Geriatrics最新文献

{"title":"Determinants of Healthcare Professionals' Intentions to Use Telemedicine for Elderly Care in Algeria: A Technology Acceptance Model Approach.","authors":"Kamel Mouloudj, Anuli Njoku, Ahmed Chemseddine Bouarar, Dachel Martínez Asanza, Marian A Evans, Snehal Baviskar","doi":"10.3390/geriatrics11040076","DOIUrl":"10.3390/geriatrics11040076","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Telemedicine offers significant potential to improve the quality and accessibility of geriatric care, particularly in resource-constrained settings. However, its effective implementation depends largely on healthcare professionals' acceptance and willingness to use such systems. Drawing on an extended Technology Acceptance Model (TAM), this study examines the determinants of doctors' and nurses' intentions to adopt telemedicine for elderly care in Algeria, with particular emphasis on self-efficacy and institutional support. <b>Methods</b>: This cross-sectional study employed a structured questionnaire administered to 130 healthcare professionals, including physicians and nurses, in Algeria. Hierarchical multiple regression analysis was conducted to test the proposed hypotheses and assess the incremental explanatory power of the extended model. <b>Results</b>: The extended TAM accounted for 48.7% of the variance in intention to use telemedicine. Institutional support (β = 0.432, <i>p</i> < 0.001) and self-efficacy (β = 0.264, <i>p</i> = 0.001) emerged as the strongest predictors. Perceived ease of use (β = 0.178, <i>p</i> = 0.038) and perceived usefulness (β = 0.139, <i>p</i> = 0.021) also had significant positive effects. The inclusion of self-efficacy and institutional support increased the model's explanatory power by 23.5%. <b>Conclusions</b>: The findings highlight the critical role of organizational support mechanisms, digital competencies, and system usability in fostering telemedicine adoption among healthcare professionals. The study provides practical implications for policymakers and healthcare institutions, emphasizing the need for targeted training programs, supportive infrastructure, and institutional policies that enhance confidence and facilitate the integration of telemedicine into clinical workflows.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398288/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toothbrushing Ability in Older Adults Across Stages of Cognitive Impairment.","authors":"Xi Chen, Jirakate Madiloggovit-Lower, Carissa Comnick, Daniel Tranel, Lisa Jacobson, Natalie Denburg","doi":"10.3390/geriatrics11040075","DOIUrl":"10.3390/geriatrics11040075","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Cognitive impairment can compromise toothbrushing and other oral self-care functions, increasing the risk of oral diseases and related complications. However, how toothbrushing ability declines across stages of cognitive impairment remains unclear. This study aimed to describe functional deficits in toothbrushing among older adults with different levels of cognitive function. <b>Method:</b> Sixty-five older adults (14 cognitively healthy and 51 with documented cognitive impairment) were classified into five cognitive levels based on Standardized Mini-Mental State Examination scores. Participants completed a toothbrushing task as they normally would at home. Performance was videotaped, coded, and evaluated across four domains (task initiation, completion, thoroughness, and quality) with total scores reflecting overall toothbrushing ability. Overall performance, functional deficits, and assistance needs were analyzed in relation to cognitive levels. <b>Results:</b> Participants averaged 76.5 years of age. Toothbrushing ability declined gradually with worsening cognitive impairment, followed by a sharp deterioration at the profound stage (e.g., SMMSE ≤ 5). Compared with cognitively healthy participants (<i>n</i> = 14), those with mild cognitive impairment (MCI, <i>n</i> = 20) or mild (<i>n</i> = 10), moderate (<i>n</i> = 10), or severe dementia (<i>n</i> = 11) lost an average of 3%, 8%, 12%, and 37% of overall toothbrushing ability, respectively. Brushing efficiency declined earlier and more rapidly, decreasing by 13% in MCI and up to 46% in severe dementia (<i>p</i> < 0.001). All participants with MCI or mild dementia completed the task independently, whereas 20% with moderate dementia and 80% with severe dementia required assistance to initiate or complete the task. <b>Conclusions:</b> Overall toothbrushing ability remains relatively preserved until the later stages of cognitive impairment, but brushing quality deteriorates much earlier and quicker. These findings highlight the importance of early caregiver-patient partnerships, functionally tailored oral self-care rehabilitation, and personalized caregiver training to support oral hygiene among older adults with cognitive impairment.