{"title":"Green synthesis of silver nanoparticles using durian rind extract and optical characteristics of surface plasmon resonance-based optical sensor for the detection of hydrogen peroxide","authors":"Fueangfakan Chutrakulwong, Kheamrutai Thamaphat","doi":"10.1515/gps-2023-0070","DOIUrl":"https://doi.org/10.1515/gps-2023-0070","url":null,"abstract":"Abstract Silver nanoparticles (AgNPs) have been efficaciously synthesized from AgNO 3 via an easy and green method, also called green synthesis, using Mon Thong durian ( Durio zibethinus L.) rind extract. The inner shell of durian rind extract was used as an intermediary for the synthesis of AgNPs because the absorption spectra of the AgNP colloid extracted from the inner shell had a higher absorption than that of the outer shell. Additionally, we have found more fructose and glucose – which act as a reducing agent – and protein and carbohydrates – which act as the stabilizer – in a higher amount in the inner shell than the extract from the outer shell. The synthesized AgNPs were mainly spherical in shape and exhibited a relatively narrow size distribution with an average particle diameter of 10.2 ± 0.2 nm. In the reduction of hydrogen peroxide (H 2 O 2 ), these nanoparticles demonstrate catalytic activity. The degradation of AgNPs, including the catalytic decomposition of H 2 O 2 , causes a considerable change in the absorbance strength of the surface plasmon resonance band depending on the H 2 O 2 concentration. Over a broad concentration range of 10 −1 –10 −6 mol·L −1 H 2 O 2 , a good sensitivity and a linear response are achieved. This sensor’s quantification limit is found to be 0.9 µmol·L −1 H 2 O 2 . Therefore, this optical sensor for the detection of H 2 O 2 can be potentially applied in the determination of color indicators in medical or clinical diagnosis, biochemical analysis, and environmental applications.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136028354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Sivasubramanian, Shanmugam Sabarinathan, Moorthy Muruganandham, P. Velmurugan, N. Arumugam, A. Almansour, Raju Suresh Kumar, S. Sivakumar
{"title":"Antioxidant, antibacterial, and cytotoxicity potential of synthesized silver nanoparticles from the Cassia alata leaf aqueous extract","authors":"K. Sivasubramanian, Shanmugam Sabarinathan, Moorthy Muruganandham, P. Velmurugan, N. Arumugam, A. Almansour, Raju Suresh Kumar, S. Sivakumar","doi":"10.1515/gps-2023-0018","DOIUrl":"https://doi.org/10.1515/gps-2023-0018","url":null,"abstract":"Abstract The current research focuses on the silver nanoparticles (AgNPs) synthesis from the Cassia alata aqueous leaf extract. Various production parameters like pH (4, 5, 6, 7, 8, 9, and 10), metal ion concentration (1, 2, 3, 4, and 5 mM), and substrate (leaf extract) concentration (0.5, 1, 1.5, 2 and 2.5 mL) were optimized. UV-visible spectroscopy was used to identify the production by scanning the wavelength from 200 to 800 nm. Visual color change from light green to brown was designated as prior confirmation of the AgNP production. Physical characterization of AgNPs was carried out using scanning electron microscopy, Fourier-transform infrared spectroscopy, X-ray energy-dispersive spectroscopy, and X-ray diffraction. Furthermore, the obtained AgNPs show significant antibacterial activity for Staphylococcus aureus, Pseudomonas sp. Klebsiella sp., Proteus sp., and Enterobacter sp. The antioxidant potential was determined by α,α-diphenyl-β-picrylhydrazyl assay and cytotoxicity by (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction assay on human lung cancer cell lines (A549). AgNPs confirmed potent antibacterial activity against skin infections, demonstrating their medicinal significance and are therefore crucial for creating a medicinal formulation with antibacterial properties.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47083290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ayesha Talib, Shafiq Ali Shah, Muhammad Saeed Jan, Muhammad Zaeem Ahsan, Abubakr Munir, Ishfaq A. Bukhari, Halima Sadia, Taghrid S. Alomar, Najla AlMasoud, Abdur Rauf
