Gaceta medica de Mexico最新文献_第7页

Assessing of antibiotic resistance in the phage-plasmids of Klebsiella pneumoniae and its inhibitory compound. 肺炎克雷伯菌噬菌体质粒及其抑菌化合物的抗生素耐药性评估。

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.25000061

Ragıp Soner-Silme

{"title":"Assessing of antibiotic resistance in the phage-plasmids of Klebsiella pneumoniae and its inhibitory compound.","authors":"Ragıp Soner-Silme","doi":"10.24875/GMM.25000061","DOIUrl":"10.24875/GMM.25000061","url":null,"abstract":"Background: Antibiotic resistance in Klebsiella pneumoniae poses an increasing risk to human health worldwide.Objectives: Whole-genome sequence data were used to characterize K. pneumoniae phage-plasmids isolated in different countries.Materials and methods: Sequences of 15 genetically similar phage-plasmids were selected based on BLASTN analysis. Antibiotic resistance genes were screened using ResFinder, PhageAI, PlasmidFinder, PHASTEST, and PhageGE tools. Phage-plasmid sequences were then analyzed for a stable region in the genome using MAUVE analysis, and the protein of this stable region and its candidate inhibitor molecule were analyzed through molecular docking studies.Results: Several resistance genes were detected in 7 of the 15 phage-plasmids screened. All plasmids had the Salmonella SSU5 prophage. MAUVE analysis indicated a common stable region encoding replication protein A. Molecular docking studies demonstrated that an interaction occurs between replication protein A and a fabimycin derivative.Conclusion: Fabimycin could be used to control both phage plasmids and their host, which could affect the severity and incidence of K. pneumoniae infections.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 4","pages":"346-357"},"PeriodicalIF":1.3,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147467864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Narrative medicine and critical epistemology in medical training. 叙事医学与医学训练中的批判认识论。

IF 1.3 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M26001079

Alain R Rodríguez-Orozco

引用次数: 0

Reflections on the clinical application of pharmacogenetics in high-prevalence chronic diseases. 药物遗传学在高流行慢性病临床应用的思考。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001070

Walter F Jacinto-Pizarro

引用次数: 0

Measles re-emergence in Mexico. 麻疹在墨西哥再次出现。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001068

Óscar Sosa-Hernández, Luis G Zárate-Sánchez

引用次数: 0

Evolution of children diagnosed with attention deficit hyperactivity disorder. 诊断为注意缺陷多动障碍儿童的进化。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001072

Manuel Y Arnao-Villegas

引用次数: 0

The new epidemic in Indigenous peoples: the adiposity syndrome in poverty. 土著人民的新流行病：贫困中的肥胖综合症。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000990

René C Crocker-Sagastume, José L Vázquez-Castellanos, Emmanuel Zúñiga-Romero

{"title":"The new epidemic in Indigenous peoples: the adiposity syndrome in poverty.","authors":"René C Crocker-Sagastume, José L Vázquez-Castellanos, Emmanuel Zúñiga-Romero","doi":"10.24875/GMM.M25000990","DOIUrl":"10.24875/GMM.M25000990","url":null,"abstract":"Background: The incorporation of industrial foods in Indigenous peoples has generated health problems in families, related to the excessive accumulation of adipose tissue, Diabetes mellitus type II, metabolic liver disease, defined as \"adiposity in poverty syndrome\".Objective: To analyze the frequency of diseases of the adiposity syndrome in poverty in Indigenous peoples in transition to modernity in the Wixarika region of the state of Jalisco, Mexico.Material and methods: An epidemiological, cross-sectional analytical design with sampling segmented by community size is applied. 238 cases over 30 years old of 221 families from three communities are studied. Statistical analysis is performed by nonparametric tests, with significant p < 0.05.Results: There is a significant difference in the frequencies of adiposity syndrome by community size, by locality and between traditional communities and those in the process of westernization.Conclusions: The study provides a sociohistorical approach to the problems of Indigenous peoples from critical epidemiology. In the Wixaritari populations there are changes in health conditions, determined by the degree of social development and by their incorporation into the processes of Westernization.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 2","pages":"185-191"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic influence on obesity: beyond bad habits in the Mexican population. 遗传对肥胖的影响：墨西哥人口的不良习惯。

