GMS Hygiene and Infection Control最新文献

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A COVID-19 outbreak with a high attack rate among inpatients in a psychiatric hospital in Wenzhou, China. 中国温州一家精神病院的住院病人中爆发了高发病率的 COVID-19。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000498
Yiwei Zhou, Xingbao Lin, Yu Huang, Chunhua Wu, Jun Li, Jieru Huang, Zumu Zhou
{"title":"A COVID-19 outbreak with a high attack rate among inpatients in a psychiatric hospital in Wenzhou, China.","authors":"Yiwei Zhou, Xingbao Lin, Yu Huang, Chunhua Wu, Jun Li, Jieru Huang, Zumu Zhou","doi":"10.3205/dgkh000498","DOIUrl":"10.3205/dgkh000498","url":null,"abstract":"<p><strong>Background: </strong>Since the emergence of COVID-19, China has taken strict prevention and control measures against the disease. At the end of 2022, when the government optimized and relaxed the COVID-19 prevention and control policy, a new wave of the epidemic appeared. This paper reports an outbreak of COVID-19 among inpatients in a psychiatric hospital in Wenzhou, China.</p><p><strong>Methods: </strong>The case definition of COVID-19 was established. Throat swab specimens were collected and examined by RT-PCT. Questionnaires were distributed to hospitalized patients. Survey data were collected and analyzed.</p><p><strong>Results: </strong>Of 902 inpatients in our hospital, 762 became infected with COVID-19, an attack rate of 84.5%. The outbreak occurred from 10 December, 2022 to January 18, 2023. Twenty patients died, yielding a case fatality rate of 2.6%. Most of the dead were among elderly people with underlying diseases, and 19 of the deceased were over 65 years old.</p><p><strong>Conclusion: </strong>Our investigation showed that the outbreak of COVID-19 among hospitalized patients had the characteristics of high incidence, strong infectivity, and rapid transmission. Infectious sources were introduced into the hospital from the community and spread within the hospital, resulting in an outbreak. In addition, special attention should be paid to elderly people with underlying diseases when treating patients with COVID-19 in the future.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc43"},"PeriodicalIF":1.7,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565407/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral mucosal lesions in the mouth as first sign of dermatological diseases and disorders. 口腔黏膜病变是皮肤病和失调的首发症状。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-10-02 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000499
Harepriya Meganathan Karthikeyini, Karthik Shunmugavelu, Evangeline Cynthia Dhinakaran
{"title":"Oral mucosal lesions in the mouth as first sign of dermatological diseases and disorders.","authors":"Harepriya Meganathan Karthikeyini, Karthik Shunmugavelu, Evangeline Cynthia Dhinakaran","doi":"10.3205/dgkh000499","DOIUrl":"10.3205/dgkh000499","url":null,"abstract":"<p><p>Oral mucosal lesions manifest as a first sign of immune-mediated disorders. Lichen planus, pemphigus and pemphigoid are the most frequent immunologically mediated mucocutaneous diseases with oral involvement. Oral lesions are initially detected by dental health practitioners. Early detection can help in appropriate treatment and better quality of life. Based on an analysis of 6,300 medical records from the period 1997 to 2018, 105 (1.66%) were attributable to these immunologically mediated diseases, of which 86 (1.36%) were due to lichen planus, 4 (0.06%) to pemphigus and 15 (0.23%) to pemphigoid.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc44"},"PeriodicalIF":1.7,"publicationDate":"2024-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11565593/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142647443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
S2k-Guideline hand antisepsis and hand hygiene. S2k-Guideline 手部防腐和手部卫生。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-09-06 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000497
