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Hepatocyte Adhesion Behavior on Modified Hydroxyapatite Nanocrystals with Quartz Crystal Microbalance 用石英晶体微天平研究改性羟基磷灰石纳米晶体的肝细胞粘附行为
Bioceramics Development and Applications Pub Date : 2011-02-03 DOI: 10.4303/BDA/D110157
M. Tagaya, Tomohiko Yamazaki, S. Migita, N. Hanagata, T. Ikoma
{"title":"Hepatocyte Adhesion Behavior on Modified Hydroxyapatite Nanocrystals with Quartz Crystal Microbalance","authors":"M. Tagaya, Tomohiko Yamazaki, S. Migita, N. Hanagata, T. Ikoma","doi":"10.4303/BDA/D110157","DOIUrl":"https://doi.org/10.4303/BDA/D110157","url":null,"abstract":"The initial adhesion, spreading and cytoskeleton changes of hepatocyte-like cells on hydroxyapatite (HAp) and oxidized poly(styrene) (PSox) sensors pre-adsorbed fetal bovine serum (FBS), collagen (Col) and fibronectin (FN) were analyzed by using a quartz crystal microbalance with dissipation technique and a confocal laser scanning microscope (CLSM). The ΔD-Δf plots of the cell adhesion behavior on HAp nanocrystals clearly depended on the pre- adsorbed proteins, while that on PSox showed almost same behavior irrespective of the proteins. The different adhesion behavior depended on the substrate surfaces was attributed to the cell-surface interactions. CLSM images showed that the morphology of the cultured cells depended on the surfaces and the cells on the HAp and PSox adsorbed Col or FN had sometimes pseudopods. The different cellular morphology indicated that the cytoskeleton changes and the rearrangement of the extracellular matrix at the interface caused the species of pre-adsorbed proteins.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125292348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Study of the Bioactive Behavior of Hydroxyapatite/SiO2?CaO?MgO Glass-Ceramics Synthesized by Transferred Arc Plasma (TAP) 羟基磷灰石/SiO2 / CaO的生物活性研究转移电弧等离子体(TAP)合成MgO微晶玻璃
Bioceramics Development and Applications Pub Date : 2011-02-03 DOI: 10.4303/BDA/D110153
E. Roumeli, O. Goudouri, C. P. Yoganand, L. Papadopoulou, N. Kantiranis, V. Selvarajan, K. Paraskevopoulos
{"title":"Study of the Bioactive Behavior of Hydroxyapatite/SiO2?CaO?MgO Glass-Ceramics Synthesized by Transferred Arc Plasma (TAP)","authors":"E. Roumeli, O. Goudouri, C. P. Yoganand, L. Papadopoulou, N. Kantiranis, V. Selvarajan, K. Paraskevopoulos","doi":"10.4303/BDA/D110153","DOIUrl":"https://doi.org/10.4303/BDA/D110153","url":null,"abstract":"The Transferred Arc Plasma (TAP) melting method is a single step process which is reported to produce highly bioactive glass ceramics. Thus, the aim of the present work was the investigation of the bioactivity and evaluation of the developed apatite layer thickness of the hydroxyapatite/SiO2-CaO-MgO systems under various compositions. Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy with associated Energy Dispersive Spectroscopy analysis (SEM-EDS) and X-ray Diffractometry (XRD) were used to characterize all specimens' surfaces before and after their immersion in c-SBF solution. It was concluded that the synthesized HA/glass-ceramic systems formed a well structured apatite layer even after the first 6 days of their immersion whilst pure glass pellets indicated a much slower apatite layer formation. SEM images and online cross sectional EDS analysis of the composite pellets after 18 days in c-SBF proved the development of an apatite layer 5-6 μm thick.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"77 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132082074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
A New Calcium Source for Bioactive Sol-Gel Hybrids 生物活性溶胶-凝胶杂交种的新钙源
Bioceramics Development and Applications Pub Date : 2011-02-03 DOI: 10.4303/BDA/D110178
Bo-Yi Yu, G. Poologasundarampillai, C. Turdean-Ionescu, Mark E. Smith, Julian R. Jones