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 4","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13398002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148578414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From Complexity to Competency: International Nursing Perspectives on Comprehensive Geriatric Assessment.","authors":"Evangelos C Fradelos, Sini Eloranta, Ioanna Tsatsou, Ioanna Dimitriadou, Susanna Mört, Nina Korsström, Anna Lundberg, Magdalena Häger, Jekaterina Šteinmiller, Agita Melbarde-Kelmere, Kristaps Circenis, Sigrun S Skuladottir, Ingibjörg Hjaltadòttir, Maria Saridi","doi":"10.3390/geriatrics11030073","DOIUrl":"10.3390/geriatrics11030073","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Population aging has increased the demand for comprehensive and coordinated care for older adults, placing primary health care (PHC) nurses at the forefront of comprehensive geriatric assessment (CGA) implementation. However, limited evidence exists regarding nurses' experiences and educational needs related to CGA across different European healthcare contexts. This study aimed to explore the experiences, perceived challenges, and educational needs of PHC nurses regarding the implementation of CGA in five European countries. <b>Methods:</b> A qualitative study design was employed using five focus groups, one in each participating country: Greece, Iceland, Finland, Estonia, and Latvia. A total of 29 PHC nurses participated in semi-structured interviews. Data were analyzed using reflexive thematic analysis. <b>Results:</b> Three overarching themes and nine subthemes were identified in relation to good practices in CGA: (1) embracing the complexity of holistic assessment; (2) balancing consistency with flexibility in clinical practice; and (3) advancing professional expertise through structured learning. Participants highlighted the importance of standardized assessment tools and effective multidisciplinary collaboration. At the same time, they reported significant gaps in formal education, limited organizational resources, and insufficient training in cultural competence, which hinder consistent CGA implementation. <b>Conclusions:</b> PHC nurses recognize the value of a holistic and structured approach to CGA but require clearer educational pathways and evidence-based training to address the complex needs of older adults. Strengthening curricula that emphasize interprofessional collaboration, practical competencies, and contextual adaptability may support more effective and sustainable implementation of CGA in primary care settings across Europe.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299193/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Active Aging and Health-Related Quality of Life.","authors":"Keon Woo, JungHoon Lee, YoonSoo Choy","doi":"10.3390/geriatrics11030074","DOIUrl":"10.3390/geriatrics11030074","url":null,"abstract":"<p><p><b>Background and Objectives</b>: This study examined the association between active aging and health-related quality of life (HRQoL) in older Korean adults. Furthermore, it examined how socioeconomic factors were related to active aging and HRQoL. <b>Methods</b>: Data were analyzed using the 8th Korea National Health and Nutrition Examination Survey (KNHANES). This study used the Health-Related Quality of Life Instrument with Eight Items (HINT-8), a Korean-specific HRQoL instrument. Multivariable regression analyses were conducted to estimate the associations of overall active aging and its health, participation, and security domains with HRQoL. <b>Results</b>: The health domain showed the largest coefficient, and the security domain was also significantly associated with HRQoL. The participation domain showed a relatively limited and statistically non-significant association, which may partly reflect measurement constraints in the operationalization of participation. Older adults with lower educational levels and those residing in rural areas had lower levels of both active aging and HRQoL. <b>Conclusions</b>: Active aging was positively associated with HRQoL among older Korean adults. These findings highlight health as the domain most strongly associated with HRQoL and identify security as an additional relevant domain, while participation-related findings should be interpreted cautiously given the limited operationalization of participation and its statistically non-significant association. However, longitudinal or intervention studies are needed to examine temporal and causal relationships between active aging and HRQoL.