Global Spine Journal最新文献

{"title":"Is There a Need for Functional Radiographs in Diagnosing Lumbar Instability?","authors":"Marie-Christine Lutschounig, Irene Katharina Sigmund, Irene Steiner, Anna Rienmüller, Christoph Stihsen, Reinhard Windhager, Josef Georg Grohs","doi":"10.1177/21925682241306025","DOIUrl":"10.1177/21925682241306025","url":null,"abstract":"<p><p>Study DesignRetrospective radiological database analysis.ObjectiveThe aim of this study was to assess the value of functional radiography (FRF = flexion; FRE = extension) compared to MRI and standing sagittal plane full spine radiography (SP) with low-grade spondylolisthesis.MethodsSagittal translation (ST) and rotation (SR) were measured between all lumbar levels to assess instability. The differences for ST and SR of SP and FRE as well as MRI and FRF were calculated. In addition, the lumbar lordosis, the sacral slope, the pelvic tilt and the pelvic incidence were measured.ResultsRadiological datasets of 55 patients with 165 lumbar segments fulfilled inclusion criteria. Instability was diagnosed in 20 segments (12.1%) with SP/MRI compared to 14 segments (8.5%) using FRF/FRE with ST. SR functional radiographs showed instability in 41 segments (25%) and 23 segments (14%) using SP/MRI. The intraclass correlation coefficients (ICC) of ST between SP and FRE for L3/L4, L4/L5, and L5/S1 were 0.74, 0.84 and 0.97, respectively, indicating moderate to excellent agreement between imaging methods. For SP/FRE, the ICCs of the SR were 0.72, 0.61 and 0.64, respectively with moderate agreement. The ICCs of the ST for L3/4, L4/5, and L5/S1 showed moderate to good agreement between MRI and FRF with values of 0.52, 0.77, and 0.80, respectively. Regarding SR, poor agreement between MRI and FRF was observed. The ICCs for L3/4, L4/5, L5/S1 were 0.16, 0.23 and 0.23.ConclusionBased on our results, instability may also be diagnosed by calculating the difference in the ST in SP and MRI without additional functional radiographs. However, FRF showed translational instability more clearly than MRI in some patients and might still be an asset in borderline cases.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2634-2644"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lateral Fusion is a Unique Feature in Oblique Lumbar Interbody Fusion Surgery: A Retrospective Cohort Study.","authors":"Tong Yongjun, Fu Chudi, Zhang Qibin, Huang Bao, Ou Changjiang, Zhang Xuyang, Liu Junhui, Fan Shunwu, Zhao Fengdong","doi":"10.1177/21925682241310151","DOIUrl":"10.1177/21925682241310151","url":null,"abstract":"<p><p>Study DesignRetrospective cohort study.ObjectiveLimited clinical literature addresses potential differences in fusion features between Oblique lumbar interbody fusion (OLIF) and transforaminal lumbar interbody fusion (TLIF). We observed that in OLIF, there are many cases with the appearance of extra-vertebral bone bridges (EVB), a phenomenon distinct from traditional TLIF fusion. This study aims to compare fusion rates, cage subsidence, and fusion features among OLIF stand-alone (OLIF-SA), OLIF with posterior pedicle screw fixation (OLIF-PS), and TLIF.MethodsWe retrospectively analyzed 198 patients (311 levels) undergoing OLIF-SA, OLIF-PS, or TLIF from July 2017 to June 2021. We assessed patient-reported outcomes, cage subsidence, fusion rate, and fusion features on CT scans.ResultsThe study included 64 OLIF-SA patients (102 levels), 60 OLIF-PS patients (99 levels), and 74 TLIF patients (110 levels). Cage settling rates were 33.3% (OLIF-SA), 17.2% (OLIF-PS), and 32.8% (TLIF), with significant differences between OLIF-PS and TLIF (<i>P</i> < 0.05). Cage subsidence rates showed no significant difference: 11.8% (OLIF-SA), 9.1% (OLIF-PS), and 12.7% (TLIF) (<i>P</i> > 0.05). Fusion rates were 100% (OLIF-SA), 97.0% (OLIF-PS), and 96.4% (TLIF) (<i>P</i> = 0.167). Lateral fusion rates significantly differed: 49.0% (OLIF-SA), 30.3% (OLIF-PS), and 10.9% (TLIF) (<i>P</i> < 0.001). Preoperative osteophytes strongly promote lateral fusion (<i>P</i> < 0.001). VAS and ODI scores improved significantly post-surgery (<i>P</i> < 0.01).ConclusionsOLIF-SA, OLIF-PS, and TLIF surgeries show satisfactory results with comparable fusion rates. Notably, distinctive differences exist in fusion features between OLIF and TLIF surgeries, with lateral fusion more prevalent in OLIF, particularly in OLIF-SA surgeries.