Geriatrics最新文献

{"title":"Development of the Self-Assessment Self-Disclosure Questionnaire to Examine the Association between Self-Disclosure and Frailty among Community-Dwelling Older Adults in Japan.","authors":"Kazuki Yokoyama, Hikaru Ihira, Yuriko Matsuzaki-Kihara, Atsushi Mizumoto, Hideyuki Tashiro, Kiyotaka Shimada, Kosuke Yama, Ryo Miyajima, Takeshi Sasaki, Naoki Kozuka, Nozomu Ikeda","doi":"10.3390/geriatrics9030067","DOIUrl":"10.3390/geriatrics9030067","url":null,"abstract":"<p><p>Self-disclosure is the attitude of communicating one's experiences and condition to others and is an indicator of mental health and an open personality. Frailty, characterized by reduced physical and psychological resistance, predicts the incidence of dependency and mortality. Although low self-disclosure may be associated with frailty, there is no scale to measure older adults' self-disclosure. This cross-sectional study assessed the validity of a self-assessment self-disclosure questionnaire and examined the association between the content of self-disclosures to friends and acquaintances and frailty among community-dwelling older adults. A total of 237 adults aged ≥65 in Japan were surveyed using a mailed self-administered questionnaire in 2021. The self-disclosure scale consisted of 10 items and showed adequate validity. Participants were classified into a robust group (<i>n</i> = 117, women 57.3%) and a frailty group (<i>n</i> = 120, women 73.3%) using the Kihon Checklist. After adjusting for covariates, multivariate-adjusted logistic regression models revealed frailty was associated with lower self-disclosure of recent positive events, motivation and strengths (indicating strong points) in life, relationships with family and relatives, experiences of work and social activities, and financial status. The proposed questionnaire must still be further tested in other populations, but our initial results may contribute to preventing frailty and improving mental health among community-dwelling older adults.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202530/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between Subjective Grip Strength and Physical Functioning among Community-Dwelling Older Women.","authors":"Kohei Iwamoto, Yuki Kikuchi, Hideki Nakano, Tsuyoshi Katsurasako, Kohei Mori, Kayoko Shiraiwa, Jun Horie, Shin Murata","doi":"10.3390/geriatrics9030068","DOIUrl":"10.3390/geriatrics9030068","url":null,"abstract":"<p><p>This study investigated the relationship between subjective grip strength and physical function in community-dwelling older women. Subjective grip strength was assessed using a questionnaire, and physical function and body composition were compared between groups with strong and weak subjective grip strength. Additionally, the two groups were compared in those with mild cognitive impairment (MCI) and those with normal cognitive function, respectively. The results showed significant differences in grip strength (<i>p</i> < 0.001), 30 s chair-stand (CS-30) test (<i>p</i> = 0.039), timed up-and-go (TUG) test (<i>p</i> = 0.027), maximal gait speed (<i>p</i> = 0.029), and skeletal muscle mass (<i>p</i> < 0.001). Older adults with normal cognitive function showed significant differences in grip strength (<i>p</i> < 0.001), quadriceps muscle strength (<i>p</i> < 0.009), one-leg standing time (<i>p</i> = 0.041), CS-30 (<i>p</i> = 0.002), TUG (<i>p</i> = 0.014), gait speed (<i>p</i> = 0.006), and skeletal muscle mass (<i>p</i> = 0.003). Older adults with low subjective grip strength had lower physical function and skeletal muscle mass. However, no items showed significant differences between groups among older adults with MCI. Thus, subjective grip strength is an indicator of an overall decline in physical function and a reduction in skeletal muscle mass in older adults, and cognitive function should be considered when assessing subjective grip strength in older adults.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 3","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11202590/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141450307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Assessment of Physical Activity and Risk Factors in People Living with Dementia: Findings from a Cross-Sectional Study in a Long-Term Care Facility in Vietnam.","authors":"Khanh Nam Do, Linh Thao Thi Le, Son Cong Dang, Ha Thu Thi Nguyen, Giang Thu Nguyen, Hang Van Thi Ngo, Huong Lan Thi Nguyen, Lieu Thu Thi Nguyen, Anh Kim Dang, Huong Thi Le","doi":"10.3390/geriatrics9030057","DOIUrl":"10.3390/geriatrics9030057","url":null,"abstract":"<p><strong>Background: </strong>People living with dementia (PLWD) may experience substantial cognitive decline as the disease progresses, which interferes with their daily activities. This study aimed to assess physical activity (PA) performance and care dependency (CD) and identify factors related to PA among PLWD.</p><p><strong>Methods: </strong>We conducted a cross-sectional study in 63 PLWD from National Geriatrics Hospital, Vietnam, from 2021 to 2023. We used the Mini Nutritional Assessment (MNA), International Physical Activity Questionnaire (IPAQ), and Care Dependency Scale (CDS) to assess the nutritional status and the levels of PA and CD, respectively. We used the Mann-Whitney test to compare the differences in the PA types and CD levels between dementia levels and a multivariable logistics regression model to analyze factors related to PA.