</p><p><strong>Conclusions: </strong>Across randomized evidence, intensive hydration offers no clinical benefit over moderate regimens and is associated with higher mortality and greater risk of fluid overload. Findings support moderate, goal-directed, individualized fluid therapy in acute pancreatitis and highlight the need for large multicenter RCTs to refine fluid targets and monitoring endpoints.</p>","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502715"},"PeriodicalIF":1.9,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147443379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Paraneoplasic cholestatic hepatitis secondary to Hodgkin lymphoma treated with MARS therapy and brentuximab vedotin.","authors":"Ana Tirado Escuder, María Paz Palacios Rosales, Pablo Bellot García, Cayetano Fabián Miralles Maciá","doi":"10.1016/j.gastrohep.2026.502713","DOIUrl":"10.1016/j.gastrohep.2026.502713","url":null,"abstract":"","PeriodicalId":12802,"journal":{"name":"Gastroenterologia y hepatologia","volume":" ","pages":"502713"},"PeriodicalIF":1.9,"publicationDate":"2026-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147377119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}