Beta Power Response After Levodopa Intake in Parkinson's Disease Patients With Chronic Sensing-Enabled Deep Brain Stimulation.

IF 7.7 1区医学 Q1 CLINICAL NEUROLOGY

Annals of Neurology Pub Date : 2025-08-29 DOI:10.1002/ana.78025

Martijn G J de Neeling, Bart J Keulen, Mariëlle J Stam, Deborah Hubers, Rob M A de Bie, Bernadette C M van Wijk, P Rick Schuurman, Arthur W G Buijink, Martijn Beudel

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引用次数: 0

Abstract

Objective: In Parkinson's disease (PD), the power of beta oscillations (± 13-30 hertz [Hz]) from subthalamic nucleus (STN) local field potentials (LFPs) is associated with motor symptoms. Beta power can be used for adaptive deep brain stimulation (aDBS) algorithms based upon symptom fluctuations. The time course of beta power modulations after levodopa intake at home remains to be described.

Methods: Ten-minute averages of beta peak power were recorded in 33 patients with PD treated with STN-DBS for a median duration of 134 days during the titration phase. Median beta power after scheduled medication intakes (n = 24,103) and the effects of peak frequency, stun effect, stimulation amplitude, levodopa dose, and preoperative levodopa response were analyzed using cluster-based permutation testing.

Results: Beta power was significantly reduced between 30 and 140 minutes after intake for stimulation amplitudes between 0 and 2.1 mA (p < 0.01). This response was seen in low (12.7-20.5 Hz) but not high (21.5-30.3 Hz) beta frequencies. Significant clusters were found regardless of stun effect and preoperative levodopa response, during low stimulation amplitudes (< 1 mA), and for 100 and 150 mg but not 50 mg doses. A linear mixed-effects model for the area under the curve (AUC) levodopa beta response (30-180 min) revealed a dose-response relationship, a stronger negative response in low-beta compared with high-beta frequencies, and no significant effect of stimulation amplitude.

Interpretation: STN beta power responds to levodopa during low to moderate stimulation amperages, depending on the beta peak frequency and dose, which is informative for aDBS implementation. ANN NEUROL 2025.

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慢性感觉激活脑深部刺激帕金森病患者左旋多巴摄入后的β功率反应

目的：在帕金森病（PD）中，丘脑下核（STN）局部场电位（LFPs）的β振荡功率（±13-30赫兹[Hz]）与运动症状相关。β功率可用于基于症状波动的自适应深部脑刺激（aDBS）算法。在家中摄入左旋多巴后β功率调制的时间过程仍有待描述。方法：记录33例接受STN-DBS治疗的PD患者的10分钟平均峰值功率，中位持续时间为134天。采用聚类排列检验分析计划用药后的中位β功率（n = 24,103）以及峰值频率、眩晕效应、刺激幅度、左旋多巴剂量和术前左旋多巴反应的影响。结果：当刺激幅度在0到2.1 mA (p)之间时，β功率在摄入后30到140分钟内显著降低。解释：在低到中等刺激安培时，STN β功率对左旋多巴有响应，这取决于β峰值频率和剂量，这对aDBS的实施提供了信息。Ann neurol 2025。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Neurology 医学-临床神经学

CiteScore

18.00

自引率

1.80%

发文量

270

审稿时长

3-8 weeks

期刊介绍： Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.