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2714-2725"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends in Sacroiliac Joint Fusion Costs and Utilization in the Privately Insured Population.","authors":"Thomas Johnstone, Ethan Schonfeld, Sina Sadeghzadeh, Neelan J Marianayagam, Kelly H Yoo, John K Ratliff, Anand Veeravagu","doi":"10.1177/21925682241309302","DOIUrl":"10.1177/21925682241309302","url":null,"abstract":"<p><p>Study DesignRetrospective Cohort Study.ObjectiveDespite innovations in minimally invasive (MI) techniques for sacroiliac joint fusion (SIJF), trends in utilization and associated costs remain unclear. In this study, we assessed these trends and costs in a database of privately insured patients.MethodsRecords of open and MI SIJFs were queried from the 2007-2021 MarketScan Databases with CPT codes. Net payments made by insurance carriers were identified, as were out-of-pocket payments made by patients for each encounter. Regression was used to model utilization, payments, and costs.Results4124 SIJFs were identified, 1626 (39.4%) of which were MI SIJF. SIJF utilization increased by 1176.2% throughout the study period (<i>P</i> < .001). However, open SIJF utilization peaked in 2012. Open SIJF utilization was not significantly associated with time (<i>P</i> = .18). By contrast, the peak utilization for MI procedures occurred in 2021. Spine surgeons' volume of MI SIJF increased by 258% over the study period (<i>P</i> < .001), while nonsurgeon volume of MI SIJF increased by 990.9% (<i>P</i> < .001).ConclusionPrivately insured patients have increasingly utilized SIJF over the past several years. This is predominantly due to the adoption of MI techniques by spine surgeons and nonsurgeons.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2708-2713"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11653382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Preoperative Depression on Cervical Spine Surgery Outcomes: A Systematic Review and Meta-Analysis.","authors":"Saad Javeed, Salim Yakdan, Braeden Benedict, Samia Saleem, Muhammad Kaleem, Justin K Zhang, Madelyn R Frumkin, Angela Hardi, Brian Neuman, Michael P Kelly, Burel R Goodin, Thomas L Rodebaugh, Wilson Z Ray, Jacob K Greenberg","doi":"10.1177/21925682251316245","DOIUrl":"10.1177/21925682251316245","url":null,"abstract":"<p><p>Study DesignSystematic review and Meta-analysis.ObjectivesTo quantify the association of preoperative depression on patient reported outcome measures (PROMS) after cervical spine surgery.MethodsWe systematically searched PubMed, Cochrane, Embase, Scopus, PsychInfo, Web of Science, and ClinicalTrials.gov until September 14, 2023. Studies including adults undergoing cervical spine surgery and comparing PROMs between depressed and non-depressed patients were included. The primary outcome was the postoperative <i>change</i> in disability, pain, and physical function. Secondary outcomes included absolute disease severity before and after surgery. We conducted random-effects meta-analysis.ResultsAfter screening 3813 articles, 20 studies were included, encompassing 3964 patients (mean age 57, 51% males) with median follow-up duration of 12 months. There was significant heterogeneity in estimates of the primary outcome (<i>I</i>^<i>2</i> = 81%). While patients with depression had a greater magnitude of improvement compared with patients without depression, it was not statistically significant (SMD = 0.04, [95% CI: -0.07, 0.16], <i>I</i>^<i>2</i> = 80%; <i>P</i> = 0.48). However, patients with depression exhibited worse <i>absolute</i> disease severity preoperatively (SMD = -0.31, [-0.44, -0.19], <i>I</i>^<i>2</i> = 84%; <i>P</i> < 0.001) and postoperatively (SMD = -0.31, [-0.48, -0.15], <i>I</i>^<i>2</i> = 89%; <i>P</i> < 0.002). Sensitivity analyses with meta-regression found that older age, sex (male-to-female ratio), percentage of comorbidities, study quality, follow-up duration, number of adjusted factors in the analysis, and surgical approach were significant sources of heterogeneity.ConclusionsPatients with depression experienced similar improvements in disability, pain, and physical function after cervical surgery compared to patients without depression. However, patients with depression exhibited worse disease severity before and after surgery.