{"title":"A New Calcium Source for Bioactive Sol-Gel Hybrids","authors":"Bo-Yi Yu, G. Poologasundarampillai, C. Turdean-Ionescu, Mark E. Smith, Julian R. Jones","doi":"10.4303/BDA/D110178","DOIUrl":"https://doi.org/10.4303/BDA/D110178","url":null,"abstract":"Poly(γ-glutamic acid) (γ-PGA) has been intro- duced into sol-gel derived silica to produce an organic/ inorganic hybrid system to improve the toughness of conventional bioactive glass. Since calcium is an important element in bioactive glass for bone regeneration, this work is trying to find a suitable calcium source for this hybrid system and determine how to incorporate the calcium within the γ-PGA hybrid. Calcium chloride and calcium methoxyethoxide (CME) were tested as calcium sources in this work. CME was found to incorporate into the silica network better than calcium chloride at low temperature.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"264 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117272636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Synthesis of Bioactive Glass by Microwave Energy Irradiation and Its In-Vitro Biocompatibility 微波辐射合成生物活性玻璃及其体外生物相容性研究
Bioceramics Development and Applications Pub Date : 2011-02-03 DOI: 10.4303/BDA/D110155
S. K. Sarkar, Byong-Taek Lee
{"title":"Synthesis of Bioactive Glass by Microwave Energy Irradiation and Its In-Vitro Biocompatibility","authors":"S. K. Sarkar, Byong-Taek Lee","doi":"10.4303/BDA/D110155","DOIUrl":"https://doi.org/10.4303/BDA/D110155","url":null,"abstract":"Bioactive glasses were synthesized in an inexpensive hydrothermal chemical route by the use of microwave energy irradiation. Compositional changes were carried out to synthesis bioactive glass with different Si content. Densification behavior was investigated by microwave sintering process from 700°C to 1000°C temperature. The powders were characterized for their physical and morphological characteristics like degree of crystallinity, crystallization temperature etc. Optimization of the heat treatment of the obtained amorphous powder was carried out. Biocompatibility test of the synthesized materials was carried out by in-vitro investigation by apatite formation behavior investigation by inserting the bioactive glass in simulated body fluid. Mechanical properties like density, compressive strength, hardness etc. were investigated for the dense bioactive glasses depending on the Si content. Apatite formation extent was investigated in SBF in 1 to 3 days.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132490899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Amorphous Calcium Phosphate Layer Prepared Ultrasonically on Titanium 超声在钛上制备无定形磷酸钙层
Bioceramics Development and Applications Pub Date : 2010-12-02 DOI: 10.4303/BDA/D110121
D. Rohanová, Milan Tou, A. Helebrant, J. Strnad
{"title":"Amorphous Calcium Phosphate Layer Prepared Ultrasonically on Titanium","authors":"D. Rohanová, Milan Tou, A. Helebrant, J. Strnad","doi":"10.4303/BDA/D110121","DOIUrl":"https://doi.org/10.4303/BDA/D110121","url":null,"abstract":"An inert titanium surface was treated with the BIO treatment (developed by the company Lasak, Ltd.), i.e. its surface area was increased by mechanical and chemical treatment with blasting and exposure to HCl and NaOH. The treated surface was provided with thin layers of calcium phosphate OCP (Octacalcium Phosphate) or ACP (Amorphous Calcium Phosphate) by means of precalcification (using a supersaturated SCS2 solution). In vitro tests in SBF (Simulated Body Fluid) under dynamic conditions have shown that precalcified layers have the ability to induce development of HAp (Hydroxyapatite) on the surface much faster than BIO surfaces without such layers. The OCP crystals are well adhesive but cytotoxicity tests have shown that a bioactive layer prepared in this manner is slightly toxic. The ACP prepared ultrasonically is incorporated directly into the TiO2 gel and thus does not increase implant’s dimension and moreover ACP is not toxic (confirmed by cytotoxicity tests).","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122594811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fabrication of Bioactive Apatite Nuclei Precipitated Titanium by Using Electromagnetic Induction Heating 电磁感应加热制备生物活性磷灰石核沉淀钛
