Geriatrics最新文献

{"title":"Personalised Prevention of Falls in Persons with Dementia-A Registry-Based Study.","authors":"Per G Farup, Knut Hestad, Knut Engedal","doi":"10.3390/geriatrics10040106","DOIUrl":"10.3390/geriatrics10040106","url":null,"abstract":"<p><strong>Background/objectives: </strong>Multifactorial prevention of falls in persons with dementia has minimal or non-significant effects. Personalised prevention is recommended. We have previously shown that gait speed, basic activities of daily living (ADL), and depression (high Cornell scores) were independent predictors of falls in persons with mild and moderate cognitive impairment. This study explored person-specific risks of falls related to physical, mental, and cognitive functions and types of dementia: Alzheimer's disease (AD), vascular dementia (VD), mixed Alzheimer's disease/vascular dementia (MixADVD), frontotemporal dementia (FTD), and dementia with Lewy bodies (DLB).</p><p><strong>Methods: </strong>The study used data from \"The Norwegian Registry of Persons Assessed for Cognitive Symptoms\" (NorCog). Differences between the dementia groups and predictors of falls, gait speed, ADL, and Cornell scores were analysed.</p><p><strong>Results: </strong>Among study participants, 537/1321 (40.7%) reported a fall in the past year, with significant variations between dementia diagnoses. Fall incidence increased with age, comorbidity/polypharmacy, depression, and MAYO fluctuation score and with reduced physical activity, gait speed, and ADL. Persons with VD and MixADVD had high fall incidences and impaired gait speed and ADL. Training of physical fitness, endurance, muscular strength, coordination, and balance and optimising treatment of comorbidities and medication enhance gait speed. Improving ADL necessitates, in addition, relief of cognitive impairment and fluctuations. Relief of depression and fluctuations by psychological and pharmacological interventions is necessary to reduce the high fall risk in persons with DLB.</p><p><strong>Conclusions: </strong>The fall incidence and fall predictors varied significantly. Personalised interventions presuppose knowledge of each individual's fall risk factors.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385412/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiorenal Syndrome in the Elderly: Challenges and Considerations.","authors":"Matthew Jarocki, Sophie Green, Henry H L Wu, Rajkumar Chinnadurai","doi":"10.3390/geriatrics10040104","DOIUrl":"10.3390/geriatrics10040104","url":null,"abstract":"<p><p>Cardiorenal syndrome (CRS) is a term used to describe the combined dysfunction of the heart and kidneys. This complex disorder is widely acknowledged to be challenging in both its diagnosis and management, and this is the case particularly in the elderly population, due to multi-morbidity, polypharmacy, and age-related physiological changes. Given advancements in medicine and more prolonged cumulative exposure to risk factors in the elderly population, it is likely that the prevalence of chronic kidney disease (CKD) and heart failure (HF) will continue to rise going forward. Hence, understanding the mechanisms involved in the development of CRS is paramount. There are five different CRS types-they are categorised depending on the primary organ involved the acuity of disease. The pathophysiological process behind CRS is complex, involving the interplay of many processes including hemodynamic changes, neurohormonal activation, inflammation, oxidative stress, and endothelial dysfunction and vascular stiffness. The numerous diagnostic and management challenges associated with CRS are significantly further exacerbated in an elderly population. Biomarkers used to aid the diagnosis of CRS, such as serum creatinine and brain natriuretic peptide (BNP), can be challenging to interpret in the elderly population due to age-related renal senescence and multiple comorbidities. Polypharmacy can contribute to the development of CRS and therefore, before initiating treatment, coordinating a patient-centred, multi-speciality, holistic review to assess potential risks versus benefits of prescribed treatments is crucial. The overall prognosis of CRS in the elderly remains poor. Treatments are primarily directed at addressing the sequelae of the underlying aetiology, which often involves the removal of fluid through diuretics or ultrafiltration. Careful considerations when managing elderly patients with CRS is essential due to the high prevalence of frailty and functional decline. As such, in these patients, early discussions around advance care planning should be prioritised.