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2767-2778"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760078/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143033023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AO Spine Clinical Practice Recommendations for Diagnosis and Management of Degenerative Cervical Myelopathy: Evidence Based Decision Making - A Review of Cutting Edge Recent Literature Related to Degenerative Cervical Myelopathy.","authors":"Michael G Fehlings, Nathan Evaniew, Paula Valerie Ter Wengel, Aditya Vedantam, Daipayan Guha, Konstantinos Margetis, Aria Nouri, Aminul I Ahmed, Chris J Neal, Benjamin M Davies, Mario Ganau, Jefferson R Wilson, Allan R Martin, Lukas Grassner, Lindsay Tetreault, Vafa Rahimi-Movaghar, Rex Marco, James Harrop, James Guest, Mohammed Ali Alvi, Karlo M Pedro, Brian K Kwon, Charles G Fisher, Shekar N Kurpad","doi":"10.1177/21925682251331050","DOIUrl":"10.1177/21925682251331050","url":null,"abstract":"<p><p>Study DesignLiterature review of key topics related to degenerative cervical myelopathy (DCM) with critical appraisal and clinical recommendations.ObjectiveThis article summarizes several key current topics related to the management of DCM.MethodsRecent literature related to the management of DCM was reviewed. Four articles were selected and critically appraised. Recommendations were graded as Strong or Conditional.ResultsArticle 1: The Relationship Between pre-operative MRI Signal Intensity and outcomes. <b>Conditional</b> recommendation to use diffusion-weighted imaging MR signal changes in the cervical cord to evaluate prognosis following surgical intervention for DCM. Article 2: Efficacy and Safety of Surgery for Mild DCM. <b>Conditional</b> recommendation that surgery is a valid option for mild DCM with favourable clinical outcomes. Article 3: Effect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial. <b>Strong</b> recommendation that there is equipoise in the outcomes of anterior vs posterior surgical approaches in cases where either technique could be used. Article 4: Machine learning-based cluster analysis of DCM phenotypes. <b>Conditional</b> recommendation that clinicians consider pain, medical frailty, and the impact on health-related quality of life when counselling patients.ConclusionsDCM requires a multidimensional assessment including neurological dysfunction, pain, impact on health-related quality of life, medical frailty and MR imaging changes in the cord. Surgical treatment is effective and is a valid option for mild DCM. In patients where either anterior or posterior surgical approaches can be used, both techniques afford similar clinical benefit albeit with different complication profiles.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2585-2593"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12012498/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143997830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and Risk Factors of Recurrent Proximal Junctional Failure in Adult Spinal Deformity Surgery.","authors":"Se-Jun Park, Jin-Sung Park, Dong-Ho Kang, Chong-Suh Lee, Hyun-Jun Kim","doi":"10.1177/21925682241308510","DOIUrl":"10.1177/21925682241308510","url":null,"abstract":"<p><p>Study DesignRetrospective cohort study.ObjectivesThis study aimed to examine the incidence and risk factors for recurrent proximal junctional failure (R-PJF) in adult spinal deformity (ASD) surgery.MethodsAmong 482 patients receiving ≥ five-level fusion to the pelvis for ASD, 60 patients who underwent fusion extension surgery for PJF were included in the study cohort. R-PJF was defined as the performance of re-revision surgery after revision surgery for PJF. Various clinical and radiographic variables were compared between no R-PJF and R-PJF groups. Stepwise multivariate logistic analysis was performed to identify the risk factors for R-PJF.ResultsOf the 60 patients, there were 51 women (85.0%) and 9 men (15.0%) with a mean age of 72.4 ± 6.7 years. The mean fusion length at the index surgery was 7.3 ± 1.6 levels and an average of 4.1 ± 1.3 levels was extended during the revision surgery. Among them, R-PJF developed in 17 patients (28.3%). Multivariate analysis revealed that overcorrection relative to age-adjusted pelvic incidence (PI) - lumbar lordosis (LL) at the index surgery and high total sum of proximal junctional kyphosis severity scale (PJKSS) at the revision surgery were significant risk factors for R-PJF development. The cutoff value for the PJKSS sum was calculated as 8.5 points.ConclusionsR-PJF was developed in 17 patients (28.3%). PI-LL overcorrection should be avoided during the index surgery to mitigate the R-PJF. In addition, timely surgical intervention is required in patients with PJF, considering that the PJF severity tends to increase over time.