Bioceramics Development and Applications Pub Date : 2010-12-02 DOI: 10.4303/BDA/D110122
Takeshi Yabutsuka, M. Hibino, T. Yao, Kojiro Tanaka, M. Takemoto, M. Neo, Takashi Nakamura
{"title":"Fabrication of Bioactive Apatite Nuclei Precipitated Titanium by Using Electromagnetic Induction Heating","authors":"Takeshi Yabutsuka, M. Hibino, T. Yao, Kojiro Tanaka, M. Takemoto, M. Neo, Takashi Nakamura","doi":"10.4303/BDA/D110122","DOIUrl":"https://doi.org/10.4303/BDA/D110122","url":null,"abstract":"Many micro pores were formed on the surface of a titanium (Ti) plate by sulfuric acid treatment, then apatite nuclei were precipitated in the pores of the Ti plate by direct heating of the plate by using electromagnetic induction in a simulated body fluid (SBF). When the Ti plate was soaked in SBF, amorphous calcium phosphate thin film covered the whole surface within 6 h and it grew into hydroxyapatite within 12 h. The hydroxyapatite layer showed high adhesive strength to the Ti plate due to a mechanical interlocking effect between hydroxyapatite grown in the micro pores and the Ti plate.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114923816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
Novel Ceramic Coating on Titanium with High Mechanical Properties 新型高力学性能钛陶瓷涂层
Bioceramics Development and Applications Pub Date : 2010-12-02 DOI: 10.4303/BDA/D110124
A. Valanezhad, K. Tsuru, Michito Maruta, G. Kawachi, S. Matsuya, K. Ishikawa
{"title":"Novel Ceramic Coating on Titanium with High Mechanical Properties","authors":"A. Valanezhad, K. Tsuru, Michito Maruta, G. Kawachi, S. Matsuya, K. Ishikawa","doi":"10.4303/BDA/D110124","DOIUrl":"https://doi.org/10.4303/BDA/D110124","url":null,"abstract":"Phosphate coating layer was produced on titanium substrates by hydrothermal treatment with zinc phosphate solutions. Phosphatizing reaction produced zinc-titanium-phosphate coating layer on the surface by hydrothermal treatment at 250 °C. Ti substrate treated with low concentration of zinc phosphate solution for 14 h was not fully covered by the coating layer. On the other hand, surface coverage on Ti substrate treated with a high concentration of zinc phosphate solution for only 6 h was enhanced completely. SEM and XPS results indicated that the formation of the coating layer was inhibited by surface oxide layer. The coating layer was strongly attached on Ti substrate, moreover, the bonding strength between the coating layer and the Ti substrate was higher than the mechanical strength of binder.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129051982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 10
A Novel Method of Preparing a Nanometer-Scale Rod Array of Hydroxyapatite Crystals 制备纳米羟基磷灰石晶体棒状阵列的新方法
Bioceramics Development and Applications Pub Date : 2010-12-02 DOI: 10.4303/BDA/D101122
S. Hayakawa, Y. Li, Y. Shirosaki, A. Osaka, E. Fujii, K. Kawabata
{"title":"A Novel Method of Preparing a Nanometer-Scale Rod Array of Hydroxyapatite Crystals","authors":"S. Hayakawa, Y. Li, Y. Shirosaki, A. Osaka, E. Fujii, K. Kawabata","doi":"10.4303/BDA/D101122","DOIUrl":"https://doi.org/10.4303/BDA/D101122","url":null,"abstract":"This study proposed a new strategy for preparing self-assembling one-dimensional HAp nanorods into organized superstructures. We employed glass of a few specific compositions in the system Na2O-CaO-SiO2 because it may yield Si-OH groups on the surface when soaked in an aqueous system, and their formation is one of the key factors to induce apatite nucleation. A nanometerscale rod array of HAp having preferred orientation to the c-axis was successfully prepared simply by soaking the soda-lime silica glass substrates in Na2HPO4 aqueous solution at 80 °C. Those HAp rods grew up perpendicularly to the glass surface, and the crystallites covered glass surface uniformly, resulting in “dental enamel-like� rod array structure. The present procedure is significant as it allows to design biomimetic materials and therapeutic agents with applicable both the biomedical and material science fields because the nano-textured HAp crystals exhibit a hierarchical architecture and may provide specific cell attachment and proliferation with controlled planes of growth and nano- and micrometer-scale topography.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123471072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effect of Nano-HAP on Proliferation of Hepatocellular Carcinoma Cells 纳米hap对肝癌细胞增殖的影响
