Annals of Neurology最新文献

{"title":"Optical Coherence Tomography for Cervical Artery Dissection.","authors":"Guangxun Shen, Jingmin Zhao, Ying Mao, Guangxian Nan","doi":"10.1002/ana.27276","DOIUrl":"https://doi.org/10.1002/ana.27276","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144191301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severely Coiled Internal Carotid Artery.","authors":"Ying Yu, Guofeng Ma, Jiabao Yang, Mingyao Li, Ning Ma","doi":"10.1002/ana.27274","DOIUrl":"https://doi.org/10.1002/ana.27274","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning Models of Voxel-Level [¹⁸F] Fluorodeoxyglucose Positron Emission Tomography Data Excel at Predicting Progressive Supranuclear Palsy Pathology.","authors":"Addison S Braun, Ryota Satoh, Nha Trang Thu Pham, Neha Singh-Reilly, Farwa Ali, Dennis W Dickson, Val J Lowe, Jennifer L Whitwell, Keith A Josephs","doi":"10.1002/ana.27265","DOIUrl":"https://doi.org/10.1002/ana.27265","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether a machine learning model of voxel level [¹⁸f]fluorodeoxyglucose positron emission tomography (PET) data could predict progressive supranuclear palsy (PSP) pathology, as well as outperform currently available biomarkers.</p><p><strong>Methods: </strong>One hundred and thirty-seven autopsied patients with PSP (n = 42) and other neurodegenerative diseases (n = 95) who underwent antemortem [¹⁸f]fluorodeoxyglucose PET and 3.0 Tesla magnetic resonance imaging (MRI) scans were analyzed. A linear support vector machine was applied to differentiate pathological groups with sensitivity analyses performed to assess the influence of voxel size and region removal. A radial basis function was also prepared to create a secondary model using the most important voxels. The models were optimized on the main dataset (n = 104), and their performance was compared with the magnetic resonance parkinsonism index measured on MRI in the independent test dataset (n = 33).</p><p><strong>Results: </strong>The model had the highest accuracy (0.91) and F-score (0.86) when voxel size was 6mm. In this optimized model, important voxels for differentiating the groups were observed in the thalamus, midbrain, and cerebellar dentate. The secondary models found the combination of thalamus and dentate to have the highest accuracy (0.89) and F-score (0.81). The optimized secondary model showed the highest accuracy (0.91) and F-scores (0.86) in the test dataset and outperformed the magnetic resonance parkinsonism index (0.81 and 0.70, respectively).</p><p><strong>Interpretation: </strong>The results suggest that glucose hypometabolism in the thalamus and cerebellar dentate have the highest potential for predicting PSP pathology. Our optimized machine learning model outperformed the best currently available biomarker to predict PSP pathology. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144179568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracranial Intra-Aneurysm Thrombi Vegetation After Flow Diverter Implantation.","authors":"Jiabao Yang, Ning Ma","doi":"10.1002/ana.27269","DOIUrl":"https://doi.org/10.1002/ana.27269","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AI in Neurology: Everything, Everywhere, all at Once PART 2: Speech, Sentience, Scruples, and Service.","authors":"Matthew Rizzo","doi":"10.1002/ana.27229","DOIUrl":"https://doi.org/10.1002/ana.27229","url":null,"abstract":"<p><p>Artificial intelligence (AI) applications are finding use in real-world neurological settings. Whereas part 1 of this 3-part review series focused on the birth of AI and its foundational principles, this part 2 review shifts gears to explore more practical aspects of neurological care. The review details how large language models, generative AI, and robotics are supporting diagnostic accuracy, patient interaction, and treatment personalization. Special attention is given to ethical and philosophical facets of AI that nonetheless impact practical aspects of care and patient safety, such as accountability for AI-driven decisions and the \"black box\" nature of many algorithms. We will discuss whether AI systems can develop sentience, and the implications for human-AI collaboration. By examining human-robot interactions in neurology, this part 2 review highlights the profound impact AI could have on patient care and, as covered in the ensuing part 3, on global health care delivery and data analytics, while maintaining ethical oversight and human control. ANN NEUROL 2025.</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":" ","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Crossed Facial Muscle Atrophy in Facioscapulohumeral Muscular Dystrophy","authors":"Masayuki Ohira MD,&nbsp;Masaki Takao MD,&nbsp;Ichizo Nishino MD, PhD","doi":"10.1002/ana.27264","DOIUrl":"10.1002/ana.27264","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":"98 1","pages":"199-200"},"PeriodicalIF":8.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive Outcome in Young Adults after Resolution of Epilepsy in Childhood","authors":"Jacob Megreli MD, MPH,&nbsp;Leo Arkush MBBS, BSc (Hons),&nbsp;Estela Derazne MSc,&nbsp;Arnon Afek MD,&nbsp;Gilad Twig MD, PhD,&nbsp;Bruria Ben-Zeev MD,&nbsp;Jaana Ahonniska Assa PhD,&nbsp;Gali Heimer MD, PhD","doi":"10.1002/ana.27258","DOIUrl":"10.1002/ana.27258","url":null,"abstract":"<p>Self-limited epilepsies of childhood are common and were considered benign. We aim to determine whether cognitive function in young adults who experienced epilepsy as children and are subsequently seizure-free and unmedicated differ from the general population. We report on a cross-sectional population-based study including 2,124,871 men and women aged 16–19 years. Participants &gt; 5 years following the last seizure and &gt; 2 years without anti-seizure medication (n = 3,452) had an odds ratio (OR) of having low cognitive function of 1.44 (95% confidence interval [CI] = 1.24–1.68, <i>p</i> &lt; 0.001) using a multinominal regression model. Our results underscore the need to avoid the term “benign” in the classification of childhood epilepsies. ANN NEUROL 2025;98:62–66</p>","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":"98 1","pages":"62-66"},"PeriodicalIF":8.1,"publicationDate":"2025-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ana.27258","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144118320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annals of Neurology: Volume 97, Number 6, June 2025","authors":"","doi":"10.1002/ana.26983","DOIUrl":"https://doi.org/10.1002/ana.26983","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":"97 6","pages":"C1"},"PeriodicalIF":8.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/ana.26983","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144074534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry” Recently Published by Matusevicius and Colleagues","authors":"Senta Frol MD, PhD,&nbsp;Peter Alan Barber MD, PhD","doi":"10.1002/ana.27254","DOIUrl":"10.1002/ana.27254","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":"98 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143957867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to “Letter to the Editor, Regarding ‘Intravenous Thrombolysis in Patients Taking Direct Oral Anticoagulation Treatment Before Stroke Onset: Results from the Safe Implementations of Treatments in Stroke International Stroke Registry’” recently Published by Matusevicius et al.","authors":"Marius Matusevicius,&nbsp;Malin Säflund MD,&nbsp;Niaz Ahmed","doi":"10.1002/ana.27256","DOIUrl":"10.1002/ana.27256","url":null,"abstract":"","PeriodicalId":127,"journal":{"name":"Annals of Neurology","volume":"98 1","pages":""},"PeriodicalIF":8.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}