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2660-2668"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11632719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythropoietin to Treat Spinal Cord Injury: Evaluation of Different Doses and Magnitudes of Trauma in Rats.","authors":"Alderico Girão Campos de Barros, Gustavo Bispo Dos Santos, Raphael Martus Marcon, Alexandre Fogaça Cristante","doi":"10.1177/21925682241306106","DOIUrl":"10.1177/21925682241306106","url":null,"abstract":"<p><p>Study designExperimental spinal cord lesion study.ObjectivesTo evaluate the effects of erythropoietin at different doses on neural regeneration in rats undergoing spinal cord injury.MethodsAnesthetized Wistar rats were submitted to standardized spinal cord injury and randomized into eight groups, receiving different magnitudes of trauma and single or repeated doses of intraperitoneal erythropoietin (500 or 5000 IU/kg of body weight). We evaluated motor function using BBB scores and sensorimotor behavior by observing the rats walking on a horizontal ladder (at 2, 4, and 6 weeks) and performed histological analysis of the spinal cord after euthanasia. We compared the scores between groups using analysis of variance (ANOVA) and Bonferroni multiple comparisons.ResultsThe experiments were conducted with 10 animals per group (n = 80), none of which died or were excluded. BBB scores increased over time (meaning recovery) in all groups (<i>P</i> < 0.001 for all). From the fourth week, animals receiving lower trauma and higher erythropoietin doses had higher BBB scores than those receiving lower doses. The total number of steps and correct steps taken on the horizontal ladder increased, and slips decreased over time with treatment in all groups. Although the number of errors was different between moments (<i>P</i> < 0.001), it was not different between groups (<i>P</i> = 0.707). Rats receiving higher impact lesions had more spinal cord necrosis and worse recovery of neuronal fibers than the rest.ConclusionsAnimals receiving a higher dose of erythropoietin and suffering minor trauma showed better and faster neurological recovery. Repeating erythropoietin after a week showed no benefit.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2617-2633"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11629366/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142800221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Halo Pelvic Traction Versus Halo Gravity Traction in Treating Severe Rigid Spinal Deformities: A Matched Retrospective Study.","authors":"Lijin Zhou, Jianqiang Wang, Honghao Yang, Yiqi Zhang, Yunsheng Wang, Yong Hai","doi":"10.1177/21925682251348670","DOIUrl":"10.1177/21925682251348670","url":null,"abstract":"<p><p>Study DesignMatched Retrospective Cohort Study.ObjectiveTo compare efficacy and safety of Halo gravity traction vs Halo pelvic traction in severe rigid spinal deformity.MethodsWe retrospectively reviewed 104 severe rigid spinal deformity patients treated with preoperative Halo traction and posterior correction surgery (2016.1-2022.12). Patients were matched 1:1 by main curve Cobb angle and age into HGT and HPT groups (33 each). Radiographic parameters were assessed before and after traction, preoperatively, and at final follow-up. Surgical planning for osteotomy and fusion segments used pre-traction imaging, compared with actual outcomes. Traction duration, surgical parameters, and complications were recorded.ResultsHGT patients had 4.5 ± 1.5 months traction, improving main curve from 138.4° to 94.9° (23.5%) and kyphosis from 87.9° to 73.1° (22.6%), with postoperative values of 51.1° and 39.7°. HPT patients had 5.1 ± 1.1 months of traction, improving main curve from 143.2° to 69.6° (51.3%) and kyphosis from 117.7° to 56.8° (49.1%), with postoperative values of 56.1° and 34.5°. HPT showed better improvement (<i>P</i> < 0.05). HPT achieved 50% deformity improvement after 3 months, vs 5 months for HGT. By 7 months, >60% of HPT vs <10% of HGT patients reached this threshold. Planned three-column osteotomy dropped from 90.9% to 51.5% (actual 36.4%) in HGT and 84.8% to 21.2% (actual 9.1%) in HPT. HPT reduced osteotomy grade (<i>P</i> < 0.05) and fusion segments (<i>P</i> = 0.02) more effectively. Complication rates were similar.ConclusionsBoth HGT and HPT improve preoperative deformity, but HPT is more effective and better in reducing osteotomy grades and fusion segments.