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A Systematic Review on Subjective Cognitive Complaints: Main Neurocognitive Domains, Myriad Assessment Tools, and New Approaches for Early Detection. 主观认知抱怨的系统综述:主要的神经认知领域、无数的评估工具和早期发现的新方法。
IF 2.1
Geriatrics Pub Date : 2025-05-09 DOI: 10.3390/geriatrics10030065
Felipe Webster-Cordero, Lydia Giménez-Llort
{"title":"A Systematic Review on Subjective Cognitive Complaints: Main Neurocognitive Domains, Myriad Assessment Tools, and New Approaches for Early Detection.","authors":"Felipe Webster-Cordero, Lydia Giménez-Llort","doi":"10.3390/geriatrics10030065","DOIUrl":"10.3390/geriatrics10030065","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Neuropsychological testing is key in defining cognitive profiles at early stages of dementia. More importantly, the detection of subtle cognitive changes, such as subjective cognitive complaints (SCCs), an understudied phenomenon, is critical for early detection and preventive interventions. <b>Methods:</b> This systematic review analyzes the empirical data on the cognitive domains and neuropsychological tests used in studies addressing SCC in the last 15 years (2009-2024). <b>Results:</b> A selection of 15 papers with exploratory, cross-sectional, and prospective scope in this field was obtained from PubMed and Embase databases. They used screening tests (17%) and a broad spectrum of neurocognitive domains. Yet, we identified three main targeted cognitive domains: executive functions (28%), language (17%), and memory (17%). Myriad assessment tools were also applied, but the most commonly used was a set of eight tests: Mini-mental Scale Examination (MMSE), Trail Making Test (A-B), Stroop test, Digit span test (DST), Semantic and Phonological fluency test, Rey Auditory Verbal Learning Test (RAVLT), Weschler Memory Scale (WMS), and Boston Naming Test (BNT). New approaches involved including the Geriatric Depression Scale (GDS) and self/informant reports. <b>Conclusions:</b> Despite scarce agreement in the assessment protocols, the identification of early neurocognitive symptoms to objectivate the SCC phenomenon envisions a broad field of research.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview of Systematic Reviews on Factors Related to the Structure and Functioning of Residential Long-Term Care Facilities for Older Adults. 老年人长期住宿护理机构结构与功能相关因素系统综述。
IF 2.1
Geriatrics Pub Date : 2025-05-03 DOI: 10.3390/geriatrics10030064
Aurélio Matos Andrade, Karine Rodrigues Afonseca, Tatiana de Almeida Jube, Suelen Meira Góes, Maíra Catharina Ramos, Flavia Tavares da Silva Elias
{"title":"Overview of Systematic Reviews on Factors Related to the Structure and Functioning of Residential Long-Term Care Facilities for Older Adults.","authors":"Aurélio Matos Andrade, Karine Rodrigues Afonseca, Tatiana de Almeida Jube, Suelen Meira Góes, Maíra Catharina Ramos, Flavia Tavares da Silva Elias","doi":"10.3390/geriatrics10030064","DOIUrl":"10.3390/geriatrics10030064","url":null,"abstract":"<p><p><b>Objective:</b> To identify factors influencing the structure and functioning of long-term residential care facilities for older adults worldwide, in order to uncover practices and support evidence-based improvements in care delivery. <b>Method:</b> An overview of systematic reviews was performed according to the PRISMA protocol and registered on the PROSPERO platform (no. CRD42023486204). Research was carried out on 21 September 2023, using the following databases: PubMed (via MedLine), EMBASE, Web of Science, Scopus, Virtual Health Library (VHL), and Epistemonikos. <b>Results:</b> The search yielded 12,040 articles, including 61 systematic reviews. Analyzing the primary outcomes, personnel structure, and risk management were the most-studied outcomes of the systematic reviews, followed by pharmaceuticals, food services, mobility/accessibility, and technological and physical structures. In terms of primary outcomes of the systematic reviews, the personnel structure was the most highlighted (in 39.34%), followed by risk management (in 32.79%), while the least highlighted was physical structure (in 9.84%). <b>Conclusions:</b> Personnel are critical to the safe and effective functioning of Long-Term Care Facility (LTCF) operations. Future research is needed to identify associations between models of care and structural concerns, including physical environment, as they relate to quality of care in LTCFs, particularly in low and middle-income countries (LMIC).</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101163/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What Combination of Generic Bedside Screening Tools Is Optimal to Capture Patients with Penetration/Aspiration Due to Dysphagia? Comparing Single Bedside Tools Versus Combinations of Tools for Sensitivity and Specificity. 通用床边筛查工具的哪些组合最适合捕获因吞咽困难而出现渗透/误吸的患者?比较单一床边工具与工具组合的敏感性和特异性。