</p><p><strong>Results: </strong>More than half of the subjects had mild dementia. In total, 35% of the PLWD had a low level of PA, and 46.3% were completely independent of care. The mean score in each CDS aspect of the subjects with moderate/severe dementia was statistically significantly lower than that of those with mild dementia (<i>p</i> ≤ 0.05). Lower dependency (OR = 0.9; 95% CI = 0.88-0.99) and malnutrition (OR = 15.4; 95% CI = 1.18-20.21) were associated with insufficient PA in the PLWD.</p><p><strong>Conclusion: </strong>Formal caregivers and healthcare workers should encourage PLWD to perform physical activities at any level and personalize the development of tailored and nutritional care strategies for each individual.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Effects of Combining Weight and Elastic Resistance Exercise on Vascular Function in Older Adults.","authors":"Kampanart Paditsaeree, Witid Mitranun","doi":"10.3390/geriatrics9030056","DOIUrl":"10.3390/geriatrics9030056","url":null,"abstract":"<p><p>Prior research has suggested that resistance exercise may result in a temporary decrease in vascular function, as measured by flow-mediated dilation (FMD), among untrained young individuals. However, the immediate impact of combined elastic and weight resistance training on older adults remains insufficiently explored. We assessed vascular function before, after, and 30 min after acute exercise under three resistance conditions to evaluate whether a combination of weight and elastic resistance exercises has an acute effect on vascular function in older adults. Fourteen older adults (65.6 ± 2.9 years) executed three sets of 12 repetitions at 65% of one repetition maximum (1 RM) of the bench press (BP) exercise. Testing was performed on three separate days as follows: (1) barbell alone (BA); (2) barbell plus elastic bands (10% of 65% 1 RM) (BE10); and (3) barbell plus elastic bands (20% of 65% 1 RM) (BE20). A two-way (time × condition) repeated measures analysis of variance was employed to assess the time and condition effects on flow-mediated dilation (FMD) and pulse wave velocity (PWV). At 0 min post-exercise, FMD was significantly higher during BE10 than during BA (<i>p</i> < 0.05); however, at 30 min post-exercise, no significant difference (<i>p</i> ≥ 0.05) was observed between the three conditions. In each condition, FMD results did not differ significantly at different times (<i>p</i> ≥ 0.05). For FMD, the main effect of the condition (F[2,26] = 3.86, <i>p</i> = 0.034) and that of the time and condition (F[4,52] = 3.66, <i>p</i> = 0.011) were significant. For PWV, only the difference between the BA and BE10 conditions was significant at 0 min (<i>p</i> < 0.05). PWV increased from baseline in the BA condition (<i>p</i> < 0.05) but not significantly in the BE10 and BE20 conditions (<i>p</i> ≥ 0.05). Therefore, BA, BE10, and BE20 demonstrated various changes in vascular function. Long-term training intervention studies are needed to validate these findings.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 3","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11130816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141157570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement in the Postural Assessment of Older Adults by Physical Therapists Using Clinical and Imaging Methods.","authors":"Naoki Sugiyama, Yoshihiro Kai, Hitoshi Koda, Toru Morihara, Noriyuki Kida","doi":"10.3390/geriatrics9020040","DOIUrl":"10.3390/geriatrics9020040","url":null,"abstract":"<p><p>Postural assessment is one of the indicators of health status in older adults. Since the number of older adults is on the rise, it is essential to assess simpler methods and automated ones in the future. Therefore, we focused on a visual method (imaging method). The purpose of this study is to determine the degree of agreement between the imaging method and the palpation and visual methods (clinical method). In addition, the influence of differences in the information content of the sagittal plane images on the assessment was also investigated. In this experiment, 28 sagittal photographs of older adults whose posture had already been assessed using the clinical method were used. Furthermore, based on these photographs, 28 gray and silhouette images (G and S images) were generated, respectively. The G and S images were assessed by 28 physical therapists (PTs) using the imaging method. The assessment was based on the Kendall classification, with one of four categories selected for each image: ideal, kyphosis lordosis, sway back, and flat back. Cross-tabulation matrices of the assessments using the clinical method and imaging method were created. In this table, four categories and two categories of ideal and non-ideal (KL, SB, and FB) were created. The agreement was evaluated using the prevalence-adjusted bias-adjusted kappa (PABAK). In addition, sensitivity and specificity were calculated to confirm the reliability. When comparing the clinical and imaging methods in the four posture categories, the PABAK values were -0.14 and -0.29 for the S and G images, respectively. In the case of the two categories, the PABAK values were 0.57 and 0.5 for the S and G images, respectively. The sensitivity and specificity were 86% and 57% for the S images and 76% and 71% for the G images, respectively. The four categories show that the imaging method is difficult to assess regardless of the image processing. However, in the case of the two categories, the same assessment of the clinical method applied to the imaging method for both the S and G images. Therefore, no differences in image processing were observed, suggesting that PTs can identify posture using the visual method.