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13300381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Breaking the Vicious Cycle? A Systematic Review of Interventions Targeting Both Falls and Fear of Falling in Older Adults.","authors":"Asiye Tuba Ozdogar, Pervin Yesiloglu, Yuval Levitan Marcus, Alon Kalron","doi":"10.3390/geriatrics11030072","DOIUrl":"10.3390/geriatrics11030072","url":null,"abstract":"<p><strong>Background: </strong>Falls and fall-related injuries are common in older adults and are frequently accompanied by fear of falling (FoF), which may lead to activity avoidance and functional decline. Because many interventions target falls or FoF in isolation, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) to identify, describe, and evaluate interventions reporting both falls and FoF outcomes in older adults.</p><p><strong>Methods: </strong>This systematic review and meta-analysis were registered in PROSPERO (CRD420251113137) and conducted in accordance with PRISMA guidelines. PubMed, Embase, and Web of Science were searched from inception to 4 November 2025. Eligible studies were English-language RCTs that included adults aged ≥60 years, evaluated nonpharmacological interventions, and reported both FoF and falls. Methodological quality was assessed using the PEDro scale. Random-effects meta-analyses were performed for FoF (Hedges g), and Bayesian random-effects binomial meta-analyses were conducted for falls.</p><p><strong>Results: </strong>Ten RCTs published between 1998 and 2018 (sample sizes per trial: <i>n</i> = 27-540) were included. Interventions included cognitive-behavioral therapy-based programs, Tai Chi, physiotherapist-led strength and balance training, computerized visual feedback, and video-guided home exercise. PEDro scores ranged from 6 to 9 (mean, 7.7). Pooled analyses showed no significant effect on FoF at the end of intervention (g = -0.20, 95% CI -1.45 to 1.05; <i>p</i> = 0.68; high heterogeneity) or at follow-up (g = -0.14, 95% CI -0.60 to 0.33; <i>p</i> = 0.50). For falls, postintervention evidence favored the null (BF₁₀ = 0.16; pooled estimate -0.01, 95% credible interval [CrI] -0.30 to 0.14). Follow-up results were inconclusive (BF₁₀ = 2.07; pooled CrI -0.56 to 0.00), with substantial uncertainty.</p><p><strong>Conclusions: </strong>Across RCTs that measured both outcomes, interventions did not consistently improve both FoF and falls outcomes. These findings may suggest a partial dissociation between psychological and physical fall-related outcomes, highlighting the need for integrated, adequately powered trials that utilize standardized measures and longer follow-up periods.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299663/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory Blurring in Nociplastic Pain: The Role of Descending Inhibitory Dysfunction and Gut-Brain Axis Alterations in Older Adults.","authors":"Takahiko Nagamine","doi":"10.3390/geriatrics11030071","DOIUrl":"10.3390/geriatrics11030071","url":null,"abstract":"<p><p><b>Background</b>: Inhibitory processes in the nervous system are traditionally conceptualized as suppressive mechanisms; however, their fundamental role is the refinement and optimization of sensory information. In nociception, this function is mediated by the descending pain inhibitory system (DPIS), which modulates nociceptive transmission at multiple hierarchical levels. Biological sex and gender-related factors significantly influence these inhibitory pathways, yet they are often overlooked in clinical frameworks. <b>Methods</b>: A narrative review was conducted using PubMed, MEDLINE, and Scopus databases, focusing on studies published between 2010 and 2025. Search terms included \"descending pain inhibitory system,\" \"nociplastic pain,\" \"aging,\" \"sex differences,\" \"gender,\" and \"gut-brain axis.\" Approximately 30 key references were synthesized. <b>Results</b>: The DPIS enhances the precision of nociceptive signals through mechanisms analogous to lateral inhibition. In chronic and nociplastic pain, this refinement process is impaired, leading to \"sensory blurring.