IF 2.1
Geriatrics Pub Date : 2025-04-30 DOI: 10.3390/geriatrics10030063
Albert Westergren, David Smithard, Johannes Riis, Christina Emborg, Anne Lund Krarup, Dorte Melgaard
{"title":"What Combination of Generic Bedside Screening Tools Is Optimal to Capture Patients with Penetration/Aspiration Due to Dysphagia? Comparing Single Bedside Tools Versus Combinations of Tools for Sensitivity and Specificity.","authors":"Albert Westergren, David Smithard, Johannes Riis, Christina Emborg, Anne Lund Krarup, Dorte Melgaard","doi":"10.3390/geriatrics10030063","DOIUrl":"10.3390/geriatrics10030063","url":null,"abstract":"<p><p><b>Background/Objectives</b>: This study aimed to explore the validity of various generic bedside screening tools, and combinations of these, for capturing dysphagia as compared to aspiration/penetration found through the Flexible Endoscopic Evaluation of Swallowing (FEES). <b>Methods</b>: In this cross-sectional study, participants diagnosed with chronic pulmonary disease (<i>n</i> = 25), Parkinson's disease (<i>n</i> = 26), multiple sclerosis (<i>n</i> = 24), or stroke (<i>n</i> = 25) participated. Patient-reported outcomes and clinical-rated assessments included: the four-question test (4QT), the Minimal Eating Observation Form-II, the Volume-Viscosity Swallow Test (V-VST), the Penetration-Aspiration Scale, and the FEES. Activities in daily living were assessed with the Barthel Index. The sensitivity, specificity, negative predictive value (NPV), positive predictive value, and accuracy were calculated. <b>Results</b>: The 100 participants' median age was 72 years, and 42 were women. In total, 78 patients had eating difficulties (MEOF-II). According to the 4QT, 69 patients had dysphagia while 62 had it according to the V-VST. Furthermore, 29 patients had penetration/aspiration according to the FEES. All generic bedside tools performed better when combined with another tool, when compared to the identification of penetration/aspiration according to the FEES. The combination of the MEOF-II and 4QT as well as the combination of the MEOF-II and V-VST proved to have very high sensitivity (96.1-96.3%) and NPVs (92.3% in both instances). Combining the three tools, the MEOF-II, 4QT, and V-VST, did not improve the sensitivity or NPV. <b>Conclusions</b>: A combination of the MEOF-II and 4QT or the MEOF-II and V-VST bedside tools is recommended for identifying patients at risk of penetration/aspiration and in need of further in-depth clinical assessment.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101184/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Validity and Reliability of the Self-Administered Timed Up and Go Test in Assessing Fall Risk in Community-Dwelling Older Adults. 社区居住老年人跌倒风险评估的自用计时起跑测试的效度和信度。
IF 2.1
Geriatrics Pub Date : 2025-04-29 DOI: 10.3390/geriatrics10030062
Magda Reis, Maria Teixeira, Carlota Carvão, Anabela Correia Martins
{"title":"Validity and Reliability of the Self-Administered Timed Up and Go Test in Assessing Fall Risk in Community-Dwelling Older Adults.","authors":"Magda Reis, Maria Teixeira, Carlota Carvão, Anabela Correia Martins","doi":"10.3390/geriatrics10030062","DOIUrl":"10.3390/geriatrics10030062","url":null,"abstract":"<p><p><b>Objectives:</b> This study aimed to evaluate the validity and reliability of the self-administered Timed Up and Go (TUG) test-a gold standard for fall risk screening-by comparing it to the traditional face-to-face assessment conducted by a physiotherapist. <b>Methods:</b> A total of 37 community-dwelling adults-mean age 61.78 ± 6.88, 73% female-who took part in fall risk screening actions in the central region of Portugal were assessed. The protocol included sociodemographic and history of falls questions, the Self-Efficacy for Exercise questionnaire, the Activities and Participation Profile Related to Mobility (PAPM), and three functional tests, namely the 10-Metre Walking Speed (10-MWS), TUG, and 30 Seconds Sit to Stand (30 s STS) tests. Within an interval of 18-24 h after the face-to-face moment, the participants were instructed to self-administer the TUG test at home. The validity and reliability of self-administered TUG test were examined using the limits of agreement, clinically acceptable limit, intra-class correlation coefficients (ICCs), paired <i>t</i>-tests, and Pearson's coefficient correlation (r). <b>Results:</b> The limits