{"title":"Exploration of ketone derivatives of succinimide for their antidiabetic potential: <i>In vitro</i> and <i>in vivo</i> approaches","authors":"Ayesha Talib, Shafiq Ali Shah, Muhammad Saeed Jan, Muhammad Zaeem Ahsan, Abubakr Munir, Ishfaq A. Bukhari, Halima Sadia, Taghrid S. Alomar, Najla AlMasoud, Abdur Rauf","doi":"10.1515/gps-2023-0103","DOIUrl":"https://doi.org/10.1515/gps-2023-0103","url":null,"abstract":"Abstract Diabetes mellitus (DM) is one of the most challenging diseases among all the other diseases in the recent era, and it is a life-threatening disorder. The best enzymes to target for treating DM are α-glucosidase and α-amylase. For this purpose, we explored numerous succinimides with ketone functionalities. First, we explored these compounds for their in vitro analysis. Compounds 1 and 4 exhibited excellent inhibition of both enzymes in in vitro studies. These compounds displayed excellent activity with IC 50 values of 3.69 and 1.526 µg·mL −1 against the α-glucosidase enzyme. In the α-amylase inhibitory assay, compound 1 has shown excellent potential with an IC 50 value of 1.07 µg·mL −1 and compound 4 with an IC 50 value of 0.115 µg·mL −1 . Based on the in vitro analysis, the potent compounds were further subjected to their in vivo analysis. Before the in vivo analysis, the toxicity profile was checked, and it was confirmed that the compounds were safe at 1,500 µg·kg −1 . Then, these compounds were subjected for their in vivo anti-diabetic potential in a mouse model of diabetes. Various concentrations of compounds 1 and 4 were explored by in vivo analysis using glibenclamide as a standard drug. The blood glucose level of the tested and control groups was measured at 0 to 15 days accordingly. Similarly, we also explored compounds 1 and 4 for the oral glucose tolerance test at 0–120 min using glibenclamide as the standard drug. Hence, the succinimide having ketone moiety displayed excellent potential against diabetes.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135562229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Wiktoria Dubiel, Andrzej Kowalczyk, Aleksandra Jankowska, Marek Michalik, Włodzimierz Mozgawa, Marcin Kobielusz, Wojciech Macyk, Lucjan Chmielarz
{"title":"Silica-titania mesoporous silicas of MCM-41 type as effective catalysts and photocatalysts for selective oxidation of diphenyl sulfide by H<sub>2</sub>O<sub>2</sub>","authors":"Wiktoria Dubiel, Andrzej Kowalczyk, Aleksandra Jankowska, Marek Michalik, Włodzimierz Mozgawa, Marcin Kobielusz, Wojciech Macyk, Lucjan Chmielarz","doi":"10.1515/gps-2023-0052","DOIUrl":"https://doi.org/10.1515/gps-2023-0052","url":null,"abstract":"Abstract Spherical Ti-MCM-41, synthetized by co-condensation method, presented very promising activity in catalytic and photocatalytic oxidation of diphenyl sulfide with H 2 O 2 to obtain diphenyl sulfoxide and diphenyl sulfone. Mesoporous silica materials with various titanium content were analyzed with respect to chemical composition (inductively coupled plasma optical emission spectrometry), structure properties (X-ray diffraction), textural properties (low-temperature N 2 adsorption–desorption), morphology (scanning electron microscopy), forms and aggregation introduced titanium species (diffuse reflectance spectroscopy, Raman spectroscopy), and surface acidity (NH 3 -TPD). Titanium introduced in the samples was present mainly in the form of highly dispersed species, presenting catalytic and photocatalytic activities in diphenyl sulfide oxidation with H 2 O 2 . Efficiency of the reaction increased with an increase in titanium loading in the samples and was significantly intensified under UV irradiation. The role of various Ti species in diphenyl sulfide oxidation was presented and discussed.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":"2018 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136004257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Mutiara, M. Fahrurrozi, H. Sulistyo, M. Hidayat