\" Aging exacerbates these changes through neurochemical depletion and neuroinflammation. Crucially, this decline follows sex-specific trajectories; estrogen depletion in post-menopausal females accelerates the loss of monoaminergic inhibitory reserves, while gender-related sociocultural stressors can further disrupt top-down executive control. Additionally, alterations in the gut-brain axis signaling-modulated by sex-specific gut microbiota profiles-further disrupt inhibitory control. <b>Conclusions</b>: Chronic pain may be conceptualized as a disorder of sensory refinement rather than excessive nociceptive input. Inclusion of sex and gender as biological variables is essential for precision pain management. Therapeutic strategies should focus on restoring inhibitory precision through both central and systemic approaches, tailored to the patient's hormonal and physiological profile.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of General Anesthetics on Postoperative Delirium: A Narrative Review Based on Clinical Randomized Controlled Trials from the Last Five Years.","authors":"Jia-Ni Wu, Jia-Huan Xu, Jia-Yi Ge, Bo-Ran Deng, Xing-Jun Liu","doi":"10.3390/geriatrics11030070","DOIUrl":"10.3390/geriatrics11030070","url":null,"abstract":"<p><p>Postoperative delirium (POD) is an acute, reversible neurocognitive disorder characterized by confusion and altered consciousness. With the improvement in research methodologies and the introduction of innovative clinical drugs in recent years, a growing number of randomized controlled trials have been conducted. This article aims to conduct a comprehensive review of the efficacy of general anesthetics-including propofol, ciprofol, sevoflurane, ketamine, esketamine, dexmedetomidine, benzodiazepines, opioids, and lidocaine-in preventing and managing POD, based on randomized controlled trials published in the past five years. Propofol has advantages in preventing POD in pediatric patients. However, its efficacy compared with inhalational anesthetics still requires individualized evaluation in elderly patients. The novel drugs ciprofol and remimazolam exhibit favorable safety profiles and do not increase the risk of POD. The efficacy of dexmedetomidine shows variability across patient populations and surgical types. In addition, specific opioid drugs and lidocaine also demonstrate preventive potential when administered in a standardized manner.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299697/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety of Cholecystectomy in Nonagenarians: A Systematic Review and Meta-Analysis.","authors":"Dimitrios Vouros, Belen Conde Inarejos, James Fowler, Sarthak Jain, Vasileios Kotsarinis, Maaz Ullah, Awais Asif Chaudhary, Martyn Charles Stott, Ahmad Hassan, Shahin Hajibandeh, Shahab Hajibandeh, Jacob Kadamapuzha, Thomas Satyadas","doi":"10.3390/geriatrics11030069","DOIUrl":"10.3390/geriatrics11030069","url":null,"abstract":"<p><p><b>Background/Objectives</b>: To evaluate the safety of cholecystectomy in nonagenarians. <b>Methods</b>: In compliance with the PRISMA statement standards, a systematic review including random-effects meta-analysis and meta-regression models was conducted. All studies reporting postoperative outcomes in patients aged ≥90 undergoing cholecystectomy were included and analyzed. <b>Results</b>: Six studies (1223 patients) were included. The risk of 30-day mortality was 5.4% (95% CI 3.1-7.7); 30-day morbidity occurred in 22% (95% CI 11.3-32.8). The mean length of hospital stay was 11.5 days (95% CI 8.3-14.6). Postoperative mortality was not affected by male sex (coefficient: 0.028, <i>p</i> = 0.832), ASA status ≥ III (coefficient: 0.051, <i>p</i> = 0.309), cholecystitis as indication for cholecystectomy (coefficient: -0.166, <i>p</i> = 0.051), cholecystectomy in emergency setting (coefficient: -0.020, <i>p</i> = 0.425), laparoscopic (coefficient: -0.104, <i>p</i> = 0.09) or open approach (coefficient: 0.104, <i>p</i> = 0.09), and conversion to open surgery (coefficient: 0.043, <i>p</i> = 0.820). The GRADE certainty of evidence was low to moderate. <b>Conclusions</b>: Subject to selection bias and confounding by fitness, the available evidence suggests that cholecystectomy in highly selected nonagenarians with good performance status, who have passed robust preoperative fitness assessment tests, may be safe with an acceptable risk of morbidity and mortality.