of agreement for self-administered assessment were within the clinically acceptable limits. The average result of the face-to-face TUG test and the self-administered TUG test was 7.47 ± 2.45 and 7.57 ± 3.10 s, respectively. When comparing the two evaluations, they were strongly associated (r = 0.716, <i>p</i> < 0.001), with an excellent ICC of 0.82 (0.65-0.91), for a 95% confidence interval and significance level of 0.05 (<i>p</i> ≤ 0.05). <b>Conclusions:</b> The use of the self-administered TUG test for the screening of risk of fall, using low-cost technology, appears to be valid and reliable in community-dwelling adults aged 50 and above. Enabling older adults to perform the TUG test at home can empower them to take an active role in managing their health and ageing process, while also offering physiotherapists regular feedback for fall prevention.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101206/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Home Caregivers of Elderly People: Perceptions and Quality of Life. 老年人家庭照顾者:认知与生活品质。
IF 2.1
Geriatrics Pub Date : 2025-04-29 DOI: 10.3390/geriatrics10030061
Luís Eduardo Genaro, José Victor Marconato, Aylton Valsecki Júnior, Tânia Adas Saliba, Fernanda Lopez Rosell
{"title":"Home Caregivers of Elderly People: Perceptions and Quality of Life.","authors":"Luís Eduardo Genaro, José Victor Marconato, Aylton Valsecki Júnior, Tânia Adas Saliba, Fernanda Lopez Rosell","doi":"10.3390/geriatrics10030061","DOIUrl":"10.3390/geriatrics10030061","url":null,"abstract":"<p><p><b>Objective:</b> In this study, we aimed to identify the main factors that influence the quality of life of caregivers in the context of home care for the elderly. <b>Methodology:</b> This is a mixed-methods study with a qualitative-quantitative approach, conducted with 138 home caregivers from the city of Itatiba, São Paulo, Brazil. Individual interviews were conducted, and the qualitative data were analyzed using the Collective Subject Discourse technique. Simultaneously, the quantitative approach involved the application of the EQ-5D questionnaire to assess health-related quality of life, and the data were analyzed using descriptive statistics and significance tests. <b>Results:</b> The majority of caregivers were female, accounting for 92.03% of the total, with the predominant age group being over 50 years old (49.28%). The interviews highlighted the regularity of home visits by healthcare professionals, emphasizing the importance of these visits for the continuity of treatment at home. However, some caregivers expressed feelings of loneliness due to social isolation and emotional burden, reporting difficulties in resting at night and experiencing pain. In the quality of life assessment, statistically significant differences were identified in various dimensions of the EQ-5D. Women showed a higher proportion of extreme problems in usual activities (<i>p</i> < 0.001) and pain/discomfort (<i>p</i> = 0.02), while men reported more moderate problems with anxiety/depression (<i>p</i> = 0.03). <b>Conclusions:</b> This study highlights the importance of personalized and accessible care for patients. It underscores the need for emotional support and educational resources for caregivers to mitigate the negative impacts of prolonged caregiving on their physical and emotional health.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101194/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recognition of Serious Infections in the Elderly Visiting the Emergency Department: The Development of a Diagnostic Prediction Model (ROSIE). 急诊科老年人严重感染的识别:诊断预测模型(ROSIE)的建立
IF 2.1
Geriatrics Pub Date : 2025-04-25 DOI: 10.3390/geriatrics10030060
Thomas Struyf, Lisa Powaga, Marc Sabbe, Nicolas Léonard, Ivan Myatchin, Ben Van Calster, Jos Tournoy, Frank Buntinx, Laurens Liesenborghs, Jan Y Verbakel, Ann Van den Bruel
{"title":"Recognition of Serious Infections in the Elderly Visiting the Emergency Department: The Development of a Diagnostic Prediction Model (ROSIE).","authors":"Thomas Struyf, Lisa Powaga, Marc Sabbe, Nicolas Léonard, Ivan Myatchin, Ben Van Calster, Jos Tournoy, Frank Buntinx, Laurens Liesenborghs, Jan Y Verbakel, Ann Van den Bruel","doi":"10.3390/geriatrics10030060","DOIUrl":"10.3390/geriatrics10030060","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Serious infections in older adults are associated with substantial mortality and morbidity. Diagnosis is challenging because of the non-specific presentation and overlap with pre-existing comorbidities. The objective of this study was to develop a clinical prediction model using clinical features