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251348670"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129954/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Risk Factors for Long-Term Surgical Outcomes Following Laminoplasty for Cervical Ossification of the Posterior Longitudinal Ligament.","authors":"Nao Otomo, Narihito Nagoshi, Junichi Yamane, Hitoshi Kono, Azusa Miyamoto, Kazuki Takeda, Tatsuya Yamamoto, Reo Shibata, Soraya Nishimura, Yasuhiro Kamata, Kenshi Daimon, Toshiki Okubo, Yoshiomi Kobayashi, Takahito Iga, Satoshi Suzuki, Masahiro Ozaki, Morio Matsumoto, Masaya Nakamura, Kota Watanabe","doi":"10.1177/21925682251347507","DOIUrl":"10.1177/21925682251347507","url":null,"abstract":"<p><p>Study DesignRetrospective multi-institutional study.ObjectivesAlthough previous studies have evaluated the surgical outcomes of laminoplasty in patients with cervical ossification of the posterior longitudinal ligament (OPLL), the long-term results remain unclear. The purpose of this study is to assess outcomes more than 10 years post-surgery and identify to identify factors that affect the long-term prognosis.MethodsEighty-four OPLL patients with more than a minimum of 10-year follow-up after surgery were divided into a good group with more than 50% improvement of the recovery rate of the cervical Japanese Orthopaedic Association (JOA) score, and a poor group with less than 50% improvement. The demographic data and radiographic parameters of cervical spinal alignment were compared, and significant poor prognostic factors were evaluated by multivariate logistic regression.ResultsFour preoperative factors showed significant differences between 2 groups: the presence of type 2 diabetes (<i>P</i> = 0.012), the baseline JOA scores (<i>P</i> = 0.001), the narrowest segment in the cervical (<i>P</i> < 0.001) and the presence of T2-weighted high signal on MRI (<i>P</i> = 0.030). Logistic regression analysis identified 3 of 4 factors were significantly associated with postoperative poor outcomes: the presence of type 2 diabetes (<i>P</i> = 0.011), the baseline JOA scores (<i>P</i> = 0.022), and the presence of T2-weighted high signal on MRI (<i>P</i> = 0.035).ConclusionThis study identified three risk factors associated with poor long-term surgical outcomes following laminoplasty for cervical OPLL. These findings could be significant indicators for predicting long-term outcomes in cervical OPLL patients.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"21925682251347507"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12129939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Esomeprazole's Antifibrotic Effects on Rats With Epidural Fibrosis.","authors":"Ali Borekci, Pinar Kuru Bektasoglu, Adnan Somay, Jülide Hazneci, Bora Gürer","doi":"10.1177/21925682241306045","DOIUrl":"10.1177/21925682241306045","url":null,"abstract":"<p><p>Study DesignRat subjects were randomly assigned to control, local, and systemic esomeprazole groups (n = 4-6 per group).ObjectiveExcessive scar formation after laminectomy can cause nerve entrapment and postoperative pain and discomfort. A rat laminectomy model determined whether topical application and systemic administration of esomeprazole can prevent epidural fibrosis.MethodsLaminectomy alone was performed in the control group. Topical esomeprazole was introduced to the laminectomy area in the local esomeprazole group. Intraperitoneal esomeprazole was introduced in the systemic esomeprazole group following laminectomy. Macroscopic and histopathologic examinations were performed four weeks after laminectomy.ResultsIn the systemic esomeprazole group, the macroscopic epidural fibrosis score was less than the control group (<i>P</i> < 0.001). Microscopic epidural fibrosis score and fibroblast cell density classification scores in local and systemic esomeprazole groups did not significantly differ. Fibrosis thickness was significantly lower in the local and systemic esomeprazole groups compared to the control group (<i>P</i> < 0.01, <i>P</i> < 0.001, respectively).ConclusionsEsomeprazole reduced the formation of epidural fibrosis in the rat laminectomy model.</p>","PeriodicalId":12680,"journal":{"name":"Global Spine Journal","volume":" ","pages":"2611-2616"},"PeriodicalIF":2.6,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11613153/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142768294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}