IF 0.6 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25000984

Ulisses Moreno-Celis, Adriana Aguilar-Galarza, Teresa García-Gasca

{"title":"Genetic influence on obesity: beyond bad habits in the Mexican population.","authors":"Ulisses Moreno-Celis, Adriana Aguilar-Galarza, Teresa García-Gasca","doi":"10.24875/GMM.M25000984","DOIUrl":"10.24875/GMM.M25000984","url":null,"abstract":"This paper addresses the genetic influence on obesity within the Mexican population, highlighting that this condition is the result of a complex interaction between genetic and environmental factors. Specific genetic variants are identified that not only predispose to obesity but may also offer protection against it. This knowledge is crucial for the development of personalized medicine and nutrition strategies that adapt health interventions to the individual genetic characteristics of patients, thus improving the effectiveness in the prevention and treatment of obesity. Despite the promising potential of personalized medicine and nutrition, the study recognizes significant challenges, such as genetic variability within the Mexican population, the infrastructure necessary to integrate genetic data into clinical practice, and ethical considerations in the management of this information. It is important to highlight the need for future research that delves deeper into the relationship between genetics and obesity, also considering environmental factors. Likewise, it is suggested that the integration of these findings into public health policies could offer more specific and effective approaches to combat obesity in Mexico, contributing significantly to improving health in the population.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 1","pages":"85-93"},"PeriodicalIF":0.6,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic clocks and aging. 表观遗传时钟和衰老。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001032

Henry C Rivas-Sucari

引用次数: 0

Decalogue of prediabetes: recommendations for its identification and comprehensive management. 前驱糖尿病十诫：对其识别和综合管理的建议。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001021

M Fernanda Zarazúa-Jiménez, M Lourdes Basurto, Cinthia G Bonifaz-Bravo, Edith Ruiz-Gastelum, Mardia G López-Alarcón, Y Carlos A Amores-Zúñiga

{"title":"Decalogue of prediabetes: recommendations for its identification and comprehensive management.","authors":"M Fernanda Zarazúa-Jiménez, M Lourdes Basurto, Cinthia G Bonifaz-Bravo, Edith Ruiz-Gastelum, Mardia G López-Alarcón, Y Carlos A Amores-Zúñiga","doi":"10.24875/GMM.M25001021","DOIUrl":"https://doi.org/10.24875/GMM.M25001021","url":null,"abstract":"Prediabetes is a condition that precedes diabetes with similar damage mechanisms but different diagnostic criteria. In prediabetes, there are certain promoting factors that encourage its development and once established, they favor the progression of comorbidity, especially cardiovascular. Excessive body weight is a main risk factor, usually part of prediabetes so it is recommended to implement lifestyle changes to prevent the development of diabetes, or even get to revert to normoglycemia. This may be possible if there is an adequate identification of risk factors and screening to establish individualized modifications and avoid associated complications. Prediabetes should not be underestimated, since it is part of the diabetes spectrum, and in the long term it has repercussions on quality and life expectancy. This document proposes 10 basic guidelines to broaden the vision of this entity, identifying in which cases there is a probability of remission, related damage mechanisms, risk factors, macrovascular complications that it entails, start of screening, diagnostic criteria, recommendations for lifestyle changes, and pharmacological and non-pharmacological treatment options.","PeriodicalId":12736,"journal":{"name":"Gaceta medica de Mexico","volume":"161 3","pages":"260-266"},"PeriodicalIF":0.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145843654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ChatGPT at the service of medicine. 为医学服务。

IF 0.8 4区医学

Gaceta medica de Mexico Pub Date : 2025-01-01 DOI: 10.24875/GMM.M25001038

Mónica Regalado-Chamorro, Aldo Medina Gamero

引用次数: 0