Axel Kramer, Julia Seifert, Marianne Abele-Horn, Mardjan Arvand, Paul Biever, Alexander Blacky, Michael Buerke, Sandra Ciesek, Iris Chaberny, Maria Deja, Steffen Engelhart, Dieter Eschberger, Bernd Gruber, Achim Hedtmann, Julia Heider, Udo B Hoyme, Christian Jäkel, Peter Kalbe, Horst Luckhaupt, Alexander Novotny, Cihan Papan, Hansjürgen Piechota, Frank-Albert Pitten, Veronika Reinecke, Dieter Schilling, Walter Schulz-Schaeffer, Ulrich Sunderdiek
{"title":"S2k-Guideline hand antisepsis and hand hygiene.","authors":"Axel Kramer, Julia Seifert, Marianne Abele-Horn, Mardjan Arvand, Paul Biever, Alexander Blacky, Michael Buerke, Sandra Ciesek, Iris Chaberny, Maria Deja, Steffen Engelhart, Dieter Eschberger, Bernd Gruber, Achim Hedtmann, Julia Heider, Udo B Hoyme, Christian Jäkel, Peter Kalbe, Horst Luckhaupt, Alexander Novotny, Cihan Papan, Hansjürgen Piechota, Frank-Albert Pitten, Veronika Reinecke, Dieter Schilling, Walter Schulz-Schaeffer, Ulrich Sunderdiek","doi":"10.3205/dgkh000497","DOIUrl":"10.3205/dgkh000497","url":null,"abstract":"<p><p>The consensus-based guideline \"hand antisepsis and hand hygiene\" for Germany has the following sections: Prevention of nosocomial infections by hygienic hand antisepsis, prevention of surgical site infections by surgical hand antisepsis, infection prevention in the community by hand antisepsis in epidemic or pandemic situations, hand washing, selection of alcohol-based hand rubs and wash lotions, medical gloves and protective gloves, preconditions for hand hygiene, skin protection and skin care, quality assurance of the implementation of hand hygiene measures and legal aspects. The guideline was developed by the German Society for Hospital Hygiene in cooperation with 22 professional societies, 2 professional organizations, the German Care Council, the Federal Working Group for Self-Help of People with Disabilities and Chronic Illness and their Family Members, the General Accident Insurance Institution Austria and the German-speaking Interest Group of Infection Prevention Experts and Hospital Hygiene Consultants.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc42"},"PeriodicalIF":1.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11465089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Medical associations and expert committees urge that ethanol be approved as a virucidal active substance for use in hand antiseptics under the European Biocidal Products Regulation, without a CMR classification. 医学协会和专家委员会敦促根据《欧洲杀菌剂产品条例》批准乙醇作为杀病毒活性物质用于手部消毒剂,而无需进行 CMR 分类。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000495
Axel Kramer, Didier Pittet, Martin Exner, Constanze Wendt
{"title":"Medical associations and expert committees urge that ethanol be approved as a virucidal active substance for use in hand antiseptics under the European Biocidal Products Regulation, without a CMR classification.","authors":"Axel Kramer, Didier Pittet, Martin Exner, Constanze Wendt","doi":"10.3205/dgkh000495","DOIUrl":"10.3205/dgkh000495","url":null,"abstract":"<p><strong>Introduction: </strong>Since 2007, the classification of ethanol under the Biocidal Products Regulation has paradoxically remained unresolved due to conflicting views among experts and authorities. Initially, there was a discussion about classifying ethanol as carcinogenic. The current proposal to extend its harmonized classification includes, among other things, categorizing it as reproductive toxicity category 2 (\"suspected to have CMR potential for humans\"; carcinogenic, mutagenic, reprotoxic). If ethanol were classified under reproductive toxicity category 2, it would mean that the only active ingredient in hand antiseptics effective against non-enveloped viruses would no longer be available.</p><p><strong>Scientific assessment of the safety of ethanol-based hand rubs ebhr: </strong>Available epidemiological studies do not confirm an increased risk for cancer from EBHR in exposed individuals, except under uncommon or unlikely routes or levels of exposure.The evidence for ethanol's reprotoxic effect originates from the consumption of alcoholic beverages by pregnant women, where ethanol uptake is incomparably higher. The amount of transdermal ethanol absorption during hand antisepsis is up to ten times lower than the oral intake of beverages containing hidden ethanol, such as apple juice, kefir, or non-alcoholic beer. Blood alcohol levels after using EBHR remain within the physiological range associated with food intake.