{"title":"Green synthesis methods and characterization of bacterial cellulose/silver nanoparticle composites","authors":"T. Mutiara, M. Fahrurrozi, H. Sulistyo, M. Hidayat","doi":"10.1515/gps-2023-0067","DOIUrl":"https://doi.org/10.1515/gps-2023-0067","url":null,"abstract":"Abstract Bacterial cellulose (BC) is a microbiologically produced cellulose with high purity and excellent biocompatibility, allowing it to be used alone or in combination with other materials, including polymers and nanoparticles. This study was conducted to incorporate silver nanoparticles (AgNPs) into a BC matrix using simple and environmentally friendly methods in order to create a composite with superior industrial properties. The fabricated composites were characterized with Fourier transform infrared, X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-ray (EDX), while the thermal stability was investigated by thermogravimetric analysis. The antimicrobial activity of the composites was determined by observing the formation of an inhibition zone during the incubation of Staphylococcus aureus (gram-positive) and Escherichia coli (gram-negative). The SEM, EDX, and XRD analysis confirmed the presence of AgNPs. The composites also exhibit excellent thermal stability and significant antimicrobial activity against S. aureus and E. coli.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45154640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Synthesis and stability of phospholipid-encapsulated nano-selenium","authors":"Jinhui Huang, Xuegui Lin, Yongchuan Zhu, Xue-Ping Sun, Jiesheng Chen, Yingde Cui","doi":"10.1515/gps-2022-8100","DOIUrl":"https://doi.org/10.1515/gps-2022-8100","url":null,"abstract":"Abstract Red elemental nano-selenium, which is an important biological form of selenium, exhibits very low toxicity and remarkable biological properties and thus has several positive effects. For instance, it shows antioxidation and antistress characteristics, promotes growth and improves immunity. However, owing to its nanoscale size, it is very difficult to disperse and stabilize during synthesis and storage. In this study, nanoscale selenium with a mass content of 2.06% and an average particle size of 49 nm was prepared by the chemical reduction method. The analysis demonstrated that the surface phospholipids formed lamellar structures after directional freezing, and the nano-selenium particles were distributed in the middle of the lamellar. The nano-selenium particles were efficiently dispersed due to their lamellar structure and amphiphilicity. The particles displayed excellent stability and remained relatively unchanged after 20 days of storage in solution or solid state. The difficulties associated with the dispersion and storage stability of nanometer selenium during preparation were solved.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44842857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Tayel, Nancy A. Elsayes, M. Zayed, M. Alsieni, Fuad A. Alatawi, A. I. Alalawy, Amany M. Diab
{"title":"Powerful antibacterial nanocomposites from Corallina officinalis-mediated nanometals and chitosan nanoparticles against fish-borne pathogens","authors":"A. Tayel, Nancy A. Elsayes, M. Zayed, M. Alsieni, Fuad A. Alatawi, A. I. Alalawy, Amany M. Diab","doi":"10.1515/gps-2023-0042","DOIUrl":"https://doi.org/10.1515/gps-2023-0042","url":null,"abstract":"Abstract The fish-borne zoonotic bacteria may pose a risk to humans; nanobiotechnological techniques could serve as effective solutions for fighting them. The direct phycosynthesis of metals’ nanoparticles (NPs), silver (AgNPs), and selenium (SeNPs) using Corallina officinalis extract (CoE) was achieved. The construction of nanocomposites (NCs) from phycosynthesized NPs and nano-chitosan (NCht) was also accomplished to evaluate these entire compounds/NCs as antibacterial amalgams against fish-borne bacteria, Aeromonas hydrophila, Pseudomonas aeruginosa, Salmonella typhimurium, and