Bioceramics Development and Applications Pub Date : 2010-12-02 DOI: 10.4303/BDA/D110136
Cao Xianying, Du Jingjing, Wen Feng, Cao Yang, Pang Sujuan
{"title":"Effect of Nano-HAP on Proliferation of Hepatocellular Carcinoma Cells","authors":"Cao Xianying, Du Jingjing, Wen Feng, Cao Yang, Pang Sujuan","doi":"10.4303/BDA/D110136","DOIUrl":"https://doi.org/10.4303/BDA/D110136","url":null,"abstract":"Recently, the treatments of hepatocellular carcinoma with nano-hydroxyapatite (nano-HAP) particles have been given much attention. In this study, a new kind of nano-HAP particles was prepared by a homogenous method, and these particle diameters and their distribution, crystallization degree, chemical bondings, and morphology were characterized by laser scattering particle analyzer, X-ray diffraction, FTIR spectrum, transmission electron microscope, and electron diffraction. The results showed that the average particle diameter of nano-HAP was 59.9 nm, the prepared nano-HAP was amorphous and having a low crystallization degree. Furthermore, the characteristic absorption peaks of HAP appeared in FTIR spectra and the electron diffraction annuli was also clear. The prepared nano-HAP particles were used for the treatment of hepatocellular carcinoma. The inhibition effect was determined in vitro for three different concentrations by MTT methods. The results demonstrated that the prepared nano-HAP with a size of 59.9 nm most effectively inhibited the proliferation of hepatocellular carcinoma cells and the inhibition rate was more than 70%.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129485756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Fabrication of Bioactive Porous Ti Metal with Structure Similar to Human Cancellous Bone by Selective Laser Melting 选择性激光熔融法制备具有生物活性、结构类似人松质骨的多孔钛金属
Bioceramics Development and Applications Pub Date : 2010-12-02 DOI: 10.4303/BDA/D101206
D. Pattanayak, T. Matsushita, H. Takadama, A. Fukuda, M. Takemoto, S. Fujibayashi, K. Sasaki, N. Nishida, Toshikazu Nakamura, T. Kokubo
{"title":"Fabrication of Bioactive Porous Ti Metal with Structure Similar to Human Cancellous Bone by Selective Laser Melting","authors":"D. Pattanayak, T. Matsushita, H. Takadama, A. Fukuda, M. Takemoto, S. Fujibayashi, K. Sasaki, N. Nishida, Toshikazu Nakamura, T. Kokubo","doi":"10.4303/BDA/D101206","DOIUrl":"https://doi.org/10.4303/BDA/D101206","url":null,"abstract":"Porous titanium (Ti) metal with a structure similar to that of human cancellous bone was fabricated by selective laser melting (SLM) process. SEM observation showed that the core part of the walls of the porous body was completely melted by the laser beam and weakly bonded with small Ti particles on its surface. These Ti particles were joined with the core part by heating above 1000 °C, with remaining micro cavities on their surfaces. Tensile strength of the as-prepared solid rod was 530MPa and gradually decreased with increasing temperatures to 400MPa at 1300 °C, whereas its ductility increased with increasing temperatures. NaOH treatment formed fine network structure of sodium hydrogen titanate (SHT) on the walls of the porous Ti metal. The SHT was transformed into hydrogen titanates by HCl treatment and finally anatase and rutile by the heat treatment. Thus treated porous Ti metal formed apatite on its surface in simulated body fluid (SBF) within 3 days.","PeriodicalId":127691,"journal":{"name":"Bioceramics Development and Applications","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2010-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131368992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
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