</p><p><strong>Conclusion: </strong>There is no epidemiological evidence of toxicity for workers handling ethanol-containing products in industry or using EBHR in healthcare settings. Given that the classification of EBHR as reproductive toxicity category 2 is not supported by current scientific research and that no alternative biocidal active substance in hand rubs is effective against non-enveloped viruses, medical associations and expert committees from Europe, the USA, Canada, the Asia-Pacific region, and the World Society for Virology unequivocally recommend, with the highest priority, that EBHR be approved as an active substance for PT1 biocides and not be classified as a reproductive toxicant in category 2.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc40"},"PeriodicalIF":1.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alcohol-based hand rubs can fulfil efficacy requirements of EN 1500 in 15 seconds. 酒精搓手液可以在 15 秒内达到 EN 1500 的功效要求。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-08-21 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000496
Erika Mönch, Astrid Bolten, Heide Niesalla, Christoph Senges
{"title":"Alcohol-based hand rubs can fulfil efficacy requirements of EN 1500 in 15 seconds.","authors":"Erika Mönch, Astrid Bolten, Heide Niesalla, Christoph Senges","doi":"10.3205/dgkh000496","DOIUrl":"10.3205/dgkh000496","url":null,"abstract":"<p><strong>Aim: </strong>Correct hand hygiene is widely regarded as an important measure to prevent healthcare-associated infections. Guidelines on how to perform hand antisepsis are often inspired by laboratory tests that focus on reproducibility rather than ease of use. These cumbersome recommendations can become barriers to hand hygiene, as optimal user acceptance requires a small rub volume and a short application time with an intuitive rubbing technique. Here we modified the EN 1500 to test the efficacy of hand rubs under more user-friendly conditions, using a highly intuitive rubbing technique in 15 seconds.</p><p><strong>Methods: </strong>The efficacy of an ethanolic and a propanolic hand rub in inactivating <i>E. coli</i> on the hands of volunteers was tested according to EN 1500 with modifications in rubbing technique and time. Pre-tests were conducted to find a suitable volume for \"responsible application\", a procedure without clearly defined steps. Finally, 20 volunteers applied both rubs for 15 seconds using 3 mL and \"responsible application\" and 5 mL using the WHO 6-step technique.</p><p><strong>Results: </strong>Both hand rubs, ethanolic and propanolic, were non-inferior to an unmodified EN 1500 reference for both application methods, 3 mL with \"responsible application\" and 5 mL with the WHO 6-step method.</p><p><strong>Conclusion: </strong>Reducing the complexity of hand rub application can have a positive impact on hand hygiene adherence. With our results showing that antimicrobial efficacy comparable to an unmodified EN 1500 can be achieved in 15 seconds using an intuitive rubbing technique, further barriers to more user-friendly hand rub application have been removed.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc41"},"PeriodicalIF":1.7,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367557/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Vaccination status, awareness, and its correlates among healthcare workers in the Delhi-National Capital Region (NCR): a mixed-method study. 德里-国家首都地区(NCR)医护人员的疫苗接种状况、意识及其相关因素:一项混合方法研究。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000494
Mohammed Ahmed, Varalakshmi Manchana