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waist-Calf Circumference Ratio Is Associated with Body Composition, Physical Performance, and Muscle Strength in Older Women.","authors":"Cecilia Arteaga-Pazmiño, Alma L Guzmán-Gurrola, Diana Fonseca-Pérez, Javier Galvez-Celi, Danielle Francesca Aycart, Ludwig Álvarez-Córdova, Evelyn Frias-Toral","doi":"10.3390/geriatrics10040103","DOIUrl":"10.3390/geriatrics10040103","url":null,"abstract":"<p><p><b>Background:</b> The waist-calf circumference ratio (WCR) is an index that combines waist and calf circumference measurements, offering a potentially effective method for evaluating the imbalance between abdominal fat and leg muscle mass in older adults. <b>Objective:</b> To assess the association between WCR and indicators of body composition, muscle strength, and physical performance in community-dwelling older women. <b>Methods:</b> This was a cross-sectional study involving 133 older women (≥65 years) from an urban-marginal community in Guayaquil, Ecuador. The WCR was categorized into quartiles (Q1: 2.07-2.57; Q2: 2.58-2.75; Q3: 2.76-3.05; Q4: 3.06-4.76). Body indicators included fat-free mass (FFM), skeletal muscle mass (SMM), appendicular muscle mass (ASM), appendicular muscle mass index (ASMI), visceral fat (VF), fat mass (FM), and fat mass index (FMI). Handgrip strength (HGS) and the Short Physical Performance Battery test (SPPB) score were used to assess muscle strength and function, respectively. <b>Results:</b> The median age of the participants was 75 [IQR: 65-82] years. The mean WCR was 2.92 ± 0.93. Statistically significant associations were found between WCR and VF (<i>p</i> < 0.001), WCR and SMM (<i>p</i> = 0.039), and WCR and ASM (<i>p</i> = 0.016). Regarding muscle function, WCR was associated with HGS (<i>p</i> = 0.025) and SPPB score (<i>p</i> = 0.029). <b>Conclusions:</b> A significant association was observed between WCR and body composition, and muscle strength and function in older women.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treated but Uncontrolled: Characterizing Hypertension in a Sample of 357 Older Adults in the Southeastern United States.","authors":"Rachel Helms, Laura A Robinson, Paul S Fiore, Kelly P Strickland, Sarah O Watts, Felicia J Tuggle, Jennifer L Slay, Jeanna Sewell, Andrew D Frugé","doi":"10.3390/geriatrics10040101","DOIUrl":"10.3390/geriatrics10040101","url":null,"abstract":"<p><p><b>Background/Objectives</b>: Hypertension (HTN) continues to be a leading cause of death and disability in older adults, especially in the southeastern United States. A cross-sectional study was conducted to evaluate the relationships among measured, diagnosed, and treated (HTN) in community-dwelling adults participating in student-led health screenings in eastern Alabama. <b>Methods</b>: Between 2017 and 2019, students from health-related disciplines facilitated screenings at 23 community and independent living sites to conduct health assessments, including measuring blood pressure (BP), obtaining medical history, and evaluating current prescriptions. Statistical analyses including chi-square tests, <i>t</i>-tests, and backward stepwise linear regression were performed. <b>Results</b>: The current sample includes data from 357 adults aged 60 to 99 years (mean age 74.6 ± 8.7), who were 70.9% females, 60.8% identifying as Black/African American (BA), and 36.8% residing in rural areas. The majority of clients had a prior HTN diagnosis (71.1%) and/or currently measured HTN (78.7%). Forty-three percent of adults screened had measured, diagnosed, and pharmaceutically treated HTN, while 31% had measured but untreated HTN. Black clients had higher measured systolic and diastolic BP and were more likely to also have been diagnosed with HTN (<i>p</i> < 0.05 for all). Linear regression indicated that lower systolic BP was predicted by not living alone (<i>p</i> = 0.003), White race (<i>p</i> = 0.004), and previous HTN diagnosis (<i>p</i> = 0.012), while female gender (<i>p</i> = 0.079) and decreasing body mass index (<i>p</i> = 0.053) had marginal predictive value. <b>Conclusions</b>: These results indicate that awareness and screening of HTN in this population are noteworthy, though management of the disease through ongoing screening and referrals is essential to reduce disparities.