Staphylococcus aureus. The entire agents/NCs were characterized and assessed. The structure and interactions of chemicals and NCs were determined using infrared analysis. CoE/AgNPs, CoE/SeNPs, NCht, NCht/CoE/AgNPs, and NCht/CoE/SeNPs had mean particles’ diameter of 5.52, 12.46, 59.81, 64.59, and 77.16 nm, respectively, which were confirmed by size studies and electron microscopy. The challenged bacteria were entirely susceptible to the inspected agents, using both qualitative and quantitative assays; S. aureus was more resistant, while A. hydrophila was the most sensitive strain. The NCs (NCht/CoE/AgNPs and NCht/CoE/SeNPs) have the utmost bactericidal potentialities, respectively; they exceeded the action of ampicillin. The total distortion, disintegration, and lysis of the treated A. hydrophila cells were highlighted by scanning imaging within 10 h of exposure. The conjugation of CoE-mediated NPs with NCht produced effective and harmless NCs, valid for applications to remove fish-borne pathogens with biosafe characteristics.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43967103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sayyed Ijazul Haq, Muhammad Nisar, Muhammad Zahoor, Muhammad Ikram, N. Islam, R. Ullah, Amal A Alotaibi
{"title":"Green fabrication of silver nanoparticles using Melia azedarach ripened fruit extract, their characterization, and biological properties","authors":"Sayyed Ijazul Haq, Muhammad Nisar, Muhammad Zahoor, Muhammad Ikram, N. Islam, R. Ullah, Amal A Alotaibi","doi":"10.1515/gps-2023-0029","DOIUrl":"https://doi.org/10.1515/gps-2023-0029","url":null,"abstract":"Abstract In the current research work, an attempt was made to synthesize silver nanoparticles (MA-AgNPs) utilizing the ripened fruit extract of Melia azedarach. Various characterization techniques such as UV-visible spectroscopic analysis, thermal gravimetric analysis (TGA), and scanning electron microscopy (SEM) were used to confirm the AgNPs synthesis. The bioreduction and color changes were tracked by UV-visible spectroscopy while SEM confirmed AgNPs of size 2–60 nm. TGA revealed the stability of the synthesized AgNPs. The antibacterial potential of the M. azedarach-based AgNPs and the fruit extract was assessed in terms of zone of inhibition (ZI), minimum bactericidal concentration, and minimum inhibitory concentration against tested bacterial strains where higher activity was noted for NPs (P. aeruginosa ZI = 22). The 2,2-diphenyl-1-picrylhydrazyl (DPPH) and (2,2-azinobis-[3-ethylbenzthiazoline]-6-sulfonic acid) (ABTS) assays revealed that NPs have significant antioxidant activities. The IC50 values recorded for extract was 340 and 350 μg·mL−1 against DPPH and ABTS whereas the corresponding values obtained for AgNPs were 40 and 58 μg·mL−1, respectively. The study suggests that the engineered NPs have promising biological activities compared to the parental extract, and thus could be used in drug designing as antibacterial and antioxidant agents; however, there should be further in vivo exploration in this regard before extending their uses to biological systems.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46275668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
B. Khan, M. Nadeem, M. Iqbal, Neelam Yaqoob, M. Javaid, R. Maqbool, Nehal Z. Elnaggar, H. Oraby
{"title":"Chitosan nanoparticles loaded with mesosulfuron methyl and mesosulfuron methyl + florasulam + MCPA isooctyl to manage weeds of wheat (Triticum aestivum L.)","authors":"B. Khan, M. Nadeem, M. Iqbal, Neelam Yaqoob, M. Javaid, R. Maqbool, Nehal Z. Elnaggar, H. Oraby","doi":"10.1515/gps-2022-8152","DOIUrl":"https://doi.org/10.1515/gps-2022-8152","url":null,"abstract":"Abstract Nanoherbicides are articulated by empowering the potential of nanotechnology for the efficacious delivery of chemical or biological herbicides with the aid of nanomaterial‐based herbicide combinations. Therefore, the goal of this work was to investigate the chitosan nanoparticles loaded with mesosulfuron methyl and mesosulfuron methyl + florasulam + (2-methyl-4-chlorophenoxyacetic acid) MCPA isooctyl herbicides as a possible environmentally benign substitute to manage weeds in wheat. Due to intriguing characteristics including biocompatibility, low allergenicity, biodegradability, and nontoxicity, chitosan biopolymers as sustainable chitin derivatives have received intense scrutiny in the biomedical business. The manufactured nanoparticles were characterized by using ultraviolet absorbance, scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared spectroscopy (FT-IR). The average particle size as revealed by SEM was 40–70 nm in a cluster form with the porous structure. The maximum absorption peaks of both nanoparticles of mesosulfuron methyl and mesosulfuron methyl + florasulam + MCPA isooctyl were 330 and 360 nm. The FT-IR analysis showed an intensive peak at 2θ value of 30.55° for mesosulfuron methyl and 32.79° for mesosulfuron methyl + florasula + MCPA isooctyl, which correspond to the 78 and 198 planes of the anatase phase, respectively. The nanoparticles were sprayed at the third to fourth leaf stages of the targeted weeds. Seven different doses were applied. A total of 100% mortality and visual injury were caused by the chitosan-based nanoparticles of both herbicides at the recommended dose of standard herbicide. The 5-fold lower dose showed the minimum chlorophyll content (5.75%), plant height (2.35 cm), fresh biomass (1.08 g), and dry biomass (0.33 g) of a weed mixture. For the same traits, the herbicide nanoparticles at 10-fold lower dose of commercial herbicides exhibited a similar effect as the recommended dose. Nanoherbicides could recuperate the conventional herbicide effectiveness by enhancing the stability and reducing the toxicity.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46052858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nano-encapsulated tanshinone IIA in PLGA-PEG-COOH inhibits apoptosis and inflammation in cerebral ischemia/reperfusion injury","authors":"Xin Zhang, Xutong Zhu, Lifa Huang, Zu-peng Chen, Yu-Cai Wang, Yajun Liu, Ruihan Pan, Ling Lv","doi":"10.1515/gps-2022-8156","DOIUrl":"https://doi.org/10.1515/gps-2022-8156","url":null,"abstract":"Abstract Tanshinone IIA has a potential therapeutic effect on cerebral ischemia/reperfusion injury (CIRI). In this study, tanshinone IIA was encapsulated in poly(lactic-co-glycolic acid)-block-poly (ethylene glycol)-carboxylic acid (PLGA-PEG-COOH) nanoparticles, and its therapeutic efficacy on CIRI was investigated. Morphology and dynamic light scattering analyses were performed to identify and optimize nano-formulations. A drug release test was conducted using the dialysis method. The cytotoxic effect of tanshinone IIA on human neuroblastoma cells (SH-SY5Y) and brain endothelial capillary cells (hCMEC/D3) was measured using the MTT assay. The protective effect of PLGA-PEG-COOH-encapsulated tanshinone IIA against CIRI was evaluated in oxygen and glucose deprivation/reoxygenation-induced SH-SY5Y/IR cells and middle cerebral artery occlusion (MCAO) rats. Results showed that PLGA-PEG-COOH-encapsulated tanshinone IIA promoted viability and inhibited apoptosis of SH-SY5Y/IR cells (P < 0.01). Moreover, PLGA-PEG-COOH-encapsulated tanshinone IIA facilitated the invasion of SH-SY5Y/IR cells and repressed inflammation in MCAO rats (P < 0.01). Noteworthy, PLGA-PEG-COOH-encapsulated tanshinone IIA combined with angiopep-2 peptide presented a better inhibitory effect on CIRI than tanshinone IIA alone (P < 0.01). Angiopep-2 peptide contributes to traversing blood–brain barrier by recognizing lipoprotein-related protein expressed in the brain capillary endothelial cells. In conclusion, PLGA-PEG-COOH-encapsulated tanshinone IIA plus angiopep-2 peptide holds promising therapeutic potential toward CIRI.","PeriodicalId":12758,"journal":{"name":"Green Processing and Synthesis","volume":" ","pages":""},"PeriodicalIF":4.3,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47863737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}