{"title":"Vaccination status, awareness, and its correlates among healthcare workers in the Delhi-National Capital Region (NCR): a mixed-method study.","authors":"Mohammed Ahmed, Varalakshmi Manchana","doi":"10.3205/dgkh000494","DOIUrl":"10.3205/dgkh000494","url":null,"abstract":"<p><strong>Introduction: </strong>Healthcare workers (HCWs) are on the frontline of infections. To safeguard HCWs from occupational exposure to infections and to curb nosocomial infection a set of vaccines has been recommended for them by the WHO. Hence, we aimed to assess the vaccination status, awareness, and its correlates amongst HCWs in the Delhi-NCR.</p><p><strong>Method: </strong>The study used a cross-sectional mixed-method approach from January to April 2023. For the quantitative arm, a structured questionnaire was circulated to the participants in conveniently-selected private and government tertiary care hospitals of the Delhi-NCR, both through e-survey using Google form, and in person, data were collected on socio-demographics, vaccination status, and awareness. SPSS version 25 was used for the analysis. For the qualitative arm, in-depth interviews were conducted and data were analyzed manually.</p><p><strong>Results: </strong>Out of 387 participants (62.8% males, 37.2% females), the awareness about the vaccines recommended for HCWs was 64.1%. However, only 15.3% of HCWs were completely aware of all the recommended vaccines. SARS CoV-2, Polio, Hepatitis B, and BCG had the highest vaccination coverage, 97.4%, 87.9%, 83.7%, and 50.9%, respectively. It was found that gender, education, type (private or governmental) of tertiary care hospital, and profession had a significance (p<0.05) on the vaccination status score and awareness of all WHO-recommended vaccines (AOR=7.6, 95% CI, 3.24-18.0). The qualitative arm further augmented the findings.</p><p><strong>Conclusion: </strong>The study reveals insufficient awareness and vaccination status regarding recommended vaccines. Prioritizing the preparation of unified standard guidelines for Indian HCWs and involving concerned stakeholders is crucial.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc39"},"PeriodicalIF":1.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the knowledge of healthcare workers on monkeypox in Nigeria. 评估尼日利亚医护人员对猴痘的了解程度。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-08-20 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000493
Uche Eze, Nnenna Okafor, Gerald Ozota, Kelechi Nworie, Christian Asogwa, Ifeanyi Richard, Ann-Pearl Ilochonwu, Samuel Ezeasor, Chineye Okorie, Kenechukwu Ben-Umeh, Adaeze Ezeh, Mercy Aboh, Abdulmuminu Isah
{"title":"Assessment of the knowledge of healthcare workers on monkeypox in Nigeria.","authors":"Uche Eze, Nnenna Okafor, Gerald Ozota, Kelechi Nworie, Christian Asogwa, Ifeanyi Richard, Ann-Pearl Ilochonwu, Samuel Ezeasor, Chineye Okorie, Kenechukwu Ben-Umeh, Adaeze Ezeh, Mercy Aboh, Abdulmuminu Isah","doi":"10.3205/dgkh000493","DOIUrl":"10.3205/dgkh000493","url":null,"abstract":"<p><strong>Background: </strong>Monkeypox, a re-emerging zoonotic disease caused by the monkeypox virus (MPXV), poses a public health challenge in Nigeria. To effectively combat this disease, it is essential to assess the knowledge of healthcare workers (HCWs) in Nigeria concerning monkeypox outbreak.</p><p><strong>Methods: </strong>A cross-sectional web-based survey with 609 healthcare workers in Nigeria was conducted using a structured questionnaire to assess their knowledge of monkeypox. Data were coded and analyzed with Microsoft Excel and Python in Anaconda Jupyter Notebook.</p><p><strong>Results: </strong>The majority of respondents (n=318, 52.2%) had good knowledge of MPXV but also had knowledge gaps regarding certain symptoms and disease similarities. Interestingly, respondents were completely unaware of the possibility of sexual transmission of the disease. However, they recognized the possible significant impact of monkeypox on the social and economic lifestyle of Nigerians (n=582, 95.6%, adjOR=21.181, 95% CI: 14.450-31.051). Respondents had mixed knowledge regarding the use of smallpox vaccines and antiviral agents for monkeypox prevention and treatment. Furthermore, a significant proportion (n=526, 86.4%, adjOR=0.159, 95% CI: 0.126-0.201) attributed the outbreak to bioterrorism. The logistic regression highlighted a strong influence of academic qualification, type of healthcare provider, years of experience, and geopolitical zone of practice, on monkeypox knowledge in Nigeria.