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Proposal for a Multidisciplinary Integrated Oral Health Network for Patients Undergoing Major Orthopaedic Surgery (IOHN-OS).","authors":"Matteo Briguglio, Thomas W Wainwright, Marialetizia Latella, Aurora Ninfa, Claudio Cordani, Cecilia Colombo, Giuseppe Banfi, Luca Francetti, Stefano Corbella","doi":"10.3390/geriatrics9020039","DOIUrl":"10.3390/geriatrics9020039","url":null,"abstract":"<p><p>The passing of the years of life physiologically leads to the accumulation of changes in tissues in the oral cavity, influencing dentition, chewing and swallowing mechanisms, and the oral microbiota. Some diseases and medications can aggravate oral symptoms and negatively influence eating behaviours, increasing the likelihood of becoming malnourished. This could make older individuals more vulnerable to complications when undergoing major orthopaedic surgery. Hidden infection foci in the oral cavity are a recognised cause of post-operative periprosthetic joint infections. Dysfunctional oral problems might also compromise feeding after surgery when good nutrition represents a fundamental aspect of a proper recovery. To manage these shortcomings, in this article, the authors hypothesise a multidisciplinary path of care named the Integrated Oral Health Network applied to major Orthopaedic Surgery (IOHN-OS). This peri-operative initiative would include pre-operative oral health screening and risk management by a dental team, patient education programmes before and after surgery, and bedside gerodontology actions like oral care and meal and eating support for fragile individuals. The IOHN-OS has the potential to reshape the concept of suitability for major orthopaedic surgery and generate momentum for designing community-based surveillance programmes that can keep the mouths of older subjects healthy for a long time.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 2","pages":""},"PeriodicalIF":2.1,"publicationDate":"2024-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hope Mediates Stress to Reduce Burden in Family Caregivers of Persons with Alzheimer's Disease.","authors":"Jocelyn Shealy McGee, Edward C Polson, Dennis R Myers, Angela McClellan, Rebecca Meraz, Weiming Ke, Holly Carlson Zhao","doi":"10.3390/geriatrics9020038","DOIUrl":"10.3390/geriatrics9020038","url":null,"abstract":"<p><p>The experience of burden among family caregivers of persons with Alzheimer's disease and other forms of dementia may be deleterious for their health and well-being. Little is known, however, about the degree to which internal positive psychological resources, such as hope, influence burden perceptions in this population. The current study is novel in that it examined how multiple dimensions of hope, hope-agency and hope-pathway, influenced burden in a sample of one-hundred and fifty-five family caregivers of persons with Alzheimer's disease. The stress process model was used as the theoretical framework for variable specification in this study. Hope was conceptualized using Snyder and colleagues' hope theory. Supporting our first hypothesis, we found that burden was negatively associated with hope-agency, r = -0.33, <i>p</i> < 0.001 and hope-pathway, r = -0.24, <i>p</i> < 0.01. Multiple regression was used to determine if hope-agency and hope-pathway independently contributed to burden. Analysis revealed that hope-agency but not hope-pathway influenced burden when other key variables were taken into consideration. Findings from mediation analysis affirmed that hope-agency had a small but significant mediation effect between stress and burden in this sample. This study provides evidence for the relevance of assessing multiple dimensions of hope when working with caregivers of persons with Alzheimer's. Although replication studies are warranted, the current study confirms a need for further development and refinement of hope-bolstering behavioral interventions which may mediate stress and burden in this population. These interventions should be systematically assessed for efficacy and effectiveness via implementation studies in real-world settings.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurocognitive Effects of an Online Brain Health Program and Weekly Telehealth Support Group in Older Adults with Subjective Memory Loss: A Pilot Study.","authors":"Ryan M Glatt, Amylee Amos, David A Merrill, John F Hodes, Claudia L Wong, Karen J Miller, Prabha Siddarth","doi":"10.3390/geriatrics9020037","DOIUrl":"10.3390/geriatrics9020037","url":null,"abstract":"<p><strong>Introduction: </strong>Adopting healthy lifestyle behaviors has the potential to slow cognitive decline in older adults by reducing risks associated with dementia. Curriculum-based group health coaching may aid in establishing behavior change centered for dementia risk factors.