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Hallucinations and Cognitive Impairment as the Initial Presentation of Severe Hypothyroidism in an Elderly Patient: A Case Report.","authors":"Hongyu Li, Chenxiang Cao, Xiaoyi Wang, Jing Zhang, Wenhui Zhao","doi":"10.3390/geriatrics11030068","DOIUrl":"10.3390/geriatrics11030068","url":null,"abstract":"<p><p><b>Background:</b> Hypothyroidism is a prevalent endocrine disorder capable of affecting multiple organ systems. While somatic symptoms are common, prominent neuropsychiatric manifestations such as visual hallucinations and cognitive deficits are exceptionally rare as an initial presentation. This atypical clinical picture frequently leads to misdiagnosis as primary psychiatric disorders or neurodegenerative conditions. <b>Case Presentation:</b> We report the case of a 75-year-old male who presented with a three-month history of complex visual hallucinations and progressive cognitive decline. The hallucinations were notably dependent on environmental light. Initial assessments raised concerns about the neurodegenerative process. However, laboratory investigations revealed severe autoimmune hypothyroidism with high titers of anti-thyroid antibodies. Following timely levothyroxine replacement therapy, the patient achieved complete remission of visual hallucinations and significant cognitive recovery. <b>Conclusions:</b> This case illustrates that severe hypothyroidism can manifest as a reversible metabolic encephalopathy mimicking dementia. It underscores the importance of screening for thyroid dysfunction in elderly patients presenting with unexplained acute neuropsychiatric symptoms to ensure appropriate management.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299075/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316843","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of Curative Esophagectomy in Octogenarians vs. Non-Octogenarians with Esophageal Cancer: A Systematic Review and Meta-Analysis.","authors":"Liyang Xiao, Kai Siang Chan, Isaac Chan, Aung Myint Oo","doi":"10.3390/geriatrics11030067","DOIUrl":"10.3390/geriatrics11030067","url":null,"abstract":"<p><p><b>Background</b>: Esophageal cancer (EC) poses a growing global challenge in the context of an ageing population. Evidence on the role of curative esophagectomy in octogenarians is limited. This study aims to compare the long-term survival and post-operative mortality and morbidity in octogenarians undergoing curative esophagectomy for EC with those in non-octogenarians. <b>Methods</b>: A systematic search was performed on PubMed, Embase, Web of Science and Cochrane Library up to Jan 2026. The inclusion criteria were studies that compared outcomes of esophagectomy for EC between octogenarians and non-octogenarians. Exclusion criteria were single-arm studies and studies using different age cut-offs. <b>Results</b>: There were 18 studies with 73,776 patients (octogenarians <i>n</i> = 6234 and non-octogenarians patients <i>n</i> = 67,542), with smaller subsets of studies being analysed for individual outcomes. The overall incidence of open esophagectomy and minimally invasive esophagectomy (MIE) were 78.4% (<i>n</i> = 459/585) and 21.2% (<i>n</i> = 124/585), respectively, in octogenarians, and 69.8% (<i>n</i> = 3270/4688) and 29.4% (<i>n</i> = 1380/4688), respectively, in non-octogenarians. R0 resection was achieved in 85.2% (<i>n</i> = 1759/2064) of octogenarians and 91.9% (<i>n</i> = 30,764/33,480) of non-octogenarians. Pooled OS was inferior in the octogenarian group compared to the non-octogenarian group (<i>n</i> = 35,441, HR 2.29, 95% CI: 1.38-3.79). Pooled in-hospital mortality, 30-day mortality and 90-day mortality were higher in octogenarians. In terms of post-operative complications, pooled analysis demonstrated a higher overall complication rate in the octogenarian group (<i>n</i> = 6515, OR 1.40, 95% CI: 1.11-1.78), while rates of anastomosis leakage, chylothorax, respiratory complication, surgical site infection and recurrent laryngeal nerve injury were comparable between the two groups. <b>Conclusions</b>: Curative esophagectomy for EC is associated with worse overall survival, mortality and overall post-operative complication rate in octogenarians than non-octogenarians. Further research on the role of MIE in octogenarians should be conducted.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"11 3","pages":""},"PeriodicalIF":2.4,"publicationDate":"2026-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13299997/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148316807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}