</p><p><strong>Conclusion: </strong>The study highlights the importance of continuous education for healthcare professionals in Nigeria to improve monkeypox outbreak management. Despite their moderate performance, there are knowledge gaps in critical areas among HCWs, necessitating further research to explore reasons and influencing factors for knowledge levels.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc38"},"PeriodicalIF":1.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virucidal activity of chlorine dioxide in combination with acetic acid or citric acid and a surfactant, in presence of interfering substances, against polio-, adeno- and murine norovirus in suspension-, carrier- and four-field tests. 在悬浮、载体和四场试验中,二氧化氯与醋酸或柠檬酸和表面活性剂结合,在存在干扰物质的情况下,对脊髓灰质炎病毒、腺病毒和小鼠诺如病毒的杀病毒活性。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-08-12 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000492
Patryk Tarka, Arkadiusz Chruściel, Wiesław Hreczuch, Krzysztof Kanecki, Aneta Nitsch-Osuch
{"title":"Virucidal activity of chlorine dioxide in combination with acetic acid or citric acid and a surfactant, in presence of interfering substances, against polio-, adeno- and murine norovirus in suspension-, carrier- and four-field tests.","authors":"Patryk Tarka, Arkadiusz Chruściel, Wiesław Hreczuch, Krzysztof Kanecki, Aneta Nitsch-Osuch","doi":"10.3205/dgkh000492","DOIUrl":"10.3205/dgkh000492","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of the study was to investigate whether the virucidal effectiveness of chlorine dioxid against adenovirus and murine norovirus can be improved by combining it with carboxylic acids and surfactants.</p><p><strong>Method: </strong>The virucidal efficacy against polio-, adeno- and murine norovirus has been tested in presence of interfering substances in the quantitative suspension test according to EN 14476, the carrier test without mechanical action according to EN 16777, and in the four-field test according to EN 16615.Three chlorine-dioxide-based surface disinfectants were tested: a two-component cleaning disinfectant concentrate for large surfaces, a ready-to-use (RTU) foam, and an RTU gel.</p><p><strong>Results: </strong>Cleaning and disinfecting preparations based on chlorine dioxide, applied at various concentrations, in combination with acetic acid or citric acid and surfactants, are virucidally active against polio-, adeno-, and norovirus after an exposure time of 5 minutes in presence of interfering substances.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc37"},"PeriodicalIF":1.7,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367254/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Secapin: a promising antimicrobial peptide against multidrug-resistant Acinetobacter baumannii. 塞卡平:一种针对耐多药鲍曼不动杆菌的前景看好的抗菌肽。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-07-09 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000491
Zohreh Sadeghi Rad, Mahnaz Farahmand, Mahsa Kavousi
{"title":"Secapin: a promising antimicrobial peptide against multidrug-resistant Acinetobacter baumannii.","authors":"Zohreh Sadeghi Rad, Mahnaz Farahmand, Mahsa Kavousi","doi":"10.3205/dgkh000491","DOIUrl":"10.3205/dgkh000491","url":null,"abstract":"<p><strong>Introduction: </strong><i>Acinetobacter baumannii</i>, renowned for its exceptional multidrug resistance and its role as a prevalent nosocomial pathogen, poses a formidable challenge to conventional antibiotic therapies. The primary objective of this investigation was to evaluate the efficacy of Secapin, an antimicrobial peptide, against multidrug-resistant (MDR) <i>baumannii</i>. Furthermore, the mechanisms underlying Secapin's antibacterial and antibiofilm activities were elucidated.</p><p><strong>Methods: </strong>The antimicrobial and antibiofilm effectiveness of Secapin against MDR <i>A. baumannii</i> was assessed through a series of experiments. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of Secapin were determined using established protocols. Time-kill kinetic analysis was performed to assess the concentration-dependent bactericidal effect of Secapin. Additionally, the capacity of Secapin to impede biofilm formation and eradicate <i>A. b</i> <i>aumannii</i> biofilms was investigated. Hemolytic potential was evaluated using human red blood cells, while mammalian cell viability was examined at varying Secapin concentrations.