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385921/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beat-to-Beat Blood Pressure Monitoring and Orthostatic Hypotension-Related Falls in Two Cohorts of Older Adults.","authors":"Liping Wang, Eveline P van Poelgeest, Marjolein Klop, Jurgen A H R Claassen, Alfons G Hoekstra, Nathalie van der Velde","doi":"10.3390/geriatrics10040102","DOIUrl":"10.3390/geriatrics10040102","url":null,"abstract":"<p><p><b>Background:</b> Falls are a major public health issue among older adults, often related to postural or orthostatic hypotension (OH). The optimal timing and methods for measuring blood pressure (BP) to assess OH and its relationship with falls are uncertain. <b>Methods:</b> We analyzed data from two older cohorts: the PROHEALTH study (<i>n</i> = 30, aged ≥ 65 years) and the NILVAD-CBF trial (<i>n</i> = 58, aged ≥ 50 years). Continuous beat-to-beat BP was measured during active stand tests. We assessed orthostatic BP responses during sit-to-stand and supine-to-stand maneuvers and calculated the associations between orthostatic BP response variables and falls. <b>Results:</b> In the PROHEALTH cohort, participants with a history of falls exhibited a significantly lower baseline BP (115 ± 13/68 ± 10 vs. 142 ± 21/79 ± 11 mmHg; <i>p</i> = 0.004/0.018) and lower systolic BP (SBP) nadir (90 ± 22 vs. 112 ± 25 mmHg; <i>p</i> = 0.043) than non-fallers. SBP recovery within three minutes post-stand was delayed in fallers but rapid in non-fallers. A lower resting BP was associated with fall risk, and a lower BP nadir within 10 s after standing showed a trend toward a higher fall risk. No significant associations were found in the NILVAD-CBF cohort (prospective falls). <b>Conclusions:</b> Our findings demonstrate that a lower resting SBP and diastolic BP (DBP) are associated with an increased fall risk in older adults, with a lower SBP and DBP nadir after standing also showing a potential association. Persistent OH or delayed BP recovery is identified as a potentially relevant fall risk factor. The supine-to-stand test was more sensitive in detecting OH than the sit-to-stand test. Continuous BP monitoring provides the advantage of detecting pathophysiologic orthostatic BP responses for fall risk assessment in older adults. Further research with larger cohorts is warranted to validate our findings.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diet Therapy and Probiotics to Improve Sleep Apnea Risk and Quality of Life in Older Adults (>60 Years) with Metabolic Syndrome: A Study from Romania.","authors":"Amina Venter, Amin-Florin El-Kharoubi, Mousa El-Kharoubi, Evelin Claudia Ghitea, Marc Cristian Ghitea, Timea Claudia Ghitea, Ciprian Florian Venter","doi":"10.3390/geriatrics10040100","DOIUrl":"10.3390/geriatrics10040100","url":null,"abstract":"<p><p><b>Background:</b> Metabolic syndrome (MetS) and obstructive sleep apnea (OSA) are prevalent and interrelated conditions in older adults, both contributing to decreased quality of life and increased health risks. Nutritional interventions, including dietary changes and probiotic supplementation, may offer effective non-pharmacological strategies to address these conditions. This study aimed to evaluate the impact of diet therapy alone and in combination with probiotics on quality of life and sleep apnea risk in older adults (>60 years) with MetS. <b>Methods:</b> In this controlled interventional study, 192 older adults with metabolic syndrome were assigned to one of three groups: control, diet therapy alone, or diet therapy plus probiotic supplementation. Participants were evaluated at baseline and after the intervention period using the SF-36 quality of life questionnaire and an apnea risk screening tool. Clinical and metabolic parameters, including BMI, HOMA index, and visceral fat, were also assessed. <b>Results:</b> Significant improvements in SF-36 scores were observed in both intervention groups compared to the control group (<i>p</i> < 0.05) (mean difference = -5.31, <i>p</i> = 0.016), with the diet + probiotics group showing the greatest enhancement. Participants who reduced their apnea risk also reported higher post-intervention SF-36 scores. The intervention led to reductions in visceral fat, inflammatory markers (CRP), and insulin resistance (HOMA index), which were correlated with improved quality of life. <b>Conclusions:</b> Integrated nutritional strategies, especially the combination of diet and probiotics, significantly improve quality of life and reduce apnea risk in older adults with metabolic syndrome. These findings support the use of personalized, non-pharmacological interventions targeting both metabolic health and sleep-related outcomes in geriatric populations.