and biomarkers to support emergency care physicians in diagnosing serious infections in acutely ill older adults. <b>Methods</b>: We conducted a prospective cross-sectional diagnostic study, consecutively including acutely ill patients (≥65 year) presenting to the emergency department. Clinical information and blood samples were collected at inclusion by a trained study nurse. A prediction model for <i>any serious infection</i> was developed based on ten candidate predictors that were further reduced to four ad interim using a penalized Firth multivariable logistic regression model. We assessed discrimination and calibration of the model after internal validation using bootstrapping. <b>Results</b>: We included 425 participants at three emergency departments, of whom 215 were diagnosed with a serious infection (51%). In the final model, we retained systolic blood pressure, oxygen saturation, and C-reactive protein as predictors. This model had good discriminatory value with an Area Under the Receiver Operating Characteristic (AUROC) curve of 0.82 (95% CI: 0.78 to 0.86) and a calibration slope of 0.96 (95% CI: 0.76 to 1.16) after internal validation. Addition of procalcitonin did not improve the discrimination of the model. <b>Conclusions</b>: The ROSIE model uses three predictors that can be easily and quickly measured in the emergency department. It provides good discriminatory power after internal validation. Next steps should include external validation and an impact assessment.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101360/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144127317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An Optimal Beneficiary Profile to Ensure Focused Interventions for Older Adults. 最佳受益人概况,以确保重点干预老年人。
IF 2.1
Geriatrics Pub Date : 2025-04-14 DOI: 10.3390/geriatrics10020059
Dorina-Claudia Bălan, Rozeta Drăghici, Ioana Găiculescu, Alexandra Rusu, Andrada-Elena Stan, Polixenia Stan
{"title":"An Optimal Beneficiary Profile to Ensure Focused Interventions for Older Adults.","authors":"Dorina-Claudia Bălan, Rozeta Drăghici, Ioana Găiculescu, Alexandra Rusu, Andrada-Elena Stan, Polixenia Stan","doi":"10.3390/geriatrics10020059","DOIUrl":"https://doi.org/10.3390/geriatrics10020059","url":null,"abstract":"<p><p><b>Background:</b> Aging is a lifelong process, and many chronic diseases and geriatric syndromes are influenced by lifestyle factors. For active aging and maintaining functional capacity facilitate health, there are essential aspects in geriatric care. Our objective was to create a specific profile focusing on the characteristics of a possible optimal beneficiary of a newly developed program that is meant to increase the social inclusion and participation in social life of older adults. <b>Methods:</b> The profile was built based on a mixed design, a quantitative and qualitative analysis that identified the typology of an optimal beneficiary of a newly developed yoga program. The quantitative analysis (50 subjects from NIGG \"Ana Aslan\" Bucharest) identified the main predictors impacting subjects' willingness to participate in a yoga program based on their pathologies at a mental and/or physical level. The main materials used for this were the Clinical Assessment Scales for the Elderly (CASE-SF) and the Quality-of-Life Assessment Questionnaire (WHOQOL-BREF). The qualitative analysis consisted of four focus groups (10 subjects from NIGG \"Ana Aslan\" and 7 subjects from GNSPY), aiming to provide the in-depth reasons for participating in a yoga program. <b>Results:</b> The results showed that a diagnosed physical impairment was correlated with an increased willingness to participate in yoga classes, while a mental pathology was associated with a decreased willingness to participate in such a program. Five main themes emerged from the qualitative analysis. <b>Conclusions:</b> The profile provides answers related to the specifics of the beneficiary based on their motivation, limits, and personality traits.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026497/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144012341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Culturally Tailored Community Brain Health Education for Chinese Americans Aged 50 or Above: A Mixed-Methods Open Pilot Study. 针对50岁或以上美籍华人的社区脑健康教育:一项混合方法的开放试点研究。
IF 2.1
Geriatrics Pub Date : 2025-04-14 DOI: 10.3390/geriatrics10020058
Kaipeng Wang, Fei Sun, Peiyuan Zhang, Carson M De Fries, Xiaoyouxiang Li, Jie Zhu, My Ngoc To
{"title":"Culturally Tailored Community Brain Health Education for Chinese Americans Aged 50 or Above: A Mixed-Methods Open Pilot Study.","authors":"Kaipeng Wang, Fei Sun, Peiyuan Zhang, Carson M De Fries, Xiaoyouxiang Li, Jie Zhu, My Ngoc To","doi":"10.3390/geriatrics10020058","DOIUrl":"https://doi.org/10.3390/geriatrics10020058","url":null,"abstract":"<p><p><b>Background:</b> Chinese Americans, the largest Asian American subgroup in the U.S., face linguistic, cultural, and socio-economic barriers to dementia prevention. To promote brain health in this population, a culturally tailored community approach is essential. This study evaluates a culturally tailored community brain health education program to enhance brain health knowledge and motivate lifestyle changes to prevent the risk of dementia among Chinese Americans aged 50 or older. <b>Methods:</b> The program was developed and evaluated in four phases. First, we assessed participants' interests in brain health topics, availability, and preferred delivery modes. Next, experts on the identified topics developed educational content and outcome assessments. The third phase focused on implementing a six-session program covering general knowledge about Alzheimer's disease and related dementias, diet, sleep, physical exercise, health checks, and mindfulness. Finally, we evaluated the program's feasibility and effectiveness using pre-post surveys, feedback questionnaires, and focus groups. <b>Results:</b> Seventy-seven participants registered for the program, and sixty-nine (90%) attended at least four sessions. The quantitative results, based on paired <i>t</i>-tests, showed significant increases in brain health knowledge, sleep quality, and behavioral motivation for lifestyle changes, and a decrease in depressive symptoms, with two-tailed <i>p</i>-values lower than 0.05. The qualitative results further revealed promising feasibility and acceptability, as well as the perceived benefits of the program. <b>Conclusions:</b> The findings highlight the feasibility, acceptability, and potential effectiveness of a culturally tailored community education approach for promoting brain health and lifestyle changes. Sustained community outreach and education efforts among Chinese Americans are needed.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients. 衰弱对老年精神病患者药物治疗依从性及药物不良反应的影响。
IF 2.1
Geriatrics Pub Date : 2025-04-07 DOI: 10.3390/geriatrics10020057
Tuan Anh Phan, Rob Kok
{"title":"The Influence of Frailty on Pharmacotherapy Adherence and Adverse Drug Reactions in Older Psychiatric Patients.","authors":"Tuan Anh Phan, Rob Kok","doi":"10.3390/geriatrics10020057","DOIUrl":"https://doi.org/10.3390/geriatrics10020057","url":null,"abstract":"<p><p><b>Aim/Objectives</b>: To investigate whether frailty predicts adherence to psychotropic drug treatment or adverse drug reactions, within 6 months after treatment initiation. <b>Methods</b>: A prospective cohort study including 77 patients over the age of 65, treated in one large psychiatric institute in the Netherlands. Patients were assessed at baseline for their frailty status, using different operationalizations of the Fried frailty criteria. Data on duration of psychotropic drug treatment and number of reported adverse drug reactions were retrieved from electronic patient files. Regression analyses were adjusted for age, sex, patient setting, and polypharmacy as potential confounders. <b>Results</b>: Frail patients were not significantly more likely to discontinue psychotropic treatment than non-frail patients (OR = 1.4; 95% CI 0.6-3.7, <i>p</i> = 0.468). Time to treatment discontinuation was also not statistically different between both study groups (HR = 0.8; 95% CI 0.4-1.6, <i>p</i> = 0.498), and neither was the number of adverse drug reactions (OR = 1.6, 95% CI 0.6-4.1, <i>p</i> = 0.345). <b>Conclusions</b>: We could not demonstrate a statistically significant effect of frailty as predictor of discontinuing psychotropic treatment or adverse drug reactions, but a lack of power may also explain our results. A more comprehensive frailty assessment may be needed to predict treatment adherence or adverse drug reactions in psychiatric patients.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12026496/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143991232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Rehabilitation Intervention for Cancer Patients with Spinal Bone Metastasis: Psychosocial and Clinical Outcomes. 康复干预对癌症患者脊柱骨转移的影响:心理社会和临床结果。
IF 2.1
Geriatrics Pub Date : 2025-04-07 DOI: 10.3390/geriatrics10020056
Noémi Németh, Lavinia Davidescu, Liviu Lazăr, Florica Voiță-Mekeres, Mariana Racoviță, Călin Tudor Hozan
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