</p><p><strong>Results: </strong>Secapin exhibited robust bactericidal activity at minimal concentrations, with an MIC of 5 µg/mL and an MBC of 10 µg/mL against MDR <i>A. baumannii</i>. The time-kill kinetic analysis confirmed the concentration-dependent efficacy of Secapin in diminishing bacterial viability. Moreover, Secapin demonstrated the ability to prevent biofilm formation and eliminate established <i>A. baumannii</i> biofilms. Notably, Secapin exhibited no hemolytic activity and preserved mammalian cell viability up to a concentration of 100 µg/mL.</p><p><strong>Conclusion: </strong>These findings underscore the substantial potential of Secapin as a potent agent against multidrug-resistant <i>A. baumannii</i>, showcasing its efficacy in both antibacterial and antibiofilm capacities. The favorable attributes of Secapin, characterized by its minimal hemolytic effects and high mammalian cell viability, position it as a promising contender in the fight against antibiotic resistance.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc36"},"PeriodicalIF":1.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11367255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142119533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bibliometric analysis of publication trends on ocular hygiene and infections in the past two decades. 对过去二十年有关眼部卫生和感染的出版物趋势进行文献计量分析。
IF 1.7
GMS Hygiene and Infection Control Pub Date : 2024-06-21 eCollection Date: 2024-01-01 DOI: 10.3205/dgkh000489
Mohsan Ali, Bisal Naseer, Rawal Alias Insaf Ahmed, Muhammad Talha, Moeez Saqib, Amar Anwar
{"title":"Bibliometric analysis of publication trends on ocular hygiene and infections in the past two decades.","authors":"Mohsan Ali, Bisal Naseer, Rawal Alias Insaf Ahmed, Muhammad Talha, Moeez Saqib, Amar Anwar","doi":"10.3205/dgkh000489","DOIUrl":"10.3205/dgkh000489","url":null,"abstract":"<p><strong>Background: </strong>Ocular hygiene encompasses a spectrum of measures to initiate and maintain adequate ocular cleanliness to prevent eye infections and their further transmission. These infections affect all age groups and can lead to severe complications such as blindness. Nearly 1 billion cases could have been prevented out of over 2.2 billion people that are visually impaired worldwide. This bibliometric analysis focuses on the papers published on ocular hygiene and infections.</p><p><strong>Methods: </strong>We searched in the Scopus database from 2004 to 2024. After manual screening, a list of the 100 most-cited original articles was obtained, which was analysed for various factors, including temporal trends, subject areas, authorship patterns, country of origin, funding bodies, etc.</p><p><strong>Results: </strong>There has been a gradual decline over the past two decades in the number of publications. The United States was affiliated with the highest number of publications (n=61), followed by The United Kingdom (n=12) and Gambia (n=8). Several authors had 4 or more publications, with the highest number of publications by Rouse, B. T. (n=14). The American Journal of Ophthalmology takes the lead with 15 publications, while the National Eye Institute (n=23) was the leading funding body. Examination of institutional contributions shows that The University of Tennessee, Knoxville and UT College of Veterinary Medicine stand out with twelve publications each. Nearly half the publications belong to the field of medicine. However, significant publications also come from the fields Neuroscience, Microbiology and Immunology, Biochemistry, Genetics and Molecular Biology, etc. These findings highlight that there is great potential to conduct research to propagate ocular hygiene to prevent adverse effects of infections.</p>","PeriodicalId":12738,"journal":{"name":"GMS Hygiene and Infection Control","volume":"19 ","pages":"Doc34"},"PeriodicalIF":1.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11238425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141590063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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