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development and Evaluation of an Immersive Virtual Reality Application for Road Crossing Training in Older Adults.","authors":"Alina Napetschnig, Wolfgang Deiters, Klara Brixius, Michael Bertram, Christoph Vogel","doi":"10.3390/geriatrics10040099","DOIUrl":"10.3390/geriatrics10040099","url":null,"abstract":"<p><p><b>Background/Objectives:</b> Aging is often accompanied by physical and cognitive decline, affecting older adults' mobility. Virtual reality (VR) offers innovative opportunities to safely practice everyday tasks, such as street crossing. This study was designed as a feasibility and pilot study to explore acceptance, usability, and preliminary effects of a VR-based road-crossing intervention for older adults. It investigates the use of virtual reality (VR) as an innovative training tool to support senior citizens in safely navigating everyday challenges such as crossing roads. By providing an immersive environment with realistic traffic scenarios, VR enables participants to practice in a safe and controlled setting, minimizing the risks associated with real-world road traffic. <b>Methods:</b> A VR training application called \"Wegfest\" was developed to facilitate targeted road-crossing practice. The application simulates various scenarios commonly encountered by older adults, such as crossing busy streets or waiting at traffic lights. The study applied a single-group pre-post design. Outcomes included the Timed Up and Go test (TUG), Falls Efficacy Scale-International (FES-I), and Montreal Cognitive Assessment (MoCA). <b>Results:</b> The development process of \"Wegfest\" demonstrates how a highly realistic street environment can be created for VR-based road-crossing training. Significant improvements were found in the Timed Up and Go test (<i>p</i> = 0.002, d = 0.784) and fall-related self-efficacy (FES-I, <i>p</i> = 0.005). No change was observed in cognitive function (MoCA, <i>p</i> = 0.56). Participants reported increased subjective safety (<i>p</i> < 0.001). <b>Discussion:</b> The development of the VR training application \"Wegfest\" highlights the feasibility of creating realistic virtual environments for skill development. By leveraging immersive technology, both physical and cognitive skills required for road-crossing can be effectively trained. The findings suggest that \"Wegfest\" has the potential to enhance the mobility and safety of older adults in road traffic through immersive experiences and targeted training interventions. <b>Conclusions:</b> As an innovative training tool, the VR application not only provides an engaging and enjoyable learning environment but also fosters self-confidence and independence among older adults in traffic settings. Regular training within the virtual world enables senior citizens to continuously refine their skills, ultimately improving their quality of life.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moving as We Age: Effects of Physical Activity Programmes on Older Adults-An Umbrella Review.","authors":"Ruth D Neill, Louise Bradley, Roger O'Sullivan","doi":"10.3390/geriatrics10040098","DOIUrl":"10.3390/geriatrics10040098","url":null,"abstract":"<p><p><b>Background</b>: This paper aims to conduct an umbrella review of the effects of physical activity programmes for older adults (aged 70 and above). <b>Methods</b>: Comprehensive literature searches were conducted in MEDLINE, PubMed, EMBASE, PsychINFO, and Cochrane Library databases for English SRs. Inclusion criteria were systematic reviews that included randomised controlled trials examining physical activity interventions in older adults. The data extracted were participant characteristics, physical activity interventions, and outcomes examined. A synthesis of results was conducted using the PRISMA guidelines, and the quality of the studies was assessed using the Assessment of Multiple Systematic Reviews-2 (AMSTAR-2). <b>Results</b>: Ten systematic reviews on 186 research articles were included. The AMSTAR-2 revealed that 4 out of 10 reviews were of high quality and 1 out of 10 were of moderate quality. The study samples in each systematic review ranged from 6 to 1254 participants. The total overall sample size for the 10 included studies was 22,652 participants. Across the included reviews, there was mixed evidence on whether physical activity interventions could improve outcomes in older adults across various settings. <b>Conclusions</b>: Sample sizes and findings in each included systematic review varied. The findings of this review emphasise the importance of physical activity as a vital component in maintaining and enhancing health, as well as combating poor health as we age. It also highlights the need for a deeper understanding of the specific physical activity requirements for those aged 70 and above. Future systematic reviews may focus on streamlined reporting of dosing of physical activity and specific intervention types, such as group versus single.