</p><p><strong>Methods: </strong>In this pilot clinical care patient group study (<i>n</i> = 6), we examined the effects of a six-month online Cognitive Health Program combined with a weekly telehealth support group led by the course creator, and personalized health optimization by a collaborating physician, in older adults with subjective cognitive decline. Cognition was assessed at baseline and post-intervention using a computerized battery.</p><p><strong>Results: </strong>Cognitive changes were estimated with nonparametric tests and effect sizes (Cohen's d). Results showed significant improvements in global cognition (<i>p</i> < 0.03, d = 1.6), spatial planning (<i>p</i> < 0.01, d = 2.3), and visuospatial processing (<i>p</i> < 0.05, d = 1.1) compared to baseline. Participants reported high levels of satisfaction with the virtual group format and online curriculum.</p><p><strong>Conclusions: </strong>This small pilot study suggests that a virtual six-month personalized health coaching group with self-paced online health education is feasible and potentially efficacious for improving cognition in participants with subjective cognitive complaints. This format may facilitate behavior change to slow cognitive decline. Future studies should include a control group, a larger, more diverse sample as well as assessing mood and other subjective measures.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moderating Effect of Muscular Strength in the Association between Cardiovascular Events and Depressive Symptoms in Middle-Aged and Older Adults-A Cross Sectional Study.","authors":"Diogo Veiga, Miguel Peralta, Élvio R Gouveia, Marcelo de Maio Nascimento, Laura Carvalho, Jorge Encantado, Adilson Marques","doi":"10.3390/geriatrics9020036","DOIUrl":"10.3390/geriatrics9020036","url":null,"abstract":"<p><strong>Background: </strong>Depression and cardiovascular diseases are two main health conditions contributing to the global disease burden. Several studies indicate a reciprocal association between them. It is still unclear how changes in overall muscle strength may impact this association. This study aimed to analyse how muscular strength moderates the relationship between cardiovascular events and depressive symptoms among middle-aged and older adults.</p><p><strong>Methods: </strong>Wave 8 of the population-based Survey of Health, Ageing, and Retirement in Europe (2019/2020) cross-sectional data, which included 41,666 participants (17,986 men) with a mean age of 70.65 (9.1) years old, was examined. Grip strength was measured twice on each hand using a dynamometer. The 12-item EURO-D scale was employed to gauge depressive symptoms.</p><p><strong>Results: </strong>Grip strength negatively moderates the link between cardiovascular events and depressive symptoms (male: B = -0.03, 95% CI = -0.04, -0.03; female: B = -0.06, 95% CI = -0.06, -0.05). Additionally, the grip strength moderation values in the significant zone for males and females were less than 63.2 kg and 48.3 kg, respectively.</p><p><strong>Conclusions: </strong>Muscular strength modifies depressive symptoms and lessens their correlation with cardiovascular diseases. Muscle-strengthening activities could be incorporated into primary and secondary preventive strategies to reduce the burden of depression in people with CVD.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Ophiocephalus striatus</i> Extract Supplementation Decreases Serum IL-6 Levels in Older People with Sarcopenia-A Single-Center Experience.","authors":"Nur Riviati, Legiran Legiran, Irsan Saleh, Taufik Indrajaya, Zulkhair Ali, Irfannuddin, Probosuseno","doi":"10.3390/geriatrics9020035","DOIUrl":"10.3390/geriatrics9020035","url":null,"abstract":"<p><p>Sarcopenia, a condition characterized by muscle loss and decreased function in older adults, is a growing public health concern. This study aimed to investigate the effects of <i>Ophiocephalus striatus</i> extract on insulin-like growth factor-1 serum, interleukin-6 serum levels, and sarcopenia-related parameters in older adults with sarcopenia. This double-blind randomized controlled trial included 80 older adults with sarcopenia. Participants were randomly assigned to receive <i>Ophiocephalus striatus</i> extract or a placebo for two weeks. The IGF-1 serum and IL-6 serum levels were assessed as primary outcomes. The <i>Ophiocephalus striatus</i> extract intervention resulted in a significant reduction in serum IL-6 levels. Although the IGF-1 levels did not show significant changes, there was an increase for the intervention group. This study demonstrated that a 2-week intervention with Ophiocephalus striatus extract positively impacted the serum IL-6 levels in older adults with sarcopenia. While the IGF-1 levels did not change significantly in this short intervention period, the observed improvements in IGF-1, calf circumference, muscle mass, and muscle strength are promising. The findings suggest that Ophiocephalus striatus extract may offer a valuable intervention for managing sarcopenia, particularly in regions with abundant Ophiocephalus striatus production, such as South Sumatera. This study was registered with trial number NCT05869383.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"9 2","pages":""},"PeriodicalIF":2.3,"publicationDate":"2024-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10961775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140206617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}