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12385685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Behavioural Change Interventions for Preventing Periodontal Disease in Older Adults: A Literature Review.","authors":"Stephanie Chu, Chun Hung Chu, Alice Kit Ying Chan","doi":"10.3390/geriatrics10040097","DOIUrl":"10.3390/geriatrics10040097","url":null,"abstract":"<p><p>Periodontal disease is a common and serious oral disease among older adults. As the global older population increases, preventing periodontal disease is vital for healthy ageing. Poor oral hygiene, uncontrolled diabetes, and smoking are key risk factors of periodontal disease. Improving oral hygiene, diabetes management, and quitting smoking are essential health behavioural change interventions to manage periodontal disease. The objective of this study is to review the prevention of periodontal disease among older adults through health behavioural change interventions. Effective strategies to improve oral hygiene include personalised education on proper brushing and interdental cleaning. Educating caregivers is equally important as they supervise care-dependent older adults to maintain oral health. For those with diabetes, physical activity improves glycated haemoglobin levels and clinical periodontal parameters by reducing reactive oxygen species and systemic inflammation. Smoking cessation could be achieved through a multi-faceted approach. Effective smoking cessation combines brief interventions with intensive behavioural/pharmacological support for long-term success, especially in highly dependent individuals. Tailored strategies for older adults, integrated care, and expanded research improve outcomes and health equity in ageing populations. In conclusion, health behavioural change interventions are non-invasive preventive measures that include oral hygiene reinforcement, diabetic management, and smoking cessation. Prioritising these interventions empowers older adults to maintain oral health, reducing disease burden and enhancing overall well-being for healthy ageing.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12386164/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Biological and Genetic Links Between Dementia and Osteoporosis: A Scoping Review.","authors":"Abayomi N Ogunwale, Paul E Schulz, Jude K des Bordes, Florent Elefteriou, Nahid J Rianon","doi":"10.3390/geriatrics10040096","DOIUrl":"10.3390/geriatrics10040096","url":null,"abstract":"<p><strong>Background: </strong>The biological mediators for the epidemiologic overlap between osteoporosis and dementia are unclear. We undertook a scoping review of clinical studies to identify genetic and biological factors linked with these degenerative conditions, exploring the mechanisms and pathways connecting both conditions.</p><p><strong>Methods: </strong>Studies selected (1) involved clinical research investigating genetic factors or biomarkers associated with dementia or osteoporosis, and (2) were published in English in a peer-reviewed journal between July 1993 and March 2025. We searched Medline Ovid, Embase, PsycINFO, the Cochrane Library, the Web of Science databases, Google Scholar, and the reference lists of studies following the guidelines for Preferred Reporting Items for Systematic Reviews and Meta-Analyses for Scoping Reviews (PRISMA-ScR).</p><p><strong>Results: </strong>Twenty-three studies were included in this review. These explored the role of the APOE polymorphism (n = 2) and the APOE4 allele (n = 13), associations between TREM2 mutation and late onset AD (n = 1), and associations between amyloid beta and bone remodeling (n = 1); bone-related biomarkers like DKK1, OPG, and TRAIL as predictors of cognitive change (n = 2); extracellular vesicles as bone-brain communication pathways (1); and the role of dementia-related genes (n = 1), AD-related CSF biomarkers (n = 1), and parathyroid hormone (PTH) (n = 1) in osteoporosis-dementia pathophysiology.</p><p><strong>Conclusions: </strong>Bone-related biomarkers active in the Wnt/β-Catenin pathway (Dkk1 and sclerostin) and the RANKL/RANK/OPG pathway (OPG/TRAIL ratio) present consistent evidence of involvement in AD and osteoporosis development. Reports proposing APOE4 as a causal genetic link for both osteoporosis and AD in women are not corroborated by newer observational studies. The role of Aβ toxicity in osteoporosis development is unverified in a large clinical study.</p>","PeriodicalId":12653,"journal":{"name":"Geriatrics","volume":"10 4","pages":""},"PeriodicalIF